EXD2 (exonuclease 3'-5' domain containing 2)

Gene

• Entrez ID: 55218
• Gene name: Exonuclease 3'-5' domain containing 2
• Gene symbol: EXD2
• Synonyms (NCBI Gene): C14orf114, EXDL2
• Chromosome: 14
• Chromosome location: 14q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018552	hsa-miR-335-5p	Microarray	18185580
MIRT027148	hsa-miR-103a-3p	Sequencing	20371350
MIRT031912	hsa-miR-16-5p	Sequencing	20371350
MIRT444861	hsa-miR-548ac	PAR-CLIP	22100165
MIRT444860	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT444859	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT444858	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT444857	hsa-miR-548z	PAR-CLIP	22100165
MIRT444856	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT444854	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT444855	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT444853	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT444852	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT444851	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT444850	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT444849	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT444848	hsa-miR-1264	PAR-CLIP	22100165
MIRT444846	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT444847	hsa-miR-153-5p	PAR-CLIP	22100165
MIRT444845	hsa-miR-7856-5p	PAR-CLIP	22100165
MIRT444861	hsa-miR-548ac	PAR-CLIP	22100165
MIRT444860	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT444859	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT444858	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT444857	hsa-miR-548z	PAR-CLIP	22100165
MIRT444856	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT444854	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT444855	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT444853	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT444852	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT444851	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT444850	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT444849	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT444848	hsa-miR-1264	PAR-CLIP	22100165
MIRT444846	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT444847	hsa-miR-153-5p	PAR-CLIP	22100165
MIRT444845	hsa-miR-7856-5p	PAR-CLIP	22100165
MIRT972403	hsa-miR-200b	CLIP-seq
MIRT972404	hsa-miR-200c	CLIP-seq
MIRT972405	hsa-miR-3140-3p	CLIP-seq
MIRT972406	hsa-miR-3163	CLIP-seq
MIRT972407	hsa-miR-374c	CLIP-seq
MIRT972408	hsa-miR-429	CLIP-seq
MIRT972409	hsa-miR-4325	CLIP-seq
MIRT972410	hsa-miR-4724-5p	CLIP-seq
