Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55152
Gene name	DALR anticodon binding domain containing 3
Gene symbol	DALRD3
Synonyms (NCBI Gene)	DEE86EIEE86
Chromosome	3
Chromosome location	3p21.31
Summary	The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture

128

Show/Hide all (128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040896	hsa-miR-18a-3p	CLASH	23622248
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0000049	Function	TRNA binding	IDA	32427860
GO:0000049	Function	TRNA binding	IMP	39482881
GO:0000166	Function	Nucleotide binding	IEA
GO:0004812	Function	Aminoacyl-tRNA ligase activity	IEA
GO:0004814	Function	Arginine-tRNA ligase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32427860, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0006399	Process	TRNA metabolic process	IEA
GO:0006418	Process	TRNA aminoacylation for protein translation	IEA
GO:0006420	Process	Arginyl-tRNA aminoacylation	IEA
GO:0010467	Process	Gene expression	IEA
GO:0106217	Process	TRNA C3-cytosine methylation	IBA
GO:0106217	Process	TRNA C3-cytosine methylation	IMP	32427860, 39482881

MIM	HGNC	e!Ensembl
618904	25536	ENSG00000178149

Q5D0E6

Protein name

DALR anticodon-binding domain-containing protein 3

Protein function

Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05746	DALR_1	403 → 543	DALR anticodon binding domain	Domain

Sequence

MATRRLGVGETLGALNAALGPGGPVWIKETRTRHLRSRDFLAPHRALQARFDDGQVPEHL
LHALACLQGPGVAPVLRCAPTPAGLSLQLQRSAVFERVLSAVAAYATPASPASLGQRVLL
HCPALRSSPCALRLSQLRTVLVADHLARALRAHGVCVRLVPAVRDPHMLTFLQQLRVDWP
AASERASSHTLRSHALEELTSANDGRTLSPGILGRLCLKELVEEQGRTAGYDPNLDNCLV
TEDLLSVLAELQEALWHWPEDSHPGLAGASDTGTGGCLVVHVVSCEEEFQQQKLDLLWQK
LVDKAPLRQKHLICGPVKVAGAPGTLMTAPEYYEFRHTQVCKASALKHGGDLAQDPAWTE
IFGVLSVATIKFEMLSTAPQSQLFLALADSSISTKGTKSGTFVMYNCARLATLFESYKCS
MEQGLYPTFPPVSSLDFSLLHDEGEWLLLFNSILPFPDLLSRTAVLDCTAPGLHIAVRTE
MICKFLVQLSMDFSSYYNRVHILGEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGLPPL
SHI

Sequence length

543

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DALRD3-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 86	—	Disgenet, HPO Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental and epileptic encephalopathy, 86	Uncertain significance; Conflicting classifications of pathogenicity	ClinVar ClinVar, GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC EARLY-ONSET EPILEPTIC ENCEPHALOPATHY	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNDETERMINED EARLY-ONSET EPILEPTIC ENCEPHALOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Brain Diseases	Brain disease	Pubtator	32427860	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	32427860	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 18	Mitochondrial Complex Deficiency	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-specific early-onset epileptic encephalopathy	Non-Specifi Epileptic Encephalopathy	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

DALRD3 (DALR anticodon binding domain containing 3)