RAVER2 (ribonucleoprotein, PTB binding 2)

Gene

• Entrez ID: 55225
• Gene name: Ribonucleoprotein, PTB binding 2
• Gene symbol: RAVER2
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002305	hsa-let-7a-5p	Immunoprecipitaion, Luciferase reporter assay, Western blot	17637574
MIRT002306	hsa-miR-99a-5p	Immunoprecipitaion, Luciferase reporter assay, Western blot	17637574
MIRT002307	hsa-miR-99b-5p	Immunoprecipitaion, Luciferase reporter assay, Western blot	17637574
MIRT001827	hsa-miR-124-3p	Microarray, qRT-PCR	16549876
MIRT001827	hsa-miR-124-3p	qRT-PCR;Other	16549876
MIRT045678	hsa-miR-149-5p	CLASH	23622248
MIRT040013	hsa-miR-615-3p	CLASH	23622248
MIRT534755	hsa-miR-1267	PAR-CLIP	20371350
MIRT534754	hsa-miR-367-5p	PAR-CLIP	20371350
MIRT534753	hsa-miR-3124-3p	PAR-CLIP	20371350
MIRT534752	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT534751	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT534750	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT534749	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT534748	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT534747	hsa-miR-4684-3p	PAR-CLIP	20371350
MIRT534746	hsa-miR-197-3p	PAR-CLIP	20371350
MIRT534745	hsa-miR-548aw	PAR-CLIP	20371350
MIRT534744	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT534743	hsa-miR-527	PAR-CLIP	20371350
MIRT534755	hsa-miR-1267	PAR-CLIP	22012620
MIRT534754	hsa-miR-367-5p	PAR-CLIP	22012620
MIRT534753	hsa-miR-3124-3p	PAR-CLIP	22012620
MIRT534752	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT534751	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT534750	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT534749	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT534748	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT534747	hsa-miR-4684-3p	PAR-CLIP	22012620
MIRT534746	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT534745	hsa-miR-548aw	PAR-CLIP	22012620
MIRT534744	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT534743	hsa-miR-527	PAR-CLIP	22012620
MIRT534748	hsa-miR-1468-3p	PAR-CLIP	27292025
MIRT534746	hsa-miR-197-3p	PAR-CLIP	27292025
MIRT534753	hsa-miR-3124-3p	PAR-CLIP	27292025
MIRT534747	hsa-miR-4684-3p	PAR-CLIP	27292025
MIRT534744	hsa-miR-518a-5p	PAR-CLIP	27292025
MIRT534743	hsa-miR-527	PAR-CLIP	27292025
MIRT534752	hsa-miR-548aj-5p	PAR-CLIP	27292025
MIRT534745	hsa-miR-548aw	PAR-CLIP	27292025
MIRT534751	hsa-miR-548f-5p	PAR-CLIP	27292025
MIRT534750	hsa-miR-548g-5p	PAR-CLIP	27292025
MIRT534749	hsa-miR-548x-5p	PAR-CLIP	27292025
MIRT534755	hsa-miR-1267	PAR-CLIP	20371350
MIRT534754	hsa-miR-367-5p	PAR-CLIP	20371350
MIRT534753	hsa-miR-3124-3p	PAR-CLIP	20371350
MIRT534752	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT534751	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT534750	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT534749	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT534748	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT534747	hsa-miR-4684-3p	PAR-CLIP	20371350
MIRT534746	hsa-miR-197-3p	PAR-CLIP	20371350
MIRT534745	hsa-miR-548aw	PAR-CLIP	20371350
MIRT534744	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT534743	hsa-miR-527	PAR-CLIP	20371350
MIRT534755	hsa-miR-1267	PAR-CLIP	22012620
MIRT534754	hsa-miR-367-5p	PAR-CLIP	22012620
MIRT534753	hsa-miR-3124-3p	PAR-CLIP	22012620
MIRT534752	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT534751	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT534750	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT534749	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT534748	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT534747	hsa-miR-4684-3p	PAR-CLIP	22012620
MIRT534746	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT534745	hsa-miR-548aw	PAR-CLIP	22012620
MIRT534744	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT534743	hsa-miR-527	PAR-CLIP	22012620
MIRT1293217	hsa-let-7a	CLIP-seq
MIRT1293218	hsa-let-7b	CLIP-seq
MIRT1293219	hsa-let-7c	CLIP-seq
MIRT1293220	hsa-let-7d	CLIP-seq
MIRT1293221	hsa-let-7e	CLIP-seq
MIRT1293222	hsa-let-7f	CLIP-seq
MIRT1293223	hsa-let-7g	CLIP-seq
MIRT1293224	hsa-let-7i	CLIP-seq
MIRT1293225	hsa-miR-100	CLIP-seq
MIRT1293226	hsa-miR-1237	CLIP-seq
MIRT1293227	hsa-miR-1238	CLIP-seq
MIRT1293228	hsa-miR-1248	CLIP-seq
MIRT1293229	hsa-miR-1273d	CLIP-seq
MIRT1293230	hsa-miR-1293	CLIP-seq
MIRT1293231	hsa-miR-1294	CLIP-seq
MIRT1293232	hsa-miR-135a	CLIP-seq
MIRT1293233	hsa-miR-135b	CLIP-seq
MIRT1293234	hsa-miR-1909	CLIP-seq
MIRT1293235	hsa-miR-1915	CLIP-seq
MIRT1293236	hsa-miR-202	CLIP-seq
MIRT1293237	hsa-miR-21	CLIP-seq
MIRT1293238	hsa-miR-2861	CLIP-seq
MIRT1293239	hsa-miR-3138	CLIP-seq
MIRT1293240	hsa-miR-3148	CLIP-seq
MIRT1293241	hsa-miR-3153	CLIP-seq
MIRT1293242	hsa-miR-3179	CLIP-seq
MIRT1293243	hsa-miR-3192	CLIP-seq
MIRT1293244	hsa-miR-3201	CLIP-seq
MIRT1293245	hsa-miR-3202	CLIP-seq
MIRT1293246	hsa-miR-345	CLIP-seq
MIRT1293247	hsa-miR-3529	CLIP-seq
MIRT1293248	hsa-miR-3656	CLIP-seq
MIRT1293249	hsa-miR-3681	CLIP-seq
MIRT1293250	hsa-miR-370	CLIP-seq
MIRT1293251	hsa-miR-371b-5p	CLIP-seq
MIRT1293252	hsa-miR-379	CLIP-seq
MIRT1293253	hsa-miR-3909	CLIP-seq
MIRT1293254	hsa-miR-3918	CLIP-seq
MIRT1293255	hsa-miR-3936	CLIP-seq
MIRT1293256	hsa-miR-4314	CLIP-seq
MIRT1293257	hsa-miR-4451	CLIP-seq
MIRT1293258	hsa-miR-4458	CLIP-seq
MIRT1293259	hsa-miR-4476	CLIP-seq
MIRT1293260	hsa-miR-4483	CLIP-seq
MIRT1293261	hsa-miR-4491	CLIP-seq
MIRT1293262	hsa-miR-4500	CLIP-seq
MIRT1293263	hsa-miR-4512	CLIP-seq
MIRT1293264	hsa-miR-4522	CLIP-seq
MIRT1293265	hsa-miR-4536	CLIP-seq
MIRT1293266	hsa-miR-4646-5p	CLIP-seq
MIRT1293267	hsa-miR-4650-3p	CLIP-seq
MIRT1293268	hsa-miR-4651	CLIP-seq
MIRT1293269	hsa-miR-4657	CLIP-seq
MIRT1293270	hsa-miR-4668-5p	CLIP-seq
MIRT1293271	hsa-miR-4691-5p	CLIP-seq
MIRT1293272	hsa-miR-4693-3p	CLIP-seq
MIRT1293273	hsa-miR-4698	CLIP-seq
MIRT1293274	hsa-miR-4703-3p	CLIP-seq
MIRT1293275	hsa-miR-4723-5p	CLIP-seq
MIRT1293276	hsa-miR-4776-3p	CLIP-seq
MIRT1293277	hsa-miR-4791	CLIP-seq
MIRT1293278	hsa-miR-4800-5p	CLIP-seq
MIRT1293279	hsa-miR-519a	CLIP-seq
MIRT1293280	hsa-miR-519b-3p	CLIP-seq
MIRT1293281	hsa-miR-519c-3p	CLIP-seq
MIRT1293282	hsa-miR-522	CLIP-seq
MIRT1293283	hsa-miR-548ac	CLIP-seq
MIRT1293284	hsa-miR-548d-3p	CLIP-seq
MIRT1293285	hsa-miR-548z	CLIP-seq
MIRT1293286	hsa-miR-590-5p	CLIP-seq
MIRT1293287	hsa-miR-608	CLIP-seq
MIRT1293288	hsa-miR-711	CLIP-seq
MIRT1293289	hsa-miR-98	CLIP-seq
MIRT1293290	hsa-miR-99a	CLIP-seq
MIRT1293291	hsa-miR-99b	CLIP-seq
MIRT2087086	hsa-miR-1268	CLIP-seq
MIRT2087087	hsa-miR-1268b	CLIP-seq
MIRT2087088	hsa-miR-138	CLIP-seq
MIRT2087089	hsa-miR-2278	CLIP-seq
MIRT2087090	hsa-miR-3074-5p	CLIP-seq
MIRT2087091	hsa-miR-3136-5p	CLIP-seq
MIRT2087092	hsa-miR-3650	CLIP-seq
MIRT2087093	hsa-miR-3652	CLIP-seq
MIRT2087094	hsa-miR-3659	CLIP-seq
MIRT2087095	hsa-miR-3668	CLIP-seq
MIRT2087096	hsa-miR-369-3p	CLIP-seq
MIRT1293250	hsa-miR-370	CLIP-seq
MIRT2087097	hsa-miR-374a	CLIP-seq
MIRT2087098	hsa-miR-374b	CLIP-seq
MIRT2087099	hsa-miR-4265	CLIP-seq
MIRT2087100	hsa-miR-4296	CLIP-seq
MIRT2087101	hsa-miR-4322	CLIP-seq
MIRT2087102	hsa-miR-4417	CLIP-seq
MIRT2087103	hsa-miR-4430	CLIP-seq
MIRT2087104	hsa-miR-4439	CLIP-seq
MIRT2087105	hsa-miR-4505	CLIP-seq
MIRT2087106	hsa-miR-450b-5p	CLIP-seq
MIRT2087107	hsa-miR-4513	CLIP-seq
MIRT2087108	hsa-miR-4639-3p	CLIP-seq
MIRT2087109	hsa-miR-4655-5p	CLIP-seq
MIRT2087110	hsa-miR-4658	CLIP-seq
MIRT2087111	hsa-miR-4732-5p	CLIP-seq
MIRT2087112	hsa-miR-4758-5p	CLIP-seq
MIRT2087113	hsa-miR-4775	CLIP-seq
MIRT2087114	hsa-miR-4778-3p	CLIP-seq
MIRT2087115	hsa-miR-495	CLIP-seq
MIRT2087116	hsa-miR-507	CLIP-seq
MIRT2087117	hsa-miR-557	CLIP-seq
MIRT2087118	hsa-miR-574-5p	CLIP-seq
MIRT2087119	hsa-miR-585	CLIP-seq
MIRT2087120	hsa-miR-590-3p	CLIP-seq
MIRT2087121	hsa-miR-629	CLIP-seq
MIRT2087122	hsa-miR-648	CLIP-seq
MIRT2087123	hsa-miR-668	CLIP-seq
MIRT2087124	hsa-miR-943	CLIP-seq
MIRT1293225	hsa-miR-100	CLIP-seq
MIRT2087086	hsa-miR-1268	CLIP-seq
MIRT2087087	hsa-miR-1268b	CLIP-seq
MIRT2311924	hsa-miR-134	CLIP-seq
MIRT2087088	hsa-miR-138	CLIP-seq
MIRT2311925	hsa-miR-1913	CLIP-seq
MIRT2311926	hsa-miR-197	CLIP-seq
MIRT2311927	hsa-miR-200b	CLIP-seq
MIRT2311928	hsa-miR-200c	CLIP-seq
MIRT2311929	hsa-miR-208a	CLIP-seq
MIRT2311930	hsa-miR-208b	CLIP-seq
MIRT2311931	hsa-miR-27a	CLIP-seq
MIRT2311932	hsa-miR-27b	CLIP-seq
MIRT2311933	hsa-miR-30a	CLIP-seq
MIRT2311934	hsa-miR-30b	CLIP-seq
MIRT2311935	hsa-miR-30c	CLIP-seq
MIRT2311936	hsa-miR-30d	CLIP-seq
MIRT2311937	hsa-miR-30e	CLIP-seq
MIRT2311938	hsa-miR-3118	CLIP-seq
MIRT1293241	hsa-miR-3153	CLIP-seq
MIRT2311939	hsa-miR-3164	CLIP-seq
MIRT2311940	hsa-miR-3189-5p	CLIP-seq
MIRT1293243	hsa-miR-3192	CLIP-seq
MIRT1293244	hsa-miR-3201	CLIP-seq
MIRT2311941	hsa-miR-324-3p	CLIP-seq
MIRT2311942	hsa-miR-340	CLIP-seq
MIRT2087092	hsa-miR-3650	CLIP-seq
MIRT2087093	hsa-miR-3652	CLIP-seq
MIRT2087099	hsa-miR-4265	CLIP-seq
MIRT2311943	hsa-miR-4277	CLIP-seq
MIRT2311944	hsa-miR-429	CLIP-seq
MIRT2087100	hsa-miR-4296	CLIP-seq
MIRT1293256	hsa-miR-4314	CLIP-seq
MIRT2311945	hsa-miR-4318	CLIP-seq
MIRT2087101	hsa-miR-4322	CLIP-seq
MIRT2087102	hsa-miR-4417	CLIP-seq
MIRT2087103	hsa-miR-4430	CLIP-seq
MIRT2311946	hsa-miR-4432	CLIP-seq
MIRT2311947	hsa-miR-4474-5p	CLIP-seq
MIRT2311948	hsa-miR-4495	CLIP-seq
MIRT2087105	hsa-miR-4505	CLIP-seq
MIRT2087106	hsa-miR-450b-5p	CLIP-seq
MIRT2087108	hsa-miR-4639-3p	CLIP-seq
MIRT1293266	hsa-miR-4646-5p	CLIP-seq
MIRT2087109	hsa-miR-4655-5p	CLIP-seq
MIRT1293270	hsa-miR-4668-5p	CLIP-seq
MIRT2311949	hsa-miR-4693-5p	CLIP-seq
MIRT2311950	hsa-miR-4727-5p	CLIP-seq
MIRT2311951	hsa-miR-4747-3p	CLIP-seq
MIRT2087113	hsa-miR-4775	CLIP-seq
MIRT2311952	hsa-miR-4777-5p	CLIP-seq
MIRT1293277	hsa-miR-4791	CLIP-seq
MIRT2311953	hsa-miR-499-5p	CLIP-seq
MIRT2087116	hsa-miR-507	CLIP-seq
MIRT2311954	hsa-miR-5096	CLIP-seq
MIRT2311955	hsa-miR-513a-5p	CLIP-seq
MIRT2311956	hsa-miR-518d-5p	CLIP-seq
MIRT2311957	hsa-miR-519b-5p	CLIP-seq
MIRT2311958	hsa-miR-519c-5p	CLIP-seq
MIRT2311959	hsa-miR-520c-5p	CLIP-seq
MIRT1293282	hsa-miR-522	CLIP-seq
MIRT2311960	hsa-miR-526a	CLIP-seq
MIRT2311961	hsa-miR-548c-3p	CLIP-seq
MIRT2311962	hsa-miR-554	CLIP-seq
MIRT2087117	hsa-miR-557	CLIP-seq
MIRT2087119	hsa-miR-585	CLIP-seq
MIRT2087120	hsa-miR-590-3p	CLIP-seq
MIRT2087121	hsa-miR-629	CLIP-seq
MIRT2087123	hsa-miR-668	CLIP-seq
MIRT2311963	hsa-miR-892a	CLIP-seq
MIRT2311964	hsa-miR-938	CLIP-seq
MIRT1293290	hsa-miR-99a	CLIP-seq
MIRT1293291	hsa-miR-99b	CLIP-seq
MIRT2608354	hsa-miR-129-5p	CLIP-seq
MIRT2608355	hsa-miR-1301	CLIP-seq
MIRT2087106	hsa-miR-450b-5p	CLIP-seq
MIRT2608356	hsa-miR-4660	CLIP-seq
MIRT2608357	hsa-miR-5047	CLIP-seq
MIRT2087116	hsa-miR-507	CLIP-seq
MIRT2087117	hsa-miR-557	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA

Other IDs

• MIM: 609953
• HGNC: 25577
• e!Ensembl: ENSG00000162437

Protein

• UniProt ID: Q9HCJ3
• Protein name: Ribonucleoprotein PTB-binding 2 (Protein raver-2)
• Protein function: May bind single-stranded nucleic acids.
• PDB: 1WG1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	71 → 134	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	144 → 213	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	233 → 303	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MAAAAGDGGGEGGAGLGSAAGLGPGPGLRGQGPSAEAHEGAPDPMPAALHPEEVAARLQR
  MQRELSNRRKILVKNLPQDSNCQEVHDLLKDYDLKYCYVDRNKRTAFVTLLNGEQAQNAI
  QMFHQYSFRGKDLIVQLQPTDALLCITNVPISFTSEEFEELVRAYGNIERCFLVYSEVTG
  HSKGYGFVEYMKKDFAAKARLELLGRQLGASALFAQWMDVNLLASELIHSKCLCIDKLPS
  DYRDSEELLQIFSSVHKPVFCQLAQDEGSYVGGFAVVEYSTAEQAEEVQQAADGMTIKGS
  KVQVSFCAPGAPGRSTLAALIAAQRVMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQPQ
  LCGRAVKPAVLGTPHSLPHLMNPSISPAFLHLNKAHQSSVMGNTSNLFLQNLSHIPLAQQ
  QLMKFENIHTNNKPGLLGEPPAVVLQTALGIGSVLPLKKELGHHHGEAHKTSSLIPTQTT
  ITAGMGMLPFFPNQHIAGQAGPGHSNTQEKQPATVGMAEGNFSGSQPYLQSFPNLAAGSL
  LVGHHKQQQSQPKGTEISSGAASKNQTSLLGEPPKEIRLSKNPYLNLASVLPSVCLSSPA
  SKTTLHKTGIASSILDAISQGSESQHALEKCIAYSPPFGDYAQVSSLRNEKRGSSYLISA
  PEGGSVECVDQHSQGTGAYYMETYLKKKRVY

• Sequence length: 691

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autoimmune Diseases	Autoimmune Diseases	BEFREE	22561236		★☆☆☆☆ Found in Text Mining only
Central Nervous System Neoplasms	Central Nervous System Neoplasms	GWASCAT_DG	28346443		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32802869	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	22561236		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	GWASCAT_DG	28346443		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	GWASCAT_DG	28346443		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	GWASCAT_DG	28346443, 29743610		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	22561236		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	22561236		★☆☆☆☆ Found in Text Mining only