HPF1 (histone PARylation factor 1)

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Gene Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54969
• Gene name: Histone PARylation factor 1
• Gene symbol: HPF1
• Synonyms (NCBI Gene): C4orf27
• Chromosome: 4
• Chromosome location: 4q33

Gene ontology (GO) Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	27067600
GO:0003682	Function	Chromatin binding	IDA	32939087
GO:0005515	Function	Protein binding	IPI	27067600, 28190768, 28514442, 32939087, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	27067600
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0006281	Process	DNA repair	IDA	32028527, 33186521, 34108479, 34486521, 34874266
GO:0006281	Process	DNA repair	IDA	32028527, 34108479
GO:0006281	Process	DNA repair	IEA
GO:0006302	Process	Double-strand break repair	IBA
GO:0006302	Process	Double-strand break repair	IDA	27568560, 28190768, 32028527
GO:0006302	Process	Double-strand break repair	IDA	32028527
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	27067600, 29480802
GO:0010835	Process	Regulation of protein ADP-ribosylation	IDA	33186521
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IDA	27067600
GO:0042393	Function	Histone binding	IEA
GO:0070212	Process	Protein poly-ADP-ribosylation	IDA	28190768
GO:0071168	Process	Protein localization to chromatin	IDA	34874266
GO:0072572	Function	Poly-ADP-D-ribose binding	IBA
GO:0090734	Component	Site of DNA damage	IDA	32028527, 34108479
GO:0090734	Component	Site of DNA damage	IDA	32939087
GO:0140768	Function	Protein ADP-ribosyltransferase-substrate adaptor activity	IDA	28190768, 29480802, 32028527, 32939087, 33186521, 33412112, 33589610, 33683197, 34108479, 34210965, 34486521, 34625544, 34732825, 34795260, 34874266
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IBA
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IDA	32939087

Other IDs

• MIM: 616614
• HGNC: 26051
• e!Ensembl: ENSG00000056050

Protein

• UniProt ID: Q9NWY4
• Protein name: Histone PARylation factor 1
• Protein function: Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response (PubMed:28190768, PubMed:29480802, PubMed:29954836, PubMed:32028527, PubMed:32939087, PubMed:33186521, PubMed:335
• PDB: 6M3G , 6M3I , 6TX2 , 6TX3 , 6X0L , 6X0M , 6X0N
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10228	DUF2228	77 → 328	Uncharacterised conserved protein (DUF2228)	Family

• Sequence:

  MVGGGGKRRPGGEGPQCEKTTDVKKSKFCEADVSSDLRKEVENHYKLSLPEDFYHFWKFC
  EELDPEKPSDSLSASLGLQLVGPYDILAGKHKTKKKSTGLNFNLHWRFYYDPPEFQTIII
  GDNKTQYHMGYFRDSPDEFPVYVGINEAKKNCIIVPNGDNVFAAVKLFLTKKLREITDKK
  KINLLKNIDEKLTEAARELGYSLEQRTVKMKQRDKKVVTKTFHGAGLVVPVDKNDVGYRE
  LPETDADLKRICKTIVEAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCY
  GSHYFHKVAGQLLPLAYNLLKRNLFAEIIEEHLANRSQENIDQLAA

• Sequence length: 346

Related Genes

No strongly related genes found yet for HPF1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HPF1.