Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55224
Gene name	Ethanolamine kinase 2
Gene symbol	ETNK2
Synonyms (NCBI Gene)	EKI2HMFT1716
Chromosome	1
Chromosome location	1q32.1
Summary	The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in mu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021559	hsa-miR-142-3p	Microarray	17612493
MIRT021789	hsa-miR-132-3p	Microarray	17612493
MIRT437580	hsa-miR-125a-5p	MicroarrayqRT-PCR	22815788
MIRT437645	hsa-miR-155-5p	MicroarrayqRT-PCR	22815788
MIRT439163	hsa-let-7c-5p	3'LIFE	25074381
MIRT439163	hsa-let-7c-5p	3'LIFE	25074381
MIRT971812	hsa-miR-1205	CLIP-seq
MIRT971813	hsa-miR-124	CLIP-seq
MIRT971814	hsa-miR-1270	CLIP-seq
MIRT971815	hsa-miR-150	CLIP-seq
MIRT971816	hsa-miR-1909	CLIP-seq
MIRT971817	hsa-miR-214	CLIP-seq
MIRT971818	hsa-miR-3064-5p	CLIP-seq
MIRT971819	hsa-miR-30a	CLIP-seq
MIRT971820	hsa-miR-30b	CLIP-seq
MIRT971821	hsa-miR-30c	CLIP-seq
MIRT971822	hsa-miR-30d	CLIP-seq
MIRT971823	hsa-miR-30e	CLIP-seq
MIRT971824	hsa-miR-3126-5p	CLIP-seq
MIRT971825	hsa-miR-3155	CLIP-seq
MIRT971826	hsa-miR-3155b	CLIP-seq
MIRT971827	hsa-miR-3179	CLIP-seq
MIRT971828	hsa-miR-3202	CLIP-seq
MIRT971829	hsa-miR-3619-5p	CLIP-seq
MIRT971830	hsa-miR-3661	CLIP-seq
MIRT971831	hsa-miR-3714	CLIP-seq
MIRT971832	hsa-miR-3910	CLIP-seq
MIRT971833	hsa-miR-3936	CLIP-seq
MIRT971834	hsa-miR-4269	CLIP-seq
MIRT971835	hsa-miR-4419a	CLIP-seq
MIRT971836	hsa-miR-4434	CLIP-seq
MIRT971837	hsa-miR-4436a	CLIP-seq
MIRT971838	hsa-miR-450b-3p	CLIP-seq
MIRT971839	hsa-miR-4510	CLIP-seq
MIRT971840	hsa-miR-4516	CLIP-seq
MIRT971841	hsa-miR-4530	CLIP-seq
MIRT971842	hsa-miR-4531	CLIP-seq
MIRT971843	hsa-miR-4695-3p	CLIP-seq
MIRT971844	hsa-miR-4710	CLIP-seq
MIRT971845	hsa-miR-4713-3p	CLIP-seq
MIRT971846	hsa-miR-4713-5p	CLIP-seq
MIRT971847	hsa-miR-4716-3p	CLIP-seq
MIRT971848	hsa-miR-4722-3p	CLIP-seq
MIRT971849	hsa-miR-4789-3p	CLIP-seq
MIRT971850	hsa-miR-484	CLIP-seq
MIRT971851	hsa-miR-492	CLIP-seq
MIRT971852	hsa-miR-506	CLIP-seq
MIRT971853	hsa-miR-532-3p	CLIP-seq
MIRT971854	hsa-miR-604	CLIP-seq
MIRT971855	hsa-miR-620	CLIP-seq
MIRT971856	hsa-miR-631	CLIP-seq
MIRT971857	hsa-miR-638	CLIP-seq
MIRT971858	hsa-miR-647	CLIP-seq
MIRT971859	hsa-miR-761	CLIP-seq
MIRT971860	hsa-miR-769-3p	CLIP-seq
MIRT1987927	hsa-miR-1285	CLIP-seq
MIRT1987928	hsa-miR-298	CLIP-seq
MIRT1987929	hsa-miR-3187-5p	CLIP-seq
MIRT1987930	hsa-miR-328	CLIP-seq
MIRT1987931	hsa-miR-342-5p	CLIP-seq
MIRT1987932	hsa-miR-378g	CLIP-seq
MIRT1987933	hsa-miR-4314	CLIP-seq
MIRT1987934	hsa-miR-4456	CLIP-seq
MIRT1987935	hsa-miR-4476	CLIP-seq
MIRT1987936	hsa-miR-4486	CLIP-seq
MIRT1987937	hsa-miR-4640-5p	CLIP-seq
MIRT1987938	hsa-miR-4651	CLIP-seq
MIRT1987939	hsa-miR-4664-5p	CLIP-seq
MIRT1987940	hsa-miR-4726-5p	CLIP-seq
MIRT1987941	hsa-miR-541	CLIP-seq
MIRT1987942	hsa-miR-608	CLIP-seq
MIRT1987943	hsa-miR-612	CLIP-seq
MIRT1987944	hsa-miR-654-5p	CLIP-seq
MIRT1987945	hsa-miR-759	CLIP-seq
MIRT2222300	hsa-miR-1266	CLIP-seq
MIRT1987927	hsa-miR-1285	CLIP-seq
MIRT2222301	hsa-miR-1294	CLIP-seq
MIRT2222302	hsa-miR-1321	CLIP-seq
MIRT2222303	hsa-miR-1324	CLIP-seq
MIRT2222304	hsa-miR-188-3p	CLIP-seq
MIRT971816	hsa-miR-1909	CLIP-seq
MIRT2222305	hsa-miR-24	CLIP-seq
MIRT2222306	hsa-miR-2467-5p	CLIP-seq
MIRT2222307	hsa-miR-28-5p	CLIP-seq
MIRT1987928	hsa-miR-298	CLIP-seq
MIRT2222308	hsa-miR-3127-5p	CLIP-seq
MIRT2222309	hsa-miR-3132	CLIP-seq
MIRT2222310	hsa-miR-3139	CLIP-seq
MIRT2222311	hsa-miR-3175	CLIP-seq
MIRT2222312	hsa-miR-3176	CLIP-seq
MIRT971827	hsa-miR-3179	CLIP-seq
MIRT1987929	hsa-miR-3187-5p	CLIP-seq
MIRT1987931	hsa-miR-342-5p	CLIP-seq
MIRT2222313	hsa-miR-3612	CLIP-seq
MIRT2222314	hsa-miR-3670	CLIP-seq
MIRT2222315	hsa-miR-3675-5p	CLIP-seq
MIRT2222316	hsa-miR-3689d	CLIP-seq
MIRT1987932	hsa-miR-378g	CLIP-seq
MIRT2222317	hsa-miR-3918	CLIP-seq
MIRT2222318	hsa-miR-3922-3p	CLIP-seq
MIRT2222319	hsa-miR-4253	CLIP-seq
MIRT2222320	hsa-miR-4257	CLIP-seq
MIRT2222321	hsa-miR-4276	CLIP-seq
MIRT1987933	hsa-miR-4314	CLIP-seq
MIRT2222322	hsa-miR-4316	CLIP-seq
MIRT2222323	hsa-miR-4330	CLIP-seq
MIRT971836	hsa-miR-4434	CLIP-seq
MIRT2222324	hsa-miR-4435	CLIP-seq
MIRT2222325	hsa-miR-4443	CLIP-seq
MIRT1987935	hsa-miR-4476	CLIP-seq
MIRT1987936	hsa-miR-4486	CLIP-seq
MIRT2222326	hsa-miR-4493	CLIP-seq
MIRT2222327	hsa-miR-4515	CLIP-seq
MIRT971840	hsa-miR-4516	CLIP-seq
MIRT2222328	hsa-miR-4518	CLIP-seq
MIRT971842	hsa-miR-4531	CLIP-seq
MIRT1987937	hsa-miR-4640-5p	CLIP-seq
MIRT2222329	hsa-miR-4650-3p	CLIP-seq
MIRT1987938	hsa-miR-4651	CLIP-seq
MIRT2222330	hsa-miR-4662a-3p	CLIP-seq
MIRT1987939	hsa-miR-4664-5p	CLIP-seq
MIRT2222331	hsa-miR-4677-3p	CLIP-seq
MIRT971843	hsa-miR-4695-3p	CLIP-seq
MIRT971847	hsa-miR-4716-3p	CLIP-seq
MIRT2222332	hsa-miR-4716-5p	CLIP-seq
MIRT2222333	hsa-miR-4717-3p	CLIP-seq
MIRT2222334	hsa-miR-4723-5p	CLIP-seq
MIRT1987940	hsa-miR-4726-5p	CLIP-seq
MIRT2222335	hsa-miR-4728-5p	CLIP-seq
MIRT2222336	hsa-miR-4731-5p	CLIP-seq
MIRT2222337	hsa-miR-4739	CLIP-seq
MIRT2222338	hsa-miR-4756-5p	CLIP-seq
MIRT2222339	hsa-miR-4768-3p	CLIP-seq
MIRT2222340	hsa-miR-4773	CLIP-seq
MIRT2222341	hsa-miR-486-3p	CLIP-seq
MIRT2222342	hsa-miR-516b	CLIP-seq
MIRT971853	hsa-miR-532-3p	CLIP-seq
MIRT2222343	hsa-miR-548aa	CLIP-seq
MIRT2222344	hsa-miR-571	CLIP-seq
MIRT2222345	hsa-miR-592	CLIP-seq
MIRT2222346	hsa-miR-597	CLIP-seq
MIRT971854	hsa-miR-604	CLIP-seq
MIRT1987942	hsa-miR-608	CLIP-seq
MIRT1987943	hsa-miR-612	CLIP-seq
MIRT971858	hsa-miR-647	CLIP-seq
MIRT2222347	hsa-miR-650	CLIP-seq
MIRT2222348	hsa-miR-665	CLIP-seq
MIRT2222349	hsa-miR-708	CLIP-seq
MIRT1987945	hsa-miR-759	CLIP-seq
MIRT971827	hsa-miR-3179	CLIP-seq
MIRT2387546	hsa-miR-3688-5p	CLIP-seq
MIRT2222317	hsa-miR-3918	CLIP-seq
MIRT2222321	hsa-miR-4276	CLIP-seq
MIRT2222339	hsa-miR-4768-3p	CLIP-seq
MIRT2222302	hsa-miR-1321	CLIP-seq
MIRT2680332	hsa-miR-2861	CLIP-seq
MIRT2680333	hsa-miR-3616-3p	CLIP-seq
MIRT2680334	hsa-miR-4270	CLIP-seq
MIRT2680335	hsa-miR-4441	CLIP-seq
MIRT2680336	hsa-miR-4512	CLIP-seq
MIRT1987937	hsa-miR-4640-5p	CLIP-seq
MIRT2680337	hsa-miR-4721	CLIP-seq
MIRT1987940	hsa-miR-4726-5p	CLIP-seq
MIRT2222335	hsa-miR-4728-5p	CLIP-seq
MIRT2222337	hsa-miR-4739	CLIP-seq
MIRT2222338	hsa-miR-4756-5p	CLIP-seq
MIRT2680338	hsa-miR-544b	CLIP-seq

