Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54993
Gene name	Zinc finger and SCAN domain containing 2
Gene symbol	ZSCAN2
Synonyms (NCBI Gene)	ZFP29ZNF854
Chromosome	15
Chromosome location	15q25.2
Summary	The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in

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Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT706025	hsa-miR-186-3p	HITS-CLIP	22927820
MIRT706024	hsa-miR-150-5p	HITS-CLIP	22927820
MIRT706023	hsa-miR-3653-5p	HITS-CLIP	22927820
MIRT706022	hsa-miR-1976	HITS-CLIP	22927820
MIRT706021	hsa-miR-6790-3p	HITS-CLIP	22927820
MIRT706020	hsa-miR-6821-3p	HITS-CLIP	22927820
MIRT706018	hsa-miR-6778-3p	HITS-CLIP	22927820
MIRT706019	hsa-miR-1193	HITS-CLIP	22927820
MIRT706017	hsa-miR-378a-5p	HITS-CLIP	22927820
MIRT706016	hsa-miR-640	HITS-CLIP	22927820
MIRT706015	hsa-miR-6843-3p	HITS-CLIP	22927820
MIRT706014	hsa-miR-6848-3p	HITS-CLIP	22927820
MIRT636857	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT636856	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT636855	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT636854	hsa-miR-2052	HITS-CLIP	23824327
MIRT636853	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT636852	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT636851	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT636850	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT636849	hsa-miR-4709-3p	HITS-CLIP	23824327
MIRT636848	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT636847	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT636846	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT636845	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT636844	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT617346	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT617345	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT617344	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT617343	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT617342	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT617341	hsa-miR-1281	HITS-CLIP	23824327
MIRT617340	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT617339	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT617338	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT617337	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT617336	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT617335	hsa-miR-1206	HITS-CLIP	23824327
MIRT617334	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT617333	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT706025	hsa-miR-186-3p	HITS-CLIP	22927820
MIRT706024	hsa-miR-150-5p	HITS-CLIP	22927820
MIRT706023	hsa-miR-3653-5p	HITS-CLIP	22927820
MIRT706022	hsa-miR-1976	HITS-CLIP	22927820
MIRT706021	hsa-miR-6790-3p	HITS-CLIP	22927820
MIRT706020	hsa-miR-6821-3p	HITS-CLIP	22927820
MIRT706018	hsa-miR-6778-3p	HITS-CLIP	22927820
MIRT706019	hsa-miR-1193	HITS-CLIP	22927820
MIRT706017	hsa-miR-378a-5p	HITS-CLIP	22927820
MIRT706016	hsa-miR-640	HITS-CLIP	22927820
MIRT706015	hsa-miR-6843-3p	HITS-CLIP	22927820
MIRT706014	hsa-miR-6848-3p	HITS-CLIP	22927820
MIRT636857	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT636856	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT636855	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT636854	hsa-miR-2052	HITS-CLIP	23824327
MIRT636853	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT636852	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT636851	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT636850	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT636849	hsa-miR-4709-3p	HITS-CLIP	23824327
MIRT636848	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT636847	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT636846	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT636845	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT636844	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT617346	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT617345	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT617344	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT617343	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT617342	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT617341	hsa-miR-1281	HITS-CLIP	23824327
MIRT617340	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT617339	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT617338	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT617337	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT617336	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT617335	hsa-miR-1206	HITS-CLIP	23824327
MIRT617334	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT617333	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT1543702	hsa-miR-1231	CLIP-seq
MIRT1543703	hsa-miR-1273d	CLIP-seq
MIRT1543704	hsa-miR-298	CLIP-seq
MIRT1543705	hsa-miR-3192	CLIP-seq
MIRT1543706	hsa-miR-4270	CLIP-seq
MIRT1543707	hsa-miR-4314	CLIP-seq
MIRT1543708	hsa-miR-4441	CLIP-seq
MIRT1543709	hsa-miR-4646-5p	CLIP-seq
MIRT1543710	hsa-miR-4711-3p	CLIP-seq
MIRT2164048	hsa-miR-1182	CLIP-seq
MIRT2164049	hsa-miR-124	CLIP-seq
MIRT2164050	hsa-miR-1299	CLIP-seq
MIRT2164051	hsa-miR-193a-5p	CLIP-seq
MIRT2164052	hsa-miR-3117-5p	CLIP-seq
MIRT2164053	hsa-miR-3121-3p	CLIP-seq
MIRT2164054	hsa-miR-3170	CLIP-seq
MIRT2164055	hsa-miR-342-5p	CLIP-seq
MIRT2164056	hsa-miR-4453	CLIP-seq
MIRT2164057	hsa-miR-4493	CLIP-seq
MIRT2164058	hsa-miR-4538	CLIP-seq
MIRT2164059	hsa-miR-4651	CLIP-seq
MIRT2164060	hsa-miR-4664-5p	CLIP-seq
MIRT2164061	hsa-miR-4724-3p	CLIP-seq
MIRT2164062	hsa-miR-4782-5p	CLIP-seq
MIRT2164063	hsa-miR-506	CLIP-seq
MIRT2164064	hsa-miR-516b	CLIP-seq
MIRT2164065	hsa-miR-608	CLIP-seq
MIRT2164066	hsa-miR-875-3p	CLIP-seq
MIRT1543702	hsa-miR-1231	CLIP-seq
MIRT1543703	hsa-miR-1273d	CLIP-seq
MIRT2383224	hsa-miR-1827	CLIP-seq
MIRT1543704	hsa-miR-298	CLIP-seq
MIRT2383225	hsa-miR-3165	CLIP-seq
MIRT1543705	hsa-miR-3192	CLIP-seq
MIRT2383226	hsa-miR-3691-5p	CLIP-seq
MIRT2383227	hsa-miR-370	CLIP-seq
MIRT2383228	hsa-miR-4257	CLIP-seq
MIRT1543706	hsa-miR-4270	CLIP-seq
MIRT1543707	hsa-miR-4314	CLIP-seq
MIRT1543708	hsa-miR-4441	CLIP-seq
MIRT1543709	hsa-miR-4646-5p	CLIP-seq
MIRT1543710	hsa-miR-4711-3p	CLIP-seq
MIRT1543702	hsa-miR-1231	CLIP-seq
MIRT1543703	hsa-miR-1273d	CLIP-seq
MIRT1543705	hsa-miR-3192	CLIP-seq
MIRT1543707	hsa-miR-4314	CLIP-seq
MIRT1543709	hsa-miR-4646-5p	CLIP-seq
MIRT1543710	hsa-miR-4711-3p	CLIP-seq
MIRT2164049	hsa-miR-124	CLIP-seq
MIRT2164054	hsa-miR-3170	CLIP-seq
MIRT2164055	hsa-miR-342-5p	CLIP-seq
MIRT2164056	hsa-miR-4453	CLIP-seq
MIRT2164057	hsa-miR-4493	CLIP-seq
MIRT2164058	hsa-miR-4538	CLIP-seq
MIRT2164059	hsa-miR-4651	CLIP-seq
MIRT2164060	hsa-miR-4664-5p	CLIP-seq
MIRT2164063	hsa-miR-506	CLIP-seq
MIRT2164065	hsa-miR-608	CLIP-seq
MIRT2164049	hsa-miR-124	CLIP-seq
MIRT2164054	hsa-miR-3170	CLIP-seq
MIRT2164055	hsa-miR-342-5p	CLIP-seq
MIRT2673690	hsa-miR-3613-3p	CLIP-seq
MIRT2673691	hsa-miR-3672	CLIP-seq
MIRT2673692	hsa-miR-371-5p	CLIP-seq
MIRT2673693	hsa-miR-371b-5p	CLIP-seq
MIRT2164056	hsa-miR-4453	CLIP-seq
MIRT2164057	hsa-miR-4493	CLIP-seq
MIRT2164058	hsa-miR-4538	CLIP-seq
MIRT2164059	hsa-miR-4651	CLIP-seq
MIRT2164060	hsa-miR-4664-5p	CLIP-seq
MIRT2673694	hsa-miR-4684-5p	CLIP-seq
MIRT2673695	hsa-miR-4793-5p	CLIP-seq
MIRT2673696	hsa-miR-4794	CLIP-seq
MIRT2164063	hsa-miR-506	CLIP-seq
MIRT2673697	hsa-miR-523	CLIP-seq
MIRT2673698	hsa-miR-548c-3p	CLIP-seq
MIRT2164065	hsa-miR-608	CLIP-seq
MIRT2164049	hsa-miR-124	CLIP-seq
MIRT2383224	hsa-miR-1827	CLIP-seq
MIRT2696432	hsa-miR-2114	CLIP-seq
MIRT2164054	hsa-miR-3170	CLIP-seq
MIRT2164055	hsa-miR-342-5p	CLIP-seq
MIRT2673690	hsa-miR-3613-3p	CLIP-seq
MIRT2673691	hsa-miR-3672	CLIP-seq
MIRT2673692	hsa-miR-371-5p	CLIP-seq
MIRT2673693	hsa-miR-371b-5p	CLIP-seq
MIRT2696433	hsa-miR-3929	CLIP-seq
MIRT2696434	hsa-miR-4419b	CLIP-seq
MIRT2164056	hsa-miR-4453	CLIP-seq
MIRT2696435	hsa-miR-4478	CLIP-seq
MIRT2164057	hsa-miR-4493	CLIP-seq
MIRT2164058	hsa-miR-4538	CLIP-seq
MIRT2696436	hsa-miR-4649-3p	CLIP-seq
MIRT2164059	hsa-miR-4651	CLIP-seq
MIRT2164060	hsa-miR-4664-5p	CLIP-seq
MIRT2673694	hsa-miR-4684-5p	CLIP-seq
MIRT2696437	hsa-miR-4722-5p	CLIP-seq
MIRT2696438	hsa-miR-4768-3p	CLIP-seq
MIRT2673695	hsa-miR-4793-5p	CLIP-seq
MIRT2673696	hsa-miR-4794	CLIP-seq
MIRT2696439	hsa-miR-485-5p	CLIP-seq
MIRT2164063	hsa-miR-506	CLIP-seq
MIRT2673697	hsa-miR-523	CLIP-seq
MIRT2673698	hsa-miR-548c-3p	CLIP-seq
MIRT2164065	hsa-miR-608	CLIP-seq
MIRT2696440	hsa-miR-940	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q7Z7L9

Protein name

Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854)

Protein function

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02023	SCAN	65 → 135	SCAN domain	Domain
PF00096	zf-C2H2	222 → 244	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	250 → 272	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	278 → 300	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	306 → 328	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	334 → 356	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	362 → 384	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	390 → 412	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	418 → 440	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	446 → 468	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	474 → 496	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	502 → 524	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	530 → 552	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	558 → 580	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	586 → 608	Zinc finger, C2H2 type	Domain

Sequence

MMAADIPRVTTPLSSLVQVPQEEDRQEEEVTTMILEDDSWVQEAVLQEDGPESEPFPQSA
GKGGPQEEVTRGPQGALGRLRELCRRWLRPEVHTKEQMLTMLPKEIQAWLQEHRPESSEE
AAALVEDLTQTLQDSDFEIQSENGENCNQDMFENESRKIFSEMPEGESAQHSDGESDFER
DAGIQRLQGHSPGEDHGEVVSQDREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLITH
ERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRIH
TGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIHTGEK
PYECKECGESFSYNSNLIRHQRIHTGEKPYKCTDCGQRFSQSSALITHRRTHTGEKPYQC
SECGKSFSRSSNLATHRRTHMVEKPYKCGVCGKSFSQSSSLIAHQGMHTGEKPYECLTCG
ESFSWSSNLLKHQRIHTGEKPYKCSECGKCFSQRSQLVVHQRTHTGEKPYKCLMCGKSFS
RGSILVMHQRAHLGDKPYRCPECGKGFSWNSVLIIHQRIHTGEKPYKCPECGKGFSNSSN
FITHQRTHMKEKLY

Sequence length

614

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormality of neuronal migration	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Depressed bipolar I disorder	Depressed bipolar disorder	GWASCAT_DG	31043756		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZSCAN2 (zinc finger and SCAN domain containing 2)