Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	54847
Gene name	SID1 transmembrane family member 1
Gene symbol	SIDT1
Synonyms (NCBI Gene)	SID-1SID1
Chromosome	3
Chromosome location	3q13.2
Summary	The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]

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Show/Hide all (225)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028748	hsa-miR-26b-5p	Microarray	19088304
MIRT1348315	hsa-miR-103a	CLIP-seq
MIRT1348316	hsa-miR-106a	CLIP-seq
MIRT1348317	hsa-miR-106b	CLIP-seq
MIRT1348318	hsa-miR-107	CLIP-seq
MIRT1348319	hsa-miR-1179	CLIP-seq
MIRT1348320	hsa-miR-1207-5p	CLIP-seq
MIRT1348321	hsa-miR-122	CLIP-seq
MIRT1348322	hsa-miR-1231	CLIP-seq
MIRT1348323	hsa-miR-1245	CLIP-seq
MIRT1348324	hsa-miR-1245b-3p	CLIP-seq
MIRT1348325	hsa-miR-125a-5p	CLIP-seq
MIRT1348326	hsa-miR-125b	CLIP-seq
MIRT1348327	hsa-miR-1324	CLIP-seq
MIRT1348328	hsa-miR-142-3p	CLIP-seq
MIRT1348329	hsa-miR-149	CLIP-seq
MIRT1348330	hsa-miR-150	CLIP-seq
MIRT1348331	hsa-miR-15a	CLIP-seq
MIRT1348332	hsa-miR-15b	CLIP-seq
MIRT1348333	hsa-miR-16	CLIP-seq
MIRT1348334	hsa-miR-17	CLIP-seq
MIRT1348335	hsa-miR-18a	CLIP-seq
MIRT1348336	hsa-miR-18b	CLIP-seq
MIRT1348337	hsa-miR-1909	CLIP-seq
MIRT1348338	hsa-miR-195	CLIP-seq
MIRT1348339	hsa-miR-1976	CLIP-seq
MIRT1348340	hsa-miR-20a	CLIP-seq
MIRT1348341	hsa-miR-20b	CLIP-seq
MIRT1348342	hsa-miR-22	CLIP-seq
MIRT1348343	hsa-miR-3064-5p	CLIP-seq
MIRT1348344	hsa-miR-3120-5p	CLIP-seq
MIRT1348345	hsa-miR-3126-5p	CLIP-seq
MIRT1348346	hsa-miR-3135b	CLIP-seq
MIRT1348347	hsa-miR-3140-5p	CLIP-seq
MIRT1348348	hsa-miR-3147	CLIP-seq
MIRT1348349	hsa-miR-3605-3p	CLIP-seq
MIRT1348350	hsa-miR-3609	CLIP-seq
MIRT1348351	hsa-miR-3652	CLIP-seq
MIRT1348352	hsa-miR-3657	CLIP-seq
MIRT1348353	hsa-miR-3664-5p	CLIP-seq
MIRT1348354	hsa-miR-3689a-3p	CLIP-seq
MIRT1348355	hsa-miR-3689c	CLIP-seq
MIRT1348356	hsa-miR-3714	CLIP-seq
MIRT1348357	hsa-miR-3918	CLIP-seq
MIRT1348358	hsa-miR-3920	CLIP-seq
MIRT1348359	hsa-miR-3944-5p	CLIP-seq
MIRT1348360	hsa-miR-424	CLIP-seq
MIRT1348361	hsa-miR-4302	CLIP-seq
MIRT1348362	hsa-miR-4310	CLIP-seq
MIRT1348363	hsa-miR-4316	CLIP-seq
MIRT1348364	hsa-miR-4319	CLIP-seq
MIRT1348365	hsa-miR-4421	CLIP-seq
MIRT1348366	hsa-miR-4425	CLIP-seq
MIRT1348367	hsa-miR-4430	CLIP-seq
MIRT1348368	hsa-miR-4438	CLIP-seq
MIRT1348369	hsa-miR-4504	CLIP-seq
MIRT1348370	hsa-miR-450b-3p	CLIP-seq
MIRT1348371	hsa-miR-4512	CLIP-seq
MIRT1348372	hsa-miR-4639-3p	CLIP-seq
MIRT1348373	hsa-miR-4645-5p	CLIP-seq
MIRT1348374	hsa-miR-4673	CLIP-seq
MIRT1348375	hsa-miR-4688	CLIP-seq
MIRT1348376	hsa-miR-4693-3p	CLIP-seq
MIRT1348377	hsa-miR-4710	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq
MIRT1348379	hsa-miR-4728-5p	CLIP-seq
MIRT1348380	hsa-miR-4732-3p	CLIP-seq
MIRT1348381	hsa-miR-4735-3p	CLIP-seq
MIRT1348382	hsa-miR-4763-3p	CLIP-seq
MIRT1348383	hsa-miR-4794	CLIP-seq
MIRT1348384	hsa-miR-4796-3p	CLIP-seq
MIRT1348385	hsa-miR-497	CLIP-seq
MIRT1348386	hsa-miR-5095	CLIP-seq
MIRT1348387	hsa-miR-519d	CLIP-seq
MIRT1348388	hsa-miR-520g	CLIP-seq
MIRT1348389	hsa-miR-520h	CLIP-seq
MIRT1348390	hsa-miR-542-3p	CLIP-seq
MIRT1348391	hsa-miR-548ah	CLIP-seq
MIRT1348392	hsa-miR-549	CLIP-seq
MIRT1348393	hsa-miR-558	CLIP-seq
MIRT1348394	hsa-miR-595	CLIP-seq
MIRT1348395	hsa-miR-604	CLIP-seq
MIRT1348396	hsa-miR-615-5p	CLIP-seq
MIRT1348397	hsa-miR-647	CLIP-seq
MIRT1348398	hsa-miR-648	CLIP-seq
MIRT1348399	hsa-miR-670	CLIP-seq
MIRT1348400	hsa-miR-720	CLIP-seq
MIRT1348401	hsa-miR-765	CLIP-seq
MIRT1348402	hsa-miR-769-3p	CLIP-seq
MIRT1348403	hsa-miR-93	CLIP-seq
MIRT2103220	hsa-miR-1200	CLIP-seq
MIRT1348321	hsa-miR-122	CLIP-seq
MIRT2103221	hsa-miR-1225-3p	CLIP-seq
MIRT2103222	hsa-miR-1233	CLIP-seq
MIRT2103223	hsa-miR-1237	CLIP-seq
MIRT1348323	hsa-miR-1245	CLIP-seq
MIRT2103224	hsa-miR-1257	CLIP-seq
MIRT2103225	hsa-miR-1275	CLIP-seq
MIRT2103226	hsa-miR-129-3p	CLIP-seq
MIRT1348327	hsa-miR-1324	CLIP-seq
MIRT2103227	hsa-miR-1343	CLIP-seq
MIRT1348330	hsa-miR-150	CLIP-seq
MIRT2103228	hsa-miR-185	CLIP-seq
MIRT1348337	hsa-miR-1909	CLIP-seq
MIRT2103229	hsa-miR-1912	CLIP-seq
MIRT1348339	hsa-miR-1976	CLIP-seq
MIRT1348342	hsa-miR-22	CLIP-seq
MIRT2103230	hsa-miR-3123	CLIP-seq
MIRT1348346	hsa-miR-3135b	CLIP-seq
MIRT2103231	hsa-miR-3150a-3p	CLIP-seq
MIRT2103232	hsa-miR-3175	CLIP-seq
MIRT1348351	hsa-miR-3652	CLIP-seq
MIRT2103233	hsa-miR-3665	CLIP-seq
MIRT2103234	hsa-miR-3668	CLIP-seq
MIRT1348354	hsa-miR-3689a-3p	CLIP-seq
MIRT1348355	hsa-miR-3689c	CLIP-seq
MIRT2103235	hsa-miR-378g	CLIP-seq
MIRT2103236	hsa-miR-3960	CLIP-seq
MIRT1348361	hsa-miR-4302	CLIP-seq
MIRT2103237	hsa-miR-4306	CLIP-seq
MIRT2103238	hsa-miR-4324	CLIP-seq
MIRT2103239	hsa-miR-4330	CLIP-seq
MIRT2103240	hsa-miR-4420	CLIP-seq
MIRT1348367	hsa-miR-4430	CLIP-seq
MIRT2103241	hsa-miR-4437	CLIP-seq
MIRT2103242	hsa-miR-4502	CLIP-seq
MIRT2103243	hsa-miR-4525	CLIP-seq
MIRT2103244	hsa-miR-4644	CLIP-seq
MIRT1348373	hsa-miR-4645-5p	CLIP-seq
MIRT2103245	hsa-miR-4659a-3p	CLIP-seq
MIRT2103246	hsa-miR-4659b-3p	CLIP-seq
MIRT2103247	hsa-miR-4663	CLIP-seq
MIRT2103248	hsa-miR-4665-5p	CLIP-seq
MIRT2103249	hsa-miR-4667-5p	CLIP-seq
MIRT1348374	hsa-miR-4673	CLIP-seq
MIRT2103250	hsa-miR-4674	CLIP-seq
MIRT1348375	hsa-miR-4688	CLIP-seq
MIRT1348376	hsa-miR-4693-3p	CLIP-seq
MIRT2103251	hsa-miR-4700-5p	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq
MIRT2103252	hsa-miR-4723-5p	CLIP-seq
MIRT2103253	hsa-miR-4727-5p	CLIP-seq
MIRT2103254	hsa-miR-4728-3p	CLIP-seq
MIRT1348379	hsa-miR-4728-5p	CLIP-seq
MIRT2103255	hsa-miR-4762-3p	CLIP-seq
MIRT2103256	hsa-miR-483-3p	CLIP-seq
MIRT1348388	hsa-miR-520g	CLIP-seq
MIRT1348389	hsa-miR-520h	CLIP-seq
MIRT2103257	hsa-miR-544b	CLIP-seq
MIRT1348393	hsa-miR-558	CLIP-seq
MIRT2103258	hsa-miR-625	CLIP-seq
MIRT2103259	hsa-miR-637	CLIP-seq
MIRT2103260	hsa-miR-939	CLIP-seq
MIRT2103220	hsa-miR-1200	CLIP-seq
MIRT1348321	hsa-miR-122	CLIP-seq
MIRT2103221	hsa-miR-1225-3p	CLIP-seq
MIRT1348322	hsa-miR-1231	CLIP-seq
MIRT2103222	hsa-miR-1233	CLIP-seq
MIRT2103223	hsa-miR-1237	CLIP-seq
MIRT1348323	hsa-miR-1245	CLIP-seq
MIRT2103224	hsa-miR-1257	CLIP-seq
MIRT2103226	hsa-miR-129-3p	CLIP-seq
MIRT1348327	hsa-miR-1324	CLIP-seq
MIRT2103227	hsa-miR-1343	CLIP-seq
MIRT2327488	hsa-miR-139-5p	CLIP-seq
MIRT1348329	hsa-miR-149	CLIP-seq
MIRT1348330	hsa-miR-150	CLIP-seq
MIRT1348331	hsa-miR-15a	CLIP-seq
MIRT1348332	hsa-miR-15b	CLIP-seq
MIRT1348333	hsa-miR-16	CLIP-seq
MIRT1348337	hsa-miR-1909	CLIP-seq
MIRT2327489	hsa-miR-1914	CLIP-seq
MIRT1348338	hsa-miR-195	CLIP-seq
MIRT1348339	hsa-miR-1976	CLIP-seq
MIRT1348342	hsa-miR-22	CLIP-seq
MIRT2327490	hsa-miR-2467-3p	CLIP-seq
MIRT1348343	hsa-miR-3064-5p	CLIP-seq
MIRT2327491	hsa-miR-3126-3p	CLIP-seq
MIRT1348346	hsa-miR-3135b	CLIP-seq
MIRT1348351	hsa-miR-3652	CLIP-seq
MIRT2327492	hsa-miR-3667-3p	CLIP-seq
MIRT2327493	hsa-miR-3678-3p	CLIP-seq
MIRT1348354	hsa-miR-3689a-3p	CLIP-seq
MIRT1348355	hsa-miR-3689c	CLIP-seq
MIRT2103235	hsa-miR-378g	CLIP-seq
MIRT2103236	hsa-miR-3960	CLIP-seq
MIRT1348360	hsa-miR-424	CLIP-seq
MIRT2327494	hsa-miR-4268	CLIP-seq
MIRT1348361	hsa-miR-4302	CLIP-seq
MIRT2103238	hsa-miR-4324	CLIP-seq
MIRT2103240	hsa-miR-4420	CLIP-seq
MIRT1348367	hsa-miR-4430	CLIP-seq
MIRT2103241	hsa-miR-4437	CLIP-seq
MIRT1348368	hsa-miR-4438	CLIP-seq
MIRT2327495	hsa-miR-4464	CLIP-seq
MIRT2327496	hsa-miR-4481	CLIP-seq
MIRT2103242	hsa-miR-4502	CLIP-seq
MIRT1348373	hsa-miR-4645-5p	CLIP-seq
MIRT1348374	hsa-miR-4673	CLIP-seq
MIRT2103250	hsa-miR-4674	CLIP-seq
MIRT1348375	hsa-miR-4688	CLIP-seq
MIRT1348376	hsa-miR-4693-3p	CLIP-seq
MIRT2327497	hsa-miR-4715-5p	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq
MIRT1348379	hsa-miR-4728-5p	CLIP-seq
MIRT2327498	hsa-miR-4745-5p	CLIP-seq
MIRT2327499	hsa-miR-4748	CLIP-seq
MIRT2327500	hsa-miR-4749-3p	CLIP-seq
MIRT2327501	hsa-miR-4758-5p	CLIP-seq
MIRT2103255	hsa-miR-4762-3p	CLIP-seq
MIRT1348383	hsa-miR-4794	CLIP-seq
MIRT2327502	hsa-miR-4797-5p	CLIP-seq
MIRT2103256	hsa-miR-483-3p	CLIP-seq
MIRT1348385	hsa-miR-497	CLIP-seq
MIRT1348386	hsa-miR-5095	CLIP-seq
MIRT1348388	hsa-miR-520g	CLIP-seq
MIRT1348389	hsa-miR-520h	CLIP-seq
MIRT2103257	hsa-miR-544b	CLIP-seq
MIRT1348393	hsa-miR-558	CLIP-seq
MIRT2327503	hsa-miR-571	CLIP-seq
MIRT2327504	hsa-miR-584	CLIP-seq
MIRT1348395	hsa-miR-604	CLIP-seq
MIRT1348397	hsa-miR-647	CLIP-seq
MIRT2327505	hsa-miR-760	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
STAT6	Unknown	18342537

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0005764	Component	Lysosome	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0015485	Function	Cholesterol binding	IDA	28785058
GO:0016020	Component	Membrane	IEA
GO:0050658	Process	RNA transport	IBA
GO:0051033	Function	RNA transmembrane transporter activity	IBA

MIM	HGNC	e!Ensembl
606816	25967	ENSG00000072858

Q9NXL6

Protein name

SID1 transmembrane family member 1

Protein function

In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. {ECO

PDB

8J6M , 8JUL , 8JUN , 8K13 , 8K1B , 8K1D , 8KCW , 8KCX , 8V38 , 8WOQ , 8WOR , 8WOS , 8WOT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13965	SID-1_RNA_chan	184 → 827	dsRNA-gated channel SID-1	Family

Sequence

MRGCLRLALLCALPWLLLAASPGHPAKSPRQPPAPRRDPFDAARGADFDHVYSGVVNLST
ENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSY
NYQEVSRTLCPSEATNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRTNVAFHFT
ASPSQPQYFLYKFPKDVDSVIIKVVSEMAYPCSVVSVQNIMCPVYDLDHNVEFNGVYQSM
TKKAAITLQKKDFPGEQFFVVFVIKPEDYACGGSFFIQEKENQTWNLQRKKNLEVTIVPS
IKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLRFQRKSIDGSFGSNDGSGNMVASHPIA
ASTPEGSNYGTIDESSSSPGRQMSSSDGGPPGQSDTDSSVEESDFDTMPDIESDKNIIRT
KMFLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICY
YNFLCAHPLGVLSAFNNILSNLGHVLLGFLFLLIVLRRDILHRRALEAKDIFAVEYGIPK
HFGLFYAMGIALMMEGVLSACYHVCPNYSNFQFDTSFMYMIAGLCMLKLYQTRHPDINAS
AYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQIYYMGRFKIDLGIF
RRAAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICN
LLLYLAFYIIMKLRSSEKVLPVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNR
ECILLDFFDDHDIWHFLSATALFFSFLVLLTLDDDLDVVRRDQIPVF

Sequence length

827

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Marfanoid habitus and intellectual disability	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	22174421		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	40644891	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	9524287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	GWASDB_DG	23535732		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31632087		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	GWASCAT_DG	23535732, 29892016		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	33758106	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	31632087		★★★★★ ★☆☆☆☆ Found in Text Mining only

SIDT1 (SID1 transmembrane family member 1)