Gene Gene information from NCBI Gene database.
Entrez ID 54876
Gene name DDB1 and CUL4 associated factor 16
Gene symbol DCAF16
Synonyms (NCBI Gene)
C4orf30
Chromosome 4
Chromosome location 4p15.31
miRNA miRNA information provided by mirtarbase database.
671
miRTarBase ID miRNA Experiments Reference
MIRT022231 hsa-miR-124-3p Microarray 18668037
MIRT028931 hsa-miR-26b-5p Microarray 19088304
MIRT049745 hsa-miR-92a-3p CLASH 23622248
MIRT045185 hsa-miR-186-5p CLASH 23622248
MIRT704350 hsa-miR-548c-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16949367, 22190034
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm TAS
GO:0016567 Process Protein ubiquitination IEA
GO:0080008 Component Cul4-RING E3 ubiquitin ligase complex IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620524 25987 ENSG00000163257
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NXF7
Protein name DDB1- and CUL4-associated factor 16
Protein function Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.
PDB 8G46 , 8OV6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15349 DCA16 1 216 DDB1- and CUL4-associated factor 16 Family
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations