LRRC1 (leucine rich repeat containing 1)

Gene

• Entrez ID: 55227
• Gene name: Leucine rich repeat containing 1
• Gene symbol: LRRC1
• Synonyms (NCBI Gene): LANO, dJ523E19.1
• Chromosome: 6
• Chromosome location: 6p12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002712	hsa-miR-124-3p	Microarray	15685193
MIRT002712	hsa-miR-124-3p	Microarray	18668037
MIRT002712	hsa-miR-124-3p	Microarray	15685193
MIRT030660	hsa-miR-22-3p	Sequencing	20371350
MIRT002712	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT002712	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT361115	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566868	hsa-miR-3714	PAR-CLIP	20371350
MIRT566869	hsa-miR-3910	PAR-CLIP	20371350
MIRT566865	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT566867	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT361120	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT361117	hsa-miR-3681-5p	PAR-CLIP	20371350
MIRT361121	hsa-miR-6849-5p	PAR-CLIP	20371350
MIRT566866	hsa-miR-5579-5p	PAR-CLIP	20371350
MIRT361113	hsa-miR-125b-2-3p	PAR-CLIP	20371350
MIRT361116	hsa-miR-1193	PAR-CLIP	20371350
MIRT361118	hsa-miR-3691-5p	PAR-CLIP	20371350
MIRT566865	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT361114	hsa-miR-432-3p	PAR-CLIP	20371350
MIRT566864	hsa-miR-150-3p	PAR-CLIP	20371350
MIRT445853	hsa-miR-4282	PAR-CLIP	22100165
MIRT445851	hsa-miR-4635	PAR-CLIP	22100165
MIRT445852	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT445850	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT440312	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT440310	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440311	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT440312	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT440310	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440311	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT733765	hsa-miR-193a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	32978367
MIRT002712	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT002712	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT361115	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566868	hsa-miR-3714	PAR-CLIP	20371350
MIRT566869	hsa-miR-3910	PAR-CLIP	20371350
MIRT566865	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT566867	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT361120	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT361117	hsa-miR-3681-5p	PAR-CLIP	20371350
MIRT361121	hsa-miR-6849-5p	PAR-CLIP	20371350
MIRT566866	hsa-miR-5579-5p	PAR-CLIP	20371350
MIRT361113	hsa-miR-125b-2-3p	PAR-CLIP	20371350
MIRT361116	hsa-miR-1193	PAR-CLIP	20371350
MIRT361118	hsa-miR-3691-5p	PAR-CLIP	20371350
MIRT566865	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT361114	hsa-miR-432-3p	PAR-CLIP	20371350
MIRT566864	hsa-miR-150-3p	PAR-CLIP	20371350
MIRT445853	hsa-miR-4282	PAR-CLIP	22100165
MIRT445851	hsa-miR-4635	PAR-CLIP	22100165
MIRT445852	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT445850	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT1118772	hsa-miR-1208	CLIP-seq
MIRT1118773	hsa-miR-124	CLIP-seq
MIRT1118774	hsa-miR-1255a	CLIP-seq
MIRT1118775	hsa-miR-1255b	CLIP-seq
MIRT1118776	hsa-miR-128	CLIP-seq
MIRT1118777	hsa-miR-1323	CLIP-seq
MIRT1118778	hsa-miR-1324	CLIP-seq
MIRT1118779	hsa-miR-134	CLIP-seq
MIRT1118780	hsa-miR-1343	CLIP-seq
MIRT1118781	hsa-miR-141	CLIP-seq
MIRT1118782	hsa-miR-200a	CLIP-seq
MIRT1118783	hsa-miR-22	CLIP-seq
MIRT1118784	hsa-miR-2467-3p	CLIP-seq
MIRT1118785	hsa-miR-2467-5p	CLIP-seq
MIRT1118786	hsa-miR-3118	CLIP-seq
MIRT1118787	hsa-miR-3125	CLIP-seq
MIRT1118788	hsa-miR-3160-3p	CLIP-seq
MIRT1118789	hsa-miR-3161	CLIP-seq
MIRT1118790	hsa-miR-3166	CLIP-seq
MIRT1118791	hsa-miR-3188	CLIP-seq
MIRT1118792	hsa-miR-3192	CLIP-seq
MIRT1118793	hsa-miR-3200-5p	CLIP-seq
MIRT1118794	hsa-miR-329	CLIP-seq
MIRT1118795	hsa-miR-3591-3p	CLIP-seq
MIRT1118796	hsa-miR-3613-3p	CLIP-seq
MIRT1118797	hsa-miR-362-3p	CLIP-seq
MIRT1118798	hsa-miR-3662	CLIP-seq
MIRT1118799	hsa-miR-3685	CLIP-seq
MIRT1118800	hsa-miR-3689d	CLIP-seq
MIRT1118801	hsa-miR-384	CLIP-seq
MIRT1118802	hsa-miR-3916	CLIP-seq
MIRT1118803	hsa-miR-3920	CLIP-seq
MIRT1118804	hsa-miR-3927	CLIP-seq
MIRT1118805	hsa-miR-3975	CLIP-seq
MIRT1118806	hsa-miR-421	CLIP-seq
MIRT1118807	hsa-miR-4303	CLIP-seq
MIRT1118808	hsa-miR-4305	CLIP-seq
MIRT1118809	hsa-miR-4316	CLIP-seq
MIRT1118810	hsa-miR-432	CLIP-seq
MIRT1118811	hsa-miR-4443	CLIP-seq
MIRT1118812	hsa-miR-4487	CLIP-seq
MIRT1118813	hsa-miR-4532	CLIP-seq
MIRT1118814	hsa-miR-4699-3p	CLIP-seq
MIRT1118815	hsa-miR-4709-5p	CLIP-seq
MIRT1118816	hsa-miR-4733-3p	CLIP-seq
MIRT1118817	hsa-miR-4738-3p	CLIP-seq
MIRT1118818	hsa-miR-4760-3p	CLIP-seq
MIRT1118819	hsa-miR-485-5p	CLIP-seq
MIRT1118820	hsa-miR-506	CLIP-seq
MIRT1118821	hsa-miR-548a-3p	CLIP-seq
MIRT1118822	hsa-miR-548ac	CLIP-seq
MIRT1118823	hsa-miR-548ae	CLIP-seq
MIRT1118824	hsa-miR-548aj	CLIP-seq
MIRT1118825	hsa-miR-548am	CLIP-seq
MIRT1118826	hsa-miR-548d-3p	CLIP-seq
MIRT1118827	hsa-miR-548e	CLIP-seq
MIRT1118828	hsa-miR-548f	CLIP-seq
MIRT1118829	hsa-miR-548o	CLIP-seq
MIRT1118830	hsa-miR-548x	CLIP-seq
MIRT1118831	hsa-miR-548z	CLIP-seq
MIRT1118832	hsa-miR-558	CLIP-seq
MIRT1118833	hsa-miR-579	CLIP-seq
MIRT1118834	hsa-miR-590-3p	CLIP-seq
MIRT1118835	hsa-miR-618	CLIP-seq
MIRT1118836	hsa-miR-646	CLIP-seq
MIRT1118837	hsa-miR-659	CLIP-seq
MIRT1118838	hsa-miR-7	CLIP-seq
MIRT1118839	hsa-miR-873	CLIP-seq
MIRT1118840	hsa-miR-890	CLIP-seq
MIRT1118841	hsa-miR-922	CLIP-seq
MIRT1118776	hsa-miR-128	CLIP-seq
MIRT1118779	hsa-miR-134	CLIP-seq
MIRT1118786	hsa-miR-3118	CLIP-seq
MIRT1118776	hsa-miR-128	CLIP-seq
MIRT1118779	hsa-miR-134	CLIP-seq
MIRT1118786	hsa-miR-3118	CLIP-seq
MIRT1118773	hsa-miR-124	CLIP-seq
MIRT1118774	hsa-miR-1255a	CLIP-seq
MIRT1118775	hsa-miR-1255b	CLIP-seq
MIRT1118780	hsa-miR-1343	CLIP-seq
MIRT1118784	hsa-miR-2467-3p	CLIP-seq
MIRT2033581	hsa-miR-3117-5p	CLIP-seq
MIRT1118787	hsa-miR-3125	CLIP-seq
MIRT1118792	hsa-miR-3192	CLIP-seq
MIRT2033582	hsa-miR-3622a-5p	CLIP-seq
MIRT2033583	hsa-miR-3660	CLIP-seq
MIRT1118802	hsa-miR-3916	CLIP-seq
MIRT1118810	hsa-miR-432	CLIP-seq
MIRT2033584	hsa-miR-4423-3p	CLIP-seq
MIRT1118811	hsa-miR-4443	CLIP-seq
MIRT2033585	hsa-miR-4459	CLIP-seq
MIRT2033586	hsa-miR-4526	CLIP-seq
MIRT2033587	hsa-miR-4528	CLIP-seq
MIRT2033588	hsa-miR-4712-3p	CLIP-seq
MIRT2033589	hsa-miR-4753-3p	CLIP-seq
MIRT2033590	hsa-miR-4768-5p	CLIP-seq
MIRT2033591	hsa-miR-4793-3p	CLIP-seq
MIRT1118820	hsa-miR-506	CLIP-seq
MIRT2033592	hsa-miR-520d-5p	CLIP-seq
MIRT2033593	hsa-miR-524-5p	CLIP-seq
MIRT1118821	hsa-miR-548a-3p	CLIP-seq
MIRT1118827	hsa-miR-548e	CLIP-seq
MIRT1118828	hsa-miR-548f	CLIP-seq
MIRT2033594	hsa-miR-556-3p	CLIP-seq
MIRT1118833	hsa-miR-579	CLIP-seq
MIRT2033595	hsa-miR-622	CLIP-seq
MIRT2033596	hsa-miR-630	CLIP-seq
MIRT1118836	hsa-miR-646	CLIP-seq
MIRT1118838	hsa-miR-7	CLIP-seq
MIRT2033597	hsa-miR-759	CLIP-seq
MIRT1118839	hsa-miR-873	CLIP-seq
MIRT1118840	hsa-miR-890	CLIP-seq
MIRT1118841	hsa-miR-922	CLIP-seq
MIRT2264024	hsa-miR-101	CLIP-seq
MIRT1118773	hsa-miR-124	CLIP-seq
MIRT2264025	hsa-miR-1275	CLIP-seq
MIRT1118776	hsa-miR-128	CLIP-seq
MIRT1118778	hsa-miR-1324	CLIP-seq
MIRT1118779	hsa-miR-134	CLIP-seq
MIRT1118781	hsa-miR-141	CLIP-seq
MIRT2264026	hsa-miR-144	CLIP-seq
MIRT2264027	hsa-miR-199a-3p	CLIP-seq
MIRT2264028	hsa-miR-199b-3p	CLIP-seq
MIRT1118782	hsa-miR-200a	CLIP-seq
MIRT1118784	hsa-miR-2467-3p	CLIP-seq
MIRT2033581	hsa-miR-3117-5p	CLIP-seq
MIRT1118786	hsa-miR-3118	CLIP-seq
MIRT1118787	hsa-miR-3125	CLIP-seq
MIRT2264029	hsa-miR-3129-5p	CLIP-seq
MIRT1118798	hsa-miR-3662	CLIP-seq
MIRT2264030	hsa-miR-3675-3p	CLIP-seq
MIRT2264031	hsa-miR-3681	CLIP-seq
MIRT1118799	hsa-miR-3685	CLIP-seq
MIRT1118800	hsa-miR-3689d	CLIP-seq
MIRT1118801	hsa-miR-384	CLIP-seq
MIRT1118802	hsa-miR-3916	CLIP-seq
MIRT1118803	hsa-miR-3920	CLIP-seq
MIRT1118804	hsa-miR-3927	CLIP-seq
MIRT1118808	hsa-miR-4305	CLIP-seq
MIRT1118810	hsa-miR-432	CLIP-seq
MIRT1118811	hsa-miR-4443	CLIP-seq
MIRT2264032	hsa-miR-4450	CLIP-seq
MIRT2033585	hsa-miR-4459	CLIP-seq
MIRT2264033	hsa-miR-4471	CLIP-seq
MIRT2264034	hsa-miR-4525	CLIP-seq
MIRT2033587	hsa-miR-4528	CLIP-seq
MIRT2264035	hsa-miR-4665-5p	CLIP-seq
MIRT2264036	hsa-miR-4698	CLIP-seq
MIRT2033588	hsa-miR-4712-3p	CLIP-seq
MIRT2264037	hsa-miR-4723-5p	CLIP-seq
MIRT1118817	hsa-miR-4738-3p	CLIP-seq
MIRT2033589	hsa-miR-4753-3p	CLIP-seq
MIRT2033590	hsa-miR-4768-5p	CLIP-seq
MIRT2033591	hsa-miR-4793-3p	CLIP-seq
MIRT1118820	hsa-miR-506	CLIP-seq
MIRT2033592	hsa-miR-520d-5p	CLIP-seq
MIRT2033593	hsa-miR-524-5p	CLIP-seq
MIRT1118821	hsa-miR-548a-3p	CLIP-seq
MIRT1118827	hsa-miR-548e	CLIP-seq
MIRT1118828	hsa-miR-548f	CLIP-seq
MIRT1118833	hsa-miR-579	CLIP-seq
MIRT2264038	hsa-miR-625	CLIP-seq
MIRT2264039	hsa-miR-642b	CLIP-seq
MIRT2264040	hsa-miR-652	CLIP-seq
MIRT1118838	hsa-miR-7	CLIP-seq
MIRT1118839	hsa-miR-873	CLIP-seq
MIRT1118840	hsa-miR-890	CLIP-seq
MIRT1118841	hsa-miR-922	CLIP-seq
MIRT2264041	hsa-miR-936	CLIP-seq
MIRT2033587	hsa-miR-4528	CLIP-seq
MIRT2033588	hsa-miR-4712-3p	CLIP-seq
MIRT2033591	hsa-miR-4793-3p	CLIP-seq
MIRT2264024	hsa-miR-101	CLIP-seq
MIRT1118773	hsa-miR-124	CLIP-seq
MIRT2264026	hsa-miR-144	CLIP-seq
MIRT2563169	hsa-miR-3117-3p	CLIP-seq
MIRT2033581	hsa-miR-3117-5p	CLIP-seq
MIRT2563170	hsa-miR-3163	CLIP-seq
MIRT2563171	hsa-miR-3169	CLIP-seq
MIRT2264031	hsa-miR-3681	CLIP-seq
MIRT2033587	hsa-miR-4528	CLIP-seq
MIRT2033588	hsa-miR-4712-3p	CLIP-seq
MIRT2563172	hsa-miR-4759	CLIP-seq
MIRT2033591	hsa-miR-4793-3p	CLIP-seq
MIRT1118820	hsa-miR-506	CLIP-seq
MIRT1118822	hsa-miR-548ac	CLIP-seq
MIRT1118823	hsa-miR-548ae	CLIP-seq
MIRT1118824	hsa-miR-548aj	CLIP-seq
MIRT1118825	hsa-miR-548am	CLIP-seq
MIRT1118826	hsa-miR-548d-3p	CLIP-seq
MIRT2563173	hsa-miR-548t	CLIP-seq
MIRT1118830	hsa-miR-548x	CLIP-seq
MIRT1118831	hsa-miR-548z	CLIP-seq
MIRT2264039	hsa-miR-642b	CLIP-seq
MIRT2563174	hsa-miR-651	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 608195
• HGNC: 14307
• e!Ensembl: ENSG00000137269

Protein

• UniProt ID: Q9BTT6
• Protein name: Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	36 → 94	Leucine rich repeat	Repeat
  PF13855	LRR_8	198 → 255	Leucine rich repeat	Repeat
  PF13855	LRR_8	266 → 324	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed strongly in testis and placenta, followed by heart, lung, kidney, thyroid, trachea, colon, prostate and pancreas. {ECO:0000269|PubMed:11440998}.
• Sequence:

  MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK
  LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL
  PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD
  LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS
  GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ
  LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL
  HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP
  SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETRTLLRRAT
  PHPGELKHMKKTVENLRNDMNAAKGLDSNKNEVNHAIDRVTTSV

• Sequence length: 524

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLOMERULONEPHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	30344009		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32213663, 37505155	Associate	★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	34898474	Associate	★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	32938779	Associate	★☆☆☆☆ Found in Text Mining only
Juvenile Myoclonic Epilepsy	Myoclonic Epilepsy	BEFREE	12200217		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	23645086		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30344009		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30344009		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	34294833	Associate	★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	32172663	Associate	★☆☆☆☆ Found in Text Mining only