TBCCD1 (TBCC domain containing 1)

Gene

• Entrez ID: 55171
• Gene name: TBCC domain containing 1
• Gene symbol: TBCCD1
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q27.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006245	hsa-miR-195-5p	Luciferase reporter assay, Western blot	22217655
MIRT006245	hsa-miR-195-5p	Luciferase reporter assay, Western blot	22217655
MIRT006245	hsa-miR-195-5p	Luciferase reporter assay, Western blot	22217655
MIRT029823	hsa-miR-26b-5p	Microarray	19088304
MIRT712134	hsa-miR-4744	HITS-CLIP	19536157
MIRT712133	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT712132	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT665909	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT665908	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT665907	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT665906	hsa-miR-612	HITS-CLIP	23824327
MIRT665905	hsa-miR-6860	HITS-CLIP	23824327
MIRT665904	hsa-miR-564	HITS-CLIP	23824327
MIRT665903	hsa-miR-4284	HITS-CLIP	23824327
MIRT665902	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT665901	hsa-miR-4505	HITS-CLIP	23824327
MIRT665900	hsa-miR-5787	HITS-CLIP	23824327
MIRT665899	hsa-miR-7977	HITS-CLIP	23824327
MIRT541792	hsa-miR-4432	PAR-CLIP	21572407
MIRT541791	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT541790	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT541789	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT541788	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT541787	hsa-miR-4486	PAR-CLIP	21572407
MIRT541786	hsa-miR-4522	PAR-CLIP	21572407
MIRT541785	hsa-miR-661	PAR-CLIP	21572407
MIRT541784	hsa-miR-1273a	PAR-CLIP	21572407
MIRT541783	hsa-miR-4649-5p	PAR-CLIP	21572407
MIRT541782	hsa-miR-6729-5p	PAR-CLIP	21572407
MIRT541781	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT541780	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT541779	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT726360	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726359	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726358	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT006245	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT541784	hsa-miR-1273a	PAR-CLIP	27292025
MIRT541792	hsa-miR-4432	PAR-CLIP	27292025
MIRT541787	hsa-miR-4486	PAR-CLIP	27292025
MIRT541786	hsa-miR-4522	PAR-CLIP	27292025
MIRT541783	hsa-miR-4649-5p	PAR-CLIP	27292025
MIRT541779	hsa-miR-5001-3p	PAR-CLIP	27292025
MIRT541791	hsa-miR-589-3p	PAR-CLIP	27292025
MIRT541781	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT541785	hsa-miR-661	PAR-CLIP	27292025
MIRT541780	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT541782	hsa-miR-6729-5p	PAR-CLIP	27292025
MIRT541790	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT541789	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT712134	hsa-miR-4744	HITS-CLIP	19536157
MIRT712133	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT712132	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT665909	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT665908	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT665907	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT665906	hsa-miR-612	HITS-CLIP	23824327
MIRT665905	hsa-miR-6860	HITS-CLIP	23824327
MIRT665904	hsa-miR-564	HITS-CLIP	23824327
MIRT665903	hsa-miR-4284	HITS-CLIP	23824327
MIRT665902	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT665901	hsa-miR-4505	HITS-CLIP	23824327
MIRT665900	hsa-miR-5787	HITS-CLIP	23824327
MIRT665899	hsa-miR-7977	HITS-CLIP	23824327
MIRT541792	hsa-miR-4432	PAR-CLIP	21572407
MIRT541791	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT541790	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT541789	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT541788	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT541787	hsa-miR-4486	PAR-CLIP	21572407
MIRT541786	hsa-miR-4522	PAR-CLIP	21572407
MIRT541785	hsa-miR-661	PAR-CLIP	21572407
MIRT541784	hsa-miR-1273a	PAR-CLIP	21572407
MIRT541783	hsa-miR-4649-5p	PAR-CLIP	21572407
MIRT541782	hsa-miR-6729-5p	PAR-CLIP	21572407
MIRT541781	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT541780	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT541779	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT1414018	hsa-miR-1268	CLIP-seq
MIRT1414019	hsa-miR-1268b	CLIP-seq
MIRT1414020	hsa-miR-1273f	CLIP-seq
MIRT1414021	hsa-miR-1285	CLIP-seq
MIRT1414022	hsa-miR-1297	CLIP-seq
MIRT1414023	hsa-miR-136	CLIP-seq
MIRT1414024	hsa-miR-1908	CLIP-seq
MIRT1414025	hsa-miR-199a-5p	CLIP-seq
MIRT1414026	hsa-miR-199b-5p	CLIP-seq
MIRT1414027	hsa-miR-2114	CLIP-seq
MIRT1414028	hsa-miR-24	CLIP-seq
MIRT1414029	hsa-miR-26a	CLIP-seq
MIRT1414030	hsa-miR-26b	CLIP-seq
MIRT1414031	hsa-miR-29a	CLIP-seq
MIRT1414032	hsa-miR-29b	CLIP-seq
MIRT1414033	hsa-miR-29c	CLIP-seq
MIRT1414034	hsa-miR-3065-5p	CLIP-seq
MIRT1414035	hsa-miR-3122	CLIP-seq
MIRT1414036	hsa-miR-3180-5p	CLIP-seq
MIRT1414037	hsa-miR-346	CLIP-seq
MIRT1414038	hsa-miR-362-5p	CLIP-seq
MIRT1414039	hsa-miR-3663-3p	CLIP-seq
MIRT1414040	hsa-miR-3689a-3p	CLIP-seq
MIRT1414041	hsa-miR-3689c	CLIP-seq
MIRT1414042	hsa-miR-3913-5p	CLIP-seq
MIRT1414043	hsa-miR-3918	CLIP-seq
MIRT1414044	hsa-miR-4252	CLIP-seq
MIRT1414045	hsa-miR-4288	CLIP-seq
MIRT1414046	hsa-miR-4433	CLIP-seq
MIRT1414047	hsa-miR-4465	CLIP-seq
MIRT1414048	hsa-miR-4685-5p	CLIP-seq
MIRT1414049	hsa-miR-4691-5p	CLIP-seq
MIRT1414050	hsa-miR-4728-5p	CLIP-seq
MIRT1414051	hsa-miR-4729	CLIP-seq
MIRT1414052	hsa-miR-4767	CLIP-seq
MIRT1414053	hsa-miR-4793-3p	CLIP-seq
MIRT1414054	hsa-miR-4796-5p	CLIP-seq
MIRT1414055	hsa-miR-487a	CLIP-seq
MIRT1414056	hsa-miR-498	CLIP-seq
MIRT1414057	hsa-miR-500b	CLIP-seq
MIRT1414058	hsa-miR-501-5p	CLIP-seq
MIRT1414059	hsa-miR-508-5p	CLIP-seq
MIRT1414060	hsa-miR-510	CLIP-seq
MIRT1414061	hsa-miR-566	CLIP-seq
MIRT1414062	hsa-miR-632	CLIP-seq
MIRT1414063	hsa-miR-643	CLIP-seq
MIRT1414064	hsa-miR-654-3p	CLIP-seq
MIRT1414065	hsa-miR-663	CLIP-seq
MIRT1414066	hsa-miR-766	CLIP-seq
MIRT1414067	hsa-miR-767-5p	CLIP-seq
MIRT1414068	hsa-miR-1273	CLIP-seq
MIRT1414021	hsa-miR-1285	CLIP-seq
MIRT1414022	hsa-miR-1297	CLIP-seq
MIRT1414023	hsa-miR-136	CLIP-seq
MIRT1414069	hsa-miR-15a	CLIP-seq
MIRT1414070	hsa-miR-15b	CLIP-seq
MIRT1414071	hsa-miR-16	CLIP-seq
MIRT1414072	hsa-miR-195	CLIP-seq
MIRT1414027	hsa-miR-2114	CLIP-seq
MIRT1414028	hsa-miR-24	CLIP-seq
MIRT1414029	hsa-miR-26a	CLIP-seq
MIRT1414030	hsa-miR-26b	CLIP-seq
MIRT1414031	hsa-miR-29a	CLIP-seq
MIRT1414032	hsa-miR-29b	CLIP-seq
MIRT1414033	hsa-miR-29c	CLIP-seq
MIRT1414038	hsa-miR-362-5p	CLIP-seq
MIRT1414039	hsa-miR-3663-3p	CLIP-seq
MIRT1414073	hsa-miR-3942-5p	CLIP-seq
MIRT1414074	hsa-miR-424	CLIP-seq
MIRT1414044	hsa-miR-4252	CLIP-seq
MIRT1414046	hsa-miR-4433	CLIP-seq
MIRT1414047	hsa-miR-4465	CLIP-seq
MIRT1414075	hsa-miR-4503	CLIP-seq
MIRT1414049	hsa-miR-4691-5p	CLIP-seq
MIRT1414076	hsa-miR-4703-5p	CLIP-seq
MIRT1414051	hsa-miR-4729	CLIP-seq
MIRT1414077	hsa-miR-4773	CLIP-seq
MIRT1414053	hsa-miR-4793-3p	CLIP-seq
MIRT1414078	hsa-miR-497	CLIP-seq
MIRT1414056	hsa-miR-498	CLIP-seq
MIRT1414057	hsa-miR-500b	CLIP-seq
MIRT1414058	hsa-miR-501-5p	CLIP-seq
MIRT1414059	hsa-miR-508-5p	CLIP-seq
MIRT1414060	hsa-miR-510	CLIP-seq
MIRT1414079	hsa-miR-593	CLIP-seq
MIRT1414063	hsa-miR-643	CLIP-seq
MIRT1414066	hsa-miR-766	CLIP-seq
MIRT1414067	hsa-miR-767-5p	CLIP-seq
MIRT1414068	hsa-miR-1273	CLIP-seq
MIRT1414044	hsa-miR-4252	CLIP-seq
MIRT1414053	hsa-miR-4793-3p	CLIP-seq
MIRT1414059	hsa-miR-508-5p	CLIP-seq
MIRT1414066	hsa-miR-766	CLIP-seq
MIRT1414020	hsa-miR-1273f	CLIP-seq
MIRT1414069	hsa-miR-15a	CLIP-seq
MIRT1414070	hsa-miR-15b	CLIP-seq
MIRT1414071	hsa-miR-16	CLIP-seq
MIRT1414072	hsa-miR-195	CLIP-seq
MIRT1414028	hsa-miR-24	CLIP-seq
MIRT1414031	hsa-miR-29a	CLIP-seq
MIRT1414032	hsa-miR-29b	CLIP-seq
MIRT1414033	hsa-miR-29c	CLIP-seq
MIRT1414035	hsa-miR-3122	CLIP-seq
MIRT1414040	hsa-miR-3689a-3p	CLIP-seq
MIRT1414041	hsa-miR-3689c	CLIP-seq
MIRT1414042	hsa-miR-3913-5p	CLIP-seq
MIRT1414073	hsa-miR-3942-5p	CLIP-seq
MIRT1414074	hsa-miR-424	CLIP-seq
MIRT1414046	hsa-miR-4433	CLIP-seq
MIRT1414075	hsa-miR-4503	CLIP-seq
MIRT1414076	hsa-miR-4703-5p	CLIP-seq
MIRT1414050	hsa-miR-4728-5p	CLIP-seq
MIRT1414078	hsa-miR-497	CLIP-seq
MIRT1414060	hsa-miR-510	CLIP-seq
MIRT1414079	hsa-miR-593	CLIP-seq
MIRT1414022	hsa-miR-1297	CLIP-seq
MIRT1414069	hsa-miR-15a	CLIP-seq
MIRT1414070	hsa-miR-15b	CLIP-seq
MIRT1414071	hsa-miR-16	CLIP-seq
MIRT1414072	hsa-miR-195	CLIP-seq
MIRT1414029	hsa-miR-26a	CLIP-seq
MIRT1414030	hsa-miR-26b	CLIP-seq
MIRT1414031	hsa-miR-29a	CLIP-seq
MIRT1414032	hsa-miR-29b	CLIP-seq
MIRT1414033	hsa-miR-29c	CLIP-seq
MIRT1414073	hsa-miR-3942-5p	CLIP-seq
MIRT1414074	hsa-miR-424	CLIP-seq
MIRT1414047	hsa-miR-4465	CLIP-seq
MIRT1414075	hsa-miR-4503	CLIP-seq
MIRT1414076	hsa-miR-4703-5p	CLIP-seq
MIRT1414078	hsa-miR-497	CLIP-seq
MIRT1414056	hsa-miR-498	CLIP-seq
MIRT1414079	hsa-miR-593	CLIP-seq
MIRT1414018	hsa-miR-1268	CLIP-seq
MIRT1414019	hsa-miR-1268b	CLIP-seq
MIRT1414020	hsa-miR-1273f	CLIP-seq
MIRT1414024	hsa-miR-1908	CLIP-seq
MIRT1414035	hsa-miR-3122	CLIP-seq
MIRT2461199	hsa-miR-3613-3p	CLIP-seq
MIRT1414040	hsa-miR-3689a-3p	CLIP-seq
MIRT1414041	hsa-miR-3689c	CLIP-seq
MIRT1414042	hsa-miR-3913-5p	CLIP-seq
MIRT2461200	hsa-miR-4684-5p	CLIP-seq
MIRT1414050	hsa-miR-4728-5p	CLIP-seq
MIRT2461201	hsa-miR-4743	CLIP-seq
MIRT1414052	hsa-miR-4767	CLIP-seq
MIRT2461202	hsa-miR-548c-3p	CLIP-seq
MIRT1414065	hsa-miR-663	CLIP-seq
MIRT1414020	hsa-miR-1273f	CLIP-seq
MIRT1414035	hsa-miR-3122	CLIP-seq
MIRT1414040	hsa-miR-3689a-3p	CLIP-seq
MIRT1414041	hsa-miR-3689c	CLIP-seq
MIRT1414042	hsa-miR-3913-5p	CLIP-seq
MIRT1414050	hsa-miR-4728-5p	CLIP-seq
MIRT1414018	hsa-miR-1268	CLIP-seq
MIRT1414019	hsa-miR-1268b	CLIP-seq
MIRT1414068	hsa-miR-1273	CLIP-seq
MIRT1414020	hsa-miR-1273f	CLIP-seq
MIRT1414024	hsa-miR-1908	CLIP-seq
MIRT2639181	hsa-miR-197	CLIP-seq
MIRT1414027	hsa-miR-2114	CLIP-seq
MIRT1414035	hsa-miR-3122	CLIP-seq
MIRT2461199	hsa-miR-3613-3p	CLIP-seq
MIRT1414040	hsa-miR-3689a-3p	CLIP-seq
MIRT1414041	hsa-miR-3689c	CLIP-seq
MIRT1414042	hsa-miR-3913-5p	CLIP-seq
MIRT2639182	hsa-miR-412	CLIP-seq
MIRT1414044	hsa-miR-4252	CLIP-seq
MIRT1414046	hsa-miR-4433	CLIP-seq
MIRT2461200	hsa-miR-4684-5p	CLIP-seq
MIRT2639183	hsa-miR-4724-3p	CLIP-seq
MIRT1414050	hsa-miR-4728-5p	CLIP-seq
MIRT2461201	hsa-miR-4743	CLIP-seq
MIRT1414052	hsa-miR-4767	CLIP-seq
MIRT1414053	hsa-miR-4793-3p	CLIP-seq
MIRT1414059	hsa-miR-508-5p	CLIP-seq
MIRT1414060	hsa-miR-510	CLIP-seq
MIRT2461202	hsa-miR-548c-3p	CLIP-seq
MIRT1414061	hsa-miR-566	CLIP-seq
MIRT2639184	hsa-miR-579	CLIP-seq
MIRT1414065	hsa-miR-663	CLIP-seq
MIRT1414066	hsa-miR-766	CLIP-seq
MIRT1414018	hsa-miR-1268	CLIP-seq
MIRT1414019	hsa-miR-1268b	CLIP-seq
MIRT1414068	hsa-miR-1273	CLIP-seq
MIRT1414020	hsa-miR-1273f	CLIP-seq
MIRT1414024	hsa-miR-1908	CLIP-seq
MIRT1414027	hsa-miR-2114	CLIP-seq
MIRT1414035	hsa-miR-3122	CLIP-seq
MIRT2461199	hsa-miR-3613-3p	CLIP-seq
MIRT1414040	hsa-miR-3689a-3p	CLIP-seq
MIRT1414041	hsa-miR-3689c	CLIP-seq
MIRT1414042	hsa-miR-3913-5p	CLIP-seq
MIRT1414044	hsa-miR-4252	CLIP-seq
MIRT1414046	hsa-miR-4433	CLIP-seq
MIRT2461200	hsa-miR-4684-5p	CLIP-seq
MIRT1414050	hsa-miR-4728-5p	CLIP-seq
MIRT2461201	hsa-miR-4743	CLIP-seq
MIRT1414052	hsa-miR-4767	CLIP-seq
MIRT1414053	hsa-miR-4793-3p	CLIP-seq
MIRT1414059	hsa-miR-508-5p	CLIP-seq
MIRT1414060	hsa-miR-510	CLIP-seq
MIRT2461202	hsa-miR-548c-3p	CLIP-seq
MIRT1414061	hsa-miR-566	CLIP-seq
MIRT1414065	hsa-miR-663	CLIP-seq
MIRT1414066	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0008360	Process	Regulation of cell shape	IMP	20168327
GO:0030334	Process	Regulation of cell migration	IMP	20168327
GO:0031616	Component	Spindle pole centrosome	IBA
GO:0031616	Component	Spindle pole centrosome	IDA	20168327
GO:0051661	Process	Maintenance of centrosome location	IBA
GO:0051661	Process	Maintenance of centrosome location	IMP	20168327
GO:0051684	Process	Maintenance of Golgi location	IBA
GO:0051684	Process	Maintenance of Golgi location	IMP	20168327

Other IDs

• MIM: 619848
• HGNC: 25546
• e!Ensembl: ENSG00000113838

Protein

• UniProt ID: Q9NVR7
• Protein name: TBCC domain-containing protein 1
• Protein function: Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07986	TBCC	329 → 446	Tubulin binding cofactor C	Domain

• Sequence:

  MDQSRVLLWVKAEPFIVGALQVPPPSKFSLHYLRKISTYVQIRATEGAYPRLYWSTWRHI
  ACGKLQLAKDLAWLYFEIFDSLSMKTPEERLEWSEVLSNCMSEEEVEKQRNQLSVDTLQF
  LLFLYIQQLNKVSLRTSLIGEEWPSPRNKSQSPDLTEKSNCHNKNWNDYSHQAFVYDHLS
  DLLELLLDPKQLTASFHSTHSSLVSREAVVALSFLIEGTISRARKIYPLHELALWQPLHA
  DSGFSKISKTFSFYKLETWLRSCLTGNPFGTSACLKSGKKLAWAHQVEGTTKRAKIACNT
  HVAPRMHRLVVMSQVYKQTLAKSSDTLAGAHVKIHRCNESFIYLLSPLRSVTIEKCRNSI
  FVLGPVGTTLHLHSCDNVKVIAVCHRLSISSTTGCIFHVLTPTRPLILSGNQTVTFAPFH
  THYPMLEDHMARTGLATVPNYWDNPMVVCRENSDTRVFQLLPPCEFYVFIIPFEMEGDTT
  EIPGGLPSVYQKALGQREQKIQIWQKTVKEAHLTKDQRKQFQVLVENKFYEWLINTGHRQ
  QLDSLVPPAAGSKQAAG

• Sequence length: 557

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations