Gene Gene information from NCBI Gene database.
Entrez ID 5504
Gene name Protein phosphatase 1 regulatory inhibitor subunit 2
Gene symbol PPP1R2
Synonyms (NCBI Gene)
IPP-2IPP2PPP1R2A
Chromosome 3
Chromosome location 3q29
Summary Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human
miRNA miRNA information provided by mirtarbase database.
374
miRTarBase ID miRNA Experiments Reference
MIRT019980 hsa-miR-375 Microarray 20215506
MIRT051667 hsa-let-7e-5p CLASH 23622248
MIRT714172 hsa-miR-1276 HITS-CLIP 19536157
MIRT714171 hsa-miR-8066 HITS-CLIP 19536157
MIRT714172 hsa-miR-1276 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0004864 Function Protein phosphatase inhibitor activity IBA
GO:0004864 Function Protein phosphatase inhibitor activity IEA
GO:0004865 Function Protein serine/threonine phosphatase inhibitor activity TAS 8119416
GO:0005515 Function Protein binding IPI 10807923, 12393858, 12761178, 20826336, 21044950, 22321011, 24366813, 25593058, 26496610, 27173435, 28330616, 28514442, 32814053, 33961781, 35384245
GO:0005977 Process Glycogen metabolic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601792 9288 ENSG00000184203
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P41236
Protein name Protein phosphatase inhibitor 2 (IPP-2)
Protein function Inhibitor of protein-phosphatase 1.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04979 IPP-2 45 173 Protein phosphatase inhibitor 2 (IPP-2) Family
Sequence
Sequence length 205
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 28603063, 31740718
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent Diabetes Mellitus BEFREE 9126490
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 28603063, 31740718
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 24629090
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 24200083
★☆☆☆☆
Found in Text Mining only
Prostate carcinoma Prostate cancer BEFREE 24629090
★☆☆☆☆
Found in Text Mining only
Pulmonary edema of mountaineers Pulmonary edema Pubtator 31827636 Associate
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach neoplasms Pubtator 37800836 Associate
★☆☆☆☆
Found in Text Mining only