Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5495
Gene name	Protein phosphatase, Mg2+/Mn2+ dependent 1B
Gene symbol	PPM1B
Synonyms (NCBI Gene)	PP2C-betaPP2C-beta-XPP2CBPP2CBETAPPC2BETAX
Chromosome	2
Chromosome location	2p21
Summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044250	hsa-miR-106b-5p	CLASH	23622248
MIRT568918	hsa-miR-551b-5p	PAR-CLIP	20371350
MIRT568917	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT568916	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT568915	hsa-miR-8485	PAR-CLIP	20371350
MIRT568918	hsa-miR-551b-5p	PAR-CLIP	20371350
MIRT568917	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT568916	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT568915	hsa-miR-8485	PAR-CLIP	20371350
MIRT1253707	hsa-miR-128	CLIP-seq
MIRT1253708	hsa-miR-27a	CLIP-seq
MIRT1253709	hsa-miR-27b	CLIP-seq
MIRT1253710	hsa-miR-338-5p	CLIP-seq
MIRT1253711	hsa-miR-4729	CLIP-seq
MIRT1253712	hsa-miR-513a-5p	CLIP-seq
MIRT1253713	hsa-miR-654-3p	CLIP-seq
MIRT1253714	hsa-miR-216a	CLIP-seq
MIRT1253715	hsa-miR-216b	CLIP-seq
MIRT1253716	hsa-miR-323-3p	CLIP-seq
MIRT1253717	hsa-miR-4282	CLIP-seq
MIRT1253718	hsa-miR-4698	CLIP-seq
MIRT1253719	hsa-miR-513a-3p	CLIP-seq
MIRT1253720	hsa-miR-587	CLIP-seq
MIRT1253721	hsa-miR-105	CLIP-seq
MIRT1253722	hsa-miR-125a-3p	CLIP-seq
MIRT1253723	hsa-miR-1270	CLIP-seq
MIRT1253724	hsa-miR-147	CLIP-seq
MIRT1253725	hsa-miR-1913	CLIP-seq
MIRT1253726	hsa-miR-221	CLIP-seq
MIRT1253727	hsa-miR-222	CLIP-seq
MIRT1253728	hsa-miR-23a	CLIP-seq
MIRT1253729	hsa-miR-23b	CLIP-seq
MIRT1253730	hsa-miR-23c	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT1253736	hsa-miR-3120-5p	CLIP-seq
MIRT1253737	hsa-miR-3130-5p	CLIP-seq
MIRT1253738	hsa-miR-320a	CLIP-seq
MIRT1253739	hsa-miR-320b	CLIP-seq
MIRT1253740	hsa-miR-320c	CLIP-seq
MIRT1253741	hsa-miR-320d	CLIP-seq
MIRT1253716	hsa-miR-323-3p	CLIP-seq
MIRT1253742	hsa-miR-324-3p	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT1253744	hsa-miR-340	CLIP-seq
MIRT1253745	hsa-miR-3620	CLIP-seq
MIRT1253746	hsa-miR-3684	CLIP-seq
MIRT1253747	hsa-miR-3688-5p	CLIP-seq
MIRT1253748	hsa-miR-374c	CLIP-seq
MIRT1253749	hsa-miR-383	CLIP-seq
MIRT1253750	hsa-miR-3911	CLIP-seq
MIRT1253751	hsa-miR-3925-3p	CLIP-seq
MIRT1253752	hsa-miR-3934	CLIP-seq
MIRT1253717	hsa-miR-4282	CLIP-seq
MIRT1253753	hsa-miR-4313	CLIP-seq
MIRT1253754	hsa-miR-4422	CLIP-seq
MIRT1253755	hsa-miR-4429	CLIP-seq
MIRT1253756	hsa-miR-4434	CLIP-seq
MIRT1253757	hsa-miR-4474-3p	CLIP-seq
MIRT1253758	hsa-miR-4475	CLIP-seq
MIRT1253759	hsa-miR-4482	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT1253761	hsa-miR-4516	CLIP-seq
MIRT1253762	hsa-miR-4517	CLIP-seq
MIRT1253763	hsa-miR-4520a-3p	CLIP-seq
MIRT1253764	hsa-miR-4520b-3p	CLIP-seq
MIRT1253765	hsa-miR-4528	CLIP-seq
MIRT1253766	hsa-miR-4529-3p	CLIP-seq
MIRT1253767	hsa-miR-4531	CLIP-seq
MIRT1253768	hsa-miR-4719	CLIP-seq
MIRT1253769	hsa-miR-4742-3p	CLIP-seq
MIRT1253770	hsa-miR-4772-5p	CLIP-seq
MIRT1253771	hsa-miR-5096	CLIP-seq
MIRT1253772	hsa-miR-520d-5p	CLIP-seq
MIRT1253773	hsa-miR-524-5p	CLIP-seq
MIRT1253774	hsa-miR-548c-3p	CLIP-seq
MIRT1253775	hsa-miR-548v	CLIP-seq
MIRT1253776	hsa-miR-552	CLIP-seq
MIRT1253777	hsa-miR-570	CLIP-seq
MIRT1253778	hsa-miR-589	CLIP-seq
MIRT1253779	hsa-miR-620	CLIP-seq
MIRT1253780	hsa-miR-626	CLIP-seq
MIRT1253781	hsa-miR-644	CLIP-seq
MIRT1253782	hsa-miR-655	CLIP-seq
MIRT1253783	hsa-miR-760	CLIP-seq
MIRT1253784	hsa-miR-764	CLIP-seq
MIRT1253785	hsa-miR-766	CLIP-seq
MIRT1253786	hsa-miR-873	CLIP-seq
MIRT1253787	hsa-miR-203	CLIP-seq
MIRT1253788	hsa-miR-3128	CLIP-seq
MIRT1253789	hsa-miR-4666-3p	CLIP-seq
MIRT1253790	hsa-miR-4720-5p	CLIP-seq
MIRT1253791	hsa-miR-4735-5p	CLIP-seq
MIRT1253792	hsa-miR-4799-3p	CLIP-seq
MIRT1253721	hsa-miR-105	CLIP-seq
MIRT2074768	hsa-miR-106a	CLIP-seq
MIRT2074769	hsa-miR-106b	CLIP-seq
MIRT2074770	hsa-miR-1178	CLIP-seq
MIRT2074771	hsa-miR-1183	CLIP-seq
MIRT2074772	hsa-miR-1207-5p	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074777	hsa-miR-17	CLIP-seq
MIRT2074778	hsa-miR-1827	CLIP-seq
MIRT2074779	hsa-miR-192	CLIP-seq
MIRT2074780	hsa-miR-20a	CLIP-seq
MIRT2074781	hsa-miR-20b	CLIP-seq
MIRT2074782	hsa-miR-215	CLIP-seq
MIRT2074783	hsa-miR-302a	CLIP-seq
MIRT2074784	hsa-miR-302b	CLIP-seq
MIRT2074785	hsa-miR-302c	CLIP-seq
MIRT2074786	hsa-miR-302d	CLIP-seq
MIRT2074787	hsa-miR-302e	CLIP-seq
MIRT2074788	hsa-miR-302f	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2074790	hsa-miR-3149	CLIP-seq
MIRT2074791	hsa-miR-337-3p	CLIP-seq
MIRT2074792	hsa-miR-3646	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2074794	hsa-miR-372	CLIP-seq
MIRT2074795	hsa-miR-373	CLIP-seq
MIRT1253752	hsa-miR-3934	CLIP-seq
MIRT2074796	hsa-miR-3942-3p	CLIP-seq
MIRT2074797	hsa-miR-411	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT2074800	hsa-miR-4438	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT1253763	hsa-miR-4520a-3p	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2074802	hsa-miR-4731-5p	CLIP-seq
MIRT2074803	hsa-miR-4742-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074805	hsa-miR-4757-5p	CLIP-seq
MIRT2074806	hsa-miR-4763-3p	CLIP-seq
MIRT2074807	hsa-miR-4772-3p	CLIP-seq
MIRT2074808	hsa-miR-494	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074810	hsa-miR-5095	CLIP-seq
MIRT1253771	hsa-miR-5096	CLIP-seq
MIRT2074811	hsa-miR-512-3p	CLIP-seq
MIRT2074812	hsa-miR-519d	CLIP-seq
MIRT2074813	hsa-miR-520a-3p	CLIP-seq
MIRT2074814	hsa-miR-520b	CLIP-seq
MIRT2074815	hsa-miR-520c-3p	CLIP-seq
MIRT2074816	hsa-miR-520d-3p	CLIP-seq
MIRT2074817	hsa-miR-520e	CLIP-seq
MIRT2074818	hsa-miR-520g	CLIP-seq
MIRT2074819	hsa-miR-520h	CLIP-seq
MIRT1253774	hsa-miR-548c-3p	CLIP-seq
MIRT1253776	hsa-miR-552	CLIP-seq
MIRT2074820	hsa-miR-640	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074822	hsa-miR-93	CLIP-seq
MIRT2074823	hsa-miR-940	CLIP-seq
MIRT2074772	hsa-miR-1207-5p	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074778	hsa-miR-1827	CLIP-seq
MIRT2301667	hsa-miR-217	CLIP-seq
MIRT2301668	hsa-miR-296-3p	CLIP-seq
MIRT2301669	hsa-miR-297	CLIP-seq
MIRT2301670	hsa-miR-29a	CLIP-seq
MIRT2301671	hsa-miR-29b	CLIP-seq
MIRT2301672	hsa-miR-29c	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2301673	hsa-miR-3138	CLIP-seq
MIRT2074790	hsa-miR-3149	CLIP-seq
MIRT1253716	hsa-miR-323-3p	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT2301674	hsa-miR-331-5p	CLIP-seq
MIRT2301675	hsa-miR-33a	CLIP-seq
MIRT2301676	hsa-miR-33b	CLIP-seq
MIRT1253744	hsa-miR-340	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT1253749	hsa-miR-383	CLIP-seq
MIRT1253752	hsa-miR-3934	CLIP-seq
MIRT2074797	hsa-miR-411	CLIP-seq
MIRT2301677	hsa-miR-4420	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT1253763	hsa-miR-4520a-3p	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2301678	hsa-miR-4652-3p	CLIP-seq
MIRT1253768	hsa-miR-4719	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074806	hsa-miR-4763-3p	CLIP-seq
MIRT2074807	hsa-miR-4772-3p	CLIP-seq
MIRT2301680	hsa-miR-487a	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074810	hsa-miR-5095	CLIP-seq
MIRT1253771	hsa-miR-5096	CLIP-seq
MIRT1253774	hsa-miR-548c-3p	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2301681	hsa-miR-759	CLIP-seq
MIRT2074823	hsa-miR-940	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2598305	hsa-miR-1273d	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2598306	hsa-miR-181a	CLIP-seq
MIRT2598307	hsa-miR-181b	CLIP-seq
MIRT2598308	hsa-miR-181c	CLIP-seq
MIRT2598309	hsa-miR-181d	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2598310	hsa-miR-3185	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT2598311	hsa-miR-3647-3p	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2598312	hsa-miR-3682-5p	CLIP-seq
MIRT2598313	hsa-miR-4262	CLIP-seq
MIRT2598314	hsa-miR-4279	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT1253754	hsa-miR-4422	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2598315	hsa-miR-4646-5p	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2598316	hsa-miR-4694-3p	CLIP-seq
MIRT2598317	hsa-miR-4700-3p	CLIP-seq
MIRT2598318	hsa-miR-4709-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2598319	hsa-miR-4747-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2301680	hsa-miR-487a	CLIP-seq
MIRT2074808	hsa-miR-494	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT1253772	hsa-miR-520d-5p	CLIP-seq
MIRT1253773	hsa-miR-524-5p	CLIP-seq
MIRT2598320	hsa-miR-664	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2598306	hsa-miR-181a	CLIP-seq
MIRT2598307	hsa-miR-181b	CLIP-seq
MIRT2598308	hsa-miR-181c	CLIP-seq
MIRT2598309	hsa-miR-181d	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2598310	hsa-miR-3185	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT1253710	hsa-miR-338-5p	CLIP-seq
MIRT2598311	hsa-miR-3647-3p	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2598313	hsa-miR-4262	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT1253754	hsa-miR-4422	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2598315	hsa-miR-4646-5p	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2598316	hsa-miR-4694-3p	CLIP-seq
MIRT2598317	hsa-miR-4700-3p	CLIP-seq
MIRT2598318	hsa-miR-4709-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2598319	hsa-miR-4747-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2301680	hsa-miR-487a	CLIP-seq
MIRT2074808	hsa-miR-494	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2688445	hsa-miR-499-3p	CLIP-seq
MIRT2688446	hsa-miR-499a-3p	CLIP-seq
MIRT1253772	hsa-miR-520d-5p	CLIP-seq
MIRT1253773	hsa-miR-524-5p	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	20801214
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS	9684878
GO:0005515	Function	Protein binding	IPI	16872604, 17620599, 18930133, 25241761, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006470	Process	Protein dephosphorylation	IMP	18930133, 22750291
GO:0006470	Process	Protein dephosphorylation	TAS	9684878
GO:0006499	Process	N-terminal protein myristoylation	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0030145	Function	Manganese ion binding	IEA
GO:0032688	Process	Negative regulation of interferon-beta production	IMP	22750291
GO:0035970	Process	Peptidyl-threonine dephosphorylation	IDA	20801214
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IBA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IEA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IMP	18930133
GO:0043169	Function	Cation binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050687	Process	Negative regulation of defense response to virus	IMP	22750291
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IMP	18930133

MIM	HGNC	e!Ensembl
603770	9276	ENSG00000138032

O75688

Protein name

Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)

Protein function

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alph

PDB

2P8E

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00481	PP2C	22 → 288	Protein phosphatase 2C	Family
PF07830	PP2C_C	289 → 368	Protein serine/threonine phosphatase 2C, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart and skeletal muscle.

Sequence

MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD
GHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNF
SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERI
QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIIL
ACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPK
VSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKR
NVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRL
AKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI

Sequence length

479

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway		ISG15 antiviral mechanism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
2p21 microdeletion syndrome	2p21 microdeletion syndrome	ORPHANET_DG	11524703		★★★★★ ★☆☆☆☆ Found in Text Mining only
2p21 microdeletion syndrome	2p21 microdeletion syndrome	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	26494000		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29307615, 29654756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36928924	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	26494000		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	30269354		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystinuria	Cystinuria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	33380426	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontal bossing	Frontal bossing	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypogonadism	Hypogonadism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypotonia-Cystinuria Syndrome	Hypotonia-Cystinuria Syndrome	BEFREE	18781961, 28726805		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypotonia-Cystinuria Syndrome	Hypotonia-Cystinuria Syndrome	CTD_human_DG	26247364		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29307615, 29654756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	26494000		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29307615, 29654756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Moderate intellectual disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	CTD_human_DG	16214533		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nephrolithiasis	Nephrolithiasis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	30816442	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	38364962	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)