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Transcription factor	Regulation	Reference
CTCF	Unknown	18632798

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001701	Process	In utero embryonic development	IEA
GO:0001890	Process	Placenta development	IEA
GO:0004305	Function	Ethanolamine kinase activity	IBA
GO:0004305	Function	Ethanolamine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	IBA
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	IEA
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	IEA
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035264	Process	Multicellular organism growth	IEA

MIM	HGNC	e!Ensembl
609859	25575	ENSG00000143845

Q9NVF9

Protein name

Ethanolamine kinase 2 (EKI 2) (EC 2.7.1.82) (Ethanolamine kinase-like protein)

Protein function

Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01633	Choline_kinase	105 → 307		Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney, liver, ovary, testis and prostate. {ECO:0000269|PubMed:11044454}.

Sequence

MAVPPSAPQPRASFHLRRHTPCPQCSWGMEEKAAASASCREPPGPPRAAAVAYFGISVDP
DDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMQDCVLVRVYGERTEL
LVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQGVALEPEHIREPRLFRLIALEMA
KIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLE
SPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYP
ARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFD
FLRYAVIRFNQYFKVKPQASALEMPK

Sequence length

386

Interactions

View interactions

	KEGG		Reactome
	Glycerophospholipid metabolism Metabolic pathways		Synthesis of PE

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PERIODONTITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	25719218	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	33408336	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ETNK2 (ethanolamine kinase 2)