Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54793
Gene name	Potassium channel tetramerization domain containing 9
Gene symbol	KCTD9
Synonyms (NCBI Gene)	BTBD27
Chromosome	8
Chromosome location	8p21.2

106

Show/Hide all (106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029678	hsa-miR-26b-5p	Microarray	19088304
MIRT1083620	hsa-miR-105	CLIP-seq
MIRT1083621	hsa-miR-1184	CLIP-seq
MIRT1083622	hsa-miR-1205	CLIP-seq
MIRT1083623	hsa-miR-1229	CLIP-seq
MIRT1083624	hsa-miR-1237	CLIP-seq
MIRT1083625	hsa-miR-1248	CLIP-seq
MIRT1083626	hsa-miR-129-5p	CLIP-seq
MIRT1083627	hsa-miR-1321	CLIP-seq
MIRT1083628	hsa-miR-154	CLIP-seq
MIRT1083629	hsa-miR-218	CLIP-seq
MIRT1083630	hsa-miR-2467-3p	CLIP-seq
MIRT1083631	hsa-miR-3136-5p	CLIP-seq
MIRT1083632	hsa-miR-3158-5p	CLIP-seq
MIRT1083633	hsa-miR-3160-5p	CLIP-seq
MIRT1083634	hsa-miR-3161	CLIP-seq
MIRT1083635	hsa-miR-3162-5p	CLIP-seq
MIRT1083636	hsa-miR-3619-3p	CLIP-seq
MIRT1083637	hsa-miR-3667-3p	CLIP-seq
MIRT1083638	hsa-miR-3678-3p	CLIP-seq
MIRT1083639	hsa-miR-3942-3p	CLIP-seq
MIRT1083640	hsa-miR-4263	CLIP-seq
MIRT1083641	hsa-miR-4282	CLIP-seq
MIRT1083642	hsa-miR-4294	CLIP-seq
MIRT1083643	hsa-miR-432	CLIP-seq
MIRT1083644	hsa-miR-4328	CLIP-seq
MIRT1083645	hsa-miR-4439	CLIP-seq
MIRT1083646	hsa-miR-4513	CLIP-seq
MIRT1083647	hsa-miR-4535	CLIP-seq
MIRT1083648	hsa-miR-4668-3p	CLIP-seq
MIRT1083649	hsa-miR-4687-3p	CLIP-seq
MIRT1083650	hsa-miR-4691-5p	CLIP-seq
MIRT1083651	hsa-miR-4695-3p	CLIP-seq
MIRT1083652	hsa-miR-4716-5p	CLIP-seq
MIRT1083653	hsa-miR-4739	CLIP-seq
MIRT1083654	hsa-miR-4756-5p	CLIP-seq
MIRT1083655	hsa-miR-4760-5p	CLIP-seq
MIRT1083656	hsa-miR-4776-5p	CLIP-seq
MIRT1083657	hsa-miR-4781-3p	CLIP-seq
MIRT1083658	hsa-miR-485-3p	CLIP-seq
MIRT1083659	hsa-miR-532-5p	CLIP-seq
MIRT1083660	hsa-miR-544	CLIP-seq
MIRT1083661	hsa-miR-576-5p	CLIP-seq
MIRT1083662	hsa-miR-587	CLIP-seq
MIRT1083663	hsa-miR-628-5p	CLIP-seq
MIRT1083664	hsa-miR-636	CLIP-seq
MIRT1083665	hsa-miR-664	CLIP-seq
MIRT1083666	hsa-miR-766	CLIP-seq
MIRT1083667	hsa-miR-924	CLIP-seq
MIRT1550469	hsa-miR-22	CLIP-seq
MIRT1550470	hsa-miR-656	CLIP-seq
MIRT1083620	hsa-miR-105	CLIP-seq
MIRT1083621	hsa-miR-1184	CLIP-seq
MIRT1083622	hsa-miR-1205	CLIP-seq
MIRT1083624	hsa-miR-1237	CLIP-seq
MIRT1083625	hsa-miR-1248	CLIP-seq
MIRT2021096	hsa-miR-1279	CLIP-seq
MIRT1083626	hsa-miR-129-5p	CLIP-seq
MIRT2021097	hsa-miR-1323	CLIP-seq
MIRT2021098	hsa-miR-188-5p	CLIP-seq
MIRT2021099	hsa-miR-3132	CLIP-seq
MIRT2021100	hsa-miR-3137	CLIP-seq
MIRT1083632	hsa-miR-3158-5p	CLIP-seq
MIRT1083633	hsa-miR-3160-5p	CLIP-seq
MIRT2021101	hsa-miR-3170	CLIP-seq
MIRT2021102	hsa-miR-3647-3p	CLIP-seq
MIRT2021103	hsa-miR-371b-5p	CLIP-seq
MIRT1083639	hsa-miR-3942-3p	CLIP-seq
MIRT2021104	hsa-miR-4251	CLIP-seq
MIRT1083640	hsa-miR-4263	CLIP-seq
MIRT2021105	hsa-miR-4303	CLIP-seq
MIRT1083644	hsa-miR-4328	CLIP-seq
MIRT2021106	hsa-miR-4329	CLIP-seq
MIRT2021107	hsa-miR-448	CLIP-seq
MIRT2021108	hsa-miR-4524	CLIP-seq
MIRT2021109	hsa-miR-4650-3p	CLIP-seq
MIRT1083648	hsa-miR-4668-3p	CLIP-seq
MIRT2021110	hsa-miR-4690-5p	CLIP-seq
MIRT1083650	hsa-miR-4691-5p	CLIP-seq
MIRT1083652	hsa-miR-4716-5p	CLIP-seq
MIRT2021111	hsa-miR-4742-5p	CLIP-seq
MIRT2021112	hsa-miR-4797-5p	CLIP-seq
MIRT2021113	hsa-miR-500a	CLIP-seq
MIRT2021114	hsa-miR-532-3p	CLIP-seq
MIRT2021115	hsa-miR-539	CLIP-seq
MIRT1083660	hsa-miR-544	CLIP-seq
MIRT2021116	hsa-miR-548o	CLIP-seq
MIRT1083661	hsa-miR-576-5p	CLIP-seq
MIRT2021117	hsa-miR-579	CLIP-seq
MIRT2021118	hsa-miR-618	CLIP-seq
MIRT2021119	hsa-miR-627	CLIP-seq
MIRT2021120	hsa-miR-635	CLIP-seq
MIRT2021121	hsa-miR-888	CLIP-seq
MIRT2021122	hsa-miR-889	CLIP-seq
MIRT1083667	hsa-miR-924	CLIP-seq
MIRT1083626	hsa-miR-129-5p	CLIP-seq
MIRT2252724	hsa-miR-4481	CLIP-seq
MIRT2252725	hsa-miR-4745-5p	CLIP-seq
MIRT2555799	hsa-miR-1587	CLIP-seq
MIRT2021102	hsa-miR-3647-3p	CLIP-seq
MIRT1083641	hsa-miR-4282	CLIP-seq
MIRT2555800	hsa-miR-4674	CLIP-seq
MIRT2555799	hsa-miR-1587	CLIP-seq
MIRT2021102	hsa-miR-3647-3p	CLIP-seq
MIRT1083641	hsa-miR-4282	CLIP-seq
MIRT2555800	hsa-miR-4674	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21145461, 25416956, 26334369, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0016567	Process	Protein ubiquitination	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042802	Function	Identical protein binding	IPI	21516116, 32296183
GO:0051260	Process	Protein homooligomerization	IEA
GO:0097602	Function	Cullin family protein binding	IDA	26334369

MIM	HGNC	e!Ensembl
617265	22401	ENSG00000104756

Q7L273

Protein name

BTB/POZ domain-containing protein KCTD9

Protein function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.

PDB

5BXH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11834	KHA	2 → 64	KHA, dimerisation domain of potassium ion channel	Family
PF02214	BTB_2	91 → 184	BTB/POZ domain	Domain
PF00805	Pentapeptide	224 → 257	Pentapeptide repeats (8 copies)	Repeat
PF00805	Pentapeptide	258 → 297	Pentapeptide repeats (8 copies)	Repeat
PF00805	Pentapeptide	303 → 342	Pentapeptide repeats (8 copies)	Repeat
PF00805	Pentapeptide	338 → 376	Pentapeptide repeats (8 copies)	Repeat

Sequence

MRRVTLFLNGSPKNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDD
VLFVCEGEPFIDPQTDSKPPEGLLGFHTDWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMF
KDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLEEARFFGIDSL
IEHLEVAIKNSQPPEDHSPISRKEFVRFLLATPTKSELRCQGLNFSGADLSRLDLRYINF
KMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASLKLCNFEDPSG
LKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDL
QEANLRGSNVKGAIFEEMLTPLHMSQSVR

Sequence length

389

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36055981	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37158531	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Complete atrioventricular block	Complete Atrioventricular Block	BEFREE	23376586		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fulminant hepatitis	Fulminant Hepatitis	BEFREE	29940856, 31024568		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure, Acute	Liver failure	BEFREE	29940856		★★★★★ ★☆☆☆☆ Found in Text Mining only

KCTD9 (potassium channel tetramerization domain containing 9)