Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55035
Gene name	Nucleolar protein 8
Gene symbol	NOL8
Synonyms (NCBI Gene)	C9orf34NOP132bA62C3.3bA62C3.4
Chromosome	9
Chromosome location	9q22.31
Summary	NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]

Show/Hide all (57)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022317	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT028453	hsa-miR-30a-5p	Proteomics	18668040
MIRT045291	hsa-miR-186-5p	CLASH	23622248
MIRT052782	hsa-miR-1260b	CLASH	23622248
MIRT1188684	hsa-miR-302a	CLIP-seq
MIRT1188685	hsa-miR-302b	CLIP-seq
MIRT1188686	hsa-miR-302c	CLIP-seq
MIRT1188687	hsa-miR-302d	CLIP-seq
MIRT1188688	hsa-miR-302e	CLIP-seq
MIRT1188689	hsa-miR-372	CLIP-seq
MIRT1188690	hsa-miR-373	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT1188692	hsa-miR-520a-3p	CLIP-seq
MIRT1188693	hsa-miR-520b	CLIP-seq
MIRT1188694	hsa-miR-520c-3p	CLIP-seq
MIRT1188695	hsa-miR-520d-3p	CLIP-seq
MIRT1188696	hsa-miR-520e	CLIP-seq
MIRT1188697	hsa-miR-520f	CLIP-seq
MIRT2054625	hsa-miR-4282	CLIP-seq
MIRT2054626	hsa-miR-4639-3p	CLIP-seq
MIRT2054627	hsa-miR-4659a-3p	CLIP-seq
MIRT2054628	hsa-miR-4659b-3p	CLIP-seq
MIRT2054629	hsa-miR-4714-5p	CLIP-seq
MIRT2054630	hsa-miR-4766-5p	CLIP-seq
MIRT2054631	hsa-miR-4778-3p	CLIP-seq
MIRT2054632	hsa-miR-513a-3p	CLIP-seq
MIRT2581900	hsa-miR-1253	CLIP-seq
MIRT2581901	hsa-miR-1305	CLIP-seq
MIRT2581902	hsa-miR-2964a-5p	CLIP-seq
MIRT2581903	hsa-miR-300	CLIP-seq
MIRT2581904	hsa-miR-3200-3p	CLIP-seq
MIRT2581905	hsa-miR-3616-3p	CLIP-seq
MIRT2581906	hsa-miR-3664-3p	CLIP-seq
MIRT2581907	hsa-miR-381	CLIP-seq
MIRT2581908	hsa-miR-4311	CLIP-seq
MIRT2581909	hsa-miR-4666-3p	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT2581910	hsa-miR-4759	CLIP-seq
MIRT2581911	hsa-miR-498	CLIP-seq
MIRT2581912	hsa-miR-510	CLIP-seq
MIRT2581913	hsa-miR-512-5p	CLIP-seq
MIRT2581914	hsa-miR-548l	CLIP-seq
MIRT2581915	hsa-miR-548n	CLIP-seq
MIRT2581916	hsa-miR-885-5p	CLIP-seq
MIRT2581900	hsa-miR-1253	CLIP-seq
MIRT2581902	hsa-miR-2964a-5p	CLIP-seq
MIRT2581903	hsa-miR-300	CLIP-seq
MIRT2581904	hsa-miR-3200-3p	CLIP-seq
MIRT2581905	hsa-miR-3616-3p	CLIP-seq
MIRT2581906	hsa-miR-3664-3p	CLIP-seq
MIRT2581907	hsa-miR-381	CLIP-seq
MIRT2581908	hsa-miR-4311	CLIP-seq
MIRT2581909	hsa-miR-4666-3p	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT2581912	hsa-miR-510	CLIP-seq
MIRT2581913	hsa-miR-512-5p	CLIP-seq
MIRT2581916	hsa-miR-885-5p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11073942, 14660641, 16963496
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	14660641, 15132771, 16963496
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	IMP	16963496
GO:1902570	Process	Protein localization to nucleolus	IBA
GO:1902570	Process	Protein localization to nucleolus	IMP	16963496

MIM	HGNC	e!Ensembl
611534	23387	ENSG00000198000

Q76FK4

Protein name

Nucleolar protein 8 (Nucleolar protein Nop132)

Protein function

Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	10 → 83	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. {ECO:0000269|PubMed:15132771}.

Sequence

MKVNRETKRLYVGGLSQDISEADLQNQFSRFGEVSDVEIITRKDDQGNPQKVFAYINISV
AEADLKKCMSVLNKTKWKGGTLQIQLAKESFLHRLAQEREAAKAKKEESTTGNANLLEKT
GGVDFHMKAVPGTEVPGHKNWVVSKFGRVLPVLHLKNQHKRKIIKYDPSKYCHNLKKIGE
DFSNTIPISSLTWELEGGNDPMSKKRRGEFSDFHGPPKKIIKVQKDESSTGSLAMSTRPR
RVIERPPLTQQQAAQKRTCDSITPSKSSPVPVSDTQKLKNLPFKTSGLETAKKRNSISDD
DTDSEDELRMMIAKEENLQRTTQPSINESESDPFEVVRDDFKSGVHKLHSLIGLGIKNRV
SCHDSDDDIMRNDREYDSGDTDEIIAMKKNVAKVKNSTEFSQMEKSTKKTSFKNRENCEL
SDHCIKLQKRKSNVESALSHGLKSLNRKSPSHSSSSEDADSASELADSEGGEEYNAMMKN
CLRVNLTLADLEQLAGSDLKVPNEDTKSDGPETTTQCKFDRGSKSPKTPTGLRRGRQCIR
PAEIVASLLEGEENTCGKQKPKENNLKPKFQAFKGVGCLYEKESMKKSLKDSVASNNKDQ
NSMKHEDPSIISMEDGSPYVNGSLGEVTPCQHAKKANGPNYIQPQKRQTTFESQDRKAVS
PSSSEKRSKNPISRPLEGKKSLSLSAKTHNIGFDKDSCHSTTKTEASQEERSDSSGLTSL
KKSPKVSSKDTREIKTDFSLSISNSSDVSAKDKHAEDNEKRLAALEARQKAKEVQKKLVH
NALANLDGHPEDKPTHIIFGSDSECETEETSTQEQSHPGEEWVKESMGKTSGKLFDSSDD
DESDSEDDSNRFKIKPQFEGRAGQKLMDLQSHFGTDDRFRMDSRFLETDSEEEQEEVNEK
KTAEEEELAEEKKKALNVVQSVLQINLSNSTNRGSVAAKKFKDIIHYDPTKQDHATYERK
RDDKPKESKAKRKKKREEAEKLPEVSKEMYYNIAMDLKEIFQTTKYTSEKEEGTPWNEDC
GKEKPEEIQDPAALTSDAEQPSGFTFSFFDSDTKDIKEETYRVETVKPGKIVWQEDPRLQ
DSSSEEEDVTEETDHRNSSPGEASLLEKETTRFFFFSKNDERLQGSDLFWRGVGSNMSRN
SWEARTTNLRMDCRKKHKDAKRKMKPK

Sequence length

1167

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30125550		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	30125550		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	15132771		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30125550		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	30125550		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	15132771	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NOL8 (nucleolar protein 8)