Gene Gene information from NCBI Gene database.
Entrez ID 55161
Gene name Transmembrane protein 33
Gene symbol TMEM33
Synonyms (NCBI Gene)
1600019D15RikPom33SHINC-3SHINC3
Chromosome 4
Chromosome location 4p13
miRNA miRNA information provided by mirtarbase database.
1283
miRTarBase ID miRNA Experiments Reference
MIRT016601 hsa-miR-193b-3p Proteomics 21512034
MIRT021042 hsa-miR-155-5p Proteomics 18668040
MIRT032486 hsa-let-7b-5p Proteomics 18668040
MIRT045784 hsa-miR-191-5p CLASH 23622248
MIRT043766 hsa-miR-328-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 17215244, 25612671, 26268696, 26514267, 28298427, 32296183
GO:0005634 Component Nucleus IEA
GO:0005635 Component Nuclear envelope IDA 25612671
GO:0005635 Component Nuclear envelope IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618515 25541 ENSG00000109133
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P57088
Protein name Transmembrane protein 33 (Protein DB83) (SHINC-3)
Protein function Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03661 TMEM33_Pom33 7 245 Transmembrane protein 33/Nucleoporin POM33 Family
Tissue specificity TISSUE SPECIFICITY: Prostate cancer and several cancer cell lines (at protein level). Widely expressed. Expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine-sensitive breast cancer cells. Expressed at higher level
Sequence
Sequence length 247
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Nucleocytoplasmic transport  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Kidney Failure, Acute Kidney Failure BEFREE 31048699
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus Systemic Systemic lupus erythematosus Pubtator 39290707 Associate
★☆☆☆☆
Found in Text Mining only
Moyamoya Disease Moyamoya disease Pubtator 39290707 Associate
★☆☆☆☆
Found in Text Mining only
Uterine Cervical Neoplasms Uterine neoplasm Pubtator 37273452 Associate
★☆☆☆☆
Found in Text Mining only