Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	5496
Gene name	Protein phosphatase, Mg2+/Mn2+ dependent 1G
Gene symbol	PPM1G
Synonyms (NCBI Gene)	PP2CGPP2CGAMMAPPP2CG
Chromosome	2
Chromosome location	2p23.3
Summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylatio

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Show/Hide all (156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020613	hsa-miR-155-5p	Proteomics	18668040
MIRT032202	hsa-let-7b-5p	Proteomics	18668040
MIRT047658	hsa-miR-10a-5p	CLASH	23622248
MIRT041984	hsa-miR-484	CLASH	23622248
MIRT037135	hsa-miR-877-3p	CLASH	23622248
MIRT1254308	hsa-miR-1203	CLIP-seq
MIRT1254309	hsa-miR-1207-5p	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254312	hsa-miR-1266	CLIP-seq
MIRT1254313	hsa-miR-132	CLIP-seq
MIRT1254314	hsa-miR-1323	CLIP-seq
MIRT1254315	hsa-miR-142-5p	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT1254318	hsa-miR-1909	CLIP-seq
MIRT1254319	hsa-miR-1910	CLIP-seq
MIRT1254320	hsa-miR-212	CLIP-seq
MIRT1254321	hsa-miR-24	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT1254324	hsa-miR-27a	CLIP-seq
MIRT1254325	hsa-miR-27b	CLIP-seq
MIRT1254326	hsa-miR-3148	CLIP-seq
MIRT1254327	hsa-miR-3177-5p	CLIP-seq
MIRT1254328	hsa-miR-3656	CLIP-seq
MIRT1254329	hsa-miR-3664-3p	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT1254331	hsa-miR-4264	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT1254333	hsa-miR-4437	CLIP-seq
MIRT1254334	hsa-miR-4464	CLIP-seq
MIRT1254335	hsa-miR-4474-5p	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT1254337	hsa-miR-4518	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT1254340	hsa-miR-4721	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT1254342	hsa-miR-4748	CLIP-seq
MIRT1254343	hsa-miR-4763-3p	CLIP-seq
MIRT1254344	hsa-miR-4766-5p	CLIP-seq
MIRT1254345	hsa-miR-4797-5p	CLIP-seq
MIRT1254346	hsa-miR-488	CLIP-seq
MIRT1254347	hsa-miR-513a-5p	CLIP-seq
MIRT1254348	hsa-miR-541	CLIP-seq
MIRT1254349	hsa-miR-548aa	CLIP-seq
MIRT1254350	hsa-miR-548ac	CLIP-seq
MIRT1254351	hsa-miR-548ae	CLIP-seq
MIRT1254352	hsa-miR-548aj	CLIP-seq
MIRT1254353	hsa-miR-548am	CLIP-seq
MIRT1254354	hsa-miR-548d-3p	CLIP-seq
MIRT1254355	hsa-miR-548o	CLIP-seq
MIRT1254356	hsa-miR-548t	CLIP-seq
MIRT1254357	hsa-miR-548x	CLIP-seq
MIRT1254358	hsa-miR-548z	CLIP-seq
MIRT1254359	hsa-miR-561	CLIP-seq
MIRT1254360	hsa-miR-570	CLIP-seq
MIRT1254361	hsa-miR-622	CLIP-seq
MIRT1254362	hsa-miR-654-5p	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq
MIRT2074998	hsa-miR-1	CLIP-seq
MIRT1254308	hsa-miR-1203	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254312	hsa-miR-1266	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT2074999	hsa-miR-206	CLIP-seq
MIRT1254321	hsa-miR-24	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT1254328	hsa-miR-3656	CLIP-seq
MIRT1254329	hsa-miR-3664-3p	CLIP-seq
MIRT2075000	hsa-miR-3673	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT1254331	hsa-miR-4264	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT2075001	hsa-miR-4419a	CLIP-seq
MIRT1254333	hsa-miR-4437	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT2075002	hsa-miR-4510	CLIP-seq
MIRT1254337	hsa-miR-4518	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT2075003	hsa-miR-4687-5p	CLIP-seq
MIRT1254340	hsa-miR-4721	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT1254360	hsa-miR-570	CLIP-seq
MIRT2075004	hsa-miR-613	CLIP-seq
MIRT1254361	hsa-miR-622	CLIP-seq
MIRT2075005	hsa-miR-9	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq
MIRT1254327	hsa-miR-3177-5p	CLIP-seq
MIRT1254328	hsa-miR-3656	CLIP-seq
MIRT1254346	hsa-miR-488	CLIP-seq
MIRT1254308	hsa-miR-1203	CLIP-seq
MIRT1254312	hsa-miR-1266	CLIP-seq
MIRT1254313	hsa-miR-132	CLIP-seq
MIRT1254320	hsa-miR-212	CLIP-seq
MIRT1254321	hsa-miR-24	CLIP-seq
MIRT1254329	hsa-miR-3664-3p	CLIP-seq
MIRT1254331	hsa-miR-4264	CLIP-seq
MIRT1254333	hsa-miR-4437	CLIP-seq
MIRT1254337	hsa-miR-4518	CLIP-seq
MIRT1254340	hsa-miR-4721	CLIP-seq
MIRT1254360	hsa-miR-570	CLIP-seq
MIRT1254361	hsa-miR-622	CLIP-seq
MIRT2074998	hsa-miR-1	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT2074999	hsa-miR-206	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT2075000	hsa-miR-3673	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT2598387	hsa-miR-4267	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT2075001	hsa-miR-4419a	CLIP-seq
MIRT2598388	hsa-miR-4468	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT2075002	hsa-miR-4510	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT2075003	hsa-miR-4687-5p	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT2598389	hsa-miR-4786-3p	CLIP-seq
MIRT2075004	hsa-miR-613	CLIP-seq
MIRT2075005	hsa-miR-9	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq
MIRT2074998	hsa-miR-1	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT2074999	hsa-miR-206	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT2075000	hsa-miR-3673	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT2598387	hsa-miR-4267	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT2075001	hsa-miR-4419a	CLIP-seq
MIRT2598388	hsa-miR-4468	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT2075002	hsa-miR-4510	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT2075003	hsa-miR-4687-5p	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT2598389	hsa-miR-4786-3p	CLIP-seq
MIRT2075004	hsa-miR-613	CLIP-seq
MIRT2075005	hsa-miR-9	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	20801214
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS	9276438
GO:0005515	Function	Protein binding	IPI	17572683, 21044950, 22190034, 23178491, 28330616, 34591612, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9271424
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006470	Process	Protein dephosphorylation	TAS	9276438
GO:0007165	Process	Signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0035970	Process	Peptidyl-threonine dephosphorylation	IDA	20801214
GO:0043169	Function	Cation binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	TAS	9271424

MIM	HGNC	e!Ensembl
605119	9278	ENSG00000115241

O15355

Protein name

Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00481	PP2C	25 → 120	Protein phosphatase 2C	Family
PF00481	PP2C	262 → 492	Protein phosphatase 2C	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Most abundant in testis, skeletal muscle, and heart.

Sequence

MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYD
GHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGR
PTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEE
PGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPS
CSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEE
AEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL
DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISA
LPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELL
DQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKK
KKAKRD

Sequence length

546

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL HYPERLIPIDEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis, Gouty	Gouty arthritis	GWASDB_DG	20884846, 23263486		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33771191	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33952716, 34366322	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Disruptive Impulse Control and Conduct Disorders	Disruptive, impulse control, and conduct disorders	Pubtator	25982659	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	31621893		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	27065332	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gout	Gout	GWASDB_DG	20884846, 23263486		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	34366322	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	37387407	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)