Gene Gene information from NCBI Gene database.
Entrez ID 55117
Gene name Solute carrier family 6 member 15
Gene symbol SLC6A15
Synonyms (NCBI Gene)
NTT73SBAT1V7-3hv7-3
Chromosome 12
Chromosome location 12q21.31
Summary This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMI
miRNA miRNA information provided by mirtarbase database.
216
miRTarBase ID miRNA Experiments Reference
MIRT050428 hsa-miR-23a-3p CLASH 23622248
MIRT046356 hsa-miR-23b-3p CLASH 23622248
MIRT042665 hsa-miR-196b-5p CLASH 23622248
MIRT1366058 hsa-miR-101 CLIP-seq
MIRT1366059 hsa-miR-1244 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0003333 Process Amino acid transmembrane transport IEA
GO:0005295 Function Neutral L-amino acid:sodium symporter activity IDA 16226721
GO:0005295 Function Neutral L-amino acid:sodium symporter activity IEA
GO:0005298 Function Proline:sodium symporter activity IBA
GO:0005298 Function Proline:sodium symporter activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607971 13621 ENSG00000072041
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H2J7
Protein name Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3)
Protein function Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, pheny
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00209 SNF 61 644 Sodium:neurotransmitter symporter family Family
Tissue specificity TISSUE SPECIFICITY: Almost exclusively expressed in the brain. {ECO:0000269|PubMed:16226721}.
Sequence
Sequence length 730
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
32
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma BEFREE 26542096
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 37543674 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 21298349, 24485021 Associate
★☆☆☆☆
Found in Text Mining only
Depressive disorder Mental Depression BEFREE 22475622, 28576941, 31344373
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Major Major depressive disorder Pubtator 23874702 Associate
★☆☆☆☆
Found in Text Mining only
Eczema Eczema BEFREE 26542096
★☆☆☆☆
Found in Text Mining only
Impaired cognition Impaired Cognition BEFREE 22475622
★☆☆☆☆
Found in Text Mining only
Insulin Resistance Diabetes mellitus, type 2 Pubtator 30913280 Associate
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression BEFREE 21521612, 23874702, 27723767, 28576941, 28915082, 29791834
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder Mental Depression PSYGENET_DG 21521612, 23874702
★★☆☆☆
Found in Text Mining + Unknown/Other Associations