PLEKHJ1 (pleckstrin homology domain containing J1)

Gene

• Entrez ID: 55111
• Gene name: Pleckstrin homology domain containing J1
• Gene symbol: PLEKHJ1
• Synonyms (NCBI Gene): GNRPX
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039590	hsa-miR-625-5p	CLASH	23622248
MIRT1242356	hsa-miR-1184	CLIP-seq
MIRT1242357	hsa-miR-1205	CLIP-seq
MIRT1242358	hsa-miR-1207-3p	CLIP-seq
MIRT1242359	hsa-miR-128	CLIP-seq
MIRT1242360	hsa-miR-1286	CLIP-seq
MIRT1242361	hsa-miR-1343	CLIP-seq
MIRT1242362	hsa-miR-138	CLIP-seq
MIRT1242363	hsa-miR-15a	CLIP-seq
MIRT1242364	hsa-miR-15b	CLIP-seq
MIRT1242365	hsa-miR-16	CLIP-seq
MIRT1242366	hsa-miR-1827	CLIP-seq
MIRT1242367	hsa-miR-1915	CLIP-seq
MIRT1242368	hsa-miR-195	CLIP-seq
MIRT1242369	hsa-miR-27a	CLIP-seq
MIRT1242370	hsa-miR-27b	CLIP-seq
MIRT1242371	hsa-miR-296-5p	CLIP-seq
MIRT1242372	hsa-miR-3120-5p	CLIP-seq
MIRT1242373	hsa-miR-3158-5p	CLIP-seq
MIRT1242374	hsa-miR-3160-3p	CLIP-seq
MIRT1242375	hsa-miR-3199	CLIP-seq
MIRT1242376	hsa-miR-346	CLIP-seq
MIRT1242377	hsa-miR-3614-5p	CLIP-seq
MIRT1242378	hsa-miR-3650	CLIP-seq
MIRT1242379	hsa-miR-3688-5p	CLIP-seq
MIRT1242380	hsa-miR-3918	CLIP-seq
MIRT1242381	hsa-miR-3974	CLIP-seq
MIRT1242382	hsa-miR-424	CLIP-seq
MIRT1242383	hsa-miR-4270	CLIP-seq
MIRT1242384	hsa-miR-4288	CLIP-seq
MIRT1242385	hsa-miR-4290	CLIP-seq
MIRT1242386	hsa-miR-4421	CLIP-seq
MIRT1242387	hsa-miR-4441	CLIP-seq
MIRT1242388	hsa-miR-4459	CLIP-seq
MIRT1242389	hsa-miR-4467	CLIP-seq
MIRT1242390	hsa-miR-4487	CLIP-seq
MIRT1242391	hsa-miR-4648	CLIP-seq
MIRT1242392	hsa-miR-4649-3p	CLIP-seq
MIRT1242393	hsa-miR-4654	CLIP-seq
MIRT1242394	hsa-miR-4667-3p	CLIP-seq
MIRT1242395	hsa-miR-4685-5p	CLIP-seq
MIRT1242396	hsa-miR-4690-3p	CLIP-seq
MIRT1242397	hsa-miR-4717-5p	CLIP-seq
MIRT1242398	hsa-miR-4722-5p	CLIP-seq
MIRT1242399	hsa-miR-4747-5p	CLIP-seq
MIRT1242400	hsa-miR-4761-5p	CLIP-seq
MIRT1242401	hsa-miR-4768-3p	CLIP-seq
MIRT1242402	hsa-miR-4769-5p	CLIP-seq
MIRT1242403	hsa-miR-493	CLIP-seq
MIRT1242404	hsa-miR-497	CLIP-seq
MIRT1242405	hsa-miR-512-5p	CLIP-seq
MIRT1242406	hsa-miR-513a-5p	CLIP-seq
MIRT1242407	hsa-miR-558	CLIP-seq
MIRT1242408	hsa-miR-627	CLIP-seq
MIRT1242409	hsa-miR-632	CLIP-seq
MIRT1242410	hsa-miR-890	CLIP-seq
MIRT1242411	hsa-miR-940	CLIP-seq
MIRT1242356	hsa-miR-1184	CLIP-seq
MIRT1242357	hsa-miR-1205	CLIP-seq
MIRT1242358	hsa-miR-1207-3p	CLIP-seq
MIRT2071403	hsa-miR-1207-5p	CLIP-seq
MIRT2071404	hsa-miR-1226	CLIP-seq
MIRT1242359	hsa-miR-128	CLIP-seq
MIRT2071405	hsa-miR-1285	CLIP-seq
MIRT1242360	hsa-miR-1286	CLIP-seq
MIRT2071406	hsa-miR-1298	CLIP-seq
MIRT1242363	hsa-miR-15a	CLIP-seq
MIRT1242364	hsa-miR-15b	CLIP-seq
MIRT1242365	hsa-miR-16	CLIP-seq
MIRT2071407	hsa-miR-181a	CLIP-seq
MIRT2071408	hsa-miR-181b	CLIP-seq
MIRT2071409	hsa-miR-181c	CLIP-seq
MIRT2071410	hsa-miR-181d	CLIP-seq
MIRT2071411	hsa-miR-1909	CLIP-seq
MIRT1242368	hsa-miR-195	CLIP-seq
MIRT1242369	hsa-miR-27a	CLIP-seq
MIRT1242370	hsa-miR-27b	CLIP-seq
MIRT2071412	hsa-miR-3065-3p	CLIP-seq
MIRT1242372	hsa-miR-3120-5p	CLIP-seq
MIRT1242373	hsa-miR-3158-5p	CLIP-seq
MIRT2071413	hsa-miR-3187-5p	CLIP-seq
MIRT2071414	hsa-miR-331-3p	CLIP-seq
MIRT1242376	hsa-miR-346	CLIP-seq
MIRT2071415	hsa-miR-3622b-5p	CLIP-seq
MIRT2071416	hsa-miR-3926	CLIP-seq
MIRT1242382	hsa-miR-424	CLIP-seq
MIRT2071417	hsa-miR-4262	CLIP-seq
MIRT2071418	hsa-miR-4269	CLIP-seq
MIRT2071419	hsa-miR-4283	CLIP-seq
MIRT2071420	hsa-miR-4284	CLIP-seq
MIRT1242384	hsa-miR-4288	CLIP-seq
MIRT2071421	hsa-miR-4291	CLIP-seq
MIRT2071422	hsa-miR-4308	CLIP-seq
MIRT1242386	hsa-miR-4421	CLIP-seq
MIRT2071423	hsa-miR-4437	CLIP-seq
MIRT1242389	hsa-miR-4467	CLIP-seq
MIRT2071424	hsa-miR-4488	CLIP-seq
MIRT2071425	hsa-miR-4514	CLIP-seq
MIRT2071426	hsa-miR-4645-5p	CLIP-seq
MIRT2071427	hsa-miR-4673	CLIP-seq
MIRT2071428	hsa-miR-4692	CLIP-seq
MIRT2071429	hsa-miR-4697-5p	CLIP-seq
MIRT2071430	hsa-miR-4715-3p	CLIP-seq
MIRT1242398	hsa-miR-4722-5p	CLIP-seq
MIRT2071431	hsa-miR-4732-3p	CLIP-seq
MIRT2071432	hsa-miR-4733-3p	CLIP-seq
MIRT2071433	hsa-miR-4742-5p	CLIP-seq
MIRT2071434	hsa-miR-4763-3p	CLIP-seq
MIRT1242401	hsa-miR-4768-3p	CLIP-seq
MIRT2071435	hsa-miR-486-3p	CLIP-seq
MIRT1242404	hsa-miR-497	CLIP-seq
MIRT2071436	hsa-miR-510	CLIP-seq
MIRT1242406	hsa-miR-513a-5p	CLIP-seq
MIRT2071437	hsa-miR-548aa	CLIP-seq
MIRT2071438	hsa-miR-548ac	CLIP-seq
MIRT2071439	hsa-miR-548d-3p	CLIP-seq
MIRT2071440	hsa-miR-548s	CLIP-seq
MIRT2071441	hsa-miR-548z	CLIP-seq
MIRT2071442	hsa-miR-612	CLIP-seq
MIRT1242409	hsa-miR-632	CLIP-seq
MIRT2071443	hsa-miR-637	CLIP-seq
MIRT2071444	hsa-miR-661	CLIP-seq
MIRT2071445	hsa-miR-664	CLIP-seq
MIRT1242411	hsa-miR-940	CLIP-seq
MIRT1242356	hsa-miR-1184	CLIP-seq
MIRT1242357	hsa-miR-1205	CLIP-seq
MIRT1242358	hsa-miR-1207-3p	CLIP-seq
MIRT2071403	hsa-miR-1207-5p	CLIP-seq
MIRT2071404	hsa-miR-1226	CLIP-seq
MIRT2298651	hsa-miR-1231	CLIP-seq
MIRT2298652	hsa-miR-1251	CLIP-seq
MIRT1242359	hsa-miR-128	CLIP-seq
MIRT2071405	hsa-miR-1285	CLIP-seq
MIRT1242360	hsa-miR-1286	CLIP-seq
MIRT2071406	hsa-miR-1298	CLIP-seq
MIRT1242361	hsa-miR-1343	CLIP-seq
MIRT1242362	hsa-miR-138	CLIP-seq
MIRT2298653	hsa-miR-149	CLIP-seq
MIRT1242363	hsa-miR-15a	CLIP-seq
MIRT1242364	hsa-miR-15b	CLIP-seq
MIRT1242365	hsa-miR-16	CLIP-seq
MIRT2071407	hsa-miR-181a	CLIP-seq
MIRT2071408	hsa-miR-181b	CLIP-seq
MIRT2071409	hsa-miR-181c	CLIP-seq
MIRT2071410	hsa-miR-181d	CLIP-seq
MIRT1242366	hsa-miR-1827	CLIP-seq
MIRT2071411	hsa-miR-1909	CLIP-seq
MIRT1242367	hsa-miR-1915	CLIP-seq
MIRT1242368	hsa-miR-195	CLIP-seq
MIRT2298654	hsa-miR-1972	CLIP-seq
MIRT2298655	hsa-miR-198	CLIP-seq
MIRT1242369	hsa-miR-27a	CLIP-seq
MIRT1242370	hsa-miR-27b	CLIP-seq
MIRT1242371	hsa-miR-296-5p	CLIP-seq
MIRT2298656	hsa-miR-3064-5p	CLIP-seq
MIRT2071412	hsa-miR-3065-3p	CLIP-seq
MIRT1242372	hsa-miR-3120-5p	CLIP-seq
MIRT1242373	hsa-miR-3158-5p	CLIP-seq
MIRT1242374	hsa-miR-3160-3p	CLIP-seq
MIRT2298657	hsa-miR-3165	CLIP-seq
MIRT2071413	hsa-miR-3187-5p	CLIP-seq
MIRT1242375	hsa-miR-3199	CLIP-seq
MIRT2071414	hsa-miR-331-3p	CLIP-seq
MIRT1242376	hsa-miR-346	CLIP-seq
MIRT1242377	hsa-miR-3614-5p	CLIP-seq
MIRT1242378	hsa-miR-3650	CLIP-seq
MIRT1242379	hsa-miR-3688-5p	CLIP-seq
MIRT1242380	hsa-miR-3918	CLIP-seq
MIRT1242381	hsa-miR-3974	CLIP-seq
MIRT1242382	hsa-miR-424	CLIP-seq
MIRT2071417	hsa-miR-4262	CLIP-seq
MIRT2071418	hsa-miR-4269	CLIP-seq
MIRT1242383	hsa-miR-4270	CLIP-seq
MIRT2071419	hsa-miR-4283	CLIP-seq
MIRT2071420	hsa-miR-4284	CLIP-seq
MIRT1242384	hsa-miR-4288	CLIP-seq
MIRT1242385	hsa-miR-4290	CLIP-seq
MIRT2071421	hsa-miR-4291	CLIP-seq
MIRT2298658	hsa-miR-4293	CLIP-seq
MIRT2071422	hsa-miR-4308	CLIP-seq
MIRT1242386	hsa-miR-4421	CLIP-seq
MIRT2071423	hsa-miR-4437	CLIP-seq
MIRT1242387	hsa-miR-4441	CLIP-seq
MIRT1242388	hsa-miR-4459	CLIP-seq
MIRT1242389	hsa-miR-4467	CLIP-seq
MIRT1242390	hsa-miR-4487	CLIP-seq
MIRT2071424	hsa-miR-4488	CLIP-seq
MIRT2071425	hsa-miR-4514	CLIP-seq
MIRT1242391	hsa-miR-4648	CLIP-seq
MIRT1242393	hsa-miR-4654	CLIP-seq
MIRT1242394	hsa-miR-4667-3p	CLIP-seq
MIRT1242395	hsa-miR-4685-5p	CLIP-seq
MIRT1242396	hsa-miR-4690-3p	CLIP-seq
MIRT2071428	hsa-miR-4692	CLIP-seq
MIRT2071429	hsa-miR-4697-5p	CLIP-seq
MIRT2071430	hsa-miR-4715-3p	CLIP-seq
MIRT1242397	hsa-miR-4717-5p	CLIP-seq
MIRT1242398	hsa-miR-4722-5p	CLIP-seq
MIRT2071431	hsa-miR-4732-3p	CLIP-seq
MIRT2071432	hsa-miR-4733-3p	CLIP-seq
MIRT2071433	hsa-miR-4742-5p	CLIP-seq
MIRT1242399	hsa-miR-4747-5p	CLIP-seq
MIRT2298659	hsa-miR-4755-3p	CLIP-seq
MIRT1242400	hsa-miR-4761-5p	CLIP-seq
MIRT2071434	hsa-miR-4763-3p	CLIP-seq
MIRT1242401	hsa-miR-4768-3p	CLIP-seq
MIRT1242402	hsa-miR-4769-5p	CLIP-seq
MIRT2298660	hsa-miR-4793-3p	CLIP-seq
MIRT2298661	hsa-miR-4794	CLIP-seq
MIRT2071435	hsa-miR-486-3p	CLIP-seq
MIRT1242403	hsa-miR-493	CLIP-seq
MIRT1242404	hsa-miR-497	CLIP-seq
MIRT2071436	hsa-miR-510	CLIP-seq
MIRT1242405	hsa-miR-512-5p	CLIP-seq
MIRT1242406	hsa-miR-513a-5p	CLIP-seq
MIRT2298662	hsa-miR-524-3p	CLIP-seq
MIRT2298663	hsa-miR-525-3p	CLIP-seq
MIRT2071437	hsa-miR-548aa	CLIP-seq
MIRT2071438	hsa-miR-548ac	CLIP-seq
MIRT2071439	hsa-miR-548d-3p	CLIP-seq
MIRT2071441	hsa-miR-548z	CLIP-seq
MIRT1242407	hsa-miR-558	CLIP-seq
MIRT2298664	hsa-miR-596	CLIP-seq
MIRT2071442	hsa-miR-612	CLIP-seq
MIRT1242408	hsa-miR-627	CLIP-seq
MIRT1242409	hsa-miR-632	CLIP-seq
MIRT2071443	hsa-miR-637	CLIP-seq
MIRT2071444	hsa-miR-661	CLIP-seq
MIRT2071445	hsa-miR-664	CLIP-seq
MIRT2298665	hsa-miR-760	CLIP-seq
MIRT1242411	hsa-miR-940	CLIP-seq
MIRT1242356	hsa-miR-1184	CLIP-seq
MIRT1242357	hsa-miR-1205	CLIP-seq
MIRT1242358	hsa-miR-1207-3p	CLIP-seq
MIRT2071403	hsa-miR-1207-5p	CLIP-seq
MIRT1242360	hsa-miR-1286	CLIP-seq
MIRT2071406	hsa-miR-1298	CLIP-seq
MIRT1242362	hsa-miR-138	CLIP-seq
MIRT2071411	hsa-miR-1909	CLIP-seq
MIRT1242369	hsa-miR-27a	CLIP-seq
MIRT1242370	hsa-miR-27b	CLIP-seq
MIRT2071412	hsa-miR-3065-3p	CLIP-seq
MIRT1242372	hsa-miR-3120-5p	CLIP-seq
MIRT1242373	hsa-miR-3158-5p	CLIP-seq
MIRT1242375	hsa-miR-3199	CLIP-seq
MIRT1242376	hsa-miR-346	CLIP-seq
MIRT1242378	hsa-miR-3650	CLIP-seq
MIRT1242384	hsa-miR-4288	CLIP-seq
MIRT2071421	hsa-miR-4291	CLIP-seq
MIRT1242386	hsa-miR-4421	CLIP-seq
MIRT1242391	hsa-miR-4648	CLIP-seq
MIRT1242393	hsa-miR-4654	CLIP-seq
MIRT1242396	hsa-miR-4690-3p	CLIP-seq
MIRT1242397	hsa-miR-4717-5p	CLIP-seq
MIRT1242398	hsa-miR-4722-5p	CLIP-seq
MIRT2071434	hsa-miR-4763-3p	CLIP-seq
MIRT1242401	hsa-miR-4768-3p	CLIP-seq
MIRT1242402	hsa-miR-4769-5p	CLIP-seq
MIRT2071435	hsa-miR-486-3p	CLIP-seq
MIRT1242405	hsa-miR-512-5p	CLIP-seq
MIRT1242406	hsa-miR-513a-5p	CLIP-seq
MIRT1242409	hsa-miR-632	CLIP-seq
MIRT2071445	hsa-miR-664	CLIP-seq
MIRT2071403	hsa-miR-1207-5p	CLIP-seq
MIRT2071405	hsa-miR-1285	CLIP-seq
MIRT1242366	hsa-miR-1827	CLIP-seq
MIRT2298655	hsa-miR-198	CLIP-seq
MIRT2071413	hsa-miR-3187-5p	CLIP-seq
MIRT1242377	hsa-miR-3614-5p	CLIP-seq
MIRT2071415	hsa-miR-3622b-5p	CLIP-seq
MIRT2595619	hsa-miR-3647-3p	CLIP-seq
MIRT2595620	hsa-miR-3652	CLIP-seq
MIRT2071416	hsa-miR-3926	CLIP-seq
MIRT2595621	hsa-miR-3934	CLIP-seq
MIRT2595622	hsa-miR-4430	CLIP-seq
MIRT2595623	hsa-miR-4455	CLIP-seq
MIRT1242388	hsa-miR-4459	CLIP-seq
MIRT1242389	hsa-miR-4467	CLIP-seq
MIRT2595624	hsa-miR-4505	CLIP-seq
MIRT2071426	hsa-miR-4645-5p	CLIP-seq
MIRT1242392	hsa-miR-4649-3p	CLIP-seq
MIRT2595625	hsa-miR-4668-3p	CLIP-seq
MIRT2071427	hsa-miR-4673	CLIP-seq
MIRT2595626	hsa-miR-4679	CLIP-seq
MIRT1242398	hsa-miR-4722-5p	CLIP-seq
MIRT2595627	hsa-miR-4743	CLIP-seq
MIRT1242399	hsa-miR-4747-5p	CLIP-seq
MIRT2071434	hsa-miR-4763-3p	CLIP-seq
MIRT2071437	hsa-miR-548aa	CLIP-seq
MIRT2071438	hsa-miR-548ac	CLIP-seq
MIRT2071439	hsa-miR-548d-3p	CLIP-seq
MIRT2071440	hsa-miR-548s	CLIP-seq
MIRT2071441	hsa-miR-548z	CLIP-seq
MIRT2071442	hsa-miR-612	CLIP-seq
MIRT1242408	hsa-miR-627	CLIP-seq
