Gene Gene information from NCBI Gene database.
Entrez ID 54700
Gene name RNA polymerase I transcription factor RRN3
Gene symbol RRN3
Synonyms (NCBI Gene)
A-270G1.2TIFIA
Chromosome 16
Chromosome location 16p13.11
miRNA miRNA information provided by mirtarbase database.
546
miRTarBase ID miRNA Experiments Reference
MIRT028106 hsa-miR-93-5p Sequencing 20371350
MIRT045801 hsa-miR-191-5p CLASH 23622248
MIRT554563 hsa-miR-3609 PAR-CLIP 21572407
MIRT554562 hsa-miR-548ah-5p PAR-CLIP 21572407
MIRT554561 hsa-miR-106a-5p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0001042 Function RNA polymerase I core binding IBA
GO:0001164 Function RNA polymerase I core promoter sequence-specific DNA binding IDA 22368283
GO:0001181 Function RNA polymerase I general transcription initiation factor activity IBA
GO:0001181 Function RNA polymerase I general transcription initiation factor activity IDA 11250903
GO:0001181 Function RNA polymerase I general transcription initiation factor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605121 30346 ENSG00000085721
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NYV6
Protein name RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA)
Protein function Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:112
PDB 7OBA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05327 RRN3 50 586 RNA polymerase I specific transcription initiation factor RRN3 Family
Sequence
Sequence length 651
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 27485818
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 27485818 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 27641688
★☆☆☆☆
Found in Text Mining only
Gallbladder Carcinoma Gallbladder cancer BEFREE 31752867
★☆☆☆☆
Found in Text Mining only
Gallbladder Neoplasms Gallbladder neoplasm Pubtator 31752867 Associate
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Myeloid leukemia Pubtator 24850755 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 27485818
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of gallbladder Gallbladder cancer BEFREE 31752867
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 27641688
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 26506235
★☆☆☆☆
Found in Text Mining only