Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54913
Gene name	Ribonuclease P/MRP subunit p25
Gene symbol	RPP25
Synonyms (NCBI Gene)	-
Chromosome	15
Chromosome location	15q24.2

175

Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT700032	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT700031	hsa-miR-338-3p	HITS-CLIP	23313552
MIRT700030	hsa-miR-4519	HITS-CLIP	23313552
MIRT700029	hsa-miR-3681-5p	HITS-CLIP	23313552
MIRT700028	hsa-miR-6849-5p	HITS-CLIP	23313552
MIRT700027	hsa-miR-622	HITS-CLIP	23313552
MIRT700026	hsa-miR-4530	HITS-CLIP	23313552
MIRT700025	hsa-miR-4264	HITS-CLIP	23313552
MIRT700024	hsa-miR-6845-3p	HITS-CLIP	23313552
MIRT700023	hsa-miR-7110-3p	HITS-CLIP	23313552
MIRT700022	hsa-miR-6817-3p	HITS-CLIP	23313552
MIRT700021	hsa-miR-3934-3p	HITS-CLIP	23313552
MIRT700020	hsa-miR-3167	HITS-CLIP	23313552
MIRT700019	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT700018	hsa-miR-1290	HITS-CLIP	23313552
MIRT700017	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT700016	hsa-miR-8056	HITS-CLIP	23313552
MIRT700015	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT700014	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT700013	hsa-miR-6749-3p	HITS-CLIP	23313552
MIRT700012	hsa-miR-4279	HITS-CLIP	23313552
MIRT700011	hsa-miR-6873-3p	HITS-CLIP	23313552
MIRT700010	hsa-miR-3180-5p	HITS-CLIP	23313552
MIRT700009	hsa-miR-2113	HITS-CLIP	23313552
MIRT573018	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT573019	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT573017	hsa-miR-3141	PAR-CLIP	20371350
MIRT573016	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT573015	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT573014	hsa-miR-4784	PAR-CLIP	20371350
MIRT573013	hsa-miR-4481	PAR-CLIP	20371350
MIRT573012	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT573011	hsa-miR-185-5p	PAR-CLIP	20371350
MIRT573010	hsa-miR-4306	PAR-CLIP	20371350
MIRT573009	hsa-miR-4644	PAR-CLIP	20371350
MIRT573007	hsa-miR-765	PAR-CLIP	20371350
MIRT573008	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT573006	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT573005	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT573004	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT573003	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT573002	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT573001	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT573000	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT572999	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT572998	hsa-miR-5698	PAR-CLIP	20371350
MIRT572997	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT572996	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT572995	hsa-miR-4525	PAR-CLIP	20371350
MIRT572993	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT572994	hsa-miR-4447	PAR-CLIP	20371350
MIRT572992	hsa-miR-4472	PAR-CLIP	20371350
MIRT572991	hsa-miR-1275	PAR-CLIP	20371350
MIRT572990	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT572989	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT700032	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT700031	hsa-miR-338-3p	HITS-CLIP	23313552
MIRT700030	hsa-miR-4519	HITS-CLIP	23313552
MIRT700029	hsa-miR-3681-5p	HITS-CLIP	23313552
MIRT700028	hsa-miR-6849-5p	HITS-CLIP	23313552
MIRT700027	hsa-miR-622	HITS-CLIP	23313552
MIRT700026	hsa-miR-4530	HITS-CLIP	23313552
MIRT700025	hsa-miR-4264	HITS-CLIP	23313552
MIRT700024	hsa-miR-6845-3p	HITS-CLIP	23313552
MIRT700023	hsa-miR-7110-3p	HITS-CLIP	23313552
MIRT700022	hsa-miR-6817-3p	HITS-CLIP	23313552
MIRT700021	hsa-miR-3934-3p	HITS-CLIP	23313552
MIRT700020	hsa-miR-3167	HITS-CLIP	23313552
MIRT700019	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT700018	hsa-miR-1290	HITS-CLIP	23313552
MIRT700017	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT700016	hsa-miR-8056	HITS-CLIP	23313552
MIRT700015	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT700014	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT700013	hsa-miR-6749-3p	HITS-CLIP	23313552
MIRT700012	hsa-miR-4279	HITS-CLIP	23313552
MIRT700011	hsa-miR-6873-3p	HITS-CLIP	23313552
MIRT700010	hsa-miR-3180-5p	HITS-CLIP	23313552
MIRT700009	hsa-miR-2113	HITS-CLIP	23313552
MIRT573018	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT573019	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT573017	hsa-miR-3141	PAR-CLIP	20371350
MIRT573016	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT573015	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT573014	hsa-miR-4784	PAR-CLIP	20371350
MIRT573013	hsa-miR-4481	PAR-CLIP	20371350
MIRT573012	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT573011	hsa-miR-185-5p	PAR-CLIP	20371350
MIRT573010	hsa-miR-4306	PAR-CLIP	20371350
MIRT573009	hsa-miR-4644	PAR-CLIP	20371350
MIRT573007	hsa-miR-765	PAR-CLIP	20371350
MIRT573008	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT573006	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT573005	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT573004	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT573003	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT573002	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT573001	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT573000	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT572999	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT572998	hsa-miR-5698	PAR-CLIP	20371350
MIRT572997	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT572996	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT572995	hsa-miR-4525	PAR-CLIP	20371350
MIRT572993	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT572994	hsa-miR-4447	PAR-CLIP	20371350
MIRT572992	hsa-miR-4472	PAR-CLIP	20371350
MIRT572991	hsa-miR-1275	PAR-CLIP	20371350
MIRT572990	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT572989	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT1317188	hsa-miR-1257	CLIP-seq
MIRT1317189	hsa-miR-1293	CLIP-seq
MIRT1317190	hsa-miR-15a	CLIP-seq
MIRT1317191	hsa-miR-15b	CLIP-seq
MIRT1317192	hsa-miR-16	CLIP-seq
MIRT1317193	hsa-miR-187	CLIP-seq
MIRT1317194	hsa-miR-195	CLIP-seq
MIRT1317195	hsa-miR-3119	CLIP-seq
MIRT1317196	hsa-miR-3197	CLIP-seq
MIRT1317197	hsa-miR-3612	CLIP-seq
MIRT1317198	hsa-miR-361-3p	CLIP-seq
MIRT1317199	hsa-miR-3945	CLIP-seq
MIRT1317200	hsa-miR-412	CLIP-seq
MIRT1317201	hsa-miR-424	CLIP-seq
MIRT1317202	hsa-miR-4443	CLIP-seq
MIRT1317203	hsa-miR-4446-5p	CLIP-seq
MIRT1317204	hsa-miR-4483	CLIP-seq
MIRT1317205	hsa-miR-4670-3p	CLIP-seq
MIRT1317206	hsa-miR-4711-3p	CLIP-seq
MIRT1317207	hsa-miR-4713-5p	CLIP-seq
MIRT1317208	hsa-miR-4731-5p	CLIP-seq
MIRT1317209	hsa-miR-4755-5p	CLIP-seq
MIRT1317210	hsa-miR-493	CLIP-seq
MIRT1317211	hsa-miR-497	CLIP-seq
MIRT1317212	hsa-miR-602	CLIP-seq
MIRT1317213	hsa-miR-650	CLIP-seq
MIRT2094155	hsa-miR-1205	CLIP-seq
MIRT2094156	hsa-miR-1254	CLIP-seq
MIRT2094157	hsa-miR-1266	CLIP-seq
MIRT2094158	hsa-miR-1343	CLIP-seq
MIRT2094159	hsa-miR-185	CLIP-seq
MIRT2094160	hsa-miR-1909	CLIP-seq
MIRT2094161	hsa-miR-1910	CLIP-seq
MIRT2094162	hsa-miR-24	CLIP-seq
MIRT2094163	hsa-miR-3116	CLIP-seq
MIRT2094164	hsa-miR-3175	CLIP-seq
MIRT1317200	hsa-miR-412	CLIP-seq
MIRT2094165	hsa-miR-4254	CLIP-seq
MIRT2094166	hsa-miR-4437	CLIP-seq
MIRT2094167	hsa-miR-4457	CLIP-seq
MIRT2094168	hsa-miR-4518	CLIP-seq
MIRT2094169	hsa-miR-455-3p	CLIP-seq
MIRT2094170	hsa-miR-4695-5p	CLIP-seq
MIRT2094171	hsa-miR-4731-3p	CLIP-seq
MIRT2094172	hsa-miR-4801	CLIP-seq
MIRT2094173	hsa-miR-766	CLIP-seq
MIRT1317190	hsa-miR-15a	CLIP-seq
MIRT1317191	hsa-miR-15b	CLIP-seq
MIRT1317192	hsa-miR-16	CLIP-seq
MIRT1317193	hsa-miR-187	CLIP-seq
MIRT1317194	hsa-miR-195	CLIP-seq
MIRT1317199	hsa-miR-3945	CLIP-seq
MIRT1317200	hsa-miR-412	CLIP-seq
MIRT1317201	hsa-miR-424	CLIP-seq
MIRT2318793	hsa-miR-4432	CLIP-seq
MIRT2318794	hsa-miR-451b	CLIP-seq
MIRT1317205	hsa-miR-4670-3p	CLIP-seq
MIRT2318795	hsa-miR-4696	CLIP-seq
MIRT1317206	hsa-miR-4711-3p	CLIP-seq
MIRT1317211	hsa-miR-497	CLIP-seq
MIRT2318796	hsa-miR-508-5p	CLIP-seq
MIRT1317212	hsa-miR-602	CLIP-seq
MIRT2318797	hsa-miR-671-5p	CLIP-seq
MIRT2094173	hsa-miR-766	CLIP-seq
MIRT2614508	hsa-miR-296-5p	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000172	Component	Ribonuclease MRP complex	IBA
GO:0000172	Component	Ribonuclease MRP complex	IDA	16723659
GO:0001682	Process	TRNA 5'-leader removal	IBA
GO:0001682	Process	TRNA 5'-leader removal	IDA	16723659, 30454648
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0004526	Function	Ribonuclease P activity	IDA	30454648
GO:0004526	Function	Ribonuclease P activity	IEA
GO:0005515	Function	Protein binding	IPI	15096576, 21044950, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0030681	Component	Multimeric ribonuclease P complex	IDA	16723659, 30454648
GO:0033204	Function	Ribonuclease P RNA binding	IDA	16723659, 30454648
GO:0034451	Component	Centriolar satellite	IDA

MIM	HGNC	e!Ensembl
619235	30361	ENSG00000178718

Q9BUL9

Protein name

Ribonuclease P protein subunit p25 (RNase P protein subunit p25)

Protein function

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA

PDB

6AHR , 6AHU , 6CWX , 6LT7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01918	Alba	36 → 101	Alba	Family

Sequence

MENFRKVRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAFATASMAQP
ATRAIVFSGCGRATTKTVTCAEILKRRLAGLHQVTRLRYRSVREVWQSLPPGPTQGQTPG
EPAASLSVLKNVPGLAILLSKDALDPRQPGYQPPNPHPGPSSPPAAPASKRSLGEPAAGE
GSAKRSQPEPGVADEDQTA

Sequence length

199

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	20632321	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	20632321	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cartilage-hair hypoplasia	Cartilage-Hair Hypoplasia	BEFREE	18164267	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31763067	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pervasive Development Disorder	Autism spectrum disorder	BEFREE	20632321	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPP25 (ribonuclease P/MRP subunit p25)