MIRT2595628	hsa-miR-644	CLIP-seq
MIRT2071444	hsa-miR-661	CLIP-seq
MIRT1242410	hsa-miR-890	CLIP-seq
MIRT1242411	hsa-miR-940	CLIP-seq
MIRT1242366	hsa-miR-1827	CLIP-seq
MIRT2298654	hsa-miR-1972	CLIP-seq
MIRT2298657	hsa-miR-3165	CLIP-seq
MIRT2071415	hsa-miR-3622b-5p	CLIP-seq
MIRT2595619	hsa-miR-3647-3p	CLIP-seq
MIRT2071416	hsa-miR-3926	CLIP-seq
MIRT2595621	hsa-miR-3934	CLIP-seq
MIRT2595623	hsa-miR-4455	CLIP-seq
MIRT1242388	hsa-miR-4459	CLIP-seq
MIRT1242389	hsa-miR-4467	CLIP-seq
MIRT2071426	hsa-miR-4645-5p	CLIP-seq
MIRT1242392	hsa-miR-4649-3p	CLIP-seq
MIRT2595625	hsa-miR-4668-3p	CLIP-seq
MIRT2071427	hsa-miR-4673	CLIP-seq
MIRT2595626	hsa-miR-4679	CLIP-seq
MIRT1242398	hsa-miR-4722-5p	CLIP-seq
MIRT2071432	hsa-miR-4733-3p	CLIP-seq
MIRT2595627	hsa-miR-4743	CLIP-seq
MIRT1242399	hsa-miR-4747-5p	CLIP-seq
MIRT2298659	hsa-miR-4755-3p	CLIP-seq
MIRT2071437	hsa-miR-548aa	CLIP-seq
MIRT2071438	hsa-miR-548ac	CLIP-seq
MIRT2071439	hsa-miR-548d-3p	CLIP-seq
MIRT2071440	hsa-miR-548s	CLIP-seq
MIRT2071441	hsa-miR-548z	CLIP-seq
MIRT2595628	hsa-miR-644	CLIP-seq
MIRT2688103	hsa-miR-764	CLIP-seq
MIRT1242410	hsa-miR-890	CLIP-seq
MIRT1242411	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001881	Process	Receptor recycling	IBA
GO:0005515	Function	Protein binding	IPI	21900206, 28514442, 32296183, 33961781
GO:0005769	Component	Early endosome	IBA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0005829	Component	Cytosol	IEA
GO:0007032	Process	Endosome organization	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0055037	Component	Recycling endosome	IBA

Other IDs

• MIM: 617834
• HGNC: 18211
• e!Ensembl: ENSG00000104886

Protein

• UniProt ID: Q9NW61
• Protein name: Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	17 → 108	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in testis and liver. {ECO:0000269|PubMed:11602354}.
• Sequence:

  MRYNEKELQALSRQPAEMAAELGMRGPKKGSVLKRRLVKLVVNFLFYFRTDEAEPVGALL
  LERCRVVREEPGTFSISFIEDPERKYHFECSSEEQCQEWMEALRRASYEFMRRSLIFYRN
  EIRKVTGKDPLEQFGISEEARFQLSGLQA

• Sequence length: 149

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations