KLHDC4 (kelch domain containing 4)

Gene

• Entrez ID: 54758
• Gene name: Kelch domain containing 4
• Gene symbol: KLHDC4
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16q24.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023572	hsa-miR-1-3p	Microarray	18668037
MIRT713966	hsa-miR-335-5p	HITS-CLIP	19536157
MIRT713965	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT713964	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT713963	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT713962	hsa-miR-505-3p	HITS-CLIP	19536157
MIRT713961	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT713966	hsa-miR-335-5p	HITS-CLIP	19536157
MIRT713965	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT713964	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT713963	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT713962	hsa-miR-505-3p	HITS-CLIP	19536157
MIRT713961	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT1097167	hsa-miR-1228	CLIP-seq
MIRT1097168	hsa-miR-1825	CLIP-seq
MIRT1097169	hsa-miR-3176	CLIP-seq
MIRT1097170	hsa-miR-335	CLIP-seq
MIRT1097171	hsa-miR-3620	CLIP-seq
MIRT1097172	hsa-miR-3648	CLIP-seq
MIRT1097173	hsa-miR-371-3p	CLIP-seq
MIRT1097174	hsa-miR-377	CLIP-seq
MIRT1097175	hsa-miR-3919	CLIP-seq
MIRT1097176	hsa-miR-3922-3p	CLIP-seq
MIRT1097177	hsa-miR-4640-5p	CLIP-seq
MIRT1097178	hsa-miR-4726-5p	CLIP-seq
MIRT1097179	hsa-miR-4756-3p	CLIP-seq
MIRT1097180	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950, 23455924, 25416956, 32814053

Other IDs

• MIM: 620518
• HGNC: 25272
• e!Ensembl: ENSG00000104731

Protein

• UniProt ID: Q8TBB5
• Protein name: Kelch domain-containing protein 4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13418	Kelch_4	63 → 117		Repeat
  PF13415	Kelch_3	131 → 184		Domain
  PF07646	Kelch_2	231 → 290	Kelch motif	Repeat
  PF07646	Kelch_2	295 → 349	Kelch motif	Repeat

• Sequence:

  MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPP
  PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRC
  AHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGH
  RMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTP
  QGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFS
  VAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRG
  RKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLE
  EAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEM
  DPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED

• Sequence length: 520

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	27030985		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	39706520	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27030985		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37340842	Associate	★☆☆☆☆ Found in Text Mining only