LGI2 (leucine rich repeat LGI family member 2)

Gene

• Entrez ID: 55203
• Gene name: Leucine rich repeat LGI family member 2
• Gene symbol: LGI2
• Synonyms (NCBI Gene): LGIL2
• Chromosome: 4
• Chromosome location: 4p15.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045542	hsa-miR-149-5p	CLASH	23622248
MIRT1108359	hsa-miR-101	CLIP-seq
MIRT1108360	hsa-miR-1197	CLIP-seq
MIRT739686	hsa-miR-1200	CLIP-seq
MIRT1108361	hsa-miR-122	CLIP-seq
MIRT1108362	hsa-miR-1236	CLIP-seq
MIRT1108363	hsa-miR-1238	CLIP-seq
MIRT1108364	hsa-miR-125a-5p	CLIP-seq
MIRT1108365	hsa-miR-125b	CLIP-seq
MIRT1108366	hsa-miR-1292	CLIP-seq
MIRT1108367	hsa-miR-1299	CLIP-seq
MIRT1108368	hsa-miR-130a	CLIP-seq
MIRT1108369	hsa-miR-130b	CLIP-seq
MIRT1108370	hsa-miR-1343	CLIP-seq
MIRT1108371	hsa-miR-137	CLIP-seq
MIRT1108372	hsa-miR-144	CLIP-seq
MIRT1108373	hsa-miR-146b-3p	CLIP-seq
MIRT1108374	hsa-miR-148a	CLIP-seq
MIRT1108375	hsa-miR-148b	CLIP-seq
MIRT1108376	hsa-miR-152	CLIP-seq
MIRT1108377	hsa-miR-1587	CLIP-seq
MIRT739687	hsa-miR-181a	CLIP-seq
MIRT739688	hsa-miR-181b	CLIP-seq
MIRT739689	hsa-miR-181c	CLIP-seq
MIRT739691	hsa-miR-181d	CLIP-seq
MIRT1108378	hsa-miR-197	CLIP-seq
MIRT1108379	hsa-miR-198	CLIP-seq
MIRT1108380	hsa-miR-205	CLIP-seq
MIRT1108381	hsa-miR-25	CLIP-seq
MIRT1108382	hsa-miR-27a	CLIP-seq
MIRT1108383	hsa-miR-27b	CLIP-seq
MIRT1108384	hsa-miR-301a	CLIP-seq
MIRT1108385	hsa-miR-301b	CLIP-seq
MIRT1108386	hsa-miR-3074-5p	CLIP-seq
MIRT1108387	hsa-miR-3126-3p	CLIP-seq
MIRT1108388	hsa-miR-3128	CLIP-seq
MIRT1108389	hsa-miR-3129-3p	CLIP-seq
MIRT1108390	hsa-miR-3151	CLIP-seq
MIRT1108391	hsa-miR-3173-5p	CLIP-seq
MIRT1108392	hsa-miR-32	CLIP-seq
MIRT1108393	hsa-miR-335	CLIP-seq
MIRT1108394	hsa-miR-34a	CLIP-seq
MIRT1108395	hsa-miR-34c-5p	CLIP-seq
MIRT1108396	hsa-miR-3613-3p	CLIP-seq
MIRT1108397	hsa-miR-3616-3p	CLIP-seq
MIRT1108398	hsa-miR-3619-3p	CLIP-seq
MIRT1108399	hsa-miR-363	CLIP-seq
MIRT1108400	hsa-miR-3661	CLIP-seq
MIRT1108401	hsa-miR-3663-3p	CLIP-seq
MIRT1108402	hsa-miR-3666	CLIP-seq
MIRT1108403	hsa-miR-367	CLIP-seq
MIRT1108404	hsa-miR-378	CLIP-seq
MIRT1108405	hsa-miR-378b	CLIP-seq
MIRT1108406	hsa-miR-378c	CLIP-seq
MIRT1108407	hsa-miR-378d	CLIP-seq
MIRT1108408	hsa-miR-378e	CLIP-seq
MIRT1108409	hsa-miR-378f	CLIP-seq
MIRT1108410	hsa-miR-378h	CLIP-seq
MIRT1108411	hsa-miR-378i	CLIP-seq
MIRT1108412	hsa-miR-382	CLIP-seq
MIRT1108413	hsa-miR-3908	CLIP-seq
MIRT1108414	hsa-miR-3920	CLIP-seq
MIRT1108415	hsa-miR-422a	CLIP-seq
MIRT1108416	hsa-miR-4254	CLIP-seq
MIRT739690	hsa-miR-4262	CLIP-seq
MIRT1108417	hsa-miR-4265	CLIP-seq
MIRT1108418	hsa-miR-4271	CLIP-seq
MIRT1108419	hsa-miR-4291	CLIP-seq
MIRT1108420	hsa-miR-4295	CLIP-seq
MIRT1108421	hsa-miR-4296	CLIP-seq
MIRT1108422	hsa-miR-4319	CLIP-seq
MIRT1108423	hsa-miR-4322	CLIP-seq
MIRT1108424	hsa-miR-4325	CLIP-seq
MIRT1108425	hsa-miR-4417	CLIP-seq
MIRT1108426	hsa-miR-4452	CLIP-seq
MIRT1108427	hsa-miR-4471	CLIP-seq
MIRT1108428	hsa-miR-448	CLIP-seq
MIRT1108429	hsa-miR-4481	CLIP-seq
MIRT1108430	hsa-miR-4492	CLIP-seq
MIRT1108431	hsa-miR-4498	CLIP-seq
MIRT1108432	hsa-miR-449a	CLIP-seq
MIRT1108433	hsa-miR-449b	CLIP-seq
MIRT1108434	hsa-miR-454	CLIP-seq
MIRT1108435	hsa-miR-4638-3p	CLIP-seq
MIRT1108436	hsa-miR-4648	CLIP-seq
MIRT1108437	hsa-miR-4654	CLIP-seq
MIRT1108438	hsa-miR-4656	CLIP-seq
MIRT1108439	hsa-miR-4662a-5p	CLIP-seq
MIRT1108440	hsa-miR-4675	CLIP-seq
MIRT1108441	hsa-miR-4691-5p	CLIP-seq
MIRT1108442	hsa-miR-4720-5p	CLIP-seq
MIRT1108443	hsa-miR-4725-3p	CLIP-seq
MIRT1108444	hsa-miR-4732-3p	CLIP-seq
MIRT1108445	hsa-miR-4741	CLIP-seq
MIRT1108446	hsa-miR-4745-5p	CLIP-seq
MIRT1108447	hsa-miR-4762-5p	CLIP-seq
MIRT1108448	hsa-miR-4769-5p	CLIP-seq
MIRT1108449	hsa-miR-4776-5p	CLIP-seq
MIRT1108450	hsa-miR-4778-3p	CLIP-seq
MIRT1108451	hsa-miR-4781-5p	CLIP-seq
MIRT1108452	hsa-miR-4782-5p	CLIP-seq
MIRT739692	hsa-miR-4789-5p	CLIP-seq
MIRT1108453	hsa-miR-4793-3p	CLIP-seq
MIRT1108454	hsa-miR-4799-3p	CLIP-seq
MIRT1108455	hsa-miR-483-3p	CLIP-seq
MIRT1108456	hsa-miR-498	CLIP-seq
MIRT1108457	hsa-miR-499-3p	CLIP-seq
MIRT1108458	hsa-miR-499a-3p	CLIP-seq
MIRT1108459	hsa-miR-513a-3p	CLIP-seq
MIRT1108460	hsa-miR-513a-5p	CLIP-seq
MIRT1108461	hsa-miR-516b	CLIP-seq
MIRT1108462	hsa-miR-520a-5p	CLIP-seq
MIRT1108463	hsa-miR-525-5p	CLIP-seq
MIRT1108464	hsa-miR-539	CLIP-seq
MIRT1108465	hsa-miR-545	CLIP-seq
MIRT1108466	hsa-miR-574-5p	CLIP-seq
MIRT1108467	hsa-miR-587	CLIP-seq
MIRT1108468	hsa-miR-619	CLIP-seq
MIRT1108469	hsa-miR-625	CLIP-seq
MIRT1108470	hsa-miR-631	CLIP-seq
MIRT1108471	hsa-miR-670	CLIP-seq
MIRT1108472	hsa-miR-762	CLIP-seq
MIRT1108473	hsa-miR-874	CLIP-seq
MIRT1108474	hsa-miR-92a	CLIP-seq
MIRT1108475	hsa-miR-92b	CLIP-seq
MIRT1108362	hsa-miR-1236	CLIP-seq
MIRT1108371	hsa-miR-137	CLIP-seq
MIRT2029941	hsa-miR-139-5p	CLIP-seq
MIRT1108380	hsa-miR-205	CLIP-seq
MIRT1108382	hsa-miR-27a	CLIP-seq
MIRT1108383	hsa-miR-27b	CLIP-seq
MIRT2029942	hsa-miR-3065-5p	CLIP-seq
MIRT2029943	hsa-miR-3125	CLIP-seq
MIRT1108387	hsa-miR-3126-3p	CLIP-seq
MIRT2029944	hsa-miR-3138	CLIP-seq
MIRT2029945	hsa-miR-3161	CLIP-seq
MIRT2029946	hsa-miR-3165	CLIP-seq
MIRT1108396	hsa-miR-3613-3p	CLIP-seq
