Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54620
Gene name	F-box and leucine rich repeat protein 19
Gene symbol	FBXL19
Synonyms (NCBI Gene)	CXXC11Fbl19JHDM1C
Chromosome	16
Chromosome location	16p11.2
Summary	This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been

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Show/Hide all (310)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049576	hsa-miR-92a-3p	CLASH	23622248
MIRT042632	hsa-miR-423-3p	CLASH	23622248
MIRT041349	hsa-miR-193b-3p	CLASH	23622248
MIRT040201	hsa-miR-615-3p	CLASH	23622248
MIRT037597	hsa-miR-744-5p	CLASH	23622248
MIRT529686	hsa-miR-4687-5p	PAR-CLIP	22012620
MIRT529685	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT074603	hsa-miR-7113-3p	PAR-CLIP	22012620
MIRT529684	hsa-miR-4290	PAR-CLIP	22012620
MIRT440665	hsa-miR-376a-5p	HITS-CLIP	24374217
MIRT440665	hsa-miR-376a-5p	HITS-CLIP	24374217
MIRT529686	hsa-miR-4687-5p	PAR-CLIP	22012620
MIRT529685	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT074603	hsa-miR-7113-3p	PAR-CLIP	22012620
MIRT529684	hsa-miR-4290	PAR-CLIP	22012620
MIRT990632	hsa-miR-1207-5p	CLIP-seq
MIRT990633	hsa-miR-1245b-3p	CLIP-seq
MIRT990634	hsa-miR-1292	CLIP-seq
MIRT990635	hsa-miR-1293	CLIP-seq
MIRT990636	hsa-miR-1294	CLIP-seq
MIRT990637	hsa-miR-1297	CLIP-seq
MIRT990638	hsa-miR-141	CLIP-seq
MIRT990639	hsa-miR-147b	CLIP-seq
MIRT990640	hsa-miR-151-5p	CLIP-seq
MIRT990641	hsa-miR-151b	CLIP-seq
MIRT990642	hsa-miR-1915	CLIP-seq
MIRT990643	hsa-miR-200a	CLIP-seq
MIRT990644	hsa-miR-210	CLIP-seq
MIRT990645	hsa-miR-22	CLIP-seq
MIRT990646	hsa-miR-26a	CLIP-seq
MIRT990647	hsa-miR-26b	CLIP-seq
MIRT990648	hsa-miR-3117-5p	CLIP-seq
MIRT990649	hsa-miR-3131	CLIP-seq
MIRT990650	hsa-miR-3160-3p	CLIP-seq
MIRT990651	hsa-miR-3173-3p	CLIP-seq
MIRT990652	hsa-miR-3202	CLIP-seq
MIRT990653	hsa-miR-361-3p	CLIP-seq
MIRT990654	hsa-miR-3664-3p	CLIP-seq
MIRT990655	hsa-miR-3925-3p	CLIP-seq
MIRT990656	hsa-miR-4256	CLIP-seq
MIRT990657	hsa-miR-4276	CLIP-seq
MIRT990658	hsa-miR-4286	CLIP-seq
MIRT990659	hsa-miR-4465	CLIP-seq
MIRT990660	hsa-miR-4471	CLIP-seq
MIRT990661	hsa-miR-4476	CLIP-seq
MIRT990662	hsa-miR-4483	CLIP-seq
MIRT990663	hsa-miR-4533	CLIP-seq
MIRT990664	hsa-miR-4688	CLIP-seq
MIRT990665	hsa-miR-4707-3p	CLIP-seq
MIRT990666	hsa-miR-4707-5p	CLIP-seq
MIRT990667	hsa-miR-4709-3p	CLIP-seq
MIRT990668	hsa-miR-4710	CLIP-seq
MIRT990669	hsa-miR-4712-5p	CLIP-seq
MIRT990670	hsa-miR-4726-3p	CLIP-seq
MIRT990671	hsa-miR-4747-5p	CLIP-seq
MIRT990672	hsa-miR-4763-3p	CLIP-seq
MIRT990673	hsa-miR-4792	CLIP-seq
MIRT990674	hsa-miR-483-3p	CLIP-seq
MIRT990675	hsa-miR-486-3p	CLIP-seq
MIRT990676	hsa-miR-490-3p	CLIP-seq
MIRT990677	hsa-miR-502-5p	CLIP-seq
MIRT990678	hsa-miR-510	CLIP-seq
MIRT990679	hsa-miR-611	CLIP-seq
MIRT990680	hsa-miR-658	CLIP-seq
MIRT990681	hsa-miR-671-3p	CLIP-seq
MIRT990682	hsa-miR-770-5p	CLIP-seq
MIRT990683	hsa-miR-802	CLIP-seq
MIRT990684	hsa-miR-873	CLIP-seq
MIRT1548625	hsa-miR-1913	CLIP-seq
MIRT1548626	hsa-miR-3120-5p	CLIP-seq
MIRT1548627	hsa-miR-324-3p	CLIP-seq
MIRT1548628	hsa-miR-346	CLIP-seq
MIRT1548629	hsa-miR-4288	CLIP-seq
MIRT1548630	hsa-miR-626	CLIP-seq
MIRT1548631	hsa-miR-632	CLIP-seq
MIRT1993771	hsa-miR-1228	CLIP-seq
MIRT990633	hsa-miR-1245b-3p	CLIP-seq
MIRT1993772	hsa-miR-125a-5p	CLIP-seq
MIRT1993773	hsa-miR-125b	CLIP-seq
MIRT1993774	hsa-miR-1266	CLIP-seq
MIRT1993775	hsa-miR-1280	CLIP-seq
MIRT1993776	hsa-miR-1286	CLIP-seq
MIRT1993777	hsa-miR-1289	CLIP-seq
MIRT990634	hsa-miR-1292	CLIP-seq
MIRT990635	hsa-miR-1293	CLIP-seq
MIRT990636	hsa-miR-1294	CLIP-seq
MIRT990637	hsa-miR-1297	CLIP-seq
MIRT990638	hsa-miR-141	CLIP-seq
MIRT1993778	hsa-miR-148a	CLIP-seq
MIRT1993779	hsa-miR-148b	CLIP-seq
MIRT1993780	hsa-miR-152	CLIP-seq
MIRT1993781	hsa-miR-1538	CLIP-seq
MIRT1993782	hsa-miR-1909	CLIP-seq
MIRT1993783	hsa-miR-1910	CLIP-seq
MIRT1548625	hsa-miR-1913	CLIP-seq
MIRT990642	hsa-miR-1915	CLIP-seq
MIRT990643	hsa-miR-200a	CLIP-seq
MIRT1993784	hsa-miR-203	CLIP-seq
MIRT1993785	hsa-miR-2113	CLIP-seq
MIRT1993786	hsa-miR-214	CLIP-seq
MIRT990645	hsa-miR-22	CLIP-seq
MIRT990646	hsa-miR-26a	CLIP-seq
MIRT990647	hsa-miR-26b	CLIP-seq
MIRT1993787	hsa-miR-302f	CLIP-seq
MIRT1993788	hsa-miR-3074-3p	CLIP-seq
MIRT990648	hsa-miR-3117-5p	CLIP-seq
MIRT1548626	hsa-miR-3120-5p	CLIP-seq
MIRT1993789	hsa-miR-3127-3p	CLIP-seq
MIRT1993790	hsa-miR-3145-5p	CLIP-seq
MIRT1993791	hsa-miR-3155	CLIP-seq
MIRT1993792	hsa-miR-3155b	CLIP-seq
MIRT1993793	hsa-miR-3176	CLIP-seq
MIRT1993794	hsa-miR-3178	CLIP-seq
MIRT1548627	hsa-miR-324-3p	CLIP-seq
MIRT1993795	hsa-miR-342-3p	CLIP-seq
MIRT1548628	hsa-miR-346	CLIP-seq
MIRT990653	hsa-miR-361-3p	CLIP-seq
MIRT1993796	hsa-miR-3619-5p	CLIP-seq
MIRT1993797	hsa-miR-3646	CLIP-seq
MIRT990654	hsa-miR-3664-3p	CLIP-seq
MIRT1993798	hsa-miR-3691-3p	CLIP-seq
MIRT1993799	hsa-miR-375	CLIP-seq
MIRT1993800	hsa-miR-3922-3p	CLIP-seq
MIRT990656	hsa-miR-4256	CLIP-seq
MIRT1993801	hsa-miR-4264	CLIP-seq
MIRT1993802	hsa-miR-4268	CLIP-seq
MIRT990657	hsa-miR-4276	CLIP-seq
MIRT1993803	hsa-miR-4281	CLIP-seq
MIRT990658	hsa-miR-4286	CLIP-seq
MIRT1548629	hsa-miR-4288	CLIP-seq
MIRT1993804	hsa-miR-4319	CLIP-seq
MIRT1993805	hsa-miR-4421	CLIP-seq
MIRT1993806	hsa-miR-4436a	CLIP-seq
MIRT1993807	hsa-miR-4447	CLIP-seq
MIRT1993808	hsa-miR-4448	CLIP-seq
MIRT990659	hsa-miR-4465	CLIP-seq
MIRT990660	hsa-miR-4471	CLIP-seq
MIRT1993809	hsa-miR-4472	CLIP-seq
MIRT1993810	hsa-miR-4474-3p	CLIP-seq
MIRT990661	hsa-miR-4476	CLIP-seq
MIRT990662	hsa-miR-4483	CLIP-seq
MIRT1993811	hsa-miR-4488	CLIP-seq
MIRT1993812	hsa-miR-4518	CLIP-seq
MIRT1993813	hsa-miR-4530	CLIP-seq
MIRT990663	hsa-miR-4533	CLIP-seq
MIRT1993814	hsa-miR-455-3p	CLIP-seq
MIRT1993815	hsa-miR-4645-5p	CLIP-seq
MIRT1993816	hsa-miR-4673	CLIP-seq
MIRT990664	hsa-miR-4688	CLIP-seq
MIRT1993817	hsa-miR-4690-5p	CLIP-seq
MIRT1993818	hsa-miR-4697-5p	CLIP-seq
MIRT990666	hsa-miR-4707-5p	CLIP-seq
MIRT990668	hsa-miR-4710	CLIP-seq
MIRT1993819	hsa-miR-4723-5p	CLIP-seq
MIRT990670	hsa-miR-4726-3p	CLIP-seq
MIRT1993820	hsa-miR-4728-5p	CLIP-seq
MIRT1993821	hsa-miR-4732-3p	CLIP-seq
MIRT1993822	hsa-miR-4745-3p	CLIP-seq
MIRT1993823	hsa-miR-4756-3p	CLIP-seq
MIRT1993824	hsa-miR-4757-5p	CLIP-seq
MIRT1993825	hsa-miR-4758-3p	CLIP-seq
MIRT1993826	hsa-miR-4786-3p	CLIP-seq
MIRT990673	hsa-miR-4792	CLIP-seq
MIRT1993827	hsa-miR-4797-3p	CLIP-seq
MIRT1993828	hsa-miR-484	CLIP-seq
MIRT990675	hsa-miR-486-3p	CLIP-seq
MIRT990676	hsa-miR-490-3p	CLIP-seq
MIRT990678	hsa-miR-510	CLIP-seq
MIRT1993829	hsa-miR-582-3p	CLIP-seq
MIRT1993830	hsa-miR-619	CLIP-seq
MIRT1993831	hsa-miR-625	CLIP-seq
MIRT1548630	hsa-miR-626	CLIP-seq
MIRT1548631	hsa-miR-632	CLIP-seq
MIRT1993832	hsa-miR-637	CLIP-seq
MIRT1993833	hsa-miR-661	CLIP-seq
MIRT1993834	hsa-miR-663b	CLIP-seq
MIRT1993835	hsa-miR-670	CLIP-seq
MIRT990681	hsa-miR-671-3p	CLIP-seq
MIRT1993836	hsa-miR-761	CLIP-seq
MIRT1993837	hsa-miR-765	CLIP-seq
MIRT990683	hsa-miR-802	CLIP-seq
MIRT990684	hsa-miR-873	CLIP-seq
MIRT2227429	hsa-miR-1224-3p	CLIP-seq
MIRT1993771	hsa-miR-1228	CLIP-seq
MIRT2227430	hsa-miR-1260	CLIP-seq
MIRT2227431	hsa-miR-1260b	CLIP-seq
MIRT1993775	hsa-miR-1280	CLIP-seq
MIRT1993776	hsa-miR-1286	CLIP-seq
MIRT1993777	hsa-miR-1289	CLIP-seq
MIRT990634	hsa-miR-1292	CLIP-seq
MIRT990635	hsa-miR-1293	CLIP-seq
MIRT990636	hsa-miR-1294	CLIP-seq
MIRT1993782	hsa-miR-1909	CLIP-seq
MIRT1548625	hsa-miR-1913	CLIP-seq
MIRT990642	hsa-miR-1915	CLIP-seq
MIRT1993784	hsa-miR-203	CLIP-seq
MIRT2227432	hsa-miR-2114	CLIP-seq
MIRT1993786	hsa-miR-214	CLIP-seq
MIRT2227433	hsa-miR-224	CLIP-seq
MIRT2227434	hsa-miR-24	CLIP-seq
MIRT2227435	hsa-miR-300	CLIP-seq
MIRT2227436	hsa-miR-3065-3p	CLIP-seq
MIRT990648	hsa-miR-3117-5p	CLIP-seq
MIRT1548626	hsa-miR-3120-5p	CLIP-seq
MIRT2227437	hsa-miR-3135b	CLIP-seq
MIRT1993793	hsa-miR-3176	CLIP-seq
MIRT1548627	hsa-miR-324-3p	CLIP-seq
MIRT2227438	hsa-miR-331-3p	CLIP-seq
MIRT1548628	hsa-miR-346	CLIP-seq
MIRT2227439	hsa-miR-34a	CLIP-seq
MIRT2227440	hsa-miR-34c-5p	CLIP-seq
MIRT990653	hsa-miR-361-3p	CLIP-seq
MIRT1993796	hsa-miR-3619-5p	CLIP-seq
MIRT1993797	hsa-miR-3646	CLIP-seq
MIRT990654	hsa-miR-3664-3p	CLIP-seq
MIRT1993798	hsa-miR-3691-3p	CLIP-seq
MIRT2227441	hsa-miR-381	CLIP-seq
MIRT1993800	hsa-miR-3922-3p	CLIP-seq
MIRT2227442	hsa-miR-4267	CLIP-seq
MIRT1993803	hsa-miR-4281	CLIP-seq
MIRT990658	hsa-miR-4286	CLIP-seq
MIRT1548629	hsa-miR-4288	CLIP-seq
MIRT2227443	hsa-miR-4292	CLIP-seq
MIRT2227444	hsa-miR-4308	CLIP-seq
MIRT2227445	hsa-miR-4323	CLIP-seq
MIRT2227446	hsa-miR-4420	CLIP-seq
MIRT1993806	hsa-miR-4436a	CLIP-seq
MIRT990660	hsa-miR-4471	CLIP-seq
MIRT990661	hsa-miR-4476	CLIP-seq
MIRT2227447	hsa-miR-4481	CLIP-seq
MIRT990662	hsa-miR-4483	CLIP-seq
MIRT2227448	hsa-miR-449a	CLIP-seq
MIRT2227449	hsa-miR-449b	CLIP-seq
MIRT1993813	hsa-miR-4530	CLIP-seq
MIRT990663	hsa-miR-4533	CLIP-seq
MIRT990664	hsa-miR-4688	CLIP-seq
MIRT1993817	hsa-miR-4690-5p	CLIP-seq
MIRT990666	hsa-miR-4707-5p	CLIP-seq
MIRT990668	hsa-miR-4710	CLIP-seq
MIRT990670	hsa-miR-4726-3p	CLIP-seq
MIRT2227450	hsa-miR-4745-5p	CLIP-seq
MIRT990671	hsa-miR-4747-5p	CLIP-seq
MIRT2227451	hsa-miR-4755-3p	CLIP-seq
MIRT1993824	hsa-miR-4757-5p	CLIP-seq
MIRT1993826	hsa-miR-4786-3p	CLIP-seq
MIRT990673	hsa-miR-4792	CLIP-seq
MIRT990674	hsa-miR-483-3p	CLIP-seq
MIRT990675	hsa-miR-486-3p	CLIP-seq
MIRT990676	hsa-miR-490-3p	CLIP-seq
MIRT990