Gene Gene information from NCBI Gene database.
Entrez ID 54861
Gene name SNF related kinase
Gene symbol SNRK
Synonyms (NCBI Gene)
HSNFRK
Chromosome 3
Chromosome location 3p22.1
Summary SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]
miRNA miRNA information provided by mirtarbase database.
794
miRTarBase ID miRNA Experiments Reference
MIRT022051 hsa-miR-128-3p Microarray 17612493
MIRT031002 hsa-miR-21-5p Microarray 18591254
MIRT041578 hsa-miR-193b-3p CLASH 23622248
MIRT721142 hsa-miR-4422 HITS-CLIP 19536157
MIRT721141 hsa-miR-154-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 12234663
GO:0000287 Function Magnesium ion binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612760 30598 ENSG00000163788
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NRH2
Protein name SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)
Protein function May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
PDB 5YKS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 16 269 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis. {ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:8654423}.
Sequence
MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL
FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF
AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY
SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK
ECKDLITRMLQRDPKRRASLEEIENHPWL
QGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ
RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR
QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA
GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR
KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS
SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE
NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG
STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER
IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI
Sequence length 765
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
22
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Cardiomyopathies Cardiomyopathy BEFREE 28117339
★☆☆☆☆
Found in Text Mining only
Colon Carcinoma Colon Carcinoma BEFREE 22874833
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 22874833 Inhibit
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 22874833 Inhibit
★☆☆☆☆
Found in Text Mining only
Gastroesophageal reflux disease Gastroesophageal Reflux Disease GWASCAT_DG 31527586
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant tumor of colon Colonic Neoplasms BEFREE 22874833
★☆☆☆☆
Found in Text Mining only
Mammary Neoplasms Mammary Neoplasms BEFREE 19717424
★☆☆☆☆
Found in Text Mining only
Ovarian Mucinous Adenocarcinoma Ovarian adenocarcinoma UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Ovarian neoplasm Pubtator 28722495 Associate
★☆☆☆☆
Found in Text Mining only
Ovarian Serous Adenocarcinoma Ovarian serous adenocarcinoma UNIPROT_DG
★☆☆☆☆
Found in Text Mining only