TMEM214 (transmembrane protein 214)

Gene

• Entrez ID: 54867
• Gene name: Transmembrane protein 214
• Gene symbol: TMEM214
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051346	hsa-miR-15a-5p	CLASH	23622248
MIRT491476	hsa-miR-634	PAR-CLIP	23592263
MIRT491477	hsa-miR-2392	PAR-CLIP	23592263
MIRT491475	hsa-miR-4802-5p	PAR-CLIP	23592263
MIRT491473	hsa-miR-4457	PAR-CLIP	23592263
MIRT491474	hsa-miR-3975	PAR-CLIP	23592263
MIRT491472	hsa-miR-4534	PAR-CLIP	23592263
MIRT491471	hsa-miR-8082	PAR-CLIP	23592263
MIRT377080	hsa-miR-3612	PAR-CLIP	23592263
MIRT377077	hsa-miR-650	PAR-CLIP	23592263
MIRT491470	hsa-miR-4443	PAR-CLIP	23592263
MIRT462109	hsa-miR-548u	PAR-CLIP	23592263
MIRT462108	hsa-miR-7161-5p	PAR-CLIP	23592263
MIRT462107	hsa-miR-4432	PAR-CLIP	23592263
MIRT462106	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT462105	hsa-miR-3925-5p	PAR-CLIP	23592263
MIRT462104	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT462103	hsa-miR-4742-5p	PAR-CLIP	23592263
MIRT462102	hsa-miR-4269	PAR-CLIP	23592263
MIRT462101	hsa-miR-6715b-5p	PAR-CLIP	23592263
MIRT462100	hsa-miR-4514	PAR-CLIP	23592263
MIRT462099	hsa-miR-4692	PAR-CLIP	23592263
MIRT462098	hsa-miR-146a-5p	PAR-CLIP	23592263
MIRT462097	hsa-miR-146b-5p	PAR-CLIP	23592263
MIRT462096	hsa-miR-7153-5p	PAR-CLIP	23592263
MIRT462095	hsa-miR-3135a	PAR-CLIP	23592263
MIRT462094	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT462093	hsa-miR-4306	PAR-CLIP	23592263
MIRT462092	hsa-miR-4644	PAR-CLIP	23592263
MIRT462091	hsa-miR-593-5p	PAR-CLIP	23592263
MIRT462090	hsa-miR-4774-3p	PAR-CLIP	23592263
MIRT462102	hsa-miR-4269	PAR-CLIP	26701625
MIRT462102	hsa-miR-4269	PAR-CLIP	26701625
MIRT462107	hsa-miR-4432	PAR-CLIP	26701625
MIRT462107	hsa-miR-4432	PAR-CLIP	26701625
MIRT462100	hsa-miR-4514	PAR-CLIP	26701625
MIRT462100	hsa-miR-4514	PAR-CLIP	26701625
MIRT462099	hsa-miR-4692	PAR-CLIP	26701625
MIRT462099	hsa-miR-4692	PAR-CLIP	26701625
MIRT462103	hsa-miR-4742-5p	PAR-CLIP	26701625
MIRT462103	hsa-miR-4742-5p	PAR-CLIP	26701625
MIRT462106	hsa-miR-510-5p	PAR-CLIP	26701625
MIRT462106	hsa-miR-510-5p	PAR-CLIP	26701625
MIRT462109	hsa-miR-548u	PAR-CLIP	26701625
MIRT462109	hsa-miR-548u	PAR-CLIP	26701625
MIRT462091	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT462091	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT462101	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT462101	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT462108	hsa-miR-7161-5p	PAR-CLIP	26701625
MIRT462108	hsa-miR-7161-5p	PAR-CLIP	26701625
MIRT491476	hsa-miR-634	PAR-CLIP	23592263
MIRT491477	hsa-miR-2392	PAR-CLIP	23592263
MIRT491475	hsa-miR-4802-5p	PAR-CLIP	23592263
MIRT491473	hsa-miR-4457	PAR-CLIP	23592263
MIRT491474	hsa-miR-3975	PAR-CLIP	23592263
MIRT491472	hsa-miR-4534	PAR-CLIP	23592263
MIRT491471	hsa-miR-8082	PAR-CLIP	23592263
MIRT377080	hsa-miR-3612	PAR-CLIP	23592263
MIRT377077	hsa-miR-650	PAR-CLIP	23592263
MIRT491470	hsa-miR-4443	PAR-CLIP	23592263
MIRT462109	hsa-miR-548u	PAR-CLIP	23592263
MIRT462108	hsa-miR-7161-5p	PAR-CLIP	23592263
MIRT462107	hsa-miR-4432	PAR-CLIP	23592263
MIRT462106	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT462105	hsa-miR-3925-5p	PAR-CLIP	23592263
MIRT462104	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT462103	hsa-miR-4742-5p	PAR-CLIP	23592263
MIRT462102	hsa-miR-4269	PAR-CLIP	23592263
MIRT462101	hsa-miR-6715b-5p	PAR-CLIP	23592263
MIRT462100	hsa-miR-4514	PAR-CLIP	23592263
MIRT462099	hsa-miR-4692	PAR-CLIP	23592263
MIRT462098	hsa-miR-146a-5p	PAR-CLIP	23592263
MIRT462097	hsa-miR-146b-5p	PAR-CLIP	23592263
MIRT462096	hsa-miR-7153-5p	PAR-CLIP	23592263
MIRT462095	hsa-miR-3135a	PAR-CLIP	23592263
MIRT462094	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT462093	hsa-miR-4306	PAR-CLIP	23592263
MIRT462092	hsa-miR-4644	PAR-CLIP	23592263
MIRT462091	hsa-miR-593-5p	PAR-CLIP	23592263
MIRT462090	hsa-miR-4774-3p	PAR-CLIP	23592263
MIRT1435402	hsa-miR-1193	CLIP-seq
MIRT1435403	hsa-miR-193a-3p	CLIP-seq
MIRT1435404	hsa-miR-193b	CLIP-seq
MIRT1435405	hsa-miR-2110	CLIP-seq
MIRT1435406	hsa-miR-298	CLIP-seq
MIRT1435407	hsa-miR-3135	CLIP-seq
MIRT1435408	hsa-miR-3141	CLIP-seq
MIRT1435409	hsa-miR-3190	CLIP-seq
MIRT1435410	hsa-miR-338-3p	CLIP-seq
MIRT1435411	hsa-miR-3677-5p	CLIP-seq
MIRT1435412	hsa-miR-3688-3p	CLIP-seq
MIRT1435413	hsa-miR-3978	CLIP-seq
MIRT1435414	hsa-miR-4271	CLIP-seq
MIRT1435415	hsa-miR-4435	CLIP-seq
MIRT1435416	hsa-miR-4476	CLIP-seq
MIRT1435417	hsa-miR-4701-5p	CLIP-seq
MIRT1435418	hsa-miR-4725-3p	CLIP-seq
MIRT1435419	hsa-miR-588	CLIP-seq
MIRT1435420	hsa-miR-601	CLIP-seq
MIRT1435421	hsa-miR-660	CLIP-seq
MIRT1435422	hsa-miR-125a-3p	CLIP-seq
MIRT1435423	hsa-miR-1291	CLIP-seq
MIRT1435424	hsa-miR-1321	CLIP-seq
MIRT1435425	hsa-miR-146b-3p	CLIP-seq
MIRT1435426	hsa-miR-2277-3p	CLIP-seq
MIRT1435427	hsa-miR-296-5p	CLIP-seq
MIRT1435406	hsa-miR-298	CLIP-seq
MIRT1435428	hsa-miR-3117-3p	CLIP-seq
MIRT1435429	hsa-miR-3169	CLIP-seq
MIRT1435430	hsa-miR-3184	CLIP-seq
MIRT1435431	hsa-miR-3185	CLIP-seq
MIRT1435432	hsa-miR-339-5p	CLIP-seq
MIRT1435433	hsa-miR-3689d	CLIP-seq
MIRT1435434	hsa-miR-3934	CLIP-seq
MIRT1435435	hsa-miR-423-5p	CLIP-seq
MIRT1435436	hsa-miR-4260	CLIP-seq
MIRT1435437	hsa-miR-4270	CLIP-seq
MIRT1435438	hsa-miR-4286	CLIP-seq
MIRT1435439	hsa-miR-4441	CLIP-seq
MIRT1435440	hsa-miR-4691-3p	CLIP-seq
MIRT1435441	hsa-miR-4728-5p	CLIP-seq
MIRT1435442	hsa-miR-4731-5p	CLIP-seq
MIRT1435443	hsa-miR-4739	CLIP-seq
MIRT1435444	hsa-miR-4756-5p	CLIP-seq
MIRT1435445	hsa-miR-4759	CLIP-seq
MIRT1435446	hsa-miR-4786-3p	CLIP-seq
MIRT1435447	hsa-miR-486-3p	CLIP-seq
MIRT1435448	hsa-miR-579	CLIP-seq
MIRT1435420	hsa-miR-601	CLIP-seq
MIRT1435449	hsa-miR-624	CLIP-seq
MIRT1435421	hsa-miR-660	CLIP-seq
MIRT1435450	hsa-miR-7	CLIP-seq
MIRT1435451	hsa-miR-764	CLIP-seq
MIRT1435452	hsa-miR-877	CLIP-seq
MIRT1435405	hsa-miR-2110	CLIP-seq
MIRT1435431	hsa-miR-3185	CLIP-seq
MIRT1435410	hsa-miR-338-3p	CLIP-seq
MIRT2130476	hsa-miR-361-3p	CLIP-seq
MIRT1435412	hsa-miR-3688-3p	CLIP-seq
MIRT1435413	hsa-miR-3978	CLIP-seq
MIRT1435414	hsa-miR-4271	CLIP-seq
MIRT2130477	hsa-miR-4511	CLIP-seq
MIRT1435418	hsa-miR-4725-3p	CLIP-seq
MIRT1435450	hsa-miR-7	CLIP-seq
MIRT2351803	hsa-miR-1285	CLIP-seq
MIRT2351804	hsa-miR-185	CLIP-seq
MIRT1435403	hsa-miR-193a-3p	CLIP-seq
MIRT1435404	hsa-miR-193b	CLIP-seq
MIRT2351805	hsa-miR-2467-5p	CLIP-seq
MIRT1435407	hsa-miR-3135	CLIP-seq
MIRT2351806	hsa-miR-3187-5p	CLIP-seq
MIRT2351807	hsa-miR-3188	CLIP-seq
MIRT1435410	hsa-miR-338-3p	CLIP-seq
MIRT2130476	hsa-miR-361-3p	CLIP-seq
MIRT2351808	hsa-miR-3667-5p	CLIP-seq
MIRT2351809	hsa-miR-3945	CLIP-seq
MIRT2351810	hsa-miR-4253	CLIP-seq
MIRT1435436	hsa-miR-4260	CLIP-seq
MIRT2351811	hsa-miR-4316	CLIP-seq
MIRT2351812	hsa-miR-4505	CLIP-seq
MIRT2130477	hsa-miR-4511	CLIP-seq
MIRT1435417	hsa-miR-4701-5p	CLIP-seq
MIRT2351813	hsa-miR-4710	CLIP-seq
MIRT2351814	hsa-miR-485-5p	CLIP-seq
MIRT1435447	hsa-miR-486-3p	CLIP-seq
MIRT1435419	hsa-miR-588	CLIP-seq
MIRT2351815	hsa-miR-612	CLIP-seq
MIRT1435450	hsa-miR-7	CLIP-seq
MIRT2395996	hsa-miR-4695-5p	CLIP-seq
MIRT2351814	hsa-miR-485-5p	CLIP-seq
MIRT1435402	hsa-miR-1193	CLIP-seq
MIRT1435422	hsa-miR-125a-3p	CLIP-seq
MIRT2351805	hsa-miR-2467-5p	CLIP-seq
MIRT2351807	hsa-miR-3188	CLIP-seq
MIRT1435433	hsa-miR-3689d	CLIP-seq
MIRT1435434	hsa-miR-3934	CLIP-seq
MIRT2351811	hsa-miR-4316	CLIP-seq
MIRT2645523	hsa-miR-432	CLIP-seq
MIRT2351813	hsa-miR-4710	CLIP-seq
MIRT2645524	hsa-miR-4715-3p	CLIP-seq
MIRT2351814	hsa-miR-485-5p	CLIP-seq
MIRT1435451	hsa-miR-764	CLIP-seq
MIRT1435402	hsa-miR-1193	CLIP-seq
MIRT1435406	hsa-miR-298	CLIP-seq
MIRT2645523	hsa-miR-432	CLIP-seq
MIRT2645524	hsa-miR-4715-3p	CLIP-seq
MIRT1435420	hsa-miR-601	CLIP-seq
MIRT1435421	hsa-miR-660	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005881	Component	Cytoplasmic microtubule	IDA	23264731
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 615301
• HGNC: 25983
• e!Ensembl: ENSG00000119777

Protein

• UniProt ID: Q6NUQ4
• Protein name: Transmembrane protein 214
• Protein function: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10151	TMEM214	8 → 684	TMEM214, C-terminal, caspase 4 activator	Family

• Sequence:

  MATKTAGVGRWEVVKKGRRPGVGAGAGGRGGGRNRRALGEANGVWKYDLTPAIQTTSTLY
  ERGFENIMKRQNKEQVPPPAVEPKKPGNKKQPKKVATPPNQNQKQGRFRSLEEALKALDV
  ADLQKELDKSQSVFSGNPSIWLKDLASYLNYKLQAPLSEPTLSQHTHDYPYSLVSRELRG
  IIRGLLAKAAGSLELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDKPKIATANLGK
  FLELLRSHQSRPAKCLTIMWALGQAGFANLTEGLKVWLGIMLPVLGIKSLSPFAITYLDR
  LLLMHPNLTKGFGMIGPKDFFPLLDFAYMPNNSLTPSLQEQLCQLYPRLKVLAFGAKPDS
  TLHTYFPSFLSRATPSCPPEMKKELLSSLTECLTVDPLSASVWRQLYPKHLSQSSLLLEH
  LLSSWEQIPKKVQKSLQETIQSLKLTNQELLRKGSSNNQDVVTCDMACKGLLQQVQGPRL
  PWTRLLLLLLVFAVGFLCHDLRSHSSFQASLTGRLLRSSGFLPASQQACAKLYSYSLQGY
  SWLGETLPLWGSHLLTVVRPSLQLAWAHTNATVSFLSAHCASHLAWFGDSLTSLSQRLQI
  QLPDSVNQLLRYLRELPLLFHQNVLLPLWHLLLEALAWAQEHCHEACRGEVTWDCMKTQL
  SEAVHWTWLCLQDITVAFLDWALALISQQ

• Sequence length: 689

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANXIETY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Flexion contracture	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations