Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54878
Gene name	Dipeptidyl peptidase 8
Gene symbol	DPP8
Synonyms (NCBI Gene)	DP8DPRP-1DPRP1MST097MSTP097MSTP135MSTP141
Chromosome	15
Chromosome location	15q22.31
Summary	This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028120	hsa-miR-93-5p	Sequencing	20371350
MIRT046773	hsa-miR-222-3p	CLASH	23622248
MIRT036687	hsa-miR-935	CLASH	23622248
MIRT624091	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT624088	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT624090	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT624089	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT624088	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT624087	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT072635	hsa-miR-5096	HITS-CLIP	23824327
MIRT624086	hsa-miR-1303	HITS-CLIP	23824327
MIRT538003	hsa-miR-520e	PAR-CLIP	22012620
MIRT538002	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT538001	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT538000	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT537999	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT537998	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT537997	hsa-miR-302e	PAR-CLIP	22012620
MIRT537996	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT537995	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT537994	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT537993	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT537992	hsa-miR-520b	PAR-CLIP	22012620
MIRT537991	hsa-miR-708-3p	PAR-CLIP	22012620
MIRT537990	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT537989	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT537988	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT537987	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT537986	hsa-miR-4275	PAR-CLIP	22012620
MIRT537985	hsa-miR-3607-3p	PAR-CLIP	22012620
MIRT537984	hsa-miR-3686	PAR-CLIP	22012620
MIRT537983	hsa-miR-135a-5p	PAR-CLIP	22012620
MIRT537982	hsa-miR-135b-5p	PAR-CLIP	22012620
MIRT537981	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT537980	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT537979	hsa-miR-1202	PAR-CLIP	22012620
MIRT537978	hsa-miR-3972	PAR-CLIP	22012620
MIRT537976	hsa-miR-5006-5p	PAR-CLIP	22012620
MIRT537977	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT440780	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT727860	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727859	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727858	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727857	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT440780	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT624091	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT624088	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT624090	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT624089	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT624088	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT624087	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT072635	hsa-miR-5096	HITS-CLIP	23824327
MIRT624086	hsa-miR-1303	HITS-CLIP	23824327
MIRT538003	hsa-miR-520e	PAR-CLIP	22012620
MIRT538002	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT538001	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT538000	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT537999	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT537998	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT537997	hsa-miR-302e	PAR-CLIP	22012620
MIRT537996	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT537995	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT537994	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT537993	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT537992	hsa-miR-520b	PAR-CLIP	22012620
MIRT537991	hsa-miR-708-3p	PAR-CLIP	22012620
MIRT537990	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT537989	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT537988	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT537987	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT537986	hsa-miR-4275	PAR-CLIP	22012620
MIRT537985	hsa-miR-3607-3p	PAR-CLIP	22012620
MIRT537984	hsa-miR-3686	PAR-CLIP	22012620
MIRT537983	hsa-miR-135a-5p	PAR-CLIP	22012620
MIRT537982	hsa-miR-135b-5p	PAR-CLIP	22012620
MIRT537981	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT537980	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT537979	hsa-miR-1202	PAR-CLIP	22012620
MIRT537978	hsa-miR-3972	PAR-CLIP	22012620
MIRT537976	hsa-miR-5006-5p	PAR-CLIP	22012620
MIRT537977	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT944228	hsa-miR-1266	CLIP-seq
MIRT944229	hsa-miR-137	CLIP-seq
MIRT944230	hsa-miR-193a-5p	CLIP-seq
MIRT944231	hsa-miR-3664-3p	CLIP-seq
MIRT944232	hsa-miR-3924	CLIP-seq
MIRT944233	hsa-miR-4433	CLIP-seq
MIRT944234	hsa-miR-4459	CLIP-seq
MIRT944235	hsa-miR-4518	CLIP-seq
MIRT944236	hsa-miR-4666-5p	CLIP-seq
MIRT944237	hsa-miR-4731-5p	CLIP-seq
MIRT944238	hsa-miR-4768-3p	CLIP-seq
MIRT944239	hsa-miR-4802-3p	CLIP-seq
MIRT944240	hsa-miR-576-3p	CLIP-seq
MIRT944241	hsa-miR-579	CLIP-seq
MIRT944242	hsa-miR-584	CLIP-seq
MIRT944243	hsa-miR-873	CLIP-seq
MIRT944244	hsa-miR-1183	CLIP-seq
MIRT944245	hsa-miR-1206	CLIP-seq
MIRT944246	hsa-miR-1287	CLIP-seq
MIRT944247	hsa-miR-200b	CLIP-seq
MIRT944248	hsa-miR-200c	CLIP-seq
MIRT944249	hsa-miR-2355-5p	CLIP-seq
MIRT944250	hsa-miR-3135b	CLIP-seq
MIRT944251	hsa-miR-3201	CLIP-seq
MIRT944252	hsa-miR-369-3p	CLIP-seq
MIRT944253	hsa-miR-371b-5p	CLIP-seq
MIRT944254	hsa-miR-374a	CLIP-seq
MIRT944255	hsa-miR-374b	CLIP-seq
MIRT944256	hsa-miR-429	CLIP-seq
MIRT944257	hsa-miR-433	CLIP-seq
MIRT944258	hsa-miR-4503	CLIP-seq
MIRT944259	hsa-miR-4670-3p	CLIP-seq
MIRT944260	hsa-miR-4704-5p	CLIP-seq
MIRT944261	hsa-miR-4768-5p	CLIP-seq
MIRT944262	hsa-miR-4791	CLIP-seq
MIRT944263	hsa-miR-495	CLIP-seq
MIRT944264	hsa-miR-548c-3p	CLIP-seq
MIRT944265	hsa-miR-548l	CLIP-seq
MIRT944266	hsa-miR-548n	CLIP-seq
MIRT944241	hsa-miR-579	CLIP-seq
MIRT944267	hsa-miR-616	CLIP-seq
MIRT944268	hsa-miR-888	CLIP-seq
MIRT944269	hsa-miR-942	CLIP-seq
MIRT1548033	hsa-miR-3662	CLIP-seq
MIRT1548034	hsa-miR-580	CLIP-seq
MIRT1548035	hsa-miR-944	CLIP-seq
MIRT1979588	hsa-miR-1299	CLIP-seq
MIRT1979589	hsa-miR-4724-5p	CLIP-seq
MIRT1979590	hsa-miR-4782-5p	CLIP-seq
MIRT1979591	hsa-miR-516b	CLIP-seq
MIRT1979592	hsa-miR-875-3p	CLIP-seq
MIRT1979593	hsa-miR-4678	CLIP-seq
MIRT944241	hsa-miR-579	CLIP-seq
MIRT2214667	hsa-miR-199a-5p	CLIP-seq
MIRT2214668	hsa-miR-199b-5p	CLIP-seq
MIRT2214669	hsa-miR-302a	CLIP-seq
MIRT2214670	hsa-miR-302b	CLIP-seq
MIRT2214671	hsa-miR-302c	CLIP-seq
MIRT2214672	hsa-miR-302d	CLIP-seq
MIRT2214673	hsa-miR-3121-3p	CLIP-seq
MIRT2214674	hsa-miR-3168	CLIP-seq
MIRT2214675	hsa-miR-372	CLIP-seq
MIRT2214676	hsa-miR-373	CLIP-seq
MIRT2214677	hsa-miR-4676-5p	CLIP-seq
MIRT2214678	hsa-miR-519a	CLIP-seq
MIRT2214679	hsa-miR-575	CLIP-seq
MIRT2448512	hsa-miR-491-3p	CLIP-seq
MIRT2519146	hsa-miR-1207-5p	CLIP-seq
MIRT944233	hsa-miR-4433	CLIP-seq
MIRT944234	hsa-miR-4459	CLIP-seq
MIRT944236	hsa-miR-4666-5p	CLIP-seq
MIRT2519147	hsa-miR-4729	CLIP-seq
MIRT2519148	hsa-miR-4736	CLIP-seq
MIRT2519149	hsa-miR-4763-3p	CLIP-seq
MIRT944238	hsa-miR-4768-3p	CLIP-seq
MIRT944239	hsa-miR-4802-3p	CLIP-seq
MIRT944240	hsa-miR-576-3p	CLIP-seq
MIRT2519146	hsa-miR-1207-5p	CLIP-seq
MIRT2679446	hsa-miR-1267	CLIP-seq
MIRT2679447	hsa-miR-3682-3p	CLIP-seq
MIRT944233	hsa-miR-4433	CLIP-seq
MIRT944234	hsa-miR-4459	CLIP-seq
MIRT2679448	hsa-miR-4652-3p	CLIP-seq
MIRT944236	hsa-miR-4666-5p	CLIP-seq
MIRT2679449	hsa-miR-4698	CLIP-seq
MIRT2519147	hsa-miR-4729	CLIP-seq
MIRT2519148	hsa-miR-4736	CLIP-seq
MIRT2519149	hsa-miR-4763-3p	CLIP-seq
MIRT944238	hsa-miR-4768-3p	CLIP-seq
MIRT2679450	hsa-miR-4778-5p	CLIP-seq
MIRT944239	hsa-miR-4802-3p	CLIP-seq
MIRT944240	hsa-miR-576-3p	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	31525884, 33961781
GO:0005737	Component	Cytoplasm	IDA	12534281
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	11012666
GO:0005829	Component	Cytosol	IDA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	NAS	11012666
GO:0006915	Process	Apoptotic process	IEA
GO:0006955	Process	Immune response	TAS	11012666
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008239	Function	Dipeptidyl-peptidase activity	IBA
GO:0008239	Function	Dipeptidyl-peptidase activity	IDA	31525884, 32796818, 33731929, 33731932
GO:0008239	Function	Dipeptidyl-peptidase activity	IEA
GO:0008239	Function	Dipeptidyl-peptidase activity	NAS	11012666
GO:0016787	Function	Hydrolase activity	IEA
GO:0043069	Process	Negative regulation of programmed cell death	IDA	32796818, 33731929, 33731932
GO:0051604	Process	Protein maturation	IDA	32109412
GO:0140633	Process	CARD8 inflammasome complex assembly	IDA	33053349
GO:0141201	Process	Pyroptotic cell death	IDA	32109412
GO:1904784	Process	NLRP1 inflammasome complex assembly	IDA	22665479, 33420028, 33420033

MIM	HGNC	e!Ensembl
606819	16490	ENSG00000074603

Q6V1X1

Protein name

Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8)

Protein function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as

PDB

6EOO , 6EOP , 6EOS , 6EOT , 6HP8 , 6QZW , 6TRW , 6TRX , 7A3G , 7A3I , 7A3J , 7A3K , 7A3L , 7AYQ , 7AYR , 7OR4 , 7OZ7 , 7SVM , 7SVO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00930	DPPIV_N	173 → 595	Dipeptidyl peptidase IV (DPP IV) N-terminal region	Family
PF00326	Peptidase_S9	683 → 891	Prolyl oligopeptidase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. {ECO:0000269|PubMed:11012666, ECO:0000269|PubMed:12662155}.

Sequence

MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI

Sequence length

898

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTROCYTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYTHEMIA VERA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alopecia	Alopecia	BEFREE	16186403		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	23608773		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	23608773		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22736146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	30467600		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	30225951		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervix carcinoma	Cervix carcinoma	BEFREE	30225951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	29693275		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	23519473, 38034011	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	37048172	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	35060938	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	29967349		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	30467600		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24038034, 28711492, 30822465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	30225951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	20043068		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	31792328		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	BEFREE	30467600		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	BEFREE	23704821		★★★★★ ★☆☆☆☆ Found in Text Mining only

DPP8 (dipeptidyl peptidase 8)