Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54707
Gene name	GPN-loop GTPase 2
Gene symbol	GPN2
Synonyms (NCBI Gene)	ATPBD1B
Chromosome	1
Chromosome location	1p36.11

121

Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050572	hsa-miR-20a-5p	CLASH	23622248
MIRT688030	hsa-miR-562	HITS-CLIP	23313552
MIRT688029	hsa-miR-552-3p	HITS-CLIP	23313552
MIRT688028	hsa-miR-5697	HITS-CLIP	23313552
MIRT688027	hsa-miR-6814-5p	HITS-CLIP	23313552
MIRT688026	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT688025	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT688024	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT688023	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT688022	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT516011	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT516010	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT516009	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT516000	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516008	hsa-miR-4307	PAR-CLIP	23446348
MIRT516007	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT516006	hsa-miR-1914-3p	PAR-CLIP	23446348
MIRT516005	hsa-miR-5194	PAR-CLIP	23446348
MIRT516004	hsa-miR-6738-5p	PAR-CLIP	23446348
MIRT516003	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT516002	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516001	hsa-miR-4775	PAR-CLIP	23446348
MIRT516000	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT515999	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT515998	hsa-miR-5096	PAR-CLIP	23446348
MIRT688026	hsa-miR-4722-3p	PAR-CLIP	27292025
MIRT688025	hsa-miR-6727-3p	PAR-CLIP	27292025
MIRT688024	hsa-miR-6747-3p	PAR-CLIP	27292025
MIRT688022	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT688030	hsa-miR-562	HITS-CLIP	23313552
MIRT688029	hsa-miR-552-3p	HITS-CLIP	23313552
MIRT688028	hsa-miR-5697	HITS-CLIP	23313552
MIRT688027	hsa-miR-6814-5p	HITS-CLIP	23313552
MIRT688026	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT688025	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT688024	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT688023	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT688022	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT516011	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT516010	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT516009	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT516000	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516008	hsa-miR-4307	PAR-CLIP	23446348
MIRT516007	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT516006	hsa-miR-1914-3p	PAR-CLIP	23446348
MIRT516005	hsa-miR-5194	PAR-CLIP	23446348
MIRT516004	hsa-miR-6738-5p	PAR-CLIP	23446348
MIRT516003	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT516002	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516001	hsa-miR-4775	PAR-CLIP	23446348
MIRT516000	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT515999	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT515998	hsa-miR-5096	PAR-CLIP	23446348
MIRT1920465	hsa-miR-4293	CLIP-seq
MIRT2005501	hsa-miR-1825	CLIP-seq
MIRT1920465	hsa-miR-4293	CLIP-seq
MIRT2005501	hsa-miR-1825	CLIP-seq
MIRT2238139	hsa-miR-4433	CLIP-seq
MIRT2238140	hsa-miR-4436b-5p	CLIP-seq
MIRT2238141	hsa-miR-4459	CLIP-seq
MIRT2238142	hsa-miR-4711-5p	CLIP-seq
MIRT2238143	hsa-miR-4768-3p	CLIP-seq
MIRT2238144	hsa-miR-596	CLIP-seq
MIRT2542097	hsa-miR-1184	CLIP-seq
MIRT2542098	hsa-miR-1205	CLIP-seq
MIRT2542099	hsa-miR-1231	CLIP-seq
MIRT2542100	hsa-miR-1271	CLIP-seq
MIRT2542101	hsa-miR-144	CLIP-seq
MIRT2542102	hsa-miR-149	CLIP-seq
MIRT2542103	hsa-miR-193a-5p	CLIP-seq
MIRT2542104	hsa-miR-3064-5p	CLIP-seq
MIRT2542105	hsa-miR-3119	CLIP-seq
MIRT2542106	hsa-miR-3121-5p	CLIP-seq
MIRT2542107	hsa-miR-3158-5p	CLIP-seq
MIRT2542108	hsa-miR-3187-3p	CLIP-seq
MIRT2542109	hsa-miR-3675-5p	CLIP-seq
MIRT2542110	hsa-miR-3678-3p	CLIP-seq
MIRT2542111	hsa-miR-4435	CLIP-seq
MIRT2542112	hsa-miR-4527	CLIP-seq
MIRT2542113	hsa-miR-4645-3p	CLIP-seq
MIRT2542114	hsa-miR-4701-5p	CLIP-seq
MIRT2238142	hsa-miR-4711-5p	CLIP-seq
MIRT2542115	hsa-miR-4794	CLIP-seq
MIRT2542116	hsa-miR-548s	CLIP-seq
MIRT2542117	hsa-miR-588	CLIP-seq
MIRT2238144	hsa-miR-596	CLIP-seq
MIRT2542118	hsa-miR-609	CLIP-seq
MIRT2542119	hsa-miR-635	CLIP-seq
MIRT2542120	hsa-miR-654-3p	CLIP-seq
MIRT2542121	hsa-miR-767-5p	CLIP-seq
MIRT2542122	hsa-miR-96	CLIP-seq
MIRT2681978	hsa-miR-1202	CLIP-seq
MIRT2542099	hsa-miR-1231	CLIP-seq
MIRT2542100	hsa-miR-1271	CLIP-seq
MIRT2542101	hsa-miR-144	CLIP-seq
MIRT2542102	hsa-miR-149	CLIP-seq
MIRT2681979	hsa-miR-2467-3p	CLIP-seq
MIRT2542104	hsa-miR-3064-5p	CLIP-seq
MIRT2542105	hsa-miR-3119	CLIP-seq
MIRT2542106	hsa-miR-3121-5p	CLIP-seq
MIRT2681980	hsa-miR-3127-3p	CLIP-seq
MIRT2681981	hsa-miR-3160-3p	CLIP-seq
MIRT2542108	hsa-miR-3187-3p	CLIP-seq
MIRT2681982	hsa-miR-3194-5p	CLIP-seq
MIRT2542109	hsa-miR-3675-5p	CLIP-seq
MIRT2542110	hsa-miR-3678-3p	CLIP-seq
MIRT2681983	hsa-miR-3972	CLIP-seq
MIRT2681984	hsa-miR-4258	CLIP-seq
MIRT2681985	hsa-miR-4267	CLIP-seq
MIRT2681986	hsa-miR-4427	CLIP-seq
MIRT2542111	hsa-miR-4435	CLIP-seq
MIRT2542113	hsa-miR-4645-3p	CLIP-seq
MIRT2542114	hsa-miR-4701-5p	CLIP-seq
MIRT2681987	hsa-miR-4707-3p	CLIP-seq
MIRT2542115	hsa-miR-4794	CLIP-seq
MIRT2542116	hsa-miR-548s	CLIP-seq
MIRT2542117	hsa-miR-588	CLIP-seq
MIRT2542118	hsa-miR-609	CLIP-seq
MIRT2542120	hsa-miR-654-3p	CLIP-seq
MIRT2542121	hsa-miR-767-5p	CLIP-seq
MIRT2542122	hsa-miR-96	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 32814053, 33961781
GO:0005525	Function	GTP binding	IEA
GO:0016787	Function	Hydrolase activity	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9H9Y4

Protein name

GPN-loop GTPase 2 (ATP-binding domain 1 family member B)

Protein function

Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03029	ATP_bind_1	14 → 261	Conserved hypothetical ATP binding protein	Domain

Sequence

MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDV
GELVGLGDVMDALRLGPNGGLLYCMEYLEANLDWLRAKLDPLRGHYFLFDCPGQVELCTH
HGALRSIFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHINLLSKM
DLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPL
NIQDKESIQRVLQAVDKANGYCFRAQEQRSLEAMMSAAMGADFHFSSTLGIQEKYLAPSN
QSVEQEAMQL

Sequence length

310

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PERRAULT SYNDROME 1	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

GPN2 (GPN-loop GTPase 2)