SLC41A3 (solute carrier family 41 member 3)

Gene

• Entrez ID: 54946
• Gene name: Solute carrier family 41 member 3
• Gene symbol: SLC41A3
• Synonyms (NCBI Gene): SLC41A1-L2
• Chromosome: 3
• Chromosome location: 3q21.2-q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047546	hsa-miR-10a-5p	CLASH	23622248
MIRT1364147	hsa-miR-31	CLIP-seq
MIRT1364148	hsa-miR-3128	CLIP-seq
MIRT1364149	hsa-miR-3661	CLIP-seq
MIRT1364150	hsa-miR-4733-5p	CLIP-seq
MIRT1364151	hsa-miR-492	CLIP-seq
MIRT1364152	hsa-miR-631	CLIP-seq
MIRT2108098	hsa-miR-1292	CLIP-seq
MIRT2108099	hsa-miR-4471	CLIP-seq
MIRT2108100	hsa-miR-4724-3p	CLIP-seq
MIRT2626372	hsa-miR-1207-5p	CLIP-seq
MIRT2626373	hsa-miR-1827	CLIP-seq
MIRT2626374	hsa-miR-1909	CLIP-seq
MIRT2626375	hsa-miR-217	CLIP-seq
MIRT2626376	hsa-miR-2467-3p	CLIP-seq
MIRT2626377	hsa-miR-3158-5p	CLIP-seq
MIRT2626378	hsa-miR-3678-3p	CLIP-seq
MIRT2626379	hsa-miR-4418	CLIP-seq
MIRT2626380	hsa-miR-4719	CLIP-seq
MIRT1364150	hsa-miR-4733-5p	CLIP-seq
MIRT2626381	hsa-miR-4763-3p	CLIP-seq
MIRT2626382	hsa-miR-509-3-5p	CLIP-seq
MIRT2626383	hsa-miR-509-5p	CLIP-seq
MIRT2626384	hsa-miR-940	CLIP-seq
MIRT2626372	hsa-miR-1207-5p	CLIP-seq
MIRT2626373	hsa-miR-1827	CLIP-seq
MIRT2626374	hsa-miR-1909	CLIP-seq
MIRT2626375	hsa-miR-217	CLIP-seq
MIRT2626376	hsa-miR-2467-3p	CLIP-seq
MIRT1364147	hsa-miR-31	CLIP-seq
MIRT1364148	hsa-miR-3128	CLIP-seq
MIRT2626377	hsa-miR-3158-5p	CLIP-seq
MIRT1364149	hsa-miR-3661	CLIP-seq
MIRT2626378	hsa-miR-3678-3p	CLIP-seq
MIRT2626379	hsa-miR-4418	CLIP-seq
MIRT2626380	hsa-miR-4719	CLIP-seq
MIRT1364150	hsa-miR-4733-5p	CLIP-seq
MIRT2626381	hsa-miR-4763-3p	CLIP-seq
MIRT1364151	hsa-miR-492	CLIP-seq
MIRT2626382	hsa-miR-509-3-5p	CLIP-seq
MIRT2626383	hsa-miR-509-5p	CLIP-seq
MIRT1364152	hsa-miR-631	CLIP-seq
MIRT2626384	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	27302215
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0008324	Function	Monoatomic cation transmembrane transporter activity	IEA
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0045016	Process	Mitochondrial magnesium ion transmembrane transport	IDA	27302215
GO:0061768	Function	Magnesium:sodium antiporter activity	IDA	27302215

Other IDs

• MIM: 610803
• HGNC: 31046
• e!Ensembl: ENSG00000114544

Protein

• UniProt ID: Q96GZ6
• Protein name: Solute carrier family 41 member 3
• Protein function: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01769	MgtE	106 → 240	Divalent cation transporter	Family
  PF01769	MgtE	319 → 461	Divalent cation transporter	Family

• Sequence:

  MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRE
  TTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTL
  ASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAK
  VELLCASSVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALV
  SSFFYRHKDSRYLTPLVCLSFAALTPVWVLIAKQSPPIVKILKFGWFPIILAMVISSFGG
  LILSKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMWSAPGVLPLQMKKFWPN
  PCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVEGQSVINSQTFVVLYLLAGLIQVT
  ILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLGSSSVGHTAAVPRRCTASPGWGLIQ
  PFICTQHLIVSLLSFYFPFCLLAKTSI

• Sequence length: 507

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BELL'S PALSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32382568, 39628683	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34819993	Stimulate	★☆☆☆☆ Found in Text Mining only