KLHL24 (kelch like family member 24)

Gene

• Entrez ID: 54800
• Gene name: Kelch like family member 24
• Gene symbol: KLHL24
• Synonyms (NCBI Gene): CMH29, DRE1, EBS6, EBSSH, KRIP6
• Chromosome: 3
• Chromosome location: 3q27.1
• Summary: The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protei

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs886037956	A>G,T	Pathogenic	Missense variant, initiator codon variant, non coding transcript variant, 5 prime UTR variant
rs886037957	G>A,T	Pathogenic	Missense variant, initiator codon variant, non coding transcript variant, 5 prime UTR variant
rs1057515580	T>C	Pathogenic	Initiator codon variant, 5 prime UTR variant, missense variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017030	hsa-miR-335-5p	Microarray	18185580
MIRT022299	hsa-miR-124-3p	Microarray	18668037
MIRT025029	hsa-miR-183-5p	Sequencing	20371350
MIRT029040	hsa-miR-26b-5p	Microarray	19088304
MIRT029040	hsa-miR-26b-5p	Sequencing	20371350
MIRT030750	hsa-miR-21-5p	Microarray	18591254
MIRT720885	hsa-miR-4310	HITS-CLIP	19536157
MIRT720884	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT720883	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT720882	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT720881	hsa-miR-3674	HITS-CLIP	19536157
MIRT708831	hsa-miR-548g-3p	HITS-CLIP	19536157
MIRT708830	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT708829	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT708828	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT708827	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT708826	hsa-miR-4262	HITS-CLIP	19536157
MIRT708825	hsa-miR-1305	HITS-CLIP	19536157
MIRT708831	hsa-miR-548g-3p	HITS-CLIP	19536157
MIRT708830	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT708829	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT708828	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT708827	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT708826	hsa-miR-4262	HITS-CLIP	19536157
MIRT708825	hsa-miR-1305	HITS-CLIP	19536157
MIRT306297	hsa-miR-4428	PAR-CLIP	21572407
MIRT306298	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT543531	hsa-miR-4501	PAR-CLIP	21572407
MIRT543530	hsa-miR-4670-3p	PAR-CLIP	21572407
MIRT306292	hsa-miR-190a-5p	PAR-CLIP	21572407
MIRT306294	hsa-miR-190b	PAR-CLIP	21572407
MIRT306295	hsa-miR-3611	PAR-CLIP	21572407
MIRT720885	hsa-miR-4310	HITS-CLIP	19536157
MIRT720884	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT720883	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT720882	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT720881	hsa-miR-3674	HITS-CLIP	19536157
MIRT708831	hsa-miR-548g-3p	HITS-CLIP	19536157
MIRT708830	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT708829	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT708828	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT708827	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT708826	hsa-miR-4262	HITS-CLIP	19536157
MIRT708825	hsa-miR-1305	HITS-CLIP	19536157
MIRT708831	hsa-miR-548g-3p	HITS-CLIP	19536157
MIRT708830	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT708829	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT708828	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT708827	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT708826	hsa-miR-4262	HITS-CLIP	19536157
MIRT708825	hsa-miR-1305	HITS-CLIP	19536157
MIRT306297	hsa-miR-4428	PAR-CLIP	21572407
MIRT306298	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT543531	hsa-miR-4501	PAR-CLIP	21572407
MIRT543530	hsa-miR-4670-3p	PAR-CLIP	21572407
MIRT306292	hsa-miR-190a-5p	PAR-CLIP	21572407
MIRT306294	hsa-miR-190b	PAR-CLIP	21572407
MIRT306295	hsa-miR-3611	PAR-CLIP	21572407
MIRT1098051	hsa-miR-1207-3p	CLIP-seq
MIRT1098052	hsa-miR-134	CLIP-seq
MIRT1098053	hsa-miR-142-5p	CLIP-seq
MIRT1098054	hsa-miR-1827	CLIP-seq
MIRT1098055	hsa-miR-210	CLIP-seq
MIRT1098056	hsa-miR-224	CLIP-seq
MIRT1098057	hsa-miR-23a	CLIP-seq
MIRT1098058	hsa-miR-23b	CLIP-seq
MIRT1098059	hsa-miR-23c	CLIP-seq
MIRT1098060	hsa-miR-299-5p	CLIP-seq
MIRT1098061	hsa-miR-3118	CLIP-seq
MIRT1098062	hsa-miR-3120-3p	CLIP-seq
MIRT1098063	hsa-miR-3168	CLIP-seq
MIRT1098064	hsa-miR-3173-3p	CLIP-seq
MIRT1098065	hsa-miR-3183	CLIP-seq
MIRT1098066	hsa-miR-3613-3p	CLIP-seq
MIRT1098067	hsa-miR-3617	CLIP-seq
MIRT1098068	hsa-miR-3689d	CLIP-seq
MIRT1098069	hsa-miR-3921	CLIP-seq
MIRT1098070	hsa-miR-3929	CLIP-seq
MIRT1098071	hsa-miR-409-3p	CLIP-seq
MIRT1098072	hsa-miR-4263	CLIP-seq
MIRT1098073	hsa-miR-4302	CLIP-seq
MIRT1098074	hsa-miR-432	CLIP-seq
MIRT1098075	hsa-miR-4419b	CLIP-seq
MIRT1098076	hsa-miR-4423-5p	CLIP-seq
MIRT1098077	hsa-miR-4455	CLIP-seq
MIRT1098078	hsa-miR-4474-3p	CLIP-seq
MIRT1098079	hsa-miR-4478	CLIP-seq
MIRT1098080	hsa-miR-4649-3p	CLIP-seq
MIRT1098081	hsa-miR-4653-5p	CLIP-seq
MIRT1098082	hsa-miR-4684-5p	CLIP-seq
MIRT1098083	hsa-miR-4694-3p	CLIP-seq
MIRT1098084	hsa-miR-4696	CLIP-seq
MIRT1098085	hsa-miR-4723-3p	CLIP-seq
MIRT1098086	hsa-miR-4729	CLIP-seq
MIRT1098087	hsa-miR-4760-5p	CLIP-seq
MIRT1098088	hsa-miR-4780	CLIP-seq
MIRT1098089	hsa-miR-485-5p	CLIP-seq
MIRT1098090	hsa-miR-522	CLIP-seq
MIRT1098091	hsa-miR-548c-3p	CLIP-seq
MIRT1098092	hsa-miR-550b	CLIP-seq
MIRT1098093	hsa-miR-564	CLIP-seq
MIRT1098094	hsa-miR-579	CLIP-seq
MIRT1098095	hsa-miR-641	CLIP-seq
MIRT1098096	hsa-miR-644	CLIP-seq
MIRT1098097	hsa-miR-936	CLIP-seq
MIRT1550608	hsa-miR-125a-5p	CLIP-seq
MIRT1550609	hsa-miR-125b	CLIP-seq
MIRT1550610	hsa-miR-374c	CLIP-seq
MIRT1550611	hsa-miR-4319	CLIP-seq
MIRT1550612	hsa-miR-4699-3p	CLIP-seq
MIRT1550613	hsa-miR-4732-3p	CLIP-seq
MIRT1550614	hsa-miR-496	CLIP-seq
MIRT1550615	hsa-miR-499-3p	CLIP-seq
MIRT1550616	hsa-miR-499a-3p	CLIP-seq
MIRT1098091	hsa-miR-548c-3p	CLIP-seq
MIRT1550617	hsa-miR-655	CLIP-seq
MIRT1550618	hsa-miR-670	CLIP-seq
MIRT1556598	hsa-miR-3647-3p	CLIP-seq
MIRT1556599	hsa-miR-4282	CLIP-seq
MIRT1556600	hsa-miR-4496	CLIP-seq
MIRT1556601	hsa-miR-889	CLIP-seq
MIRT1922198	hsa-miR-188-5p	CLIP-seq
MIRT1922199	hsa-miR-3667-5p	CLIP-seq
MIRT1922200	hsa-miR-4457	CLIP-seq
MIRT1922201	hsa-miR-451b	CLIP-seq
MIRT1098084	hsa-miR-4696	CLIP-seq
MIRT1922202	hsa-miR-4711-5p	CLIP-seq
MIRT1922203	hsa-miR-4713-5p	CLIP-seq
MIRT1922204	hsa-miR-513b	CLIP-seq
MIRT2026655	hsa-miR-1238	CLIP-seq
MIRT2026656	hsa-miR-1303	CLIP-seq
MIRT2026657	hsa-miR-136	CLIP-seq
MIRT2026658	hsa-miR-24	CLIP-seq
MIRT1098062	hsa-miR-3120-3p	CLIP-seq
MIRT2026659	hsa-miR-3124-3p	CLIP-seq
MIRT2026660	hsa-miR-3148	CLIP-seq
MIRT2026661	hsa-miR-3613-5p	CLIP-seq
MIRT1922199	hsa-miR-3667-5p	CLIP-seq
MIRT2026662	hsa-miR-3692	CLIP-seq
MIRT2026663	hsa-miR-376c	CLIP-seq
MIRT2026664	hsa-miR-377	CLIP-seq
MIRT2026665	hsa-miR-378g	CLIP-seq
MIRT1556599	hsa-miR-4282	CLIP-seq
MIRT2026666	hsa-miR-4284	CLIP-seq
MIRT2026667	hsa-miR-4494	CLIP-seq
MIRT1922201	hsa-miR-451b	CLIP-seq
MIRT2026668	hsa-miR-4643	CLIP-seq
MIRT1098083	hsa-miR-4694-3p	CLIP-seq
MIRT1098084	hsa-miR-4696	CLIP-seq
MIRT2026669	hsa-miR-4699-5p	CLIP-seq
MIRT2026670	hsa-miR-511	CLIP-seq
MIRT2026671	hsa-miR-513a-3p	CLIP-seq
MIRT2026672	hsa-miR-514	CLIP-seq
MIRT2026673	hsa-miR-514b-3p	CLIP-seq
MIRT2026674	hsa-miR-526b	CLIP-seq
MIRT1098091	hsa-miR-548c-3p	CLIP-seq
MIRT2026675	hsa-miR-561	CLIP-seq
MIRT2026676	hsa-miR-659	CLIP-seq
MIRT1098097	hsa-miR-936	CLIP-seq
MIRT2257739	hsa-let-7a	CLIP-seq
MIRT2257740	hsa-let-7b	CLIP-seq
MIRT2257741	hsa-let-7c	CLIP-seq
MIRT2257742	hsa-let-7d	CLIP-seq
MIRT2257743	hsa-let-7e	CLIP-seq
MIRT2257744	hsa-let-7f	CLIP-seq
MIRT2257745	hsa-let-7g	CLIP-seq
MIRT2257746	hsa-let-7i	CLIP-seq
MIRT2257747	hsa-miR-101	CLIP-seq
MIRT2257748	hsa-miR-103b	CLIP-seq
MIRT2257749	hsa-miR-1183	CLIP-seq
MIRT1098051	hsa-miR-1207-3p	CLIP-seq
MIRT2257750	hsa-miR-1208	CLIP-seq
MIRT2257751	hsa-miR-1236	CLIP-seq
MIRT2257752	hsa-miR-124	CLIP-seq
MIRT2257753	hsa-miR-1244	CLIP-seq
MIRT2257754	hsa-miR-1260	CLIP-seq
MIRT2257755	hsa-miR-1260b	CLIP-seq
MIRT2257756	hsa-miR-1267	CLIP-seq
MIRT2257757	hsa-miR-1273	CLIP-seq
MIRT2257758	hsa-miR-1294	CLIP-seq
MIRT2257759	hsa-miR-129-5p	CLIP-seq
MIRT2257760	hsa-miR-1324	CLIP-seq
MIRT2257761	hsa-miR-1343	CLIP-seq
MIRT2026657	hsa-miR-136	CLIP-seq
MIRT1098053	hsa-miR-142-5p	CLIP-seq
MIRT2257762	hsa-miR-144	CLIP-seq
MIRT1098054	hsa-miR-1827	CLIP-seq
MIRT2257763	hsa-miR-183	CLIP-seq
MIRT2257764	hsa-miR-188-3p	CLIP-seq
MIRT1922198	hsa-miR-188-5p	CLIP-seq
MIRT2257765	hsa-miR-190	CLIP-seq
MIRT2257766	hsa-miR-1913	CLIP-seq
MIRT2257767	hsa-miR-1976	CLIP-seq
MIRT2257768	hsa-miR-202	CLIP-seq
MIRT2257769	hsa-miR-204	CLIP-seq
MIRT2257770	hsa-miR-211	CLIP-seq
MIRT2257771	hsa-miR-217	CLIP-seq
MIRT1098056	hsa-miR-224	CLIP-seq
MIRT2026658	hsa-miR-24	CLIP-seq
MIRT2257772	hsa-miR-3117-5p	CLIP-seq
MIRT2026659	hsa-miR-3124-3p	CLIP-seq
MIRT2257773	hsa-miR-3125	CLIP-seq
MIRT2257774	hsa-miR-3129-3p	CLIP-seq
MIRT2257775	hsa-miR-3137	CLIP-seq
MIRT2026660	hsa-miR-3148	CLIP-seq
MIRT2257776	hsa-miR-3156-3p	CLIP-seq
MIRT2257777	hsa-miR-3163	CLIP-seq
MIRT2257778	hsa-miR-3166	CLIP-seq
MIRT2257779	hsa-miR-3175	CLIP-seq
MIRT2257780	hsa-miR-3179	CLIP-seq
MIRT2257781	hsa-miR-3182	CLIP-seq
MIRT2257782	hsa-miR-3189-5p	CLIP-seq
MIRT2257783	hsa-miR-3202	CLIP-seq
MIRT2257784	hsa-miR-324-3p	CLIP-seq
MIRT2257785	hsa-miR-34b	CLIP-seq
MIRT2026661	hsa-miR-3613-5p	CLIP-seq
MIRT2257786	hsa-miR-3616-5p	CLIP-seq
MIRT2257787	hsa-miR-3647-5p	CLIP-seq
MIRT2257788	hsa-miR-3653	CLIP-seq
MIRT2257789	hsa-miR-3658	CLIP-seq
MIRT2257790	hsa-miR-3662	CLIP-seq
MIRT2257791	hsa-miR-3668	CLIP-seq
MIRT2257792	hsa-miR-3689a-3p	CLIP-seq
MIRT2257793	hsa-miR-3689c	CLIP-seq
MIRT1098068	hsa-miR-3689d	CLIP-seq
MIRT2026662	hsa-miR-3692	CLIP-seq
MIRT2257794	hsa-miR-370	CLIP-seq
MIRT2257795	hsa-miR-3714	CLIP-seq
MIRT1550610	hsa-miR-374c	CLIP-seq
MIRT2257796	hsa-miR-376a	CLIP-seq
MIRT2257797	hsa-miR-376b	CLIP-seq
MIRT2026663	hsa-miR-376c	CLIP-seq
MIRT2026664	hsa-miR-377	CLIP-seq
MIRT2026665	hsa-miR-378g	CLIP-seq
MIRT2257798	hsa-miR-3910	CLIP-seq
MIRT2257799	hsa-miR-3916	CLIP-seq
MIRT2257800	hsa-miR-3920	CLIP-seq
MIRT1098070	hsa-miR-3929	CLIP-seq
MIRT2257801	hsa-miR-3935	CLIP-seq
MIRT2257802	hsa-miR-3938	CLIP-seq
MIRT2257803	hsa-miR-409-5p	CLIP-seq
MIRT2257804	hsa-miR-4252	CLIP-seq
MIRT2257805	hsa-miR-4256	CLIP-seq
MIRT2257806	hsa-miR-4259	CLIP-seq
MIRT2257807	hsa-miR-4274	CLIP-seq
MIRT2257808	hsa-miR-4275	CLIP-seq
MIRT2257809	hsa-miR-4281	CLIP-seq
MIRT2026666	hsa-miR-4284	CLIP-seq
MIRT2257810	hsa-miR-4299	CLIP-seq
MIRT2257811	hsa-miR-4301	CLIP-seq
MIRT1098073	hsa-miR-4302	CLIP-seq
MIRT2257812	hsa-miR-4418	CLIP-seq
MIRT1098075	hsa-miR-4419b	CLIP-seq
MIRT2257813	hsa-miR-4421	CLIP-seq
MIRT2257814	hsa-miR-4425	CLIP-seq
MIRT2257815	hsa-miR-4432	CLIP-seq
MIRT2257816	hsa-miR-4436b-5p	CLIP-seq
MIRT2257817	hsa-miR-4437	CLIP-seq
MIRT1098077	hsa-miR-4455	CLIP-seq
MIRT2257818	hsa-miR-4456	CLIP-seq
MIRT2257819	hsa-miR-4458	CLIP-seq
MIRT1098078	hsa-miR-4474-3p	CLIP-seq
MIRT1098079	hsa-miR-4478	CLIP-seq
MIRT2257820	hsa-miR-4480	CLIP-seq
MIRT2257821	hsa-miR-4486	CLIP-seq
MIRT2026667	hsa-miR-4494	CLIP-seq
MIRT2257822	hsa-miR-4495	CLIP-seq
MIRT2257823	hsa-miR-4500	CLIP-seq
MIRT2257824	hsa-miR-4522	CLIP-seq
MIRT1098080	hsa-miR-4649-3p	CLIP-seq
MIRT2257825	hsa-miR-4649-5p	CLIP-seq
MIRT2257826	hsa-miR-4651	CLIP-seq
MIRT2257827	hsa-miR-4654	CLIP-seq
MIRT2257828	hsa-miR-4663	CLIP-seq
MIRT2257829	hsa-miR-4674	CLIP-seq
MIRT2257830	hsa-miR-4697-3p	CLIP-seq
MIRT2026669	hsa-miR-4699-5p	CLIP-seq
MIRT2257831	hsa-miR-4703-3p	CLIP-seq
MIRT2257832	hsa-miR-4705	CLIP-seq
MIRT2257833	hsa-miR-4710	CLIP-seq
MIRT2257834	hsa-miR-4714-3p	CLIP-seq
MIRT2257835	hsa-miR-4715-5p	CLIP-seq
MIRT2257836	hsa-miR-4718	CLIP-seq
MIRT2257837	hsa-miR-4719	CLIP-seq
MIRT2257838	hsa-miR-4722-3p	CLIP-seq
MIRT2257839	hsa-miR-4728-3p	CLIP-seq
MIRT2257840	hsa-miR-4732-5p	CLIP-seq
MIRT2257841	hsa-miR-4735-5p	CLIP-seq
MIRT2257842	hsa-miR-4747-5p	CLIP-seq
MIRT2257843	hsa-miR-4753-5p	CLIP-seq
MIRT2257844	hsa-miR-4755-5p	CLIP-seq
MIRT2257845	hsa-miR-4758-3p	CLIP-seq
MIRT2257846	hsa-miR-4762-3p	CLIP-seq
MIRT2257847	hsa-miR-4766-3p	CLIP-seq
MIRT2257848	hsa-miR-4769-5p	CLIP-seq
MIRT2257849	hsa-miR-4771	CLIP-seq
MIRT2257850	hsa-miR-4778-3p	CLIP-seq
MIRT1098088	hsa-miR-4780	CLIP-seq
MIRT2257851	hsa-miR-4789-5p	CLIP-seq
MIRT2257852	hsa-miR-4793-3p	CLIP-seq
MIRT2257853	hsa-miR-4796-3p	CLIP-seq
MIRT1098089	hsa-miR-485-5p	CLIP-seq
MIRT2257854	hsa-miR-489	CLIP-seq
MIRT2257855	hsa-miR-499a-5p	CLIP-seq
MIRT2257856	hsa-miR-506	CLIP-seq
MIRT2257857	hsa-miR-508-5p	CLIP-seq
MIRT2257858	hsa-miR-509-3-5p	CLIP-seq
MIRT2257859	hsa-miR-509-5p	CLIP-seq
MIRT2257860	hsa-miR-5096	CLIP-seq
MIRT2026670	hsa-miR-511	CLIP-seq
MIRT2026672	hsa-miR-514	CLIP-seq
MIRT2026673	hsa-miR-514b-3p	CLIP-seq
MIRT2257861	hsa-miR-516b	CLIP-seq
MIRT2257862	hsa-miR-548a-5p	CLIP-seq
MIRT2257863	hsa-miR-548ab	CLIP-seq
MIRT2257864	hsa-miR-548ac	CLIP-seq
MIRT2257865	hsa-miR-548ak	CLIP-seq
MIRT2257866	hsa-miR-548b-5p	CLIP-seq
MIRT2257867	hsa-miR-548c-5p	CLIP-seq
MIRT2257868	hsa-miR-548d-3p	CLIP-seq
MIRT2257869	hsa-miR-548d-5p	CLIP-seq
MIRT2257870	hsa-miR-548h	CLIP-seq
MIRT2257871	hsa-miR-548i	CLIP-seq
MIRT2257872	hsa-miR-548j	CLIP-seq
MIRT2257873	hsa-miR-548m	CLIP-seq
MIRT2257874	hsa-miR-548n	CLIP-seq
MIRT2257875	hsa-miR-548p	CLIP-seq
MIRT2257876	hsa-miR-548q	CLIP-seq
MIRT2257877	hsa-miR-548w	CLIP-seq
MIRT2257878	hsa-miR-548y	CLIP-seq
MIRT2257879	hsa-miR-548z	CLIP-seq
MIRT2257880	hsa-miR-559	CLIP-seq
MIRT2257881	hsa-miR-563	CLIP-seq
MIRT1098093	hsa-miR-564	CLIP-seq
MIRT2257882	hsa-miR-573	CLIP-seq
MIRT2257883	hsa-miR-576-3p	CLIP-seq
MIRT1098094	hsa-miR-579	CLIP-seq
MIRT2257884	hsa-miR-582-5p	CLIP-seq
MIRT2257885	hsa-miR-590-3p	CLIP-seq
MIRT2257886	hsa-miR-596	CLIP-seq
MIRT2257887	hsa-miR-608	CLIP-seq
MIRT2257888	hsa-miR-622	CLIP-seq
MIRT2257889	hsa-miR-623	CLIP-seq
MIRT2257890	hsa-miR-629	CLIP-seq
MIRT1098096	hsa-miR-644	CLIP-seq
MIRT1550617	hsa-miR-655	CLIP-seq
MIRT2257891	hsa-miR-656	CLIP-seq
MIRT2026676	hsa-miR-659	CLIP-seq
MIRT2257892	hsa-miR-661	CLIP-seq
MIRT2257893	hsa-miR-766	CLIP-seq
MIRT2257894	hsa-miR-802	CLIP-seq
MIRT2257895	hsa-miR-877	CLIP-seq
MIRT2257896	hsa-miR-890	CLIP-seq
MIRT1098097	hsa-miR-936	CLIP-seq
MIRT2257897	hsa-miR-98	CLIP-seq
MIRT2389955	hsa-miR-21	CLIP-seq
MIRT2389956	hsa-miR-3145-3p	CLIP-seq
MIRT2257790	hsa-miR-3662	CLIP-seq
MIRT2389957	hsa-miR-539	CLIP-seq
MIRT2389958	hsa-miR-570	CLIP-seq
MIRT2389959	hsa-miR-590-5p	CLIP-seq
MIRT2452662	hsa-miR-29a	CLIP-seq
MIRT2452663	hsa-miR-29b	CLIP-seq
MIRT2452664	hsa-miR-29c	CLIP-seq
MIRT2452665	hsa-miR-330-3p	CLIP-seq
MIRT1098066	hsa-miR-3613-3p	CLIP-seq
MIRT1098077	hsa-miR-4455	CLIP-seq
MIRT1098082	hsa-miR-4684-5p	CLIP-seq
MIRT1098091	hsa-miR-548c-3p	CLIP-seq
MIRT1098093	hsa-miR-564	CLIP-seq
MIRT2452666	hsa-miR-767-5p	CLIP-seq
MIRT2257749	hsa-miR-1183	CLIP-seq
MIRT2558841	hsa-miR-1206	CLIP-seq
MIRT2257754	hsa-miR-1260	CLIP-seq
MIRT2257755	hsa-miR-1260b	CLIP-seq
MIRT2257756	hsa-miR-1267	CLIP-seq
MIRT2026657	hsa-miR-136	CLIP-seq
MIRT1098053	hsa-miR-142-5p	CLIP-seq
MIRT2257764	hsa-miR-188-3p	CLIP-seq
MIRT1922198	hsa-miR-188-5p	CLIP-seq
MIRT2257765	hsa-miR-190	CLIP-seq
MIRT2558842	hsa-miR-1912	CLIP-seq
MIRT2558843	hsa-miR-214	CLIP-seq
MIRT1098057	hsa-miR-23a	CLIP-seq
MIRT1098058	hsa-miR-23b	CLIP-seq
MIRT1098059	hsa-miR-23c	CLIP-seq
MIRT2257772	hsa-miR-3117-5p	CLIP-seq
MIRT1098062	hsa-miR-3120-3p	CLIP-seq
MIRT2558844	hsa-miR-3120-5p	CLIP-seq
MIRT2257773	hsa-miR-3125	CLIP-seq
MIRT2257774	hsa-miR-3129-3p	CLIP-seq
MIRT2026660	hsa-miR-3148	CLIP-seq
MIRT2257776	hsa-miR-3156-3p	CLIP-seq
MIRT1098063	hsa-miR-3168	CLIP-seq
MIRT2558845	hsa-miR-339-5p	CLIP-seq
MIRT2558846	hsa-miR-340	CLIP-seq
MIRT1098066	hsa-miR-3613-3p	CLIP-seq
MIRT2026661	hsa-miR-3613-5p	CLIP-seq
MIRT2558847	hsa-miR-3619-5p	CLIP-seq
MIRT2558848	hsa-miR-3622b-5p	CLIP-seq
MIRT2558849	hsa-miR-365	CLIP-seq
MIRT2257790	hsa-miR-3662	CLIP-seq
MIRT2558850	hsa-miR-3685	CLIP-seq
MIRT2026663	hsa-miR-376c	CLIP-seq
MIRT2558851	hsa-miR-384	CLIP-seq
MIRT2257799	hsa-miR-3916	CLIP-seq
MIRT1098071	hsa-miR-409-3p	CLIP-seq
MIRT2257803	hsa-miR-409-5p	CLIP-seq
MIRT2257807	hsa-miR-4274	CLIP-seq
MIRT2257811	hsa-miR-4301	CLIP-seq
MIRT1098074	hsa-miR-432	CLIP-seq
MIRT1098077	hsa-miR-4455	CLIP-seq
MIRT2026667	hsa-miR-4494	CLIP-seq
MIRT2558852	hsa-miR-4642	CLIP-seq
MIRT1098082	hsa-miR-4684-5p	CLIP-seq
MIRT2558853	hsa-miR-4688	CLIP-seq
MIRT2558854	hsa-miR-4690-5p	CLIP-seq
MIRT1922202	hsa-miR-4711-5p	CLIP-seq
MIRT2257837	hsa-miR-4719	CLIP-seq
MIRT2257840	hsa-miR-4732-5p	CLIP-seq
MIRT2558855	hsa-miR-4760-3p	CLIP-seq
MIRT2558856	hsa-miR-4773	CLIP-seq
MIRT2558857	hsa-miR-4777-5p	CLIP-seq
MIRT2558858	hsa-miR-4800-3p	CLIP-seq
MIRT2257855	hsa-miR-499a-5p	CLIP-seq
MIRT2257860	hsa-miR-5096	CLIP-seq
MIRT2026671	hsa-miR-513a-3p	CLIP-seq
MIRT1922204	hsa-miR-513b	CLIP-seq
MIRT2558859	hsa-miR-518d-5p	CLIP-seq
MIRT2558860	hsa-miR-519b-5p	CLIP-seq
MIRT2558861	hsa-miR-519c-5p	CLIP-seq
MIRT2558862	hsa-miR-520c-5p	CLIP-seq
MIRT2558863	hsa-miR-526a	CLIP-seq
MIRT2558864	hsa-miR-548aa	CLIP-seq
MIRT1098091	hsa-miR-548c-3p	CLIP-seq
MIRT2257873	hsa-miR-548m	CLIP-seq
MIRT2026675	hsa-miR-561	CLIP-seq
MIRT1098093	hsa-miR-564	CLIP-seq
MIRT2558865	hsa-miR-580	CLIP-seq
MIRT2558866	hsa-miR-600	CLIP-seq
MIRT2257888	hsa-miR-622	CLIP-seq
MIRT2558867	hsa-miR-626	CLIP-seq
MIRT2558868	hsa-miR-761	CLIP-seq
MIRT2257895	hsa-miR-877	CLIP-seq
MIRT2257896	hsa-miR-890	CLIP-seq
MIRT2257757	hsa-miR-1273	CLIP-seq
MIRT2026657	hsa-miR-136	CLIP-seq
MIRT1098053	hsa-miR-142-5p	CLIP-seq
MIRT1922198	hsa-miR-188-5p	CLIP-seq
MIRT2257765	hsa-miR-190	CLIP-seq
MIRT2558842	hsa-miR-1912	CLIP-seq
MIRT2558843	hsa-miR-214	CLIP-seq
MIRT1098057	hsa-miR-23a	CLIP-seq
MIRT1098058	hsa-miR-23b	CLIP-seq
MIRT1098059	hsa-miR-23c	CLIP-seq
MIRT2683577	hsa-miR-28-3p	CLIP-seq
MIRT2257772	hsa-miR-3117-5p	CLIP-seq
MIRT1098062	hsa-miR-3120-3p	CLIP-seq
MIRT2558844	hsa-miR-3120-5p	CLIP-seq
MIRT2683578	hsa-miR-3122	CLIP-seq
MIRT2257773	hsa-miR-3125	CLIP-seq
MIRT2026660	hsa-miR-3148	CLIP-seq
MIRT1098063	hsa-miR-3168	CLIP-seq
MIRT2558845	hsa-miR-339-5p	CLIP-seq
MIRT2558846	hsa-miR-340	CLIP-seq
MIRT2257785	hsa-miR-34b	CLIP-seq
MIRT1098066	hsa-miR-3613-3p	CLIP-seq
MIRT2026661	hsa-miR-3613-5p	CLIP-seq
MIRT2558847	hsa-miR-3619-5p	CLIP-seq
MIRT2558848	hsa-miR-3622b-5p	CLIP-seq
MIRT2558849	hsa-miR-365	CLIP-seq
MIRT2257790	hsa-miR-3662	CLIP-seq
MIRT1922199	hsa-miR-3667-5p	CLIP-seq
MIRT2558850	hsa-miR-3685	CLIP-seq
MIRT2257792	hsa-miR-3689a-3p	CLIP-seq
MIRT2257793	hsa-miR-3689c	CLIP-seq
MIRT2026663	hsa-miR-376c	CLIP-seq
MIRT2683579	hsa-miR-382	CLIP-seq
MIRT2558851	hsa-miR-384	CLIP-seq
MIRT2683580	hsa-miR-3913-5p	CLIP-seq
MIRT2257799	hsa-miR-3916	CLIP-seq
MIRT1098071	hsa-miR-409-3p	CLIP-seq
MIRT2257803	hsa-miR-409-5p	CLIP-seq
MIRT2257804	hsa-miR-4252	CLIP-seq
MIRT2683581	hsa-miR-431	CLIP-seq
MIRT1098076	hsa-miR-4423-5p	CLIP-seq
MIRT1098077	hsa-miR-4455	CLIP-seq
MIRT1922200	hsa-miR-4457	CLIP-seq
MIRT2257821	hsa-miR-4486	CLIP-seq
MIRT1922201	hsa-miR-451b	CLIP-seq
MIRT2558852	hsa-miR-4642	CLIP-seq
MIRT2257825	hsa-miR-4649-5p	CLIP-seq
MIRT1098082	hsa-miR-4684-5p	CLIP-seq
MIRT2558854	hsa-miR-4690-5p	CLIP-seq
MIRT1098084	hsa-miR-4696	CLIP-seq
MIRT1922202	hsa-miR-4711-5p	CLIP-seq
MIRT2257837	hsa-miR-4719	CLIP-seq
MIRT2257839	hsa-miR-4728-3p	CLIP-seq
MIRT2683582	hsa-miR-4728-5p	CLIP-seq
MIRT2257840	hsa-miR-4732-5p	CLIP-seq
MIRT2558855	hsa-miR-4760-3p	CLIP-seq
MIRT2558856	hsa-miR-4773	CLIP-seq
MIRT2558857	hsa-miR-4777-5p	CLIP-seq
MIRT2257852	hsa-miR-4793-3p	CLIP-seq
MIRT2558858	hsa-miR-4800-3p	CLIP-seq
MIRT2257857	hsa-miR-508-5p	CLIP-seq
MIRT2257860	hsa-miR-5096	CLIP-seq
MIRT2026670	hsa-miR-511	CLIP-seq
MIRT1922204	hsa-miR-513b	CLIP-seq
MIRT2558859	hsa-miR-518d-5p	CLIP-seq
MIRT2558860	hsa-miR-519b-5p	CLIP-seq
MIRT2558861	hsa-miR-519c-5p	CLIP-seq
MIRT2558862	hsa-miR-520c-5p	CLIP-seq
MIRT2558863	hsa-miR-526a	CLIP-seq
MIRT2026674	hsa-miR-526b	CLIP-seq
MIRT2683583	hsa-miR-541	CLIP-seq
MIRT2558864	hsa-miR-548aa	CLIP-seq
MIRT1098091	hsa-miR-548c-3p	CLIP-seq
MIRT2257873	hsa-miR-548m	CLIP-seq
MIRT2026675	hsa-miR-561	CLIP-seq
MIRT1098093	hsa-miR-564	CLIP-seq
MIRT2558865	hsa-miR-580	CLIP-seq
MIRT2558866	hsa-miR-600	CLIP-seq
MIRT2558867	hsa-miR-626	CLIP-seq
MIRT2683584	hsa-miR-654-5p	CLIP-seq
MIRT2257892	hsa-miR-661	CLIP-seq
MIRT2558868	hsa-miR-761	CLIP-seq
MIRT2257893	hsa-miR-766	CLIP-seq
MIRT2257895	hsa-miR-877	CLIP-seq
MIRT2257896	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27798626, 30190310, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	27889062
GO:0005737	Component	Cytoplasm	IEA
GO:0005912	Component	Adherens junction	IDA	27889062
GO:0005912	Component	Adherens junction	IEA
GO:0016567	Process	Protein ubiquitination	IDA	27798626
GO:0030057	Component	Desmosome	IDA	27889062
GO:0030057	Component	Desmosome	IEA
GO:0030424	Component	Axon	IEA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IBA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IMP	27798626
GO:0042995	Component	Cell projection	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043204	Component	Perikaryon	IEA
GO:0045109	Process	Intermediate filament organization	IMP	27889062
GO:0051865	Process	Protein autoubiquitination	IMP	27798626
GO:0070161	Component	Anchoring junction	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IBA

Other IDs

• MIM: 611295
• HGNC: 25947
• e!Ensembl: ENSG00000114796

Protein

• UniProt ID: Q6TFL4
• Protein name: Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)
• Protein function: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	56 → 163	BTB/POZ domain	Domain
  PF07707	BACK	168 → 270	BTB And C-terminal Kelch	Domain
  PF01344	Kelch_1	307 → 349	Kelch motif	Repeat
  PF01344	Kelch_1	353 → 394	Kelch motif	Repeat
  PF01344	Kelch_1	397 → 441	Kelch motif	Repeat
  PF01344	Kelch_1	443 → 483	Kelch motif	Repeat
  PF01344	Kelch_1	535 → 571	Kelch motif	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the skin (PubMed:27798626, PubMed:27889062). Found in keratinocytes, dermal fibroblasts, and melanocytes (PubMed:27889062). Basal-layer keratinocytes have lower KLHL24 expression than suprabasal keratinocytes (PubMed:27798
• Sequence:

  MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFR
  DSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECF
  LQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
  KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRA
  VDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMS
  PRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA
  LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR
  LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETN
  SWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMS
  VCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL
  

• Sequence length: 600

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Cardiomyopathy, familial hypertrophic, 29, with polyglucosan bodies	Pathogenic	rs2545651806, rs778943927	RCV003152371 RCV003152372	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Epidermolysis bullosa simplex 6, generalized, with scarring and hair loss	Pathogenic	rs886037957, rs886037956, rs1057515580	RCV000415529 RCV000415601 RCV000415556 RCV000415575 RCV001197323	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Epidermolysis bullosa simplex, Koebner type	Pathogenic	rs886037957, rs886037956, rs1057515580	RCV000258019 RCV000258008 RCV000258014 RCV000408918	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
KLHL24-related disorder	Pathogenic	rs886037956	RCV004758678	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARDIOMYOPATHIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathy	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPIDERMOLYSIS BULLOSA SIMPLEX	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPIDERMOLYSIS BULLOSA SIMPLEX 1B, GENERALIZED INTERMEDIATE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPIDERMOLYSIS BULLOSA SIMPLEX 6, GENERALIZED INTERMEDIATE, WITH OR WITHOUT CARDIOMYOPATHY	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertrophic cardiomyopathy	Uncertain significance	ClinVar CTD, ClinGen, Disgenet CTD, ClinGen, Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
INTERMEDIATE EPIDERMOLYSIS BULLOSA SIMPLEX WITH CARDIOMYOPATHY	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	34990474	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	30715372		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathies	Cardiomyopathy	Pubtator	34740256, 36672924	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	30579426, 35975634, 36672924	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Hypertrophic	Hypertrophic cardiomyopathy	Pubtator	36672924, 39971408	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Dilated	Cardiomyopathy	BEFREE	30579426		★☆☆☆☆ Found in Text Mining only
Congenital Heart Defects	Congenital heart defects	BEFREE	30715372		★☆☆☆☆ Found in Text Mining only
Epidermolysis Bullosa	Epidermolysis Bullosa	BEFREE	27798626		★☆☆☆☆ Found in Text Mining only
Epidermolysis Bullosa Simplex	Epidermolysis Bullosa Simplex	BEFREE	28532758, 29574966, 30579426		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epidermolysis Bullosa Simplex	Epidermolysis bullosa	Pubtator	30579426, 34740256, 35975634, 39317060	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epidermolysis Bullosa Simplex Kobner	Epidermolysis Bullosa	CLINVAR_DG	27798626, 27889062		★☆☆☆☆ Found in Text Mining only
EPIDERMOLYSIS BULLOSA SIMPLEX, GENERALIZED, WITH SCARRING AND HAIR LOSS	Epidermolysis Bullosa Simplex, With Scarring And Hair Loss	ORPHANET_DG	27798626, 27889062, 28532758, 29574966		★☆☆☆☆ Found in Text Mining only
EPIDERMOLYSIS BULLOSA SIMPLEX, GENERALIZED, WITH SCARRING AND HAIR LOSS	Epidermolysis Bullosa Simplex, With Scarring And Hair Loss	CLINGEN_DG	27798626, 27889062		★☆☆☆☆ Found in Text Mining only
EPIDERMOLYSIS BULLOSA SIMPLEX, GENERALIZED, WITH SCARRING AND HAIR LOSS	Epidermolysis Bullosa Simplex, With Scarring And Hair Loss	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
EPIDERMOLYSIS BULLOSA SIMPLEX, GENERALIZED, WITH SCARRING AND HAIR LOSS	Epidermolysis Bullosa Simplex, With Scarring And Hair Loss	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	30715372		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intermediate epidermolysis bullosa simplex with cardiomyopathy	Epidermolysis Bullosa Simplex With Cardiomyopathy	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Keratoderma, Palmoplantar, Diffuse	Palmoplantar keratoderma	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	32783661	Associate	★☆☆☆☆ Found in Text Mining only
Skin Abnormalities	Skin abnormalities	Pubtator	34740256	Associate	★☆☆☆☆ Found in Text Mining only