Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55106
Gene name	Schlafen family member 12
Gene symbol	SLFN12
Synonyms (NCBI Gene)	SLFN3
Chromosome	17
Chromosome location	17q12

Show/Hide all (78)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030301	hsa-miR-26b-5p	Microarray	19088304
MIRT721675	hsa-miR-6782-5p	HITS-CLIP	19536157
MIRT721674	hsa-miR-4723-5p	HITS-CLIP	19536157
MIRT721673	hsa-miR-5698	HITS-CLIP	19536157
MIRT721672	hsa-miR-6870-5p	HITS-CLIP	19536157
MIRT721671	hsa-miR-7111-5p	HITS-CLIP	19536157
MIRT721670	hsa-miR-6795-5p	HITS-CLIP	19536157
MIRT721669	hsa-miR-6887-5p	HITS-CLIP	19536157
MIRT721668	hsa-miR-328-5p	HITS-CLIP	19536157
MIRT721667	hsa-miR-6885-5p	HITS-CLIP	19536157
MIRT721666	hsa-miR-4651	HITS-CLIP	19536157
MIRT721665	hsa-miR-608	HITS-CLIP	19536157
MIRT721664	hsa-miR-6756-5p	HITS-CLIP	19536157
MIRT721663	hsa-miR-6766-5p	HITS-CLIP	19536157
MIRT721662	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT721661	hsa-miR-4447	HITS-CLIP	19536157
MIRT721660	hsa-miR-4472	HITS-CLIP	19536157
MIRT721659	hsa-miR-7109-5p	HITS-CLIP	19536157
MIRT721658	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT662348	hsa-miR-6785-3p	HITS-CLIP	23824327
MIRT644488	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT644486	hsa-miR-6072	HITS-CLIP	23824327
MIRT644487	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT644485	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT644484	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT644483	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT644482	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT644481	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT644488	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT644486	hsa-miR-6072	HITS-CLIP	23824327
MIRT644487	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT644485	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT644484	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT644483	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT644482	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT644481	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT721675	hsa-miR-6782-5p	HITS-CLIP	19536157
MIRT721674	hsa-miR-4723-5p	HITS-CLIP	19536157
MIRT721673	hsa-miR-5698	HITS-CLIP	19536157
MIRT721672	hsa-miR-6870-5p	HITS-CLIP	19536157
MIRT721671	hsa-miR-7111-5p	HITS-CLIP	19536157
MIRT721670	hsa-miR-6795-5p	HITS-CLIP	19536157
MIRT721669	hsa-miR-6887-5p	HITS-CLIP	19536157
MIRT721668	hsa-miR-328-5p	HITS-CLIP	19536157
MIRT721667	hsa-miR-6885-5p	HITS-CLIP	19536157
MIRT721666	hsa-miR-4651	HITS-CLIP	19536157
MIRT721665	hsa-miR-608	HITS-CLIP	19536157
MIRT721664	hsa-miR-6756-5p	HITS-CLIP	19536157
MIRT721663	hsa-miR-6766-5p	HITS-CLIP	19536157
MIRT721662	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT721661	hsa-miR-4447	HITS-CLIP	19536157
MIRT721660	hsa-miR-4472	HITS-CLIP	19536157
MIRT721659	hsa-miR-7109-5p	HITS-CLIP	19536157
MIRT721658	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT662348	hsa-miR-6785-3p	HITS-CLIP	23824327
MIRT644488	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT644486	hsa-miR-6072	HITS-CLIP	23824327
MIRT644487	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT644485	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT644484	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT644483	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT644482	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT644481	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT644488	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT644486	hsa-miR-6072	HITS-CLIP	23824327
MIRT644487	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT644485	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT644484	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT644483	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT644482	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT644481	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT2109690	hsa-miR-1303	CLIP-seq
MIRT2109691	hsa-miR-27a	CLIP-seq
MIRT2109692	hsa-miR-27b	CLIP-seq
MIRT2109693	hsa-miR-3123	CLIP-seq
MIRT2109694	hsa-miR-3925-5p	CLIP-seq
MIRT2109695	hsa-miR-5096	CLIP-seq
MIRT2109696	hsa-miR-513a-5p	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004540	Function	RNA nuclease activity	IDA	34272366
GO:0004540	Function	RNA nuclease activity	IEA
GO:0004540	Function	RNA nuclease activity	IMP	35104454
GO:0005515	Function	Protein binding	IPI	31420216, 32814053, 34272366, 35104454
GO:0005634	Component	Nucleus	IDA	35104454
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	35104454
GO:0005829	Component	Cytosol	IEA
GO:0016075	Process	RRNA catabolic process	IDA	34272366
GO:0016075	Process	RRNA catabolic process	IEA
GO:0016075	Process	RRNA catabolic process	IMP	35104454
GO:0016787	Function	Hydrolase activity	IEA
GO:0043022	Function	Ribosome binding	IDA	31420216
GO:0043022	Function	Ribosome binding	IEA
GO:0097190	Process	Apoptotic signaling pathway	IMP	31420216, 35104454

MIM	HGNC	e!Ensembl
614955	25500	ENSG00000172123

Q8IYM2

Protein name

Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12)

Protein function

Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ri

PDB

7EG0 , 7EG1 , 7EG4 , 7LRC , 7LRD , 7LRE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04326	AlbA_2	200 → 334	Putative DNA-binding domain	Domain

Sequence

MNISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCALLNSGGGVIK
AEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGNYFLIFVKSWSLNTSGLRIT
TLSSNLYKRDITSAKVMNATAALEFLKDMKKTRGRLYLRPELLAKRPCVDIQEENNMKAL
AGVFFDRTELDRKEKLTFTESTHVEIKNFSTEKLLQRIKEILPQYVSAFANTDGGYLFIG
LNEDKEIIGFKAEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCG
YVCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQIN
TSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFLQHEGLKQLICEEMDSVRKG
SLIFSRSWSVDLGLQENHKVLCDALLISQDSPPVLYTFHMVQDEEFKGYSTQTALTLKQK
LAKIGGYTKKVCVMTKIFYLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKR
LKSLRDQFSFAENLYQIIGIDCFQKNDKKMFKSCRRLT

Sequence length

578

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BARRETT'S ESOPHAGUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atrophy	Atrophy	Pubtator	30045019	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31838790	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	21596996		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21596996	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	BEFREE	28454120		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	39740094	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hashimoto Disease	Hashimoto disease	Pubtator	38075038	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21596996, 24768141, 31749907, 31838790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	21596996		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	30379917	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis, Relapsing-Remitting	Multiple Sclerosis	BEFREE	30379917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31838790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30045019, 36291149	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	24768141	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sezary Syndrome	Sezary Syndrome	BEFREE	24689486		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36090985	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	31838790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	31838790, 35430566	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

SLFN12 (schlafen family member 12)