WBP1L (WW domain binding protein 1 like)

Gene

• Entrez ID: 54838
• Gene name: WW domain binding protein 1 like
• Gene symbol: WBP1L
• Synonyms (NCBI Gene): C10orf26, OPA1L, OPAL1
• Chromosome: 10
• Chromosome location: 10q24.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017867	hsa-miR-335-5p	Microarray	18185580
MIRT020792	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT031188	hsa-miR-19b-3p	Sequencing	20371350
MIRT044576	hsa-miR-320a	CLASH	23622248
MIRT040377	hsa-miR-615-3p	CLASH	23622248
MIRT036784	hsa-miR-760	CLASH	23622248
MIRT445887	hsa-miR-582-3p	PAR-CLIP	22100165
MIRT445886	hsa-miR-4667-5p	PAR-CLIP	22100165
MIRT445885	hsa-miR-4700-5p	PAR-CLIP	22100165
MIRT445884	hsa-miR-8089	PAR-CLIP	22100165
MIRT445883	hsa-miR-3153	PAR-CLIP	22100165
MIRT445881	hsa-miR-6733-5p	PAR-CLIP	22100165
MIRT445882	hsa-miR-6739-5p	PAR-CLIP	22100165
MIRT445880	hsa-miR-4271	PAR-CLIP	22100165
MIRT445879	hsa-miR-4725-3p	PAR-CLIP	22100165
MIRT445878	hsa-miR-6780b-5p	PAR-CLIP	22100165
MIRT445877	hsa-miR-2110	PAR-CLIP	22100165
MIRT445887	hsa-miR-582-3p	PAR-CLIP	22100165
MIRT445886	hsa-miR-4667-5p	PAR-CLIP	22100165
MIRT445885	hsa-miR-4700-5p	PAR-CLIP	22100165
MIRT445884	hsa-miR-8089	PAR-CLIP	22100165
MIRT445883	hsa-miR-3153	PAR-CLIP	22100165
MIRT445881	hsa-miR-6733-5p	PAR-CLIP	22100165
MIRT445882	hsa-miR-6739-5p	PAR-CLIP	22100165
MIRT445880	hsa-miR-4271	PAR-CLIP	22100165
MIRT445879	hsa-miR-4725-3p	PAR-CLIP	22100165
MIRT445878	hsa-miR-6780b-5p	PAR-CLIP	22100165
MIRT445877	hsa-miR-2110	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0016020	Component	Membrane	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0031398	Process	Positive regulation of protein ubiquitination	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0038160	Process	CXCL12-activated CXCR4 signaling pathway	IBA
GO:0038160	Process	CXCL12-activated CXCR4 signaling pathway	IEA

Other IDs

• MIM: 611129
• HGNC: 23510
• e!Ensembl: ENSG00000166272

Protein

• UniProt ID: Q9NX94
• Protein name: WW domain binding protein 1-like (Outcome predictor in acute leukemia 1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11669	WBP-1	22 → 123	WW domain-binding protein 1	Family

• Sequence:

  MPFLLGLRQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCV
  CHHRRAKHRLQAQQRQHEINLIAYREAHNYSALPFYFRFLPNYLLPPYEEVVNRPPTPPP
  PYSAFQLQQQQLLPPQCGPAGGSPPGIDPTRGSQGAQSSPLSEPSRSSTRPPSIADPDPS
  DLPVDRAATKAPGMEPSGSVAGLGELDPGAFLDKDAECREELLKDDSSEHGAPDSKEKTP
  GRHRRFTGDSGIEVCVCNRGHHDDDLKEFNTLIDDALDGPLDFCDSCHVRPPGDEEEGLC
  QSSEEQAREPGHPHLPRPPACLLLNTINEQDSPNSQSSSSPS

• Sequence length: 342

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL ADENOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	16709928		★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	16709928		★☆☆☆☆ Found in Text Mining only
Adrenal hyperplasia, congenital, type 5	Adrenal Hyperplasia, Congenital	CLINVAR_DG	11549685, 12466376, 12706306, 1577471, 15844475, 16477341, 16772352, 22087567, 26770544, 2786493, 27959413, 2843762, 9326943		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	16709928		★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	16709928		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	30422892		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	31845480		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	33883344	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	GWASCAT_DG	19915575		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	GWASDB_DG	19915575		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	LHGDN	16709928		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	22883350	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	31840934		★★☆☆☆ Found in Text Mining + Unknown/Other Associations