Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54981
Gene name	Nicotinamide riboside kinase 1
Gene symbol	NMRK1
Synonyms (NCBI Gene)	C9orf95NRK1bA235O14.2
Chromosome	9
Chromosome location	9q21.13
Summary	Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028785	hsa-miR-26b-5p	Microarray	19088304
MIRT608308	hsa-miR-8485	HITS-CLIP	23313552
MIRT608308	hsa-miR-8485	HITS-CLIP	23313552
MIRT608309	hsa-miR-603	HITS-CLIP	23313552
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23313552
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23313552
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT615510	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT615509	hsa-miR-4801	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	23824327
MIRT608309	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608308	hsa-miR-8485	HITS-CLIP	24906430
MIRT608309	hsa-miR-603	HITS-CLIP	24906430
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	24906430
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	24906430
MIRT608308	hsa-miR-8485	HITS-CLIP	24906430
MIRT608309	hsa-miR-603	HITS-CLIP	24906430
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	24906430
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	24906430
MIRT575588	hsa-miR-8485	HITS-CLIP	27418678
MIRT575588	hsa-miR-8485	HITS-CLIP	27418678
MIRT575588	hsa-miR-8485	HITS-CLIP	23313552
MIRT575588	hsa-miR-8485	HITS-CLIP	23313552
MIRT575587	hsa-miR-603	HITS-CLIP	23313552
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23313552
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23313552
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT628652	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT618762	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618761	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT618760	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT618759	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618758	hsa-miR-3941	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT615510	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT615509	hsa-miR-4801	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT575588	hsa-miR-8485	HITS-CLIP	23824327
MIRT575587	hsa-miR-603	HITS-CLIP	23824327
MIRT608307	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT608306	hsa-miR-7159-5p	HITS-CLIP	23824327

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006741	Process	NADP+ biosynthetic process	IEA
GO:0009435	Process	NAD+ biosynthetic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019363	Process	Pyridine nucleotide biosynthetic process	IEA
GO:0019674	Process	NAD+ metabolic process	IEA
GO:0019674	Process	NAD+ metabolic process	TAS
GO:0034317	Function	Nicotinate riboside kinase activity	IEA
GO:0034355	Process	NAD+ biosynthetic process via the salvage pathway	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050262	Function	Ribosylnicotinamide kinase activity	EXP	15137942, 17914902
GO:0050262	Function	Ribosylnicotinamide kinase activity	IBA
GO:0050262	Function	Ribosylnicotinamide kinase activity	IEA
GO:0061769	Function	Ribosylnicotinate kinase activity	EXP	15137942, 17914902
GO:0061769	Function	Ribosylnicotinate kinase activity	IBA
GO:0061769	Function	Ribosylnicotinate kinase activity	IEA

MIM	HGNC	e!Ensembl
608704	26057	ENSG00000106733

Q9NWW6

Protein name

Nicotinamide riboside kinase 1 (NRK 1) (NmR-K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1)

Protein function

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3

PDB

2P0E , 2QG6 , 2QL6 , 2QSY , 2QSZ , 2QT0 , 2QT1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13238	AAA_18	6 → 149		Domain

Sequence

MKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEA
LNMEKMMSAISCWMESARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTI
PYEECKRRRSTRVYQPPDSPGYFDGHVWPMYLKYRQEMQDITWEVVYLDGTKSEEDLFLQ
VYEDLIQELAKQKCLQVTA

Sequence length

199

Interactions

View interactions

	KEGG		Reactome
	Nicotinate and nicotinamide metabolism Metabolic pathways		Nicotinate metabolism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GILLES DE LA TOURETTE SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	35271662	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	29678570		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcopenia	Sarcopenia	Pubtator	35271662	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	29678570		★★★★★ ★☆☆☆☆ Found in Text Mining only

NMRK1 (nicotinamide riboside kinase 1)