SOHLH2 (spermatogenesis and oogenesis specific basic helix-loop-helix 2)

Gene

• Entrez ID: 54937
• Gene name: Spermatogenesis and oogenesis specific basic helix-loop-helix 2
• Gene symbol: SOHLH2
• Synonyms (NCBI Gene): SOSF2, SPATA28, TEB1, bHLHe81
• Chromosome: 13
• Chromosome location: 13q13.3
• Summary: This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription fact

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1379251	hsa-miR-203	CLIP-seq
MIRT1379252	hsa-miR-3611	CLIP-seq
MIRT1379253	hsa-miR-375	CLIP-seq
MIRT1379254	hsa-miR-4436b-5p	CLIP-seq
MIRT1379255	hsa-miR-4633-3p	CLIP-seq
MIRT1379256	hsa-miR-4698	CLIP-seq
MIRT1379257	hsa-miR-607	CLIP-seq
MIRT2336379	hsa-miR-4276	CLIP-seq
MIRT2336380	hsa-miR-4457	CLIP-seq
MIRT2336381	hsa-miR-4731-3p	CLIP-seq
MIRT2336382	hsa-miR-4801	CLIP-seq
MIRT2336383	hsa-miR-510	CLIP-seq
MIRT2336384	hsa-miR-512-5p	CLIP-seq
MIRT2336385	hsa-miR-624	CLIP-seq
MIRT2336386	hsa-miR-642b	CLIP-seq
MIRT2440715	hsa-miR-187	CLIP-seq
MIRT2440716	hsa-miR-3618	CLIP-seq
MIRT2440717	hsa-miR-4802-3p	CLIP-seq
MIRT2440718	hsa-miR-490-5p	CLIP-seq
MIRT2440719	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0009994	Process	Oocyte differentiation	ISS
GO:0030154	Process	Cell differentiation	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030154	Process	Cell differentiation	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048477	Process	Oogenesis	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: 616066
• HGNC: 26026
• e!Ensembl: ENSG00000120669

Interactions View interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE MYELOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SOHLH2-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations