DUSP23 (dual specificity phosphatase 23)

Gene

• Entrez ID: 54935
• Gene name: Dual specificity phosphatase 23
• Gene symbol: DUSP23
• Synonyms (NCBI Gene): DUSP25, LDP-3, LDP3, MOSP, VHZ
• Chromosome: 1
• Chromosome location: 1q23.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001635	hsa-let-7b-5p	pSILAC	18668040
MIRT025740	hsa-miR-7-5p	Microarray	19073608
MIRT001635	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT947791	hsa-miR-3157-5p	CLIP-seq
MIRT947792	hsa-miR-4276	CLIP-seq
MIRT947793	hsa-miR-4300	CLIP-seq
MIRT947794	hsa-miR-4302	CLIP-seq
MIRT947795	hsa-miR-4633-3p	CLIP-seq
MIRT947796	hsa-miR-4691-3p	CLIP-seq
MIRT947797	hsa-miR-4711-3p	CLIP-seq
MIRT947798	hsa-miR-629	CLIP-seq
MIRT947799	hsa-miR-920	CLIP-seq
MIRT1980819	hsa-miR-4705	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IDA	17498703
GO:0016311	Process	Dephosphorylation	IDA	24531476
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	24531476
GO:0016791	Function	Phosphatase activity	IEA
GO:0060271	Process	Cilium assembly	IBA

Other IDs

• MIM: 618361
• HGNC: 21480
• e!Ensembl: ENSG00000158716

Protein

• UniProt ID: Q9BVJ7
• Protein name: Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z)
• Protein function: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAP
• PDB: 2IMG, 4ERC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00782	DSPc	26 → 148	Dual specificity phosphatase, catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach. {ECO:0000269|P
• Sequence:

  MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHR
  LRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGD
  AIAEIRRLRPGSIETYEQEKAVFQFYQRTK

• Sequence length: 150

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GLOMERULONEPHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTERSTITIAL LUNG DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations