Gene Gene information from NCBI Gene database.
Entrez ID 54852
Gene name Progestin and adipoQ receptor family member 5
Gene symbol PAQR5
Synonyms (NCBI Gene)
MPRG
Chromosome 15
Chromosome location 15q23
miRNA miRNA information provided by mirtarbase database.
2115
miRTarBase ID miRNA Experiments Reference
MIRT052583 hsa-let-7a-5p CLASH 23622248
MIRT050543 hsa-miR-20a-5p CLASH 23622248
MIRT471616 hsa-miR-4432 HITS-CLIP 21572407
MIRT471615 hsa-miR-8087 HITS-CLIP 21572407
MIRT471614 hsa-miR-519a-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005496 Function Steroid binding IEA
GO:0005515 Function Protein binding IPI 25416956, 28514442, 32296183, 33961781
GO:0005886 Component Plasma membrane IEA
GO:0008289 Function Lipid binding IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607781 29645 ENSG00000137819
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NXK6
Protein name Membrane progestin receptor gamma (mPR gamma) (Membrane progesterone P4 receptor gamma) (Membrane progesterone receptor gamma) (Progesterone and adipoQ receptor family member 5) (Progestin and adipoQ receptor family member 5) (Progestin and adipoQ recepto
Protein function Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). {ECO:0000269|PubMed:12601167, ECO:0000303
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03006 HlyIII 43 269 Haemolysin-III related Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the brain, lung, kidney, colon, adrenal and lung. {ECO:0000269|PubMed:12601167, ECO:0000269|PubMed:16044242}.
Sequence
Sequence length 330
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Chemical carcinogenesis - receptor activation  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEART FAILURE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 22350867 Associate
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases GWASCAT_DG 30595370
★☆☆☆☆
Found in Text Mining only
Endometrial Carcinoma Endometrial carcinoma BEFREE 29353001
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Endometrial neoplasm Pubtator 32733932 Inhibit
★☆☆☆☆
Found in Text Mining only
Endometriosis Endometriosis Pubtator 32733932 Associate
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 32077034 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of endometrium Endometrial Cancer BEFREE 29353001
★☆☆☆☆
Found in Text Mining only