TEX10 (testis expressed 10)

Gene

• Entrez ID: 54881
• Gene name: Testis expressed 10
• Gene symbol: TEX10
• Synonyms (NCBI Gene): Ipi1, bA208F1.2
• Chromosome: 9
• Chromosome location: 9q31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027630	hsa-miR-98-5p	Microarray	19088304
MIRT049147	hsa-miR-92a-3p	CLASH	23622248
MIRT046576	hsa-miR-222-3p	CLASH	23622248
MIRT1419168	hsa-miR-1257	CLIP-seq
MIRT1419169	hsa-miR-576-3p	CLIP-seq
MIRT1419168	hsa-miR-1257	CLIP-seq
MIRT2125858	hsa-miR-3671	CLIP-seq
MIRT2125859	hsa-miR-4659a-3p	CLIP-seq
MIRT2125860	hsa-miR-4659b-3p	CLIP-seq
MIRT2125861	hsa-miR-4662a-3p	CLIP-seq
MIRT2125862	hsa-miR-499-3p	CLIP-seq
MIRT2125863	hsa-miR-499a-3p	CLIP-seq
MIRT1419169	hsa-miR-576-3p	CLIP-seq
MIRT2125864	hsa-miR-607	CLIP-seq
MIRT2125865	hsa-miR-622	CLIP-seq
MIRT2125862	hsa-miR-499-3p	CLIP-seq
MIRT2125863	hsa-miR-499a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21326211, 28514442, 33961781, 36351913
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0071339	Component	MLL1 complex	IBA
GO:0071339	Component	MLL1 complex	IDA	15960975

Other IDs

• MIM: 616717
• HGNC: 25988
• e!Ensembl: ENSG00000136891

Protein

• UniProt ID: Q9NXF1
• Protein name: Testis-expressed protein 10
• Protein function: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:228728
• PDB: 8FL2, 8FL3, 8FL4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12333	Ipi1_N	132 → 235	Rix1 complex component involved in 60S ribosome maturation	Family

• Sequence:

  MTKKRKRQHDFQKVKLKVGKKKPKLQNATPTNFKTKTIHLPEQLKEDGTLPTNNRKLNIK
  DLLSQMHHYNAGVKQSALLGLKDLLSQYPFIIDAHLSNILSEVTAVFTDKDANVRLAAVQ
  LLQFLAPKIRAEQISPFFPLVSAHLSSAMTHITEGIQEDSLKVLDILLEQYPALITGRSS
  ILLKNFVELISHQQLSKGLINRDRSQSWILSVNPNRRLTSQQWRLKVLVRLSKFLQALAD
  GSSRLRESEGLQEQKENPHATSNSIFINWKEHANDQQHIQVYENGGSQPNVSSQFRLRYL
  VGGLSGVDEGLSSTENLKGFIEIIIPLLIECWVEAVPPQLATPVGNGIEREPLQVMQQVL
  NIISLLWKLSKQQDETHKLESWLRKNYLIDFKHHFMSRFPYVLKEITKHKRKEPNKSIKH
  CTVLSNNIDHLLLNLTLSDIMVSLANASTLQKDCSWIEMIRKFVTETLEDGSRLNSKQLN
  RLLGVSWRLMQIQPNREDTETLIKAVYTLYQQRGLILPVRTLLLKFFSKIYQTEELRSCR
  FRYRSKVLSRWLAGLPLQLAHLGSRNPELSTQLIDIIHTAAARANKELLKSLQATALRIY
  DPQEGAVVVLPADSQQRLVQLVYFLPSLPADLLSRLSRCCIMGRLSSSLAAMLIGILHMR
  SSFSGWKYSAKDWLMSDVDYFSFLFSTLTGFSKEELTWLQSLRGVPHVIQTQLSPVLLYL
  TDLDQFLHHWDVTEAVFHSLLVIPARSQNFDILQSAISKHLVGLTVIPDSTAGCVFGVIC
  KLLDHTCVVSETLLPFLASCCYSLLYFLLTIEKGEAEHLRKRDKLWGVCVSILALLPRVL
  RLMLQSLRVNRVGPEELPVVGQLLRLLLQHAPLRTHMLTNAILVQQIIKNITTLKSGSVQ
  EQWLTDLHYCFNVYITGHPQGPSALATVY

• Sequence length: 929

Pathways

KEGG:

Polycomb repressive complex

Reactome:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	25824743	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31638260	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	31638260	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30045663, 31638260		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	30045663		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30045663, 31638260		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29106665, 29703424, 31638260		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31638260		★☆☆☆☆ Found in Text Mining only