UBA6 (ubiquitin like modifier activating enzyme 6)

Gene

• Entrez ID: 55236
• Gene name: Ubiquitin like modifier activating enzyme 6
• Gene symbol: UBA6
• Synonyms (NCBI Gene): E1-L2, MOP-4, UBE1L2
• Chromosome: 4
• Chromosome location: 4q13.2
• Summary: Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023853	hsa-miR-1-3p	Proteomics	18668040
MIRT052594	hsa-let-7a-5p	CLASH	23622248
MIRT049880	hsa-miR-31-5p	CLASH	23622248
MIRT045891	hsa-miR-125b-5p	CLASH	23622248
MIRT040121	hsa-miR-615-3p	CLASH	23622248
MIRT652003	hsa-miR-3667-5p	HITS-CLIP	23824327
MIRT652002	hsa-miR-548ao-3p	HITS-CLIP	23824327
MIRT652001	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT652000	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT651999	hsa-miR-4673	HITS-CLIP	23824327
MIRT651998	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT533389	hsa-miR-660-5p	HITS-CLIP	23824327
MIRT533388	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT651997	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT651996	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT533385	hsa-miR-5591-3p	HITS-CLIP	23824327
MIRT651995	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT651994	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT651993	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT651992	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT651991	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT509677	hsa-miR-1272	PAR-CLIP	20371350
MIRT509676	hsa-miR-5690	PAR-CLIP	20371350
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT509674	hsa-miR-8069	PAR-CLIP	20371350
MIRT509673	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT509672	hsa-miR-4502	PAR-CLIP	20371350
MIRT509677	hsa-miR-1272	PAR-CLIP	20371350
MIRT509676	hsa-miR-5690	PAR-CLIP	20371350
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT509674	hsa-miR-8069	PAR-CLIP	20371350
MIRT509673	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT509672	hsa-miR-4502	PAR-CLIP	20371350
MIRT544850	hsa-miR-5092	PAR-CLIP	21572407
MIRT533389	hsa-miR-660-5p	PAR-CLIP	22012620
MIRT533388	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT533387	hsa-miR-3127-3p	PAR-CLIP	22012620
MIRT533386	hsa-miR-6756-3p	PAR-CLIP	22012620
MIRT533385	hsa-miR-5591-3p	PAR-CLIP	22012620
MIRT533384	hsa-miR-6826-3p	PAR-CLIP	22012620
MIRT533383	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT533382	hsa-miR-3617-3p	PAR-CLIP	22012620
MIRT509677	hsa-miR-1272	PAR-CLIP	22012620
MIRT509676	hsa-miR-5690	PAR-CLIP	22012620
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	22012620
MIRT509674	hsa-miR-8069	PAR-CLIP	22012620
MIRT509673	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT509672	hsa-miR-4502	PAR-CLIP	22012620
MIRT509677	hsa-miR-1272	PAR-CLIP	23446348
MIRT509676	hsa-miR-5690	PAR-CLIP	23446348
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT509674	hsa-miR-8069	PAR-CLIP	23446348
MIRT509673	hsa-miR-187-5p	PAR-CLIP	23446348
MIRT509672	hsa-miR-4502	PAR-CLIP	23446348
MIRT652003	hsa-miR-3667-5p	HITS-CLIP	23824327
MIRT652002	hsa-miR-548ao-3p	HITS-CLIP	23824327
MIRT652001	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT652000	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT651999	hsa-miR-4673	HITS-CLIP	23824327
MIRT651998	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT533389	hsa-miR-660-5p	HITS-CLIP	23824327
MIRT533388	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT651997	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT651996	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT533385	hsa-miR-5591-3p	HITS-CLIP	23824327
MIRT651995	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT651994	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT651993	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT651992	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT651991	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT509677	hsa-miR-1272	PAR-CLIP	20371350
MIRT509676	hsa-miR-5690	PAR-CLIP	20371350
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT509674	hsa-miR-8069	PAR-CLIP	20371350
MIRT509673	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT509672	hsa-miR-4502	PAR-CLIP	20371350
MIRT509677	hsa-miR-1272	PAR-CLIP	20371350
MIRT509676	hsa-miR-5690	PAR-CLIP	20371350
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT509674	hsa-miR-8069	PAR-CLIP	20371350
MIRT509673	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT509672	hsa-miR-4502	PAR-CLIP	20371350
MIRT544850	hsa-miR-5092	PAR-CLIP	21572407
MIRT533389	hsa-miR-660-5p	PAR-CLIP	22012620
MIRT533388	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT533387	hsa-miR-3127-3p	PAR-CLIP	22012620
MIRT533386	hsa-miR-6756-3p	PAR-CLIP	22012620
MIRT533385	hsa-miR-5591-3p	PAR-CLIP	22012620
MIRT533384	hsa-miR-6826-3p	PAR-CLIP	22012620
MIRT533383	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT533382	hsa-miR-3617-3p	PAR-CLIP	22012620
MIRT509677	hsa-miR-1272	PAR-CLIP	22012620
MIRT509676	hsa-miR-5690	PAR-CLIP	22012620
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	22012620
MIRT509674	hsa-miR-8069	PAR-CLIP	22012620
MIRT509673	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT509672	hsa-miR-4502	PAR-CLIP	22012620
MIRT509677	hsa-miR-1272	PAR-CLIP	23446348
MIRT509676	hsa-miR-5690	PAR-CLIP	23446348
MIRT509675	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT509674	hsa-miR-8069	PAR-CLIP	23446348
MIRT509673	hsa-miR-187-5p	PAR-CLIP	23446348
MIRT509672	hsa-miR-4502	PAR-CLIP	23446348
MIRT1466517	hsa-miR-103b	CLIP-seq
MIRT1466518	hsa-miR-1197	CLIP-seq
MIRT1466519	hsa-miR-1224-5p	CLIP-seq
MIRT1466520	hsa-miR-1243	CLIP-seq
MIRT1466521	hsa-miR-1269	CLIP-seq
MIRT1466522	hsa-miR-1269b	CLIP-seq
MIRT1466523	hsa-miR-1273e	CLIP-seq
MIRT1466524	hsa-miR-1279	CLIP-seq
MIRT1466525	hsa-miR-1286	CLIP-seq
MIRT1466526	hsa-miR-1288	CLIP-seq
MIRT1466527	hsa-miR-1299	CLIP-seq
MIRT1466528	hsa-miR-137	CLIP-seq
MIRT1466529	hsa-miR-141	CLIP-seq
MIRT1466530	hsa-miR-145	CLIP-seq
MIRT1466531	hsa-miR-148a	CLIP-seq
MIRT1466532	hsa-miR-148b	CLIP-seq
MIRT1466533	hsa-miR-152	CLIP-seq
MIRT1466534	hsa-miR-153	CLIP-seq
MIRT1466535	hsa-miR-192	CLIP-seq
MIRT1466536	hsa-miR-200a	CLIP-seq
MIRT1466537	hsa-miR-200b	CLIP-seq
MIRT1466538	hsa-miR-200c	CLIP-seq
MIRT1466539	hsa-miR-208a	CLIP-seq