MIRT972411	hsa-miR-4760-3p	CLIP-seq
MIRT972412	hsa-miR-4766-5p	CLIP-seq
MIRT972413	hsa-miR-488	CLIP-seq
MIRT972414	hsa-miR-501-3p	CLIP-seq
MIRT972415	hsa-miR-502-3p	CLIP-seq
MIRT972416	hsa-miR-513c	CLIP-seq
MIRT972417	hsa-miR-514b-5p	CLIP-seq
MIRT972418	hsa-miR-655	CLIP-seq
MIRT972419	hsa-miR-1303	CLIP-seq
MIRT972420	hsa-miR-1537	CLIP-seq
MIRT972421	hsa-miR-1912	CLIP-seq
MIRT972422	hsa-miR-30a	CLIP-seq
MIRT972423	hsa-miR-30b	CLIP-seq
MIRT972424	hsa-miR-30c	CLIP-seq
MIRT972425	hsa-miR-30d	CLIP-seq
MIRT972426	hsa-miR-30e	CLIP-seq
MIRT972427	hsa-miR-3134	CLIP-seq
MIRT972428	hsa-miR-3154	CLIP-seq
MIRT972429	hsa-miR-3185	CLIP-seq
MIRT972430	hsa-miR-3616-5p	CLIP-seq
MIRT972431	hsa-miR-3647-5p	CLIP-seq
MIRT972432	hsa-miR-4305	CLIP-seq
MIRT972433	hsa-miR-4424	CLIP-seq
MIRT972434	hsa-miR-4477a	CLIP-seq
MIRT972435	hsa-miR-4533	CLIP-seq
MIRT972436	hsa-miR-4681	CLIP-seq
MIRT972437	hsa-miR-4733-5p	CLIP-seq
MIRT972438	hsa-miR-4747-5p	CLIP-seq
MIRT972439	hsa-miR-4775	CLIP-seq
MIRT972440	hsa-miR-4786-3p	CLIP-seq
MIRT972441	hsa-miR-4795-3p	CLIP-seq
MIRT972442	hsa-miR-4795-5p	CLIP-seq
MIRT972443	hsa-miR-499-3p	CLIP-seq
MIRT972444	hsa-miR-499a-3p	CLIP-seq
MIRT972445	hsa-miR-548ae	CLIP-seq
MIRT972446	hsa-miR-548aj	CLIP-seq
MIRT972447	hsa-miR-548am	CLIP-seq
MIRT972448	hsa-miR-548x	CLIP-seq
MIRT972449	hsa-miR-573	CLIP-seq
MIRT972450	hsa-miR-577	CLIP-seq
MIRT972451	hsa-miR-586	CLIP-seq
MIRT972452	hsa-miR-590-3p	CLIP-seq
MIRT972453	hsa-miR-635	CLIP-seq
MIRT972454	hsa-miR-7	CLIP-seq
MIRT972455	hsa-miR-944	CLIP-seq
MIRT972456	hsa-miR-1245b-3p	CLIP-seq
MIRT972457	hsa-miR-1273f	CLIP-seq
MIRT972458	hsa-miR-1273g	CLIP-seq
MIRT972459	hsa-miR-1279	CLIP-seq
MIRT972460	hsa-miR-151-3p	CLIP-seq
MIRT972461	hsa-miR-1827	CLIP-seq
MIRT972421	hsa-miR-1912	CLIP-seq
MIRT972462	hsa-miR-1913	CLIP-seq
MIRT972463	hsa-miR-219-2-3p	CLIP-seq
MIRT972464	hsa-miR-25	CLIP-seq
MIRT972465	hsa-miR-2964a-3p	CLIP-seq
MIRT972427	hsa-miR-3134	CLIP-seq
MIRT972466	hsa-miR-3153	CLIP-seq
MIRT972428	hsa-miR-3154	CLIP-seq
MIRT972467	hsa-miR-3168	CLIP-seq
MIRT972429	hsa-miR-3185	CLIP-seq
MIRT972468	hsa-miR-3189-5p	CLIP-seq
MIRT972469	hsa-miR-3192	CLIP-seq
MIRT972470	hsa-miR-32	CLIP-seq
MIRT972471	hsa-miR-324-3p	CLIP-seq
MIRT972472	hsa-miR-326	CLIP-seq
MIRT972473	hsa-miR-330-5p	CLIP-seq
MIRT972474	hsa-miR-3612	CLIP-seq
MIRT972430	hsa-miR-3616-5p	CLIP-seq
MIRT972475	hsa-miR-363	CLIP-seq
MIRT972431	hsa-miR-3647-5p	CLIP-seq
MIRT972476	hsa-miR-3662	CLIP-seq
MIRT972477	hsa-miR-367	CLIP-seq
MIRT972478	hsa-miR-3689a-3p	CLIP-seq
MIRT972479	hsa-miR-3689c	CLIP-seq
MIRT972480	hsa-miR-4311	CLIP-seq
