Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54769
Gene name	DIRAS family GTPase 2
Gene symbol	DIRAS2
Synonyms (NCBI Gene)	Di-Ras2
Chromosome	9
Chromosome location	9q22.2
Summary	DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

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Show/Hide all (220)

miRTarBase ID	miRNA	Experiments	Reference
MIRT512059	hsa-miR-8485	PAR-CLIP	20371350
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT512057	hsa-miR-6134	PAR-CLIP	20371350
MIRT512056	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT512054	hsa-miR-5698	PAR-CLIP	20371350
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT512050	hsa-miR-4525	PAR-CLIP	20371350
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT512049	hsa-miR-1294	PAR-CLIP	20371350
MIRT512048	hsa-miR-1275	PAR-CLIP	20371350
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT512059	hsa-miR-8485	PAR-CLIP	20371350
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT512057	hsa-miR-6134	PAR-CLIP	20371350
MIRT512056	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT512054	hsa-miR-5698	PAR-CLIP	20371350
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT512050	hsa-miR-4525	PAR-CLIP	20371350
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT512049	hsa-miR-1294	PAR-CLIP	20371350
MIRT512048	hsa-miR-1275	PAR-CLIP	20371350
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT512059	hsa-miR-8485	PAR-CLIP	23446348
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT512057	hsa-miR-6134	PAR-CLIP	23446348
MIRT512056	hsa-miR-625-5p	PAR-CLIP	23446348
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	23446348
MIRT512054	hsa-miR-5698	PAR-CLIP	23446348
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	23446348
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	23446348
MIRT512050	hsa-miR-4525	PAR-CLIP	23446348
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	23446348
MIRT512049	hsa-miR-1294	PAR-CLIP	23446348
MIRT512048	hsa-miR-1275	PAR-CLIP	23446348
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	23446348
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	23446348
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	23446348
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	23446348
MIRT512059	hsa-miR-8485	PAR-CLIP	23446348
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT512057	hsa-miR-6134	PAR-CLIP	23446348
MIRT512056	hsa-miR-625-5p	PAR-CLIP	23446348
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	23446348
MIRT512054	hsa-miR-5698	PAR-CLIP	23446348
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	23446348
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	23446348
MIRT512050	hsa-miR-4525	PAR-CLIP	23446348
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	23446348
MIRT512049	hsa-miR-1294	PAR-CLIP	23446348
MIRT512048	hsa-miR-1275	PAR-CLIP	23446348
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	23446348
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	23446348
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	23446348
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	23446348
MIRT497372	hsa-miR-548a-3p	PAR-CLIP	22291592
MIRT497371	hsa-miR-548ar-3p	PAR-CLIP	22291592
MIRT497370	hsa-miR-548az-3p	PAR-CLIP	22291592
MIRT497369	hsa-miR-548e-3p	PAR-CLIP	22291592
MIRT497368	hsa-miR-548f-3p	PAR-CLIP	22291592
MIRT497367	hsa-miR-5582-3p	PAR-CLIP	22291592
MIRT512059	hsa-miR-8485	PAR-CLIP	20371350
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT512057	hsa-miR-6134	PAR-CLIP	20371350
MIRT512056	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT512054	hsa-miR-5698	PAR-CLIP	20371350
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT512050	hsa-miR-4525	PAR-CLIP	20371350
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT512049	hsa-miR-1294	PAR-CLIP	20371350
MIRT512048	hsa-miR-1275	PAR-CLIP	20371350
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT512059	hsa-miR-8485	PAR-CLIP	20371350
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	20371350
MIRT512057	hsa-miR-6134	PAR-CLIP	20371350
MIRT512056	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT512054	hsa-miR-5698	PAR-CLIP	20371350
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT512050	hsa-miR-4525	PAR-CLIP	20371350
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT512049	hsa-miR-1294	PAR-CLIP	20371350
MIRT512048	hsa-miR-1275	PAR-CLIP	20371350
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT512059	hsa-miR-8485	PAR-CLIP	23446348
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT512057	hsa-miR-6134	PAR-CLIP	23446348
MIRT512056	hsa-miR-625-5p	PAR-CLIP	23446348
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	23446348
MIRT512054	hsa-miR-5698	PAR-CLIP	23446348
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	23446348
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	23446348
MIRT512050	hsa-miR-4525	PAR-CLIP	23446348
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	23446348
MIRT512049	hsa-miR-1294	PAR-CLIP	23446348
MIRT512048	hsa-miR-1275	PAR-CLIP	23446348
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	23446348
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	23446348
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	23446348
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	23446348
MIRT512059	hsa-miR-8485	PAR-CLIP	23446348
MIRT512058	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT512057	hsa-miR-6134	PAR-CLIP	23446348
MIRT512056	hsa-miR-625-5p	PAR-CLIP	23446348
MIRT512055	hsa-miR-4723-5p	PAR-CLIP	23446348
MIRT512054	hsa-miR-5698	PAR-CLIP	23446348
MIRT512053	hsa-miR-6870-5p	PAR-CLIP	23446348
MIRT512052	hsa-miR-7111-5p	PAR-CLIP	23446348
MIRT512050	hsa-miR-4525	PAR-CLIP	23446348
MIRT512051	hsa-miR-5010-5p	PAR-CLIP	23446348
MIRT512049	hsa-miR-1294	PAR-CLIP	23446348
MIRT512048	hsa-miR-1275	PAR-CLIP	23446348
MIRT512047	hsa-miR-4665-5p	PAR-CLIP	23446348
MIRT512046	hsa-miR-7109-5p	PAR-CLIP	23446348
MIRT512045	hsa-miR-6751-5p	PAR-CLIP	23446348
MIRT512044	hsa-miR-6803-5p	PAR-CLIP	23446348
MIRT497372	hsa-miR-548a-3p	PAR-CLIP	22291592
MIRT497371	hsa-miR-548ar-3p	PAR-CLIP	22291592
MIRT497370	hsa-miR-548az-3p	PAR-CLIP	22291592
MIRT497369	hsa-miR-548e-3p	PAR-CLIP	22291592
MIRT497368	hsa-miR-548f-3p	PAR-CLIP	22291592
MIRT497367	hsa-miR-5582-3p	PAR-CLIP	22291592
MIRT936992	hsa-miR-1193	CLIP-seq
MIRT936993	hsa-miR-1206	CLIP-seq
MIRT936994	hsa-miR-1287	CLIP-seq
MIRT936995	hsa-miR-302f	CLIP-seq
MIRT936996	hsa-miR-3117-5p	CLIP-seq
MIRT936997	hsa-miR-3145-3p	CLIP-seq
MIRT936998	hsa-miR-3180-5p	CLIP-seq
MIRT936999	hsa-miR-3182	CLIP-seq
MIRT937000	hsa-miR-3184	CLIP-seq
MIRT937001	hsa-miR-3659	CLIP-seq
MIRT937002	hsa-miR-3674	CLIP-seq
MIRT937003	hsa-miR-3689a-3p	CLIP-seq
MIRT937004	hsa-miR-3689c	CLIP-seq
MIRT937005	hsa-miR-3935	CLIP-seq
MIRT937006	hsa-miR-3943	CLIP-seq
MIRT937007	hsa-miR-3973	CLIP-seq
MIRT937008	hsa-miR-423-5p	CLIP-seq
MIRT937009	hsa-miR-4283	CLIP-seq
MIRT937010	hsa-miR-4291	CLIP-seq
MIRT937011	hsa-miR-4424	CLIP-seq
MIRT937012	hsa-miR-4437	CLIP-seq
MIRT937013	hsa-miR-4494	CLIP-seq
MIRT937014	hsa-miR-4534	CLIP-seq
MIRT937015	hsa-miR-4652-3p	CLIP-seq
MIRT937016	hsa-miR-4658	CLIP-seq
MIRT937017	hsa-miR-4663	CLIP-seq
MIRT937018	hsa-miR-4715-3p	CLIP-seq
MIRT937019	hsa-miR-4728-3p	CLIP-seq
MIRT937020	hsa-miR-4779	CLIP-seq
MIRT937021	hsa-miR-4786-5p	CLIP-seq
MIRT937022	hsa-miR-4802-5p	CLIP-seq
MIRT937023	hsa-miR-499a-5p	CLIP-seq
MIRT937024	hsa-miR-5096	CLIP-seq
MIRT937025	hsa-miR-520a-5p	CLIP-seq
MIRT937026	hsa-miR-520g	CLIP-seq
MIRT937027	hsa-miR-520h	CLIP-seq
MIRT937028	hsa-miR-525-5p	CLIP-seq
MIRT937029	hsa-miR-545	CLIP-seq
MIRT937030	hsa-miR-548l	CLIP-seq
MIRT937031	hsa-miR-574-5p	CLIP-seq
MIRT937032	hsa-miR-607	CLIP-seq
MIRT937033	hsa-miR-628-5p	CLIP-seq
MIRT937034	hsa-miR-765	CLIP-seq
MIRT1547974	hsa-miR-4496	CLIP-seq
MIRT1977415	hsa-miR-1236	CLIP-seq
MIRT1977416	hsa-miR-137	CLIP-seq
MIRT936999	hsa-miR-3182	CLIP-seq
MIRT937026	hsa-miR-520g	CLIP-seq
MIRT937027	hsa-miR-520h	CLIP-seq
MIRT1977416	hsa-miR-137	CLIP-seq
MIRT2212680	hsa-miR-200b	CLIP-seq
MIRT2212681	hsa-miR-200c	CLIP-seq
MIRT936997	hsa-miR-3145-3p	CLIP-seq
MIRT936998	hsa-miR-3180-5p	CLIP-seq
MIRT2212682	hsa-miR-323-3p	CLIP-seq
MIRT937002	hsa-miR-3674	CLIP-seq
MIRT2212683	hsa-miR-3691-3p	CLIP-seq
MIRT2212684	hsa-miR-374c	CLIP-seq
MIRT937005	hsa-miR-3935	CLIP-seq
MIRT2212685	hsa-miR-4268	CLIP-seq
MIRT2212686	hsa-miR-429	CLIP-seq
MIRT2212687	hsa-miR-4307	CLIP-seq
MIRT2212688	hsa-miR-4448	CLIP-seq
MIRT2212689	hsa-miR-4480	CLIP-seq
MIRT937025	hsa-miR-520a-5p	CLIP-seq
MIRT2212690	hsa-miR-520d-5p	CLIP-seq
MIRT2212691	hsa-miR-524-5p	CLIP-seq
MIRT937028	hsa-miR-525-5p	CLIP-seq
MIRT2212692	hsa-miR-655	CLIP-seq
MIRT2212693	hsa-miR-873	CLIP-seq
MIRT2386913	hsa-miR-4786-3p	CLIP-seq
MIRT2212693	hsa-miR-873	CLIP-seq
MIRT2448268	hsa-miR-1253	CLIP-seq
MIRT2448269	hsa-miR-3148	CLIP-seq
MIRT2448270	hsa-miR-432	CLIP-seq
MIRT2448271	hsa-miR-4443	CLIP-seq
MIRT2448272	hsa-miR-548aa	CLIP-seq
MIRT937034	hsa-miR-765	CLIP-seq
MIRT2212685	hsa-miR-4268	CLIP-seq
MIRT2212688	hsa-miR-4448	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	12194967
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IDA	12194967
GO:0005525	Function	GTP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12194967
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019003	Function	GDP binding	IBA
GO:0043406	Process	Positive regulation of MAP kinase activity	IDA	12194967

MIM	HGNC	e!Ensembl
607863	19323	ENSG00000165023

Q96HU8

Protein name

GTP-binding protein Di-Ras2 (EC 3.6.5.-) (Distinct subgroup of the Ras family member 2)

Protein function

Displays low GTPase activity and exists predominantly in the GTP-bound form.

PDB

2ERX , 6NAZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	9 → 171	Ras family	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain. {ECO:0000269|PubMed:12194967}.

Sequence

MPEQSNDYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQIT
DTTGSHQFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVG
NKCDESPSREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDG
KKSKQQKRKEKLKGKCVIM

Sequence length

199

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BLADDER EXSTROPHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	21750579, 27364329	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	BEFREE	21750579, 27364329, 29488099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	21750579	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36407085	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35173535	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Disruptive Impulse Control and Conduct Disorders	Disruptive, impulse control, and conduct disorders	Pubtator	21750579	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	21750579	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DIRAS2 (DIRAS family GTPase 2)