MIRT1108412	hsa-miR-382	CLIP-seq
MIRT1108413	hsa-miR-3908	CLIP-seq
MIRT2029947	hsa-miR-3916	CLIP-seq
MIRT2029948	hsa-miR-3942-3p	CLIP-seq
MIRT2029949	hsa-miR-4299	CLIP-seq
MIRT1108426	hsa-miR-4452	CLIP-seq
MIRT2029950	hsa-miR-4456	CLIP-seq
MIRT2029951	hsa-miR-4496	CLIP-seq
MIRT2029952	hsa-miR-4501	CLIP-seq
MIRT2029953	hsa-miR-4659a-5p	CLIP-seq
MIRT2029954	hsa-miR-4659b-5p	CLIP-seq
MIRT2029955	hsa-miR-4768-5p	CLIP-seq
MIRT2029956	hsa-miR-4776-3p	CLIP-seq
MIRT1108450	hsa-miR-4778-3p	CLIP-seq
MIRT2029957	hsa-miR-511	CLIP-seq
MIRT1108460	hsa-miR-513a-5p	CLIP-seq
MIRT2029958	hsa-miR-548q	CLIP-seq
MIRT2029959	hsa-miR-873	CLIP-seq
MIRT2260820	hsa-miR-106a	CLIP-seq
MIRT2260821	hsa-miR-106b	CLIP-seq
MIRT2260822	hsa-miR-1264	CLIP-seq
MIRT1108371	hsa-miR-137	CLIP-seq
MIRT2260823	hsa-miR-142-5p	CLIP-seq
MIRT2260824	hsa-miR-17	CLIP-seq
MIRT2260825	hsa-miR-20a	CLIP-seq
MIRT2260826	hsa-miR-20b	CLIP-seq
MIRT2260827	hsa-miR-2116	CLIP-seq
MIRT2029942	hsa-miR-3065-5p	CLIP-seq
MIRT2260828	hsa-miR-3119	CLIP-seq
MIRT2260829	hsa-miR-3124-3p	CLIP-seq
MIRT2260830	hsa-miR-3148	CLIP-seq
MIRT2260831	hsa-miR-3192	CLIP-seq
MIRT2260832	hsa-miR-320a	CLIP-seq
MIRT2260833	hsa-miR-320b	CLIP-seq
MIRT2260834	hsa-miR-320c	CLIP-seq
MIRT2260835	hsa-miR-320d	CLIP-seq
MIRT2260836	hsa-miR-326	CLIP-seq
MIRT2260837	hsa-miR-330-5p	CLIP-seq
MIRT2260838	hsa-miR-338-5p	CLIP-seq
MIRT2260839	hsa-miR-340	CLIP-seq
MIRT2260840	hsa-miR-3658	CLIP-seq
MIRT2260841	hsa-miR-3685	CLIP-seq
MIRT2260842	hsa-miR-384	CLIP-seq
MIRT2260843	hsa-miR-4293	CLIP-seq
MIRT2260844	hsa-miR-4314	CLIP-seq
MIRT2260845	hsa-miR-4429	CLIP-seq
MIRT2260846	hsa-miR-4646-5p	CLIP-seq
MIRT2260847	hsa-miR-4728-3p	CLIP-seq
MIRT2029955	hsa-miR-4768-5p	CLIP-seq
MIRT2260848	hsa-miR-4771	CLIP-seq
MIRT2260849	hsa-miR-499a-5p	CLIP-seq
MIRT2260850	hsa-miR-519d	CLIP-seq
MIRT2260851	hsa-miR-548c-3p	CLIP-seq
MIRT2260852	hsa-miR-548t	CLIP-seq
MIRT2260853	hsa-miR-596	CLIP-seq
MIRT2029959	hsa-miR-873	CLIP-seq
MIRT2260854	hsa-miR-93	CLIP-seq
MIRT2029953	hsa-miR-4659a-5p	CLIP-seq
MIRT2029954	hsa-miR-4659b-5p	CLIP-seq
MIRT2029956	hsa-miR-4776-3p	CLIP-seq
MIRT1108450	hsa-miR-4778-3p	CLIP-seq
MIRT2390106	hsa-miR-578	CLIP-seq
MIRT2560888	hsa-miR-3667-3p	CLIP-seq
MIRT2560889	hsa-miR-3692	CLIP-seq
MIRT2560888	hsa-miR-3667-3p	CLIP-seq
MIRT2560889	hsa-miR-3692	CLIP-seq
MIRT2029955	hsa-miR-4768-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:1904862	Process	Inhibitory synapse assembly	IBA
GO:1904862	Process	Inhibitory synapse assembly	IEA
GO:1904862	Process	Inhibitory synapse assembly	ISS

Other IDs

• MIM: 608301
• HGNC: 18710
• e!Ensembl: ENSG00000153012

Protein

• UniProt ID: Q8N0V4
• Protein name: Leucine-rich repeat LGI family member 2 (LGI1-like protein 2) (Leucine-rich glioma-inactivated protein 2)
• Protein function: Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	62 → 121	Leucine rich repeat	Repeat
  PF13855	LRR_8	110 → 169	Leucine rich repeat	Repeat
  PF03736	EPTP	219 → 260	EPTP domain	Repeat
  PF03736	EPTP	265 → 306	EPTP domain	Repeat
  PF03736	EPTP	311 → 357	EPTP domain	Repeat
  PF03736	EPTP	360 → 402	EPTP domain	Repeat
  PF03736	EPTP	407 → 449	EPTP domain	Repeat
  PF03736	EPTP	452 → 493	EPTP domain	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Brain, heart and placenta. {ECO:0000269|PubMed:12023020}.
• Sequence:

  MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
  IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
  WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
  DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
  HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG
  FYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDV
  LAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLAL
  GSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHII
  VDLSL

• Sequence length: 545

Pathways

Reactome:

LGI-ADAM interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinogenesis	Carcinogenesis	Pubtator	12023020	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35800238	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsies Partial	Partial epilepsy	Pubtator	20863412	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsies, Partial	Epilepsy	BEFREE	20863412, 21829378		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	20863412, 21829378, 22037590, 26032921		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	20863412	Associate	★☆☆☆☆ Found in Text Mining only