MIRT972481	hsa-miR-4314	CLIP-seq
MIRT972433	hsa-miR-4424	CLIP-seq
MIRT972482	hsa-miR-4452	CLIP-seq
MIRT972483	hsa-miR-4459	CLIP-seq
MIRT972484	hsa-miR-4463	CLIP-seq
MIRT972485	hsa-miR-4499	CLIP-seq
MIRT972486	hsa-miR-4522	CLIP-seq
MIRT972435	hsa-miR-4533	CLIP-seq
MIRT972487	hsa-miR-4534	CLIP-seq
MIRT972488	hsa-miR-4646-5p	CLIP-seq
MIRT972489	hsa-miR-4653-3p	CLIP-seq
MIRT972490	hsa-miR-4662a-3p	CLIP-seq
MIRT972491	hsa-miR-4668-5p	CLIP-seq
MIRT972492	hsa-miR-4670-3p	CLIP-seq
MIRT972436	hsa-miR-4681	CLIP-seq
MIRT972493	hsa-miR-4695-5p	CLIP-seq
MIRT972494	hsa-miR-4698	CLIP-seq
MIRT972495	hsa-miR-4716-3p	CLIP-seq
MIRT972496	hsa-miR-4720-3p	CLIP-seq
MIRT972497	hsa-miR-4727-5p	CLIP-seq
MIRT972437	hsa-miR-4733-5p	CLIP-seq
MIRT972438	hsa-miR-4747-5p	CLIP-seq
MIRT972498	hsa-miR-4758-3p	CLIP-seq
MIRT972440	hsa-miR-4786-3p	CLIP-seq
MIRT972442	hsa-miR-4795-5p	CLIP-seq
MIRT972499	hsa-miR-4804-3p	CLIP-seq
MIRT972500	hsa-miR-518a-5p	CLIP-seq
MIRT972501	hsa-miR-527	CLIP-seq
MIRT972502	hsa-miR-544	CLIP-seq
MIRT972449	hsa-miR-573	CLIP-seq
MIRT972503	hsa-miR-578	CLIP-seq
MIRT972504	hsa-miR-583	CLIP-seq
MIRT972505	hsa-miR-624	CLIP-seq
MIRT972506	hsa-miR-625	CLIP-seq
MIRT972507	hsa-miR-650	CLIP-seq
MIRT972508	hsa-miR-665	CLIP-seq
MIRT972454	hsa-miR-7	CLIP-seq
MIRT972509	hsa-miR-92a	CLIP-seq
MIRT972510	hsa-miR-92b	CLIP-seq
MIRT972455	hsa-miR-944	CLIP-seq
MIRT1988102	hsa-miR-3121-3p	CLIP-seq
MIRT972439	hsa-miR-4775	CLIP-seq
MIRT1988103	hsa-miR-561	CLIP-seq
MIRT1988104	hsa-miR-579	CLIP-seq
MIRT972452	hsa-miR-590-3p	CLIP-seq
MIRT972469	hsa-miR-3192	CLIP-seq
MIRT2448997	hsa-miR-223	CLIP-seq
MIRT2448998	hsa-miR-4496	CLIP-seq
MIRT2448999	hsa-miR-4697-3p	CLIP-seq
MIRT2449000	hsa-miR-596	CLIP-seq
MIRT2449001	hsa-miR-622	CLIP-seq
MIRT2526108	hsa-miR-1207-5p	CLIP-seq
MIRT2526109	hsa-miR-1243	CLIP-seq
MIRT2526110	hsa-miR-127-5p	CLIP-seq
MIRT2526111	hsa-miR-1297	CLIP-seq
MIRT972419	hsa-miR-1303	CLIP-seq
MIRT2526112	hsa-miR-1305	CLIP-seq
MIRT2526113	hsa-miR-130a	CLIP-seq
MIRT2526114	hsa-miR-130b	CLIP-seq
MIRT2526115	hsa-miR-133a	CLIP-seq
MIRT2526116	hsa-miR-133b	CLIP-seq
MIRT2526117	hsa-miR-147	CLIP-seq
MIRT2526118	hsa-miR-149	CLIP-seq
MIRT972460	hsa-miR-151-3p	CLIP-seq
MIRT972420	hsa-miR-1537	CLIP-seq
MIRT972421	hsa-miR-1912	CLIP-seq
MIRT2526119	hsa-miR-26a	CLIP-seq
MIRT2526120	hsa-miR-26b	CLIP-seq
MIRT2526121	hsa-miR-301a	CLIP-seq
MIRT2526122	hsa-miR-301b	CLIP-seq
MIRT2526123	hsa-miR-3064-5p	CLIP-seq
MIRT2526124	hsa-miR-3065-5p	CLIP-seq
MIRT2526125	hsa-miR-3119	CLIP-seq
MIRT972427	hsa-miR-3134	CLIP-seq
MIRT2526126	hsa-miR-3143	CLIP-seq
MIRT2526127	hsa-miR-323-3p	CLIP-seq
MIRT972430	hsa-miR-3616-5p	CLIP-seq
MIRT972431	hsa-miR-3647-5p	CLIP-seq
MIRT2526128	hsa-miR-3654	CLIP-seq
MIRT2526129	hsa-miR-3666	CLIP-seq
MIRT2526130	hsa-miR-3690	CLIP-seq
MIRT2526131	hsa-miR-3925-3p	CLIP-seq
MIRT2526132	hsa-miR-3936	CLIP-seq
MIRT2526133	hsa-miR-411	CLIP-seq
MIRT2526134	hsa-miR-4254	CLIP-seq
MIRT2526135	hsa-miR-4277	CLIP-seq
MIRT2526136	hsa-miR-4295	CLIP-seq
MIRT972432	hsa-miR-4305	CLIP-seq
MIRT972481	hsa-miR-4314	CLIP-seq
MIRT2526137	hsa-miR-4330	CLIP-seq
MIRT972433	hsa-miR-4424	CLIP-seq
MIRT972483	hsa-miR-4459	CLIP-seq
MIRT972484	hsa-miR-4463	CLIP-seq
MIRT2526138	hsa-miR-4465	CLIP-seq
MIRT972485	hsa-miR-4499	CLIP-seq
MIRT2526139	hsa-miR-4511	CLIP-seq
MIRT2526140	hsa-miR-4520a-3p	CLIP-seq
MIRT2526141	hsa-miR-454	CLIP-seq
MIRT2526142	hsa-miR-4638-3p	CLIP-seq
MIRT2526143	hsa-miR-4667-3p	CLIP-seq
MIRT2526144	hsa-miR-4667-5p	CLIP-seq
MIRT972436	hsa-miR-4681	CLIP-seq
MIRT2526145	hsa-miR-4690-5p	CLIP-seq
MIRT2526146	hsa-miR-4700-3p	CLIP-seq
MIRT2526147	hsa-miR-4700-5p	CLIP-seq
MIRT2526148	hsa-miR-4713-5p	CLIP-seq
MIRT2526149	hsa-miR-4722-5p	CLIP-seq
MIRT972437	hsa-miR-4733-5p	CLIP-seq
MIRT2526150	hsa-miR-4736	CLIP-seq
MIRT2526151	hsa-miR-4742-5p	CLIP-seq
MIRT2526152	hsa-miR-4762-3p	CLIP-seq
MIRT2526153	hsa-miR-4763-3p	CLIP-seq
MIRT972440	hsa-miR-4786-3p	CLIP-seq
MIRT2526154	hsa-miR-4794	CLIP-seq
MIRT972442	hsa-miR-4795-5p	CLIP-seq
MIRT2526155	hsa-miR-486-3p	CLIP-seq
MIRT2526156	hsa-miR-495	CLIP-seq
MIRT2526157	hsa-miR-498	CLIP-seq
MIRT2526158	hsa-miR-515-5p	CLIP-seq
MIRT2526159	hsa-miR-543	CLIP-seq
MIRT972445	hsa-miR-548ae	CLIP-seq
MIRT972446	hsa-miR-548aj	CLIP-seq
MIRT972447	hsa-miR-548am	CLIP-seq
MIRT2526160	hsa-miR-548c-3p	CLIP-seq
MIRT972448	hsa-miR-548x	CLIP-seq
MIRT972449	hsa-miR-573	CLIP-seq
MIRT972450	hsa-miR-577	CLIP-seq
MIRT2526161	hsa-miR-581	CLIP-seq
MIRT972451	hsa-miR-586	CLIP-seq
MIRT2449001	hsa-miR-622	CLIP-seq
MIRT2526162	hsa-miR-637	CLIP-seq
MIRT972454	hsa-miR-7	CLIP-seq
MIRT2526163	hsa-miR-765	CLIP-seq
MIRT2526164	hsa-miR-766	CLIP-seq
MIRT2526108	hsa-miR-1207-5p	CLIP-seq
MIRT2526109	hsa-miR-1243	CLIP-seq
MIRT2526110	hsa-miR-127-5p	CLIP-seq
MIRT2526111	hsa-miR-1297	CLIP-seq
MIRT972419	hsa-miR-1303	CLIP-seq
MIRT2526112	hsa-miR-1305	CLIP-seq
MIRT2526113	hsa-miR-130a	CLIP-seq
MIRT2526114	hsa-miR-130b	CLIP-seq
MIRT2526115	hsa-miR-133a	CLIP-seq
MIRT2526116	hsa-miR-133b	CLIP-seq
MIRT972460	hsa-miR-151-3p	CLIP-seq
MIRT972420	hsa-miR-1537	CLIP-seq
MIRT972421	hsa-miR-1912	CLIP-seq
MIRT2526119	hsa-miR-26a	CLIP-seq
MIRT2526120	hsa-miR-26b	CLIP-seq
MIRT2526121	hsa-miR-301a	CLIP-seq
MIRT2526122	hsa-miR-301b	CLIP-seq
