Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55176
Gene name	SEC61 translocon subunit alpha 2
Gene symbol	SEC61A2
Synonyms (NCBI Gene)	-
Chromosome	10
Chromosome location	10p14
Summary	The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. A

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029682	hsa-miR-26b-5p	Microarray	19088304
MIRT051301	hsa-miR-16-5p	CLASH	23622248
MIRT047197	hsa-miR-182-5p	CLASH	23622248
MIRT534429	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT534428	hsa-miR-181a-2-3p	PAR-CLIP	22012620
MIRT534427	hsa-miR-4286	PAR-CLIP	22012620
MIRT534426	hsa-miR-4539	PAR-CLIP	22012620
MIRT534425	hsa-miR-6802-3p	PAR-CLIP	22012620
MIRT534423	hsa-miR-7158-3p	PAR-CLIP	22012620
MIRT534424	hsa-miR-1273e	PAR-CLIP	22012620
MIRT448493	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT448492	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT448491	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT448490	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT448489	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT448488	hsa-miR-4495	PAR-CLIP	22100165
MIRT448493	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT448492	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT448491	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT448490	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT448489	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT448488	hsa-miR-4495	PAR-CLIP	22100165
MIRT534429	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT534428	hsa-miR-181a-2-3p	PAR-CLIP	22012620
MIRT534427	hsa-miR-4286	PAR-CLIP	22012620
MIRT534426	hsa-miR-4539	PAR-CLIP	22012620
MIRT534425	hsa-miR-6802-3p	PAR-CLIP	22012620
MIRT534423	hsa-miR-7158-3p	PAR-CLIP	22012620
MIRT534424	hsa-miR-1273e	PAR-CLIP	22012620
MIRT448493	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT448492	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT448491	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT448490	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT448489	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT448488	hsa-miR-4495	PAR-CLIP	22100165
MIRT448493	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT448492	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT448491	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT448490	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT448489	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT448488	hsa-miR-4495	PAR-CLIP	22100165
MIRT1333443	hsa-miR-4749-3p	CLIP-seq
MIRT1333444	hsa-miR-873	CLIP-seq
MIRT1333445	hsa-miR-103b	CLIP-seq
MIRT1333446	hsa-miR-1243	CLIP-seq
MIRT1333447	hsa-miR-1322	CLIP-seq
MIRT1333448	hsa-miR-200b	CLIP-seq
MIRT1333449	hsa-miR-200c	CLIP-seq
MIRT1333450	hsa-miR-3150b-3p	CLIP-seq
MIRT1333451	hsa-miR-3154	CLIP-seq
MIRT1333452	hsa-miR-3198	CLIP-seq
MIRT1333453	hsa-miR-323b-3p	CLIP-seq
MIRT1333454	hsa-miR-3613-3p	CLIP-seq
MIRT1333455	hsa-miR-3654	CLIP-seq
MIRT1333456	hsa-miR-371b-5p	CLIP-seq
MIRT1333457	hsa-miR-3910	CLIP-seq
MIRT1333458	hsa-miR-3978	CLIP-seq
MIRT1333459	hsa-miR-429	CLIP-seq
MIRT1333460	hsa-miR-4309	CLIP-seq
MIRT1333461	hsa-miR-4438	CLIP-seq
MIRT1333462	hsa-miR-4470	CLIP-seq
MIRT1333463	hsa-miR-4646-5p	CLIP-seq
MIRT1333464	hsa-miR-4653-3p	CLIP-seq
MIRT1333465	hsa-miR-4662a-5p	CLIP-seq
MIRT1333466	hsa-miR-4742-5p	CLIP-seq
MIRT1333467	hsa-miR-4747-5p	CLIP-seq
MIRT1333468	hsa-miR-4784	CLIP-seq
MIRT1333469	hsa-miR-4796-3p	CLIP-seq
MIRT1333470	hsa-miR-5095	CLIP-seq
MIRT1333471	hsa-miR-626	CLIP-seq
MIRT1333472	hsa-miR-668	CLIP-seq
MIRT1333473	hsa-miR-765	CLIP-seq
MIRT1333474	hsa-miR-875-3p	CLIP-seq
MIRT1333475	hsa-miR-28-3p	CLIP-seq
MIRT1333476	hsa-miR-3120-3p	CLIP-seq
MIRT1333477	hsa-miR-3180-5p	CLIP-seq
MIRT1333478	hsa-miR-338-3p	CLIP-seq
MIRT1333479	hsa-miR-3927	CLIP-seq
MIRT1333480	hsa-miR-3935	CLIP-seq
MIRT1333481	hsa-miR-4310	CLIP-seq
MIRT1333461	hsa-miR-4438	CLIP-seq
MIRT1333482	hsa-miR-4530	CLIP-seq
MIRT1333483	hsa-miR-4704-5p	CLIP-seq
MIRT1333466	hsa-miR-4742-5p	CLIP-seq
MIRT1333470	hsa-miR-5095	CLIP-seq
MIRT1333484	hsa-miR-576-3p	CLIP-seq
MIRT1333485	hsa-miR-580	CLIP-seq
MIRT1333445	hsa-miR-103b	CLIP-seq
MIRT2098616	hsa-miR-204	CLIP-seq
MIRT2098617	hsa-miR-211	CLIP-seq
MIRT2098618	hsa-miR-30a	CLIP-seq
MIRT2098619	hsa-miR-30b	CLIP-seq
MIRT2098620	hsa-miR-30c	CLIP-seq
MIRT2098621	hsa-miR-30d	CLIP-seq
MIRT2098622	hsa-miR-30e	CLIP-seq
MIRT1333477	hsa-miR-3180-5p	CLIP-seq
MIRT1333453	hsa-miR-323b-3p	CLIP-seq
MIRT1333478	hsa-miR-338-3p	CLIP-seq
MIRT2098623	hsa-miR-3646	CLIP-seq
MIRT2098624	hsa-miR-3662	CLIP-seq
MIRT2098625	hsa-miR-377	CLIP-seq
MIRT1333481	hsa-miR-4310	CLIP-seq
MIRT1333461	hsa-miR-4438	CLIP-seq
MIRT2098626	hsa-miR-4446-5p	CLIP-seq
MIRT1333462	hsa-miR-4470	CLIP-seq
MIRT1333482	hsa-miR-4530	CLIP-seq
MIRT1333465	hsa-miR-4662a-5p	CLIP-seq
MIRT2098627	hsa-miR-4698	CLIP-seq
MIRT1333466	hsa-miR-4742-5p	CLIP-seq
MIRT2098628	hsa-miR-4755-5p	CLIP-seq
MIRT1333470	hsa-miR-5095	CLIP-seq
MIRT2098629	hsa-miR-623	CLIP-seq
MIRT2323325	hsa-miR-19a	CLIP-seq
MIRT2323326	hsa-miR-19b	CLIP-seq
MIRT2098618	hsa-miR-30a	CLIP-seq
MIRT2098619	hsa-miR-30b	CLIP-seq
MIRT2098620	hsa-miR-30c	CLIP-seq
MIRT2098621	hsa-miR-30d	CLIP-seq
MIRT2098622	hsa-miR-30e	CLIP-seq
MIRT1333477	hsa-miR-3180-5p	CLIP-seq
MIRT1333478	hsa-miR-338-3p	CLIP-seq
MIRT1333481	hsa-miR-4310	CLIP-seq
MIRT1333461	hsa-miR-4438	CLIP-seq
MIRT1333482	hsa-miR-4530	CLIP-seq
MIRT1333466	hsa-miR-4742-5p	CLIP-seq
MIRT1333470	hsa-miR-5095	CLIP-seq
MIRT2323327	hsa-miR-548ad	CLIP-seq
MIRT2459053	hsa-miR-1245b-5p	CLIP-seq
MIRT2459054	hsa-miR-1252	CLIP-seq
MIRT2459055	hsa-miR-3125	CLIP-seq
MIRT2459056	hsa-miR-3142	CLIP-seq
MIRT1333450	hsa-miR-3150b-3p	CLIP-seq
MIRT2459057	hsa-miR-3173-3p	CLIP-seq
MIRT2459058	hsa-miR-3916	CLIP-seq
MIRT2459059	hsa-miR-4434	CLIP-seq
MIRT2459060	hsa-miR-4516	CLIP-seq
MIRT2459061	hsa-miR-4695-5p	CLIP-seq
MIRT1333468	hsa-miR-4784	CLIP-seq
MIRT1333473	hsa-miR-765	CLIP-seq
MIRT2459053	hsa-miR-1245b-5p	CLIP-seq
MIRT2459054	hsa-miR-1252	CLIP-seq
MIRT2619166	hsa-miR-186	CLIP-seq
MIRT2619167	hsa-miR-2909	CLIP-seq
MIRT2619168	hsa-miR-299-3p	CLIP-seq
MIRT2459055	hsa-miR-3125	CLIP-seq
MIRT2459056	hsa-miR-3142	CLIP-seq
MIRT1333450	hsa-miR-3150b-3p	CLIP-seq
MIRT2619169	hsa-miR-3162-5p	CLIP-seq
MIRT2459057	hsa-miR-3173-3p	CLIP-seq
MIRT2619170	hsa-miR-3688-5p	CLIP-seq
MIRT2619171	hsa-miR-384	CLIP-seq
MIRT2459058	hsa-miR-3916	CLIP-seq
MIRT2619172	hsa-miR-4265	CLIP-seq
MIRT2619173	hsa-miR-4289	CLIP-seq
MIRT2619174	hsa-miR-4296	CLIP-seq
MIRT2619175	hsa-miR-4322	CLIP-seq
MIRT2619176	hsa-miR-4417	CLIP-seq
MIRT2459059	hsa-miR-4434	CLIP-seq
MIRT2619177	hsa-miR-4474-3p	CLIP-seq
MIRT2459060	hsa-miR-4516	CLIP-seq
MIRT2619178	hsa-miR-4641	CLIP-seq
MIRT1333463	hsa-miR-4646-5p	CLIP-seq
MIRT2459061	hsa-miR-4695-5p	CLIP-seq
MIRT2619179	hsa-miR-4719	CLIP-seq
MIRT1333467	hsa-miR-4747-5p	CLIP-seq
MIRT1333468	hsa-miR-4784	CLIP-seq
MIRT1333485	hsa-miR-580	CLIP-seq
MIRT2619180	hsa-miR-582-3p	CLIP-seq
MIRT2619181	hsa-miR-664	CLIP-seq
MIRT1333472	hsa-miR-668	CLIP-seq
MIRT1333473	hsa-miR-765	CLIP-seq
MIRT2459053	hsa-miR-1245b-5p	CLIP-seq
MIRT2459054	hsa-miR-1252	CLIP-seq
MIRT2619168	hsa-miR-299-3p	CLIP-seq
MIRT2459055	hsa-miR-3125	CLIP-seq
MIRT2459056	hsa-miR-3142	CLIP-seq
MIRT1333450	hsa-miR-3150b-3p	CLIP-seq
MIRT2459057	hsa-miR-3173-3p	CLIP-seq
MIRT2619170	hsa-miR-3688-5p	CLIP-seq
MIRT2619171	hsa-miR-384	CLIP-seq
MIRT2459058	hsa-miR-3916	CLIP-seq
MIRT2619172	hsa-miR-4265	CLIP-seq
MIRT2619173	hsa-miR-4289	CLIP-seq
MIRT2619174	hsa-miR-4296	CLIP-seq
MIRT2619175	hsa-miR-4322	CLIP-seq
MIRT2619176	hsa-miR-4417	CLIP-seq
MIRT2459059	hsa-miR-4434	CLIP-seq
MIRT2619177	hsa-miR-4474-3p	CLIP-seq
MIRT2459060	hsa-miR-4516	CLIP-seq
MIRT2619178	hsa-miR-4641	CLIP-seq
MIRT1333463	hsa-miR-4646-5p	CLIP-seq
MIRT2459061	hsa-miR-4695-5p	CLIP-seq
MIRT2619179	hsa-miR-4719	CLIP-seq
MIRT1333467	hsa-miR-4747-5p	CLIP-seq
MIRT1333468	hsa-miR-4784	CLIP-seq
MIRT1333485	hsa-miR-580	CLIP-seq
MIRT2619180	hsa-miR-582-3p	CLIP-seq
MIRT2619181	hsa-miR-664	CLIP-seq
MIRT1333472	hsa-miR-668	CLIP-seq
MIRT1333473	hsa-miR-765	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005048	Function	Signal sequence binding	IBA
GO:0005515	Function	Protein binding	IPI	30021884, 35271311
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005784	Component	Sec61 translocon complex	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006616	Process	SRP-dependent cotranslational protein targeting to membrane, translocation	IBA
GO:0008320	Function	Protein transmembrane transporter activity	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0031204	Process	Post-translational protein targeting to membrane, translocation	IBA
GO:0043022	Function	Ribosome binding	IBA
GO:0043022	Function	Ribosome binding	IEA

MIM	HGNC	e!Ensembl
618271	17702	ENSG00000065665

Q9H9S3

Protein name

Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2)

Protein function

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both function

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10559	Plug_translocon	40 → 74	Plug domain of Sec61p	Domain
PF00344	SecY	75 → 458	SecY translocase	Family

Sequence

MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSAD
PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG
MIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGIS
LFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLP
NLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSN
LYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVH
VVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTA
AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF

Sequence length

476

Interactions

View interactions

	KEGG
	Protein export Protein processing in endoplasmic reticulum Phagosome Vibrio cholerae infection

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Autosomal dominant polycystic liver disease	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

SEC61A2 (SEC61 translocon subunit alpha 2)