MIRT1466540	hsa-miR-208b	CLIP-seq
MIRT1466541	hsa-miR-215	CLIP-seq
MIRT1466542	hsa-miR-216a	CLIP-seq
MIRT1466543	hsa-miR-2277-3p	CLIP-seq
MIRT1466544	hsa-miR-2467-3p	CLIP-seq
MIRT1466545	hsa-miR-302a	CLIP-seq
MIRT1466546	hsa-miR-302b	CLIP-seq
MIRT1466547	hsa-miR-302c	CLIP-seq
MIRT1466548	hsa-miR-302d	CLIP-seq
MIRT1466549	hsa-miR-302e	CLIP-seq
MIRT1466550	hsa-miR-3074-3p	CLIP-seq
MIRT1466551	hsa-miR-3117-3p	CLIP-seq
MIRT1466552	hsa-miR-3120-3p	CLIP-seq
MIRT1466553	hsa-miR-3124-3p	CLIP-seq
MIRT1466554	hsa-miR-3148	CLIP-seq
MIRT1466555	hsa-miR-3163	CLIP-seq
MIRT1466556	hsa-miR-3200-5p	CLIP-seq
MIRT1466557	hsa-miR-320e	CLIP-seq
MIRT1466558	hsa-miR-329	CLIP-seq
MIRT1466559	hsa-miR-330-3p	CLIP-seq
MIRT1466560	hsa-miR-3545-3p	CLIP-seq
MIRT1466561	hsa-miR-3545-5p	CLIP-seq
MIRT1466562	hsa-miR-3591-3p	CLIP-seq
MIRT1466563	hsa-miR-361-5p	CLIP-seq
MIRT1466564	hsa-miR-3617	CLIP-seq
MIRT1466565	hsa-miR-362-3p	CLIP-seq
MIRT1466566	hsa-miR-362-5p	CLIP-seq
MIRT1466567	hsa-miR-3654	CLIP-seq
MIRT1466568	hsa-miR-3660	CLIP-seq
MIRT1466569	hsa-miR-3682-5p	CLIP-seq
MIRT1466570	hsa-miR-3690	CLIP-seq
MIRT1466571	hsa-miR-369-3p	CLIP-seq
MIRT1466572	hsa-miR-371-5p	CLIP-seq
MIRT1466573	hsa-miR-371b-5p	CLIP-seq
MIRT1466574	hsa-miR-372	CLIP-seq
MIRT1466575	hsa-miR-373	CLIP-seq
MIRT1466576	hsa-miR-374a	CLIP-seq
MIRT1466577	hsa-miR-374b	CLIP-seq
MIRT1466578	hsa-miR-3941	CLIP-seq
MIRT1466579	hsa-miR-3973	CLIP-seq
MIRT1466580	hsa-miR-3977	CLIP-seq
MIRT1466581	hsa-miR-421	CLIP-seq
MIRT1466582	hsa-miR-4254	CLIP-seq
MIRT1466583	hsa-miR-4256	CLIP-seq
MIRT1466584	hsa-miR-4257	CLIP-seq
MIRT1466585	hsa-miR-4261	CLIP-seq
MIRT1466586	hsa-miR-4268	CLIP-seq
MIRT1466587	hsa-miR-4276	CLIP-seq
MIRT1466588	hsa-miR-4282	CLIP-seq
MIRT1466589	hsa-miR-429	CLIP-seq
MIRT1466590	hsa-miR-4427	CLIP-seq
MIRT1466591	hsa-miR-4448	CLIP-seq
MIRT1466592	hsa-miR-4468	CLIP-seq
MIRT1466593	hsa-miR-4474-5p	CLIP-seq
MIRT1466594	hsa-miR-448	CLIP-seq
MIRT1466595	hsa-miR-4496	CLIP-seq
MIRT1466596	hsa-miR-450b-5p	CLIP-seq
MIRT1466597	hsa-miR-451	CLIP-seq
MIRT1466598	hsa-miR-4515	CLIP-seq
MIRT1466599	hsa-miR-4517	CLIP-seq
MIRT1466600	hsa-miR-452	CLIP-seq
MIRT1466601	hsa-miR-4526	CLIP-seq
MIRT1466602	hsa-miR-4539	CLIP-seq
MIRT1466603	hsa-miR-4645-3p	CLIP-seq
MIRT1466604	hsa-miR-4649-3p	CLIP-seq
MIRT1466605	hsa-miR-466	CLIP-seq
MIRT1466606	hsa-miR-4666-5p	CLIP-seq
MIRT1466607	hsa-miR-4672	CLIP-seq
MIRT1466608	hsa-miR-4676-3p	CLIP-seq
MIRT1466609	hsa-miR-4680-3p	CLIP-seq
MIRT1466610	hsa-miR-4686	CLIP-seq
MIRT1466611	hsa-miR-4709-5p	CLIP-seq
MIRT1466612	hsa-miR-4722-5p	CLIP-seq
MIRT1466613	hsa-miR-4740-5p	CLIP-seq
MIRT1466614	hsa-miR-4751	CLIP-seq
MIRT1466615	hsa-miR-4762-3p	CLIP-seq
MIRT1466616	hsa-miR-4762-5p	CLIP-seq
MIRT1466617	hsa-miR-4775	CLIP-seq
MIRT1466618	hsa-miR-4778-3p	CLIP-seq
MIRT1466619	hsa-miR-4782-5p	CLIP-seq
MIRT1466620	hsa-miR-4789-3p	CLIP-seq
MIRT1466621	hsa-miR-485-3p	CLIP-seq
MIRT1466622	hsa-miR-499-5p	CLIP-seq
MIRT1466623	hsa-miR-500b	CLIP-seq
MIRT1466624	hsa-miR-507	CLIP-seq
MIRT1466625	hsa-miR-513c	CLIP-seq
MIRT1466626	hsa-miR-514b-5p	CLIP-seq
MIRT1466627	hsa-miR-516b	CLIP-seq
MIRT1466628	hsa-miR-519a	CLIP-seq