MIRT2526124	hsa-miR-3065-5p	CLIP-seq
MIRT972427	hsa-miR-3134	CLIP-seq
MIRT2526126	hsa-miR-3143	CLIP-seq
MIRT2680377	hsa-miR-320a	CLIP-seq
MIRT2680378	hsa-miR-320b	CLIP-seq
MIRT2680379	hsa-miR-320c	CLIP-seq
MIRT2680380	hsa-miR-320d	CLIP-seq
MIRT2526127	hsa-miR-323-3p	CLIP-seq
MIRT972430	hsa-miR-3616-5p	CLIP-seq
MIRT972431	hsa-miR-3647-5p	CLIP-seq
MIRT2526128	hsa-miR-3654	CLIP-seq
MIRT2526129	hsa-miR-3666	CLIP-seq
MIRT2526130	hsa-miR-3690	CLIP-seq
MIRT2526131	hsa-miR-3925-3p	CLIP-seq
MIRT2526132	hsa-miR-3936	CLIP-seq
MIRT2526133	hsa-miR-411	CLIP-seq
MIRT2526134	hsa-miR-4254	CLIP-seq
MIRT2526135	hsa-miR-4277	CLIP-seq
MIRT2526136	hsa-miR-4295	CLIP-seq
MIRT972432	hsa-miR-4305	CLIP-seq
MIRT972481	hsa-miR-4314	CLIP-seq
MIRT2526137	hsa-miR-4330	CLIP-seq
MIRT972433	hsa-miR-4424	CLIP-seq
MIRT2680381	hsa-miR-4429	CLIP-seq
MIRT972483	hsa-miR-4459	CLIP-seq
MIRT972484	hsa-miR-4463	CLIP-seq
MIRT2526138	hsa-miR-4465	CLIP-seq
MIRT972485	hsa-miR-4499	CLIP-seq
MIRT2526139	hsa-miR-4511	CLIP-seq
MIRT2526140	hsa-miR-4520a-3p	CLIP-seq
MIRT2526141	hsa-miR-454	CLIP-seq
MIRT2526142	hsa-miR-4638-3p	CLIP-seq
MIRT2526143	hsa-miR-4667-3p	CLIP-seq
MIRT2526144	hsa-miR-4667-5p	CLIP-seq
MIRT972436	hsa-miR-4681	CLIP-seq
MIRT2526145	hsa-miR-4690-5p	CLIP-seq
MIRT2526146	hsa-miR-4700-3p	CLIP-seq
MIRT2526147	hsa-miR-4700-5p	CLIP-seq
MIRT2526148	hsa-miR-4713-5p	CLIP-seq
MIRT2526149	hsa-miR-4722-5p	CLIP-seq
MIRT2680382	hsa-miR-4728-3p	CLIP-seq
MIRT972437	hsa-miR-4733-5p	CLIP-seq
MIRT2526150	hsa-miR-4736	CLIP-seq
MIRT2526151	hsa-miR-4742-5p	CLIP-seq
MIRT2526152	hsa-miR-4762-3p	CLIP-seq
MIRT2526153	hsa-miR-4763-3p	CLIP-seq
MIRT972440	hsa-miR-4786-3p	CLIP-seq
MIRT972442	hsa-miR-4795-5p	CLIP-seq
MIRT2526155	hsa-miR-486-3p	CLIP-seq
MIRT972413	hsa-miR-488	CLIP-seq
MIRT2526156	hsa-miR-495	CLIP-seq
MIRT2526157	hsa-miR-498	CLIP-seq
MIRT2526158	hsa-miR-515-5p	CLIP-seq
MIRT2526159	hsa-miR-543	CLIP-seq
MIRT2526160	hsa-miR-548c-3p	CLIP-seq
MIRT972449	hsa-miR-573	CLIP-seq
MIRT972450	hsa-miR-577	CLIP-seq
MIRT2526162	hsa-miR-637	CLIP-seq
MIRT972454	hsa-miR-7	CLIP-seq
MIRT2526163	hsa-miR-765	CLIP-seq
MIRT2526164	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-RNA exonuclease activity	IDA	31127291
GO:0000175	Function	3'-5'-RNA exonuclease activity	IEA
GO:0000287	Function	Magnesium ion binding	IDA	31127291
GO:0000724	Process	Double-strand break repair via homologous recombination	IDA	26807646
GO:0000729	Process	DNA double-strand break processing	IDA	26807646
GO:0003676	Function	Nucleic acid binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	26807646
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IDA	29599527, 31127291
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006302	Process	Double-strand break repair	IDA	26807646
GO:0006310	Process	DNA recombination	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008296	Function	3'-5'-DNA exonuclease activity	IDA	31127291
GO:0008310	Function	Single-stranded DNA 3'-5' DNA exonuclease activity	IDA	26807646
GO:0008310	Function	Single-stranded DNA 3'-5' DNA exonuclease activity	IEA
GO:0008408	Function	3'-5' exonuclease activity	IBA
GO:0008408	Function	3'-5' exonuclease activity	IDA	26807646
GO:0008408	Function	3'-5' exonuclease activity	IEA
GO:0008408	Function	3'-5' exonuclease activity	IMP	31255466
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030145	Function	Manganese ion binding	IDA	31127291
GO:0031297	Process	Replication fork processing	IMP	31255466
GO:0042803	Function	Protein homodimerization activity	IDA	31127291
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0046872	Function	Metal ion binding	IEA
GO:0090304	Process	Nucleic acid metabolic process	IDA	26807646
GO:0090734	Component	Site of DNA damage	IDA	31255466

Other IDs

• MIM: 616940
• HGNC: 20217
• e!Ensembl: ENSG00000081177

Protein

• UniProt ID: Q9NVH0
• Protein name: Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2)
• Protein function: Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, wh
• PDB: 6K17, 6K18, 6K19, 6K1A, 6K1B, 6K1C, 6K1D, 6K1E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01612	DNA_pol_A_exo1	79 → 259		Domain

• Sequence:

  MSRQNLVALTVTTLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQ
  LHSSAPRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASP
  LSLLQMASPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYG
  LVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQV
  IYAARDAQISVALFLHLLGYPFSRNSPGEKNDDHSSWRKVLEKCQGVVDIPFRSKGMSRL
  GEEVNGEATESQQKPRNKKSKMDGMVPGNHQGRDPRKHKRKPLGVGYSARKSPLYDNCFL
  HAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLRFEPAGRPESPGDYYLMVKENLC
  VVCGKRDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKE
  FQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPTQRKEELLQALREFYNTDVVTEEM
  LQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPKHLPQQWS
  VDHNHQKLLRKFGEDLPIQLS

• Sequence length: 621

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HYPERALDOSTERONISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERICARDITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Major Depressive Disorder	Mental Depression	GWASCAT_DG	29942085		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only