Gene Gene information from NCBI Gene database.
Entrez ID 54900
Gene name Lymphocyte transmembrane adaptor 1
Gene symbol LAX1
Synonyms (NCBI Gene)
LAX
Chromosome 1
Chromosome location 1q32.1
miRNA miRNA information provided by mirtarbase database.
360
miRTarBase ID miRNA Experiments Reference
MIRT721051 hsa-miR-4302 HITS-CLIP 19536157
MIRT721050 hsa-miR-199a-5p HITS-CLIP 19536157
MIRT721049 hsa-miR-199b-5p HITS-CLIP 19536157
MIRT643444 hsa-miR-4284 HITS-CLIP 19536157
MIRT643443 hsa-miR-24-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 12359715, 25416956, 31515488, 32296183
GO:0005794 Component Golgi apparatus IDA
GO:0005829 Component Cytosol IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619622 26005 ENSG00000122188
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IWV1
Protein name Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)
Protein function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15681 LAX 29 376 Lymphocyte activation family X Family
Tissue specificity TISSUE SPECIFICITY: Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. {ECO:0000269|PubMed:12359715}.
Sequence
Sequence length 398
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Chronic Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 29367434
★☆☆☆☆
Found in Text Mining only