MIRT1466629	hsa-miR-519b-3p	CLIP-seq
MIRT1466630	hsa-miR-519c-3p	CLIP-seq
MIRT1466631	hsa-miR-520a-3p	CLIP-seq
MIRT1466632	hsa-miR-520b	CLIP-seq
MIRT1466633	hsa-miR-520c-3p	CLIP-seq
MIRT1466634	hsa-miR-520d-3p	CLIP-seq
MIRT1466635	hsa-miR-520d-5p	CLIP-seq
MIRT1466636	hsa-miR-520e	CLIP-seq
MIRT1466637	hsa-miR-520g	CLIP-seq
MIRT1466638	hsa-miR-520h	CLIP-seq
MIRT1466639	hsa-miR-524-5p	CLIP-seq
MIRT1466640	hsa-miR-548g	CLIP-seq
MIRT1466641	hsa-miR-548u	CLIP-seq
MIRT1466642	hsa-miR-550b	CLIP-seq
MIRT1466643	hsa-miR-557	CLIP-seq
MIRT1466644	hsa-miR-590-3p	CLIP-seq
MIRT1466645	hsa-miR-603	CLIP-seq
MIRT1466646	hsa-miR-606	CLIP-seq
MIRT1466647	hsa-miR-626	CLIP-seq
MIRT1466648	hsa-miR-641	CLIP-seq
MIRT1466649	hsa-miR-653	CLIP-seq
MIRT1466650	hsa-miR-654-3p	CLIP-seq
MIRT1466651	hsa-miR-656	CLIP-seq
MIRT1466652	hsa-miR-873	CLIP-seq
MIRT1466653	hsa-miR-875-3p	CLIP-seq
MIRT1466654	hsa-miR-889	CLIP-seq
MIRT2140230	hsa-miR-1179	CLIP-seq
MIRT1466518	hsa-miR-1197	CLIP-seq
MIRT1466520	hsa-miR-1243	CLIP-seq
MIRT2140231	hsa-miR-1248	CLIP-seq
MIRT1466524	hsa-miR-1279	CLIP-seq
MIRT2140232	hsa-miR-128	CLIP-seq
MIRT2140233	hsa-miR-1303	CLIP-seq
MIRT2140234	hsa-miR-196a	CLIP-seq
MIRT2140235	hsa-miR-196b	CLIP-seq
MIRT2140236	hsa-miR-204	CLIP-seq
MIRT2140237	hsa-miR-211	CLIP-seq
MIRT2140238	hsa-miR-2110	CLIP-seq
MIRT1466551	hsa-miR-3117-3p	CLIP-seq
MIRT2140239	hsa-miR-3117-5p	CLIP-seq
MIRT2140240	hsa-miR-3144-5p	CLIP-seq
MIRT2140241	hsa-miR-3150a-3p	CLIP-seq
MIRT1466555	hsa-miR-3163	CLIP-seq
MIRT2140242	hsa-miR-3191	CLIP-seq
MIRT2140243	hsa-miR-3201	CLIP-seq
MIRT1466557	hsa-miR-320e	CLIP-seq
MIRT1466559	hsa-miR-330-3p	CLIP-seq
MIRT2140244	hsa-miR-342-3p	CLIP-seq
MIRT2140245	hsa-miR-3614-5p	CLIP-seq
MIRT1466567	hsa-miR-3654	CLIP-seq
MIRT2140246	hsa-miR-3689a-5p	CLIP-seq
MIRT2140247	hsa-miR-3689b	CLIP-seq
MIRT2140248	hsa-miR-3689e	CLIP-seq
MIRT2140249	hsa-miR-3689f	CLIP-seq
MIRT1466570	hsa-miR-3690	CLIP-seq
MIRT1466572	hsa-miR-371-5p	CLIP-seq
MIRT1466573	hsa-miR-371b-5p	CLIP-seq
MIRT2140250	hsa-miR-374c	CLIP-seq
MIRT2140251	hsa-miR-3919	CLIP-seq
MIRT2140252	hsa-miR-3942-3p	CLIP-seq
MIRT2140253	hsa-miR-410	CLIP-seq
MIRT1466582	hsa-miR-4254	CLIP-seq
MIRT2140254	hsa-miR-4260	CLIP-seq
MIRT2140255	hsa-miR-4263	CLIP-seq
MIRT1466588	hsa-miR-4282	CLIP-seq
MIRT2140256	hsa-miR-4287	CLIP-seq
MIRT2140257	hsa-miR-4422	CLIP-seq
MIRT2140258	hsa-miR-4509	CLIP-seq
MIRT2140259	hsa-miR-450b-3p	CLIP-seq
MIRT1466600	hsa-miR-452	CLIP-seq
MIRT2140260	hsa-miR-4652-5p	CLIP-seq
MIRT1466608	hsa-miR-4676-3p	CLIP-seq
MIRT2140261	hsa-miR-4685-3p	CLIP-seq
MIRT2140262	hsa-miR-4744	CLIP-seq
MIRT2140263	hsa-miR-4756-3p	CLIP-seq
MIRT2140264	hsa-miR-4791	CLIP-seq
MIRT2140265	hsa-miR-4799-5p	CLIP-seq
MIRT2140266	hsa-miR-501-3p	CLIP-seq
MIRT2140267	hsa-miR-502-3p	CLIP-seq
MIRT1466625	hsa-miR-513c	CLIP-seq
MIRT1466626	hsa-miR-514b-5p	CLIP-seq
MIRT1466635	hsa-miR-520d-5p	CLIP-seq
MIRT1466639	hsa-miR-524-5p	CLIP-seq
MIRT2140268	hsa-miR-548m	CLIP-seq
MIRT1466641	hsa-miR-548u	CLIP-seq
MIRT2140269	hsa-miR-576-5p	CLIP-seq
MIRT1466647	hsa-miR-626	CLIP-seq
MIRT2140270	hsa-miR-655	CLIP-seq
MIRT1466651	hsa-miR-656	CLIP-seq
MIRT2140271	hsa-miR-769-3p	CLIP-seq
MIRT1466517	hsa-miR-103b	CLIP-seq
MIRT2140230	hsa-miR-1179	CLIP-seq
MIRT2360990	hsa-miR-1231	CLIP-seq
MIRT2140232	hsa-miR-128	CLIP-seq
MIRT2360991	hsa-miR-1323	CLIP-seq
MIRT1466528	hsa-miR-137	CLIP-seq
MIRT1466530	hsa-miR-145	CLIP-seq
MIRT1466531	hsa-miR-148a	CLIP-seq
MIRT1466532	hsa-miR-148b	CLIP-seq
MIRT1466533	hsa-miR-152	CLIP-seq
MIRT2360992	hsa-miR-181a	CLIP-seq
MIRT2360993	hsa-miR-181b	CLIP-seq
MIRT2360994	hsa-miR-181c	CLIP-seq
MIRT2360995	hsa-miR-181d	CLIP-seq
MIRT2360996	hsa-miR-190	CLIP-seq
MIRT2360997	hsa-miR-190b	CLIP-seq
MIRT1466535	hsa-miR-192	CLIP-seq
MIRT2140236	hsa-miR-204	CLIP-seq
MIRT2140237	hsa-miR-211	CLIP-seq
MIRT1466541	hsa-miR-215	CLIP-seq
MIRT1466542	hsa-miR-216a	CLIP-seq
MIRT2360998	hsa-miR-23a	CLIP-seq
MIRT2360999	hsa-miR-23b	CLIP-seq
MIRT2361000	hsa-miR-23c	CLIP-seq
MIRT1466550	hsa-miR-3074-3p	CLIP-seq
MIRT2140239	hsa-miR-3117-5p	CLIP-seq
MIRT1466552	hsa-miR-3120-3p	CLIP-seq
MIRT2361001	hsa-miR-3121-3p	CLIP-seq
MIRT1466553	hsa-miR-3124-3p	CLIP-seq
MIRT2361002	hsa-miR-3153	CLIP-seq
MIRT2361003	hsa-miR-3154	CLIP-seq
MIRT1466555	hsa-miR-3163	CLIP-seq
MIRT2361004	hsa-miR-3189-5p	CLIP-seq
MIRT2140243	hsa-miR-3201	CLIP-seq
MIRT1466559	hsa-miR-330-3p	CLIP-seq
MIRT2140244	hsa-miR-342-3p	CLIP-seq
MIRT1466560	hsa-miR-3545-3p	CLIP-seq
MIRT2140245	hsa-miR-3614-5p	CLIP-seq
MIRT1466563	hsa-miR-361-5p	CLIP-seq
MIRT1466570	hsa-miR-3690	CLIP-seq
MIRT2361005	hsa-miR-3692	CLIP-seq
MIRT1466572	hsa-miR-371-5p	CLIP-seq
MIRT1466573	hsa-miR-371b-5p	CLIP-seq
MIRT1466576	hsa-miR-374a	CLIP-seq
MIRT1466577	hsa-miR-374b	CLIP-seq
MIRT2140250	hsa-miR-374c	CLIP-seq
MIRT2361006	hsa-miR-3910	CLIP-seq
MIRT1466579	hsa-miR-3973	CLIP-seq
MIRT1466581	hsa-miR-421	CLIP-seq
MIRT1466582	hsa-miR-4254	CLIP-seq
MIRT1466583	hsa-miR-4256	CLIP-seq
MIRT1466584	hsa-miR-4257	CLIP-seq
MIRT1466585	hsa-miR-4261	CLIP-seq
MIRT2361007	hsa-miR-4262	CLIP-seq
MIRT1466587	hsa-miR-4276	CLIP-seq
MIRT1466588	hsa-miR-4282	CLIP-seq
MIRT2140256	hsa-miR-4287	CLIP-seq
MIRT2361008	hsa-miR-4288	CLIP-seq
MIRT2361009	hsa-miR-4307	CLIP-seq
MIRT2361010	hsa-miR-4320	CLIP-seq
MIRT2361011	hsa-miR-4420	CLIP-seq
MIRT2361012	hsa-miR-4436b-5p	CLIP-seq
MIRT2361013	hsa-miR-4501	CLIP-seq
MIRT2140259	hsa-miR-450b-3p	CLIP-seq
MIRT1466599	hsa-miR-4517	CLIP-seq
MIRT1466602	hsa-miR-4539	CLIP-seq
MIRT2361014	hsa-miR-4639-3p	CLIP-seq
MIRT1466603	hsa-miR-4645-3p	CLIP-seq
MIRT2361015	hsa-miR-4668-5p	CLIP-seq
MIRT1466607	hsa-miR-4672	CLIP-seq
MIRT2361016	hsa-miR-4682	CLIP-seq
MIRT2361017	hsa-miR-4684-5p	CLIP-seq
MIRT2140261	hsa-miR-4685-3p	CLIP-seq
MIRT2361018	hsa-miR-4698	CLIP-seq
MIRT2361019	hsa-miR-4704-3p	CLIP-seq
MIRT1466611	hsa-miR-4709-5p	CLIP-seq
MIRT2361020	hsa-miR-4731-3p	CLIP-seq
MIRT2140262	hsa-miR-4744	CLIP-seq
MIRT2361021	hsa-miR-4758-3p	CLIP-seq
MIRT2361022	hsa-miR-4760-3p	CLIP-seq
MIRT2140264	hsa-miR-4791	CLIP-seq
MIRT2361023	hsa-miR-4801	CLIP-seq
MIRT2361024	hsa-miR-495	CLIP-seq
MIRT2140266	hsa-miR-501-3p	CLIP-seq
MIRT2140267	hsa-miR-502-3p	CLIP-seq
MIRT1466635	hsa-miR-520d-5p	CLIP-seq
MIRT1466637	hsa-miR-520g	CLIP-seq
MIRT1466638	hsa-miR-520h	CLIP-seq
