OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 55239 |
| Gene name | 2-oxoglutarate and iron dependent oxygenase domain containing 1 |
| Gene symbol | OGFOD1 |
| Synonyms (NCBI Gene) |
TPA1
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| Chromosome | 16 |
| Chromosome location | 16q13 |
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miRNA
miRNA information provided by mirtarbase database.
598
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8N543 | |||||||||||||||
| Protein name | Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog) (uS12 prolyl 3-hydroxylase) | |||||||||||||||
| Protein function | Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. {ECO:0000269|PubMed:20154146, ECO:00002 | |||||||||||||||
| PDB | 4NHX , 4NHY | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 542 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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