Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54951
Gene name	COMM domain containing 8
Gene symbol	COMMD8
Synonyms (NCBI Gene)	-
Chromosome	4
Chromosome location	4p12
Summary	The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]

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Show/Hide all (223)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047054	hsa-miR-183-5p	CLASH	23622248
MIRT903562	hsa-miR-132	CLIP-seq
MIRT903563	hsa-miR-137	CLIP-seq
MIRT903564	hsa-miR-212	CLIP-seq
MIRT903565	hsa-miR-3160-5p	CLIP-seq
MIRT903566	hsa-miR-3617	CLIP-seq
MIRT903567	hsa-miR-3686	CLIP-seq
MIRT903568	hsa-miR-369-3p	CLIP-seq
MIRT903569	hsa-miR-374a	CLIP-seq
MIRT903570	hsa-miR-374b	CLIP-seq
MIRT903571	hsa-miR-3913-3p	CLIP-seq
MIRT903572	hsa-miR-4457	CLIP-seq
MIRT903573	hsa-miR-4652-3p	CLIP-seq
MIRT903574	hsa-miR-4709-5p	CLIP-seq
MIRT903575	hsa-miR-4742-3p	CLIP-seq
MIRT903576	hsa-miR-499-3p	CLIP-seq
MIRT903577	hsa-miR-499a-3p	CLIP-seq
MIRT903578	hsa-miR-513b	CLIP-seq
MIRT903579	hsa-miR-526b	CLIP-seq
MIRT903580	hsa-miR-548q	CLIP-seq
MIRT903581	hsa-miR-579	CLIP-seq
MIRT903582	hsa-miR-624	CLIP-seq
MIRT903583	hsa-miR-630	CLIP-seq
MIRT903584	hsa-miR-641	CLIP-seq
MIRT903585	hsa-miR-889	CLIP-seq
MIRT1967909	hsa-miR-1200	CLIP-seq
MIRT1967910	hsa-miR-1976	CLIP-seq
MIRT1967911	hsa-miR-3180-5p	CLIP-seq
MIRT1967912	hsa-miR-3942-5p	CLIP-seq
MIRT1967913	hsa-miR-4324	CLIP-seq
MIRT1967914	hsa-miR-4424	CLIP-seq
MIRT1967915	hsa-miR-4639-3p	CLIP-seq
MIRT1967916	hsa-miR-4682	CLIP-seq
MIRT1967917	hsa-miR-4703-5p	CLIP-seq
MIRT1967918	hsa-miR-4727-5p	CLIP-seq
MIRT1967919	hsa-miR-4769-3p	CLIP-seq
MIRT1967920	hsa-miR-4774-5p	CLIP-seq
MIRT1967921	hsa-miR-4789-5p	CLIP-seq
MIRT1967922	hsa-miR-544b	CLIP-seq
MIRT1967923	hsa-miR-664	CLIP-seq
MIRT1967909	hsa-miR-1200	CLIP-seq
MIRT2203797	hsa-miR-1279	CLIP-seq
MIRT903562	hsa-miR-132	CLIP-seq
MIRT1967910	hsa-miR-1976	CLIP-seq
MIRT903564	hsa-miR-212	CLIP-seq
MIRT2203798	hsa-miR-217	CLIP-seq
MIRT2203799	hsa-miR-329	CLIP-seq
MIRT903566	hsa-miR-3617	CLIP-seq
MIRT2203800	hsa-miR-362-3p	CLIP-seq
MIRT2203801	hsa-miR-376c	CLIP-seq
MIRT903571	hsa-miR-3913-3p	CLIP-seq
MIRT2203802	hsa-miR-3941	CLIP-seq
MIRT1967913	hsa-miR-4324	CLIP-seq
MIRT1967914	hsa-miR-4424	CLIP-seq
MIRT903572	hsa-miR-4457	CLIP-seq
MIRT2203803	hsa-miR-4539	CLIP-seq
MIRT1967916	hsa-miR-4682	CLIP-seq
MIRT903574	hsa-miR-4709-5p	CLIP-seq
MIRT2203804	hsa-miR-4762-3p	CLIP-seq
MIRT1967921	hsa-miR-4789-5p	CLIP-seq
MIRT903576	hsa-miR-499-3p	CLIP-seq
MIRT903577	hsa-miR-499a-3p	CLIP-seq
MIRT903578	hsa-miR-513b	CLIP-seq
MIRT1967922	hsa-miR-544b	CLIP-seq
MIRT903580	hsa-miR-548q	CLIP-seq
MIRT2203805	hsa-miR-603	CLIP-seq
MIRT903582	hsa-miR-624	CLIP-seq
MIRT903584	hsa-miR-641	CLIP-seq
MIRT903581	hsa-miR-579	CLIP-seq
MIRT2506902	hsa-miR-1	CLIP-seq
MIRT1967909	hsa-miR-1200	CLIP-seq
MIRT2506903	hsa-miR-1238	CLIP-seq
MIRT2506904	hsa-miR-1301	CLIP-seq
MIRT2506905	hsa-miR-1303	CLIP-seq
MIRT903562	hsa-miR-132	CLIP-seq
MIRT2506906	hsa-miR-1323	CLIP-seq
MIRT903563	hsa-miR-137	CLIP-seq
MIRT2506907	hsa-miR-181a	CLIP-seq
MIRT2506908	hsa-miR-181b	CLIP-seq
MIRT2506909	hsa-miR-181c	CLIP-seq
MIRT2506910	hsa-miR-181d	CLIP-seq
MIRT1967910	hsa-miR-1976	CLIP-seq
MIRT2506911	hsa-miR-206	CLIP-seq
MIRT2506912	hsa-miR-21	CLIP-seq
MIRT2506913	hsa-miR-2117	CLIP-seq
MIRT903564	hsa-miR-212	CLIP-seq
MIRT2506914	hsa-miR-2277-3p	CLIP-seq
MIRT2506915	hsa-miR-23a	CLIP-seq
MIRT2506916	hsa-miR-23b	CLIP-seq
MIRT2506917	hsa-miR-23c	CLIP-seq
MIRT2506918	hsa-miR-298	CLIP-seq
MIRT2506919	hsa-miR-3074-5p	CLIP-seq
MIRT2506920	hsa-miR-3124-3p	CLIP-seq
MIRT903565	hsa-miR-3160-5p	CLIP-seq
MIRT2506921	hsa-miR-3161	CLIP-seq
MIRT2506922	hsa-miR-3183	CLIP-seq
MIRT2506923	hsa-miR-361-5p	CLIP-seq
MIRT903566	hsa-miR-3617	CLIP-seq
MIRT2506924	hsa-miR-3662	CLIP-seq
MIRT903567	hsa-miR-3686	CLIP-seq
MIRT903568	hsa-miR-369-3p	CLIP-seq
MIRT2506925	hsa-miR-371b-5p	CLIP-seq
MIRT903569	hsa-miR-374a	CLIP-seq
MIRT903570	hsa-miR-374b	CLIP-seq
MIRT2203801	hsa-miR-376c	CLIP-seq
MIRT2506926	hsa-miR-380	CLIP-seq
MIRT2506927	hsa-miR-3908	CLIP-seq
MIRT2506928	hsa-miR-409-3p	CLIP-seq
MIRT2506929	hsa-miR-4262	CLIP-seq
MIRT2506930	hsa-miR-4273	CLIP-seq
MIRT1967913	hsa-miR-4324	CLIP-seq
MIRT1967914	hsa-miR-4424	CLIP-seq
MIRT2506931	hsa-miR-4477b	CLIP-seq
MIRT2506932	hsa-miR-4517	CLIP-seq
MIRT903573	hsa-miR-4652-3p	CLIP-seq
MIRT2506933	hsa-miR-4660	CLIP-seq
MIRT1967916	hsa-miR-4682	CLIP-seq
MIRT2506934	hsa-miR-4684-5p	CLIP-seq
MIRT903574	hsa-miR-4709-5p	CLIP-seq
MIRT2506935	hsa-miR-4712-3p	CLIP-seq
MIRT2506936	hsa-miR-4723-3p	CLIP-seq
MIRT903575	hsa-miR-4742-3p	CLIP-seq
MIRT2506937	hsa-miR-4760-3p	CLIP-seq
MIRT2506938	hsa-miR-4766-5p	CLIP-seq
MIRT2506939	hsa-miR-4777-5p	CLIP-seq
MIRT1967921	hsa-miR-4789-5p	CLIP-seq
MIRT2506940	hsa-miR-4802-3p	CLIP-seq
MIRT2506941	hsa-miR-491-3p	CLIP-seq
MIRT2506942	hsa-miR-496	CLIP-seq
MIRT2506943	hsa-miR-5047	CLIP-seq
MIRT2506944	hsa-miR-513a-3p	CLIP-seq
MIRT2506945	hsa-miR-518d-5p	CLIP-seq
MIRT2506946	hsa-miR-519b-5p	CLIP-seq
MIRT2506947	hsa-miR-519c-5p	CLIP-seq
MIRT2506948	hsa-miR-520c-5p	CLIP-seq
MIRT2506949	hsa-miR-526a	CLIP-seq
MIRT903579	hsa-miR-526b	CLIP-seq
MIRT2506950	hsa-miR-539	CLIP-seq
MIRT1967922	hsa-miR-544b	CLIP-seq
MIRT2506951	hsa-miR-548a-3p	CLIP-seq
MIRT2506952	hsa-miR-548e	CLIP-seq
MIRT2506953	hsa-miR-548f	CLIP-seq
MIRT2506954	hsa-miR-548g	CLIP-seq
MIRT2506955	hsa-miR-548o	CLIP-seq
MIRT903580	hsa-miR-548q	CLIP-seq
MIRT903581	hsa-miR-579	CLIP-seq
MIRT2506956	hsa-miR-583	CLIP-seq
MIRT2506957	hsa-miR-586	CLIP-seq
MIRT2506958	hsa-miR-590-3p	CLIP-seq
MIRT2506959	hsa-miR-590-5p	CLIP-seq
MIRT2506960	hsa-miR-613	CLIP-seq
MIRT903583	hsa-miR-630	CLIP-seq
MIRT903584	hsa-miR-641	CLIP-seq
MIRT2506961	hsa-miR-888	CLIP-seq
MIRT903585	hsa-miR-889	CLIP-seq
MIRT2506902	hsa-miR-1	CLIP-seq
MIRT1967909	hsa-miR-1200	CLIP-seq
MIRT2506903	hsa-miR-1238	CLIP-seq
MIRT2506904	hsa-miR-1301	CLIP-seq
MIRT2506906	hsa-miR-1323	CLIP-seq
MIRT903563	hsa-miR-137	CLIP-seq
MIRT1967910	hsa-miR-1976	CLIP-seq
MIRT2506911	hsa-miR-206	CLIP-seq
MIRT2506913	hsa-miR-2117	CLIP-seq
MIRT2506914	hsa-miR-2277-3p	CLIP-seq
MIRT2506918	hsa-miR-298	CLIP-seq
MIRT2506919	hsa-miR-3074-5p	CLIP-seq
MIRT2506920	hsa-miR-3124-3p	CLIP-seq
MIRT2506921	hsa-miR-3161	CLIP-seq
MIRT2506922	hsa-miR-3183	CLIP-seq
MIRT2506923	hsa-miR-361-5p	CLIP-seq
MIRT903566	hsa-miR-3617	CLIP-seq
MIRT2506924	hsa-miR-3662	CLIP-seq
MIRT903567	hsa-miR-3686	CLIP-seq
MIRT903568	hsa-miR-369-3p	CLIP-seq
MIRT2506925	hsa-miR-371b-5p	CLIP-seq
MIRT903569	hsa-miR-374a	CLIP-seq
MIRT903570	hsa-miR-374b	CLIP-seq
MIRT2203801	hsa-miR-376c	CLIP-seq
MIRT2506926	hsa-miR-380	CLIP-seq
MIRT2506927	hsa-miR-3908	CLIP-seq
MIRT2506928	hsa-miR-409-3p	CLIP-seq
MIRT2506930	hsa-miR-4273	CLIP-seq
MIRT1967913	hsa-miR-4324	CLIP-seq
MIRT1967914	hsa-miR-4424	CLIP-seq
MIRT2506931	hsa-miR-4477b	CLIP-seq
MIRT2506932	hsa-miR-4517	CLIP-seq
MIRT903573	hsa-miR-4652-3p	CLIP-seq
MIRT2506933	hsa-miR-4660	CLIP-seq
MIRT1967916	hsa-miR-4682	CLIP-seq
MIRT2506934	hsa-miR-4684-5p	CLIP-seq
MIRT2506935	hsa-miR-4712-3p	CLIP-seq
MIRT2506936	hsa-miR-4723-3p	CLIP-seq
MIRT903575	hsa-miR-4742-3p	CLIP-seq
MIRT2506937	hsa-miR-4760-3p	CLIP-seq
MIRT2506938	hsa-miR-4766-5p	CLIP-seq
MIRT2506939	hsa-miR-4777-5p	CLIP-seq
MIRT2506940	hsa-miR-4802-3p	CLIP-seq
MIRT2506941	hsa-miR-491-3p	CLIP-seq
MIRT2506943	hsa-miR-5047	CLIP-seq
MIRT2506944	hsa-miR-513a-3p	CLIP-seq
MIRT2506945	hsa-miR-518d-5p	CLIP-seq
MIRT2506946	hsa-miR-519b-5p	CLIP-seq
MIRT2506947	hsa-miR-519c-5p	CLIP-seq
MIRT2506948	hsa-miR-520c-5p	CLIP-seq
MIRT2506949	hsa-miR-526a	CLIP-seq
MIRT903579	hsa-miR-526b	CLIP-seq
MIRT2506950	hsa-miR-539	CLIP-seq
MIRT1967922	hsa-miR-544b	CLIP-seq
MIRT2506951	hsa-miR-548a-3p	CLIP-seq
MIRT2506952	hsa-miR-548e	CLIP-seq
MIRT2506953	hsa-miR-548f	CLIP-seq
MIRT2506954	hsa-miR-548g	CLIP-seq
MIRT2506955	hsa-miR-548o	CLIP-seq
MIRT903581	hsa-miR-579	CLIP-seq
MIRT2506956	hsa-miR-583	CLIP-seq
MIRT2506957	hsa-miR-586	CLIP-seq
MIRT2506958	hsa-miR-590-3p	CLIP-seq
MIRT2506960	hsa-miR-613	CLIP-seq
MIRT903583	hsa-miR-630	CLIP-seq
MIRT903584	hsa-miR-641	CLIP-seq
MIRT2506961	hsa-miR-888	CLIP-seq
MIRT903585	hsa-miR-889	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15799966, 21778237, 21900206, 23563313, 25355947, 26496610, 28514442, 28892079, 30833792, 32296183, 33961781, 35271311, 37172566
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IBA
GO:0051059	Function	NF-kappaB binding	IBA

MIM	HGNC	e!Ensembl
616656	26036	ENSG00000169019

Q9NX08

Protein name

COMM domain-containing protein 8

Protein function

Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate ac

PDB

8F2R , 8F2U , 8P0W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07258	COMM_domain	114 → 183	COMM domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest expression in thyroid. {ECO:0000269|PubMed:15799966}.

Sequence

MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAK
FFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDF
DWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVL
QLK

Sequence length

183

Interactions

View interactions

	Reactome
			Neddylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEMOLYTIC ANEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34493238	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30982576		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	27871936, 31566716		★★★★★ ★☆☆☆☆ Found in Text Mining only

COMMD8 (COMM domain containing 8)