MIRT1466639	hsa-miR-524-5p	CLIP-seq
MIRT2361025	hsa-miR-548o	CLIP-seq
MIRT1466641	hsa-miR-548u	CLIP-seq
MIRT1466642	hsa-miR-550b	CLIP-seq
MIRT2361026	hsa-miR-582-5p	CLIP-seq
MIRT1466647	hsa-miR-626	CLIP-seq
MIRT2361027	hsa-miR-632	CLIP-seq
MIRT1466650	hsa-miR-654-3p	CLIP-seq
MIRT2140270	hsa-miR-655	CLIP-seq
MIRT2140271	hsa-miR-769-3p	CLIP-seq
MIRT1466654	hsa-miR-889	CLIP-seq
MIRT1466528	hsa-miR-137	CLIP-seq
MIRT1466535	hsa-miR-192	CLIP-seq
MIRT1466541	hsa-miR-215	CLIP-seq
MIRT1466583	hsa-miR-4256	CLIP-seq
MIRT1466586	hsa-miR-4268	CLIP-seq
MIRT1466588	hsa-miR-4282	CLIP-seq
MIRT1466591	hsa-miR-4448	CLIP-seq
MIRT1466599	hsa-miR-4517	CLIP-seq
MIRT1466650	hsa-miR-654-3p	CLIP-seq
MIRT1466654	hsa-miR-889	CLIP-seq
MIRT2462734	hsa-miR-4768-5p	CLIP-seq
MIRT2462735	hsa-miR-561	CLIP-seq
MIRT2462736	hsa-miR-570	CLIP-seq
MIRT1466520	hsa-miR-1243	CLIP-seq
MIRT1466521	hsa-miR-1269	CLIP-seq
MIRT1466522	hsa-miR-1269b	CLIP-seq
MIRT1466524	hsa-miR-1279	CLIP-seq
MIRT1466526	hsa-miR-1288	CLIP-seq
MIRT1466531	hsa-miR-148a	CLIP-seq
MIRT1466532	hsa-miR-148b	CLIP-seq
MIRT1466533	hsa-miR-152	CLIP-seq
MIRT2654537	hsa-miR-186	CLIP-seq
MIRT2360996	hsa-miR-190	CLIP-seq
MIRT2360997	hsa-miR-190b	CLIP-seq
MIRT2140234	hsa-miR-196a	CLIP-seq
MIRT2140235	hsa-miR-196b	CLIP-seq
MIRT1466543	hsa-miR-2277-3p	CLIP-seq
MIRT2654538	hsa-miR-2355-5p	CLIP-seq
MIRT2140239	hsa-miR-3117-5p	CLIP-seq
MIRT2654539	hsa-miR-3133	CLIP-seq
MIRT2361002	hsa-miR-3153	CLIP-seq
MIRT1466555	hsa-miR-3163	CLIP-seq
MIRT2140243	hsa-miR-3201	CLIP-seq
MIRT2654540	hsa-miR-340	CLIP-seq
MIRT2140245	hsa-miR-3614-5p	CLIP-seq
MIRT1466566	hsa-miR-362-5p	CLIP-seq
MIRT1466567	hsa-miR-3654	CLIP-seq
MIRT1466569	hsa-miR-3682-5p	CLIP-seq
MIRT2361005	hsa-miR-3692	CLIP-seq
MIRT1466576	hsa-miR-374a	CLIP-seq
MIRT1466577	hsa-miR-374b	CLIP-seq
MIRT1466587	hsa-miR-4276	CLIP-seq
MIRT1466588	hsa-miR-4282	CLIP-seq
MIRT2654541	hsa-miR-4286	CLIP-seq
MIRT2361009	hsa-miR-4307	CLIP-seq
MIRT2361012	hsa-miR-4436b-5p	CLIP-seq
MIRT2654542	hsa-miR-4446-5p	CLIP-seq
MIRT2361013	hsa-miR-4501	CLIP-seq
MIRT2140259	hsa-miR-450b-3p	CLIP-seq
MIRT1466598	hsa-miR-4515	CLIP-seq
MIRT1466603	hsa-miR-4645-3p	CLIP-seq
MIRT2361015	hsa-miR-4668-5p	CLIP-seq
MIRT1466609	hsa-miR-4680-3p	CLIP-seq
MIRT2361018	hsa-miR-4698	CLIP-seq
MIRT2654543	hsa-miR-4699-3p	CLIP-seq
MIRT2654544	hsa-miR-4709-3p	CLIP-seq
MIRT2654545	hsa-miR-4729	CLIP-seq
MIRT1466613	hsa-miR-4740-5p	CLIP-seq
MIRT2361022	hsa-miR-4760-3p	CLIP-seq
MIRT1466617	hsa-miR-4775	CLIP-seq
MIRT2140264	hsa-miR-4791	CLIP-seq
MIRT2654546	hsa-miR-4793-5p	CLIP-seq
MIRT2140265	hsa-miR-4799-5p	CLIP-seq
MIRT1466623	hsa-miR-500b	CLIP-seq
MIRT2140266	hsa-miR-501-3p	CLIP-seq
MIRT2140267	hsa-miR-502-3p	CLIP-seq
MIRT2654547	hsa-miR-513a-3p	CLIP-seq
MIRT2654548	hsa-miR-548ac	CLIP-seq
MIRT2654549	hsa-miR-548ae	CLIP-seq
MIRT2654550	hsa-miR-548aj	CLIP-seq
MIRT2654551	hsa-miR-548am	CLIP-seq
MIRT2654552	hsa-miR-548d-3p	CLIP-seq
MIRT2654553	hsa-miR-548l	CLIP-seq
MIRT2140268	hsa-miR-548m	CLIP-seq
MIRT2654554	hsa-miR-548n	CLIP-seq
MIRT2654555	hsa-miR-548x	CLIP-seq
MIRT2654556	hsa-miR-548z	CLIP-seq
MIRT1466646	hsa-miR-606	CLIP-seq
MIRT2654557	hsa-miR-607	CLIP-seq
MIRT2140271	hsa-miR-769-3p	CLIP-seq
MIRT2654558	hsa-miR-935	CLIP-seq
MIRT2694567	hsa-miR-1225-5p	CLIP-seq
MIRT1466520	hsa-miR-1243	CLIP-seq
MIRT1466521	hsa-miR-1269	CLIP-seq
MIRT1466522	hsa-miR-1269b	CLIP-seq
MIRT1466524	hsa-miR-1279	CLIP-seq
MIRT1466526	hsa-miR-1288	CLIP-seq
MIRT2654537	hsa-miR-186	CLIP-seq
MIRT2360996	hsa-miR-190	CLIP-seq
MIRT2360997	hsa-miR-190b	CLIP-seq
MIRT2140234	hsa-miR-196a	CLIP-seq
MIRT2140235	hsa-miR-196b	CLIP-seq
MIRT1466543	hsa-miR-2277-3p	CLIP-seq
MIRT2654538	hsa-miR-2355-5p	CLIP-seq
MIRT2140239	hsa-miR-3117-5p	CLIP-seq
MIRT2694568	hsa-miR-3147	CLIP-seq
MIRT2361002	hsa-miR-3153	CLIP-seq
MIRT1466555	hsa-miR-3163	CLIP-seq
MIRT2140243	hsa-miR-3201	CLIP-seq
MIRT2654540	hsa-miR-340	CLIP-seq
MIRT2140245	hsa-miR-3614-5p	CLIP-seq
MIRT1466566	hsa-miR-362-5p	CLIP-seq
MIRT1466567	hsa-miR-3654	CLIP-seq
MIRT1466569	hsa-miR-3682-5p	CLIP-seq
MIRT2361005	hsa-miR-3692	CLIP-seq
MIRT1466588	hsa-miR-4282	CLIP-seq
MIRT2654541	hsa-miR-4286	CLIP-seq
MIRT2361011	hsa-miR-4420	CLIP-seq
MIRT2694569	hsa-miR-4425	CLIP-seq
MIRT2361012	hsa-miR-4436b-5p	CLIP-seq
MIRT2654542	hsa-miR-4446-5p	CLIP-seq
MIRT2361013	hsa-miR-4501	CLIP-seq
MIRT2140259	hsa-miR-450b-3p	CLIP-seq
MIRT1466598	hsa-miR-4515	CLIP-seq
MIRT1466600	hsa-miR-452	CLIP-seq
MIRT1466603	hsa-miR-4645-3p	CLIP-seq
MIRT2361015	hsa-miR-4668-5p	CLIP-seq
MIRT1466608	hsa-miR-4676-3p	CLIP-seq
MIRT1466609	hsa-miR-4680-3p	CLIP-seq
MIRT2361016	hsa-miR-4682	CLIP-seq
MIRT2654543	hsa-miR-4699-3p	CLIP-seq
MIRT2654544	hsa-miR-4709-3p	CLIP-seq
MIRT2654545	hsa-miR-4729	CLIP-seq
MIRT1466613	hsa-miR-4740-5p	CLIP-seq
MIRT2361022	hsa-miR-4760-3p	CLIP-seq
MIRT1466617	hsa-miR-4775	CLIP-seq
MIRT2140264	hsa-miR-4791	CLIP-seq
MIRT2654546	hsa-miR-4793-5p	CLIP-seq
MIRT2140265	hsa-miR-4799-5p	CLIP-seq
MIRT1466621	hsa-miR-485-3p	CLIP-seq
MIRT2694570	hsa-miR-499-3p	CLIP-seq
MIRT2694571	hsa-miR-499a-3p	CLIP-seq
MIRT1466623	hsa-miR-500b	CLIP-seq
MIRT2140266	hsa-miR-501-3p	CLIP-seq
MIRT2140267	hsa-miR-502-3p	CLIP-seq
MIRT2694572	hsa-miR-5096	CLIP-seq
MIRT2654547	hsa-miR-513a-3p	CLIP-seq
MIRT2654548	hsa-miR-548ac	CLIP-seq
MIRT2654549	hsa-miR-548ae	CLIP-seq
MIRT2654550	hsa-miR-548aj	CLIP-seq
MIRT2654551	hsa-miR-548am	CLIP-seq
MIRT2654552	hsa-miR-548d-3p	CLIP-seq
MIRT2654553	hsa-miR-548l	CLIP-seq
MIRT2140268	hsa-miR-548m	CLIP-seq
MIRT2654554	hsa-miR-548n	CLIP-seq
MIRT2654555	hsa-miR-548x	CLIP-seq
MIRT2654556	hsa-miR-548z	CLIP-seq
MIRT2361026	hsa-miR-582-5p	CLIP-seq
MIRT1466646	hsa-miR-606	CLIP-seq
MIRT2140271	hsa-miR-769-3p	CLIP-seq
MIRT2654558	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004839	Function	Ubiquitin activating enzyme activity	IBA
GO:0004839	Function	Ubiquitin activating enzyme activity	IEA
GO:0005515	Function	Protein binding	IPI	17889673, 25416956, 25422469
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	17889673
GO:0006974	Process	DNA damage response	IBA
GO:0008641	Function	Ubiquitin-like modifier activating enzyme activity	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	IMP	17889673
GO:0016874	Function	Ligase activity	IEA
GO:0019780	Function	FAT10 activating enzyme activity	IBA
GO:0019780	Function	FAT10 activating enzyme activity	IEA
GO:0019780	Function	FAT10 activating enzyme activity	IMP	17889673
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 611361
• HGNC: 25581
• e!Ensembl: ENSG00000033178

Protein

• UniProt ID: A0AVT1
• Protein name: Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
• Protein function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001
• PDB: 7PVN, 7PYV, 7SOL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00899	ThiF	44 → 435	ThiF family	Domain
  PF16190	E1_FCCH	224 → 293	Ubiquitin-activating enzyme E1 FCCH domain	Domain
  PF16191	E1_4HB	294 → 362	Ubiquitin-activating enzyme E1 four-helix bundle	Domain
  PF00899	ThiF	442 → 948	ThiF family	Domain
  PF10585	UBA_e1_thiolCys	631 → 884	Ubiquitin-activating enzyme active site	Domain
  PF09358	E1_UFD	955 → 1043	Ubiquitin fold domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759}.
• Sequence:

  MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA
  KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE
  AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP
  IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE
  TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE
  SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS
  ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE
  AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA
  LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA
  HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT
  EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW
  QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH
  CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA
  DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS
  DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT
  VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV
  HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK
  YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD

• Sequence length: 1052

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
INTELLECTUAL DISABILITY	—	Disgenet, GenCC Disgenet, GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aneuploidy	Aneuploidy	Pubtator	36576405	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	32127416	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	31060776		★☆☆☆☆ Found in Text Mining only
Behavior Disorders	Behavior Disorders	BEFREE	26284580		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29152096		★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	29152096		★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	Pubtator	36576405	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28376205		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	26284580		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	29152096		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28376205		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	31692446	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	31692446		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34951345	Associate	★☆☆☆☆ Found in Text Mining only