MANSC1 (MANSC domain containing 1)

Gene

• Entrez ID: 54682
• Gene name: MANSC domain containing 1
• Gene symbol: MANSC1
• Synonyms (NCBI Gene): 9130403P13Rik, LOH12CR3
• Chromosome: 12
• Chromosome location: 12p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017570	hsa-miR-335-5p	Microarray	18185580
MIRT029238	hsa-miR-26b-5p	Microarray	19088304
MIRT052298	hsa-let-7b-5p	CLASH	23622248
MIRT661441	hsa-miR-4779	HITS-CLIP	23313552
MIRT689952	hsa-miR-34c-3p	HITS-CLIP	23313552
MIRT689951	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT689950	hsa-miR-151a-5p	HITS-CLIP	23313552
MIRT689949	hsa-miR-151b	HITS-CLIP	23313552
MIRT689948	hsa-miR-6089	HITS-CLIP	23313552
MIRT689947	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT689946	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT689945	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT689944	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT689943	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT689942	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT689941	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT689940	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT689939	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT689938	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT689937	hsa-miR-6745	HITS-CLIP	23313552
MIRT689936	hsa-miR-3165	HITS-CLIP	23313552
MIRT689935	hsa-miR-7977	HITS-CLIP	23313552
MIRT689934	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT689933	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT689932	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT689931	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689930	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689929	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689928	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689927	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689926	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689925	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689924	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689923	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689922	hsa-miR-3122	HITS-CLIP	23313552
MIRT689921	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689920	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689919	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT661443	hsa-miR-374c-3p	HITS-CLIP	23824327
MIRT661442	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT661441	hsa-miR-4779	HITS-CLIP	23824327
MIRT661440	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT661439	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT661438	hsa-miR-940	HITS-CLIP	23824327
MIRT661437	hsa-miR-3929	HITS-CLIP	23824327
MIRT661436	hsa-miR-4419b	HITS-CLIP	23824327
MIRT661435	hsa-miR-4478	HITS-CLIP	23824327
MIRT661434	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT661433	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT661432	hsa-miR-1827	HITS-CLIP	23824327
MIRT661431	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT661430	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT661429	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT661428	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT661427	hsa-miR-4266	HITS-CLIP	23824327
MIRT661426	hsa-miR-1273e	HITS-CLIP	23824327
MIRT661425	hsa-miR-665	HITS-CLIP	23824327
MIRT661441	hsa-miR-4779	HITS-CLIP	23313552
MIRT689952	hsa-miR-34c-3p	HITS-CLIP	23313552
MIRT689951	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT689950	hsa-miR-151a-5p	HITS-CLIP	23313552
MIRT689949	hsa-miR-151b	HITS-CLIP	23313552
MIRT689948	hsa-miR-6089	HITS-CLIP	23313552
MIRT689947	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT689946	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT689945	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT689944	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT689943	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT689942	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT689941	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT689940	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT689939	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT689938	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT689937	hsa-miR-6745	HITS-CLIP	23313552
MIRT689936	hsa-miR-3165	HITS-CLIP	23313552
MIRT689935	hsa-miR-7977	HITS-CLIP	23313552
MIRT689934	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT689933	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT689932	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT689931	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689930	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689929	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689928	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689927	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689926	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689925	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689924	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689923	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689922	hsa-miR-3122	HITS-CLIP	23313552
MIRT689921	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689920	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689919	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT661443	hsa-miR-374c-3p	HITS-CLIP	23824327
MIRT661442	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT661441	hsa-miR-4779	HITS-CLIP	23824327
MIRT661440	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT661439	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT661438	hsa-miR-940	HITS-CLIP	23824327
MIRT661437	hsa-miR-3929	HITS-CLIP	23824327
MIRT661436	hsa-miR-4419b	HITS-CLIP	23824327
MIRT661435	hsa-miR-4478	HITS-CLIP	23824327
MIRT661434	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT661433	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT661432	hsa-miR-1827	HITS-CLIP	23824327
MIRT661431	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT661430	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT661429	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT661428	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT661427	hsa-miR-4266	HITS-CLIP	23824327
MIRT661426	hsa-miR-1273e	HITS-CLIP	23824327
MIRT661425	hsa-miR-665	HITS-CLIP	23824327
MIRT1127553	hsa-miR-3120-5p	CLIP-seq
MIRT1127554	hsa-miR-3613-3p	CLIP-seq
MIRT1127555	hsa-miR-3664-5p	CLIP-seq
MIRT1127556	hsa-miR-3934	CLIP-seq
MIRT1127557	hsa-miR-4293	CLIP-seq
MIRT1127558	hsa-miR-4432	CLIP-seq
MIRT1127559	hsa-miR-451b	CLIP-seq
MIRT1127560	hsa-miR-4522	CLIP-seq
MIRT1127561	hsa-miR-4684-5p	CLIP-seq
MIRT1127562	hsa-miR-4696	CLIP-seq
MIRT1127563	hsa-miR-4726-3p	CLIP-seq
MIRT1127564	hsa-miR-4786-5p	CLIP-seq
MIRT1127565	hsa-miR-515-5p	CLIP-seq
MIRT1127566	hsa-miR-548c-3p	CLIP-seq
MIRT1127567	hsa-miR-769-5p	CLIP-seq
MIRT1127568	hsa-miR-885-5p	CLIP-seq
MIRT2036129	hsa-miR-1237	CLIP-seq
MIRT2036130	hsa-miR-1248	CLIP-seq
MIRT2036131	hsa-miR-1285	CLIP-seq
MIRT2036132	hsa-miR-3065-5p	CLIP-seq
MIRT2036133	hsa-miR-3154	CLIP-seq
MIRT2036134	hsa-miR-3179	CLIP-seq
MIRT2036135	hsa-miR-3187-5p	CLIP-seq
MIRT2036136	hsa-miR-330-3p	CLIP-seq
MIRT1127554	hsa-miR-3613-3p	CLIP-seq
MIRT2036137	hsa-miR-371-5p	CLIP-seq
MIRT2036138	hsa-miR-371b-5p	CLIP-seq
MIRT2036139	hsa-miR-4640-5p	CLIP-seq
MIRT2036140	hsa-miR-4726-5p	CLIP-seq
MIRT2036141	hsa-miR-4746-3p	CLIP-seq
MIRT2036142	hsa-miR-4793-3p	CLIP-seq
MIRT2036143	hsa-miR-4803	CLIP-seq
MIRT2036144	hsa-miR-508-5p	CLIP-seq
MIRT2036145	hsa-miR-513c	CLIP-seq
MIRT2036146	hsa-miR-514b-5p	CLIP-seq
MIRT2036147	hsa-miR-548aa	CLIP-seq
MIRT2036148	hsa-miR-548ac	CLIP-seq
MIRT2036149	hsa-miR-548d-3p	CLIP-seq
MIRT2036150	hsa-miR-548z	CLIP-seq
MIRT2036151	hsa-miR-612	CLIP-seq
MIRT2036152	hsa-miR-661	CLIP-seq
MIRT2036153	hsa-miR-766	CLIP-seq
MIRT2266479	hsa-miR-151-5p	CLIP-seq
MIRT2266480	hsa-miR-3672	CLIP-seq
MIRT1127556	hsa-miR-3934	CLIP-seq
MIRT1127557	hsa-miR-4293	CLIP-seq
MIRT2266481	hsa-miR-4433	CLIP-seq
MIRT2266482	hsa-miR-4459	CLIP-seq
MIRT1127561	hsa-miR-4684-5p	CLIP-seq
MIRT1127563	hsa-miR-4726-3p	CLIP-seq
MIRT1127564	hsa-miR-4786-5p	CLIP-seq
MIRT1127567	hsa-miR-769-5p	CLIP-seq
MIRT2266479	hsa-miR-151-5p	CLIP-seq
MIRT2036132	hsa-miR-3065-5p	CLIP-seq
MIRT1127553	hsa-miR-3120-5p	CLIP-seq
MIRT2036136	hsa-miR-330-3p	CLIP-seq
MIRT1127554	hsa-miR-3613-3p	CLIP-seq
MIRT1127555	hsa-miR-3664-5p	CLIP-seq
MIRT1127558	hsa-miR-4432	CLIP-seq
MIRT1127559	hsa-miR-451b	CLIP-seq
MIRT1127560	hsa-miR-4522	CLIP-seq
MIRT1127562	hsa-miR-4696	CLIP-seq
MIRT1127565	hsa-miR-515-5p	CLIP-seq
MIRT2036131	hsa-miR-1285	CLIP-seq
MIRT2266479	hsa-miR-151-5p	CLIP-seq
MIRT2565867	hsa-miR-217	CLIP-seq
MIRT2036132	hsa-miR-3065-5p	CLIP-seq
MIRT1127553	hsa-miR-3120-5p	CLIP-seq
MIRT2036135	hsa-miR-3187-5p	CLIP-seq
MIRT2036136	hsa-miR-330-3p	CLIP-seq
MIRT1127554	hsa-miR-3613-3p	CLIP-seq
MIRT1127555	hsa-miR-3664-5p	CLIP-seq
MIRT2565868	hsa-miR-4418	CLIP-seq
MIRT1127558	hsa-miR-4432	CLIP-seq
MIRT2266481	hsa-miR-4433	CLIP-seq
MIRT2266482	hsa-miR-4459	CLIP-seq
MIRT1127559	hsa-miR-451b	CLIP-seq
MIRT1127560	hsa-miR-4522	CLIP-seq
MIRT2565869	hsa-miR-4537	CLIP-seq
MIRT1127561	hsa-miR-4684-5p	CLIP-seq
MIRT1127562	hsa-miR-4696	CLIP-seq
MIRT2036141	hsa-miR-4746-3p	CLIP-seq
MIRT2036142	hsa-miR-4793-3p	CLIP-seq
MIRT2036144	hsa-miR-508-5p	CLIP-seq
MIRT2565870	hsa-miR-509-3-5p	CLIP-seq
MIRT2565871	hsa-miR-509-5p	CLIP-seq
MIRT1127565	hsa-miR-515-5p	CLIP-seq
MIRT1127566	hsa-miR-548c-3p	CLIP-seq
MIRT2036151	hsa-miR-612	CLIP-seq
MIRT2036152	hsa-miR-661	CLIP-seq
MIRT2036153	hsa-miR-766	CLIP-seq
MIRT2036131	hsa-miR-1285	CLIP-seq
MIRT2266479	hsa-miR-151-5p	CLIP-seq
MIRT2565867	hsa-miR-217	CLIP-seq
MIRT2036132	hsa-miR-3065-5p	CLIP-seq
MIRT1127553	hsa-miR-3120-5p	CLIP-seq
MIRT2036135	hsa-miR-3187-5p	CLIP-seq
MIRT2036136	hsa-miR-330-3p	CLIP-seq
MIRT1127554	hsa-miR-3613-3p	CLIP-seq
MIRT1127555	hsa-miR-3664-5p	CLIP-seq
MIRT2565868	hsa-miR-4418	CLIP-seq
MIRT1127558	hsa-miR-4432	CLIP-seq
MIRT1127559	hsa-miR-451b	CLIP-seq
MIRT1127560	hsa-miR-4522	CLIP-seq
MIRT1127561	hsa-miR-4684-5p	CLIP-seq
MIRT1127562	hsa-miR-4696	CLIP-seq
MIRT2036141	hsa-miR-4746-3p	CLIP-seq
MIRT2036142	hsa-miR-4793-3p	CLIP-seq
MIRT2036144	hsa-miR-508-5p	CLIP-seq
MIRT2565870	hsa-miR-509-3-5p	CLIP-seq
MIRT2565871	hsa-miR-509-5p	CLIP-seq
MIRT1127565	hsa-miR-515-5p	CLIP-seq
MIRT1127566	hsa-miR-548c-3p	CLIP-seq
MIRT2036151	hsa-miR-612	CLIP-seq
MIRT2036152	hsa-miR-661	CLIP-seq
MIRT2036153	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	IBA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9H8J5
• Protein name: MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07502	MANEC	27 → 116	MANEC domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11896457}.
• Sequence:

  MFFGGEGSLTYTLVIICFLTLRLSASQNCLKKSLEDVVIDIQSSLSKGIRGNEPVYTSTQ
  EDCINSCCSTKNISGDKACNLMIFDTRKTARQPNCYLFFCPNEEACPLKPAKGLMSYRII
  TDFPSLTRNLPSQELPQEDSLLHGQFSQAVTPLAHHHTDYSKPTDISWRDTLSQKFGSSD
  HLEKLFKMDEASAQLLAYKEKGHSQSSQFSSDQEIAHLLPENVSALPATVAVASPHTTSA
  TPKPATLLPTNASVTPSGTSQPQLATTAPPVTTVTSQPPTTLISTVFTRAAATLQAMATT
  AVLTTTFQAPTDSKGSLETIPFTEISNLTLNTGNVYNPTALSMSNVESSTMNKTASWEGR
  EASPGSSSQGSVPENQYGLPFEKWLLIGSLLFGVLFLVIGLVLLGRILSESLRRKRYSRL
  DYLINGIYVDI

• Sequence length: 431

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	32751923	Associate	★☆☆☆☆ Found in Text Mining only