Gene Gene information from NCBI Gene database.
Entrez ID 55014
Gene name Syntaxin 17
Gene symbol STX17
Synonyms (NCBI Gene)
-
Chromosome 9
Chromosome location 9q31.1
miRNA miRNA information provided by mirtarbase database.
912
miRTarBase ID miRNA Experiments Reference
MIRT046119 hsa-miR-30b-5p CLASH 23622248
MIRT520887 hsa-miR-6769a-3p PAR-CLIP 23446348
MIRT520886 hsa-miR-512-3p PAR-CLIP 23446348
MIRT520885 hsa-miR-6801-3p PAR-CLIP 23446348
MIRT520884 hsa-miR-6810-3p PAR-CLIP 23446348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
60
GO ID Ontology Definition Evidence Reference
GO:0000149 Function SNARE binding IBA
GO:0000149 Function SNARE binding IDA 23217709
GO:0000149 Function SNARE binding IEA
GO:0000421 Component Autophagosome membrane IBA
GO:0000421 Component Autophagosome membrane IDA 23217709, 26416964, 28306502
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604204 11432 ENSG00000136874
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P56962
Protein name Syntaxin-17
Protein function SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four al
PDB 4WY4 , 7BV4 , 7BV6
Family and domains
Sequence
MSEDEEKVKLRRLEPAIQKFIKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGR
TVQQLRSNIREIEKLCLKVRKDDLVLLKRMIDPVKEEASAATAEFLQLHLESVEELKKQF
NDEETLLQPPLTRSMTVGGAFHTTEAEASSQSLTQIYALPEIPQDQNAAESWETLEADLI
ELSQLVTDFSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIG
GMVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQRKKQKMMEKLTSSCPDLPSQTDKK
CS
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  SNARE interactions in vesicular transport
Autophagy - animal
  COPII-mediated vesicle transport
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MELANOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alopecia Areata Alopecia Areata GWASDB_DG 20596022
★☆☆☆☆
Found in Text Mining only
Alopecia Areata Alopecia Areata GWASCAT_DG 20596022
★☆☆☆☆
Found in Text Mining only
Alopecia Areata Alopecia Areata CTD_human_DG 20596022
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy BEFREE 30584088
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy Pubtator 30584088 Associate
★☆☆☆☆
Found in Text Mining only
Cutaneous Melanoma Melanoma BEFREE 19209086, 25413220
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Major Major depressive disorder Pubtator 36394763 Associate
★☆☆☆☆
Found in Text Mining only
Down Syndrome Down Syndrome BEFREE 31714914
★☆☆☆☆
Found in Text Mining only
Down Syndrome Down syndrome Pubtator 31714914 Associate
★☆☆☆☆
Found in Text Mining only
Glycogen Storage Disease Type II Glycogen storage disease Pubtator 33799647 Associate
★☆☆☆☆
Found in Text Mining only