Gene Gene information from NCBI Gene database.
Entrez ID 54797
Gene name Mediator complex subunit 18
Gene symbol MED18
Synonyms (NCBI Gene)
SRB5p28b
Chromosome 1
Chromosome location 1p35.3
Summary MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
miRNA miRNA information provided by mirtarbase database.
362
miRTarBase ID miRNA Experiments Reference
MIRT037915 hsa-miR-532-3p CLASH 23622248
MIRT662928 hsa-miR-130a-3p HITS-CLIP 23824327
MIRT662927 hsa-miR-130b-3p HITS-CLIP 23824327
MIRT662926 hsa-miR-301a-3p HITS-CLIP 23824327
MIRT662925 hsa-miR-301b-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity IBA
GO:0003712 Function Transcription coregulator activity IEA
GO:0005515 Function Protein binding IPI 12584197, 14576168, 14638676, 15175163, 24882805, 24981860, 25281560, 25416956, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005634 Component Nucleus IDA 24882805
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612384 25944 ENSG00000130772
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BUE0
Protein name Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b)
Protein function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN
PDB 7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09637 Med18 19 207 Med18 protein Domain
Sequence
Sequence length 208
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
UTERINE FIBROID GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Aortic Aneurysm Aortic Aneurysm BEFREE 26820064
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 27464310
★☆☆☆☆
Found in Text Mining only
Cystic Fibrosis Cystic Fibrosis BEFREE 26656651
★☆☆☆☆
Found in Text Mining only
Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome BEFREE 26765342, 27011056
★☆☆☆☆
Found in Text Mining only
Fragile X Syndrome Fragile X Syndrome BEFREE 26741412
★☆☆☆☆
Found in Text Mining only
Gerstmann-Straussler-Scheinker Disease Gerstmann-Straussler-Scheinker syndrome BEFREE 26913919
★☆☆☆☆
Found in Text Mining only
Hereditary Malignant Neoplasm Hereditary cancer BEFREE 26681312
★☆☆☆☆
Found in Text Mining only
Intellectual Disability Mental retardation BEFREE 26181491
★☆☆☆☆
Found in Text Mining only
Leiomyoma Leiomyoma Pubtator 27889101 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 27464310
★☆☆☆☆
Found in Text Mining only