FBXO34 (F-box protein 34)

Gene

• Entrez ID: 55030
• Gene name: F-box protein 34
• Gene symbol: FBXO34
• Synonyms (NCBI Gene): CGI-301, Fbx34
• Chromosome: 14
• Chromosome location: 14q22.3
• Summary: Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025171	hsa-miR-181a-5p	Microarray	17612493
MIRT030511	hsa-miR-24-3p	Microarray	19748357
MIRT440655	hsa-miR-432-3p	HITS-CLIP	24374217
MIRT440655	hsa-miR-432-3p	HITS-CLIP	24374217
MIRT992160	hsa-miR-1243	CLIP-seq
MIRT992161	hsa-miR-1290	CLIP-seq
MIRT992162	hsa-miR-1303	CLIP-seq
MIRT992163	hsa-miR-1305	CLIP-seq
MIRT992164	hsa-miR-140-3p	CLIP-seq
MIRT992165	hsa-miR-145	CLIP-seq
MIRT992166	hsa-miR-1468	CLIP-seq
MIRT992167	hsa-miR-181a	CLIP-seq
MIRT992168	hsa-miR-181b	CLIP-seq
MIRT992169	hsa-miR-181c	CLIP-seq
MIRT992170	hsa-miR-181d	CLIP-seq
MIRT992171	hsa-miR-18a	CLIP-seq
MIRT992172	hsa-miR-18b	CLIP-seq
MIRT992173	hsa-miR-198	CLIP-seq
MIRT992174	hsa-miR-216a	CLIP-seq
MIRT992175	hsa-miR-22	CLIP-seq
MIRT992176	hsa-miR-2682	CLIP-seq
MIRT992177	hsa-miR-27a	CLIP-seq
MIRT992178	hsa-miR-27b	CLIP-seq
MIRT992179	hsa-miR-300	CLIP-seq
MIRT992180	hsa-miR-30a	CLIP-seq
MIRT992181	hsa-miR-30b	CLIP-seq
MIRT992182	hsa-miR-30c	CLIP-seq
MIRT992183	hsa-miR-30d	CLIP-seq
MIRT992184	hsa-miR-30e	CLIP-seq
MIRT992185	hsa-miR-3121-5p	CLIP-seq
MIRT992186	hsa-miR-3122	CLIP-seq
MIRT992187	hsa-miR-3153	CLIP-seq
MIRT992188	hsa-miR-3167	CLIP-seq
MIRT992189	hsa-miR-3184	CLIP-seq
MIRT992190	hsa-miR-323b-5p	CLIP-seq
MIRT992191	hsa-miR-330-3p	CLIP-seq
MIRT992192	hsa-miR-33a	CLIP-seq
MIRT992193	hsa-miR-33b	CLIP-seq
MIRT992194	hsa-miR-342-3p	CLIP-seq
MIRT992195	hsa-miR-342-5p	CLIP-seq
MIRT992196	hsa-miR-3591-3p	CLIP-seq
MIRT992197	hsa-miR-3607-3p	CLIP-seq
MIRT992198	hsa-miR-3614-3p	CLIP-seq
MIRT992199	hsa-miR-362-5p	CLIP-seq
MIRT992200	hsa-miR-3651	CLIP-seq
MIRT992201	hsa-miR-376a	CLIP-seq
MIRT992202	hsa-miR-376b	CLIP-seq
MIRT992203	hsa-miR-381	CLIP-seq
MIRT992204	hsa-miR-3913-5p	CLIP-seq
MIRT992205	hsa-miR-3926	CLIP-seq
MIRT992206	hsa-miR-423-5p	CLIP-seq
MIRT992207	hsa-miR-4253	CLIP-seq
MIRT992208	hsa-miR-4261	CLIP-seq
MIRT992209	hsa-miR-4262	CLIP-seq
MIRT992210	hsa-miR-4289	CLIP-seq
MIRT992211	hsa-miR-4468	CLIP-seq
MIRT992212	hsa-miR-4484	CLIP-seq
MIRT992213	hsa-miR-4496	CLIP-seq
MIRT992214	hsa-miR-449c	CLIP-seq
MIRT992215	hsa-miR-4509	CLIP-seq
MIRT992216	hsa-miR-4514	CLIP-seq
MIRT992217	hsa-miR-4521	CLIP-seq
MIRT992218	hsa-miR-4528	CLIP-seq
MIRT992219	hsa-miR-4651	CLIP-seq
MIRT992220	hsa-miR-4664-5p	CLIP-seq
MIRT992221	hsa-miR-4666-3p	CLIP-seq
MIRT992222	hsa-miR-4668-5p	CLIP-seq
MIRT992223	hsa-miR-4692	CLIP-seq
MIRT992224	hsa-miR-4700-3p	CLIP-seq
MIRT992225	hsa-miR-4735-3p	CLIP-seq
MIRT992226	hsa-miR-4744	CLIP-seq
MIRT992227	hsa-miR-4761-3p	CLIP-seq
MIRT992228	hsa-miR-4789-5p	CLIP-seq
MIRT992229	hsa-miR-494	CLIP-seq
MIRT992230	hsa-miR-500b	CLIP-seq
MIRT992231	hsa-miR-501-5p	CLIP-seq
MIRT992232	hsa-miR-513a-5p	CLIP-seq
MIRT992233	hsa-miR-524-3p	CLIP-seq
MIRT992234	hsa-miR-525-3p	CLIP-seq
MIRT992235	hsa-miR-543	CLIP-seq
MIRT992236	hsa-miR-548ag	CLIP-seq
MIRT992237	hsa-miR-548ai	CLIP-seq
MIRT992238	hsa-miR-548an	CLIP-seq
MIRT992239	hsa-miR-548m	CLIP-seq
MIRT992240	hsa-miR-548n	CLIP-seq
MIRT992241	hsa-miR-548t	CLIP-seq
MIRT992242	hsa-miR-550a	CLIP-seq
MIRT992243	hsa-miR-570	CLIP-seq
MIRT992244	hsa-miR-608	CLIP-seq
MIRT992245	hsa-miR-651	CLIP-seq
MIRT992246	hsa-miR-656	CLIP-seq
MIRT992247	hsa-miR-657	CLIP-seq
MIRT992248	hsa-miR-876-5p	CLIP-seq
MIRT992249	hsa-miR-885-5p	CLIP-seq
MIRT992177	hsa-miR-27a	CLIP-seq
MIRT992178	hsa-miR-27b	CLIP-seq
MIRT992250	hsa-miR-338-5p	CLIP-seq
MIRT992251	hsa-miR-370	CLIP-seq
MIRT992252	hsa-miR-4436a	CLIP-seq
MIRT992224	hsa-miR-4700-3p	CLIP-seq
MIRT992253	hsa-miR-5096	CLIP-seq
MIRT992232	hsa-miR-513a-5p	CLIP-seq
MIRT992240	hsa-miR-548n	CLIP-seq
MIRT992241	hsa-miR-548t	CLIP-seq
MIRT992167	hsa-miR-181a	CLIP-seq
MIRT992168	hsa-miR-181b	CLIP-seq
MIRT992169	hsa-miR-181c	CLIP-seq
MIRT992170	hsa-miR-181d	CLIP-seq
MIRT992208	hsa-miR-4261	CLIP-seq
MIRT992209	hsa-miR-4262	CLIP-seq
MIRT992235	hsa-miR-543	CLIP-seq
MIRT992160	hsa-miR-1243	CLIP-seq
MIRT992161	hsa-miR-1290	CLIP-seq
MIRT1994257	hsa-miR-1301	CLIP-seq
MIRT992164	hsa-miR-140-3p	CLIP-seq
MIRT992166	hsa-miR-1468	CLIP-seq
MIRT992167	hsa-miR-181a	CLIP-seq
MIRT992168	hsa-miR-181b	CLIP-seq
MIRT992169	hsa-miR-181c	CLIP-seq
MIRT992170	hsa-miR-181d	CLIP-seq
MIRT1994258	hsa-miR-2052	CLIP-seq
MIRT992175	hsa-miR-22	CLIP-seq
MIRT992177	hsa-miR-27a	CLIP-seq
MIRT992178	hsa-miR-27b	CLIP-seq
MIRT992179	hsa-miR-300	CLIP-seq
MIRT992180	hsa-miR-30a	CLIP-seq
MIRT992181	hsa-miR-30b	CLIP-seq
MIRT992182	hsa-miR-30c	CLIP-seq
MIRT992183	hsa-miR-30d	CLIP-seq
MIRT992184	hsa-miR-30e	CLIP-seq
MIRT992188	hsa-miR-3167	CLIP-seq
MIRT992189	hsa-miR-3184	CLIP-seq
MIRT992191	hsa-miR-330-3p	CLIP-seq
MIRT992192	hsa-miR-33a	CLIP-seq
MIRT992193	hsa-miR-33b	CLIP-seq
MIRT992196	hsa-miR-3591-3p	CLIP-seq
MIRT992197	hsa-miR-3607-3p	CLIP-seq
MIRT992200	hsa-miR-3651	CLIP-seq
MIRT992201	hsa-miR-376a	CLIP-seq
MIRT992202	hsa-miR-376b	CLIP-seq
MIRT992203	hsa-miR-381	CLIP-seq
MIRT992205	hsa-miR-3926	CLIP-seq
MIRT992206	hsa-miR-423-5p	CLIP-seq
MIRT992208	hsa-miR-4261	CLIP-seq
MIRT992209	hsa-miR-4262	CLIP-seq
MIRT992210	hsa-miR-4289	CLIP-seq
MIRT1994259	hsa-miR-4330	CLIP-seq
MIRT992213	hsa-miR-4496	CLIP-seq
MIRT1994260	hsa-miR-450b-5p	CLIP-seq
MIRT992218	hsa-miR-4528	CLIP-seq
MIRT1994261	hsa-miR-4659a-3p	CLIP-seq
MIRT1994262	hsa-miR-4659b-3p	CLIP-seq
MIRT1994263	hsa-miR-4660	CLIP-seq
MIRT992221	hsa-miR-4666-3p	CLIP-seq
MIRT992224	hsa-miR-4700-3p	CLIP-seq
MIRT992228	hsa-miR-4789-5p	CLIP-seq
MIRT992229	hsa-miR-494	CLIP-seq
MIRT1994264	hsa-miR-5047	CLIP-seq
MIRT1994265	hsa-miR-507	CLIP-seq
MIRT992232	hsa-miR-513a-5p	CLIP-seq
MIRT992235	hsa-miR-543	CLIP-seq
MIRT1994266	hsa-miR-557	CLIP-seq
MIRT992246	hsa-miR-656	CLIP-seq
MIRT992248	hsa-miR-876-5p	CLIP-seq
MIRT992249	hsa-miR-885-5p	CLIP-seq
MIRT1994267	hsa-miR-942	CLIP-seq
MIRT992163	hsa-miR-1305	CLIP-seq
MIRT992164	hsa-miR-140-3p	CLIP-seq
MIRT992165	hsa-miR-145	CLIP-seq
MIRT992166	hsa-miR-1468	CLIP-seq
MIRT992173	hsa-miR-198	CLIP-seq
MIRT992174	hsa-miR-216a	CLIP-seq
MIRT992175	hsa-miR-22	CLIP-seq
MIRT992177	hsa-miR-27a	CLIP-seq
MIRT992178	hsa-miR-27b	CLIP-seq
MIRT992180	hsa-miR-30a	CLIP-seq
MIRT992181	hsa-miR-30b	CLIP-seq
MIRT992182	hsa-miR-30c	CLIP-seq
MIRT992183	hsa-miR-30d	CLIP-seq
MIRT992184	hsa-miR-30e	CLIP-seq
MIRT992189	hsa-miR-3184	CLIP-seq
MIRT992190	hsa-miR-323b-5p	CLIP-seq
MIRT992191	hsa-miR-330-3p	CLIP-seq
MIRT992192	hsa-miR-33a	CLIP-seq
MIRT992193	hsa-miR-33b	CLIP-seq
MIRT992194	hsa-miR-342-3p	CLIP-seq
MIRT992196	hsa-miR-3591-3p	CLIP-seq
MIRT992197	hsa-miR-3607-3p	CLIP-seq
MIRT992198	hsa-miR-3614-3p	CLIP-seq
MIRT992200	hsa-miR-3651	CLIP-seq
MIRT992205	hsa-miR-3926	CLIP-seq
MIRT992206	hsa-miR-423-5p	CLIP-seq
MIRT992207	hsa-miR-4253	CLIP-seq
MIRT992210	hsa-miR-4289	CLIP-seq
MIRT992211	hsa-miR-4468	CLIP-seq
MIRT992218	hsa-miR-4528	CLIP-seq
MIRT992227	hsa-miR-4761-3p	CLIP-seq
MIRT2228302	hsa-miR-4775	CLIP-seq
MIRT992228	hsa-miR-4789-5p	CLIP-seq
MIRT992232	hsa-miR-513a-5p	CLIP-seq
MIRT2228303	hsa-miR-590-3p	CLIP-seq
MIRT992247	hsa-miR-657	CLIP-seq
MIRT992249	hsa-miR-885-5p	CLIP-seq
MIRT992160	hsa-miR-1243	CLIP-seq
MIRT992166	hsa-miR-1468	CLIP-seq
MIRT992167	hsa-miR-181a	CLIP-seq
MIRT992168	hsa-miR-181b	CLIP-seq
MIRT992169	hsa-miR-181c	CLIP-seq
MIRT992170	hsa-miR-181d	CLIP-seq
MIRT992177	hsa-miR-27a	CLIP-seq
MIRT992178	hsa-miR-27b	CLIP-seq
MIRT992180	hsa-miR-30a	CLIP-seq
MIRT992181	hsa-miR-30b	CLIP-seq
MIRT992182	hsa-miR-30c	CLIP-seq
MIRT992183	hsa-miR-30d	CLIP-seq
MIRT992184	hsa-miR-30e	CLIP-seq
MIRT992189	hsa-miR-3184	CLIP-seq
MIRT992191	hsa-miR-330-3p	CLIP-seq
MIRT992197	hsa-miR-3607-3p	CLIP-seq
MIRT992205	hsa-miR-3926	CLIP-seq
MIRT992206	hsa-miR-423-5p	CLIP-seq
MIRT992209	hsa-miR-4262	CLIP-seq
MIRT992218	hsa-miR-4528	CLIP-seq
MIRT2387938	hsa-miR-4710	CLIP-seq
MIRT992228	hsa-miR-4789-5p	CLIP-seq
MIRT2387939	hsa-miR-4792	CLIP-seq
MIRT992229	hsa-miR-494	CLIP-seq
MIRT992232	hsa-miR-513a-5p	CLIP-seq
MIRT992235	hsa-miR-543	CLIP-seq
MIRT2387940	hsa-miR-627	CLIP-seq
MIRT2387941	hsa-miR-924	CLIP-seq
MIRT2532097	hsa-miR-1266	CLIP-seq
MIRT2532098	hsa-miR-4489	CLIP-seq
MIRT2532099	hsa-miR-4518	CLIP-seq
MIRT2532100	hsa-miR-510	CLIP-seq
MIRT2532101	hsa-miR-574-3p	CLIP-seq
MIRT2532102	hsa-miR-579	CLIP-seq
MIRT2532103	hsa-miR-887	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183

Other IDs

• MIM: 609104
• HGNC: 20201
• e!Ensembl: ENSG00000178974

Protein

• UniProt ID: Q9NWN3
• Protein name: F-box only protein 34
• Protein function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
• Sequence:

  MHLKPYWKLQKKEHPPEVSRETQRTPMNHQKAVNDETCKASHITSSVFPSASLGKASSRK
  PFGILSPNVLCSMSGKSPVESSLNVKTKKNAPSATIHQGEEEGPLDIWAVVKPGNTKEKI
  AFFASHQCSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAKVQVERMREVNSRCYQPEPF
  ACGIEHCSVHYVSDSGDGVYAGRPLSVIQMVAFLEQRASALLASCSKNCTNSPAIVRFSG
  QSRGVPAVSESYSAPGACEEPTERGNLEVGEPQSEPVRVLDMVAKLESECLKRQGQREPG
  SLSRNNSFRRNVGRVLLANSTQADEGKTKKGVLEAPDTQVNPVGSVSVDCGPSRADRCSP
  KEDQAWDGASQDCPPLPAGVSFHIDSAELEPGSQTAVKNSNRYDVEMTDELVGLPFSSHT
  YSQASELPTDAVDCMSRELVSLTSRNPDQRKESLCISITVSKVDKDQPSILNSCEDPVPG
  MLFFLPPGQHLSDYSQLNESTTKESSEASQLEDAAGGDSASEEKSGSAEPFVLPASSVES
  TLPVLEASSWKKQVSHDFLETRFKIQQLLEPQQYMAFLPHHIMVKIFRLLPTKSLVALKC
  TCCYFKFIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPY
  GPGYWMCCHRSQKGFPGCKLGLHDNHWVPACHSFNRAIHKKAKGTEAEEEY

• Sequence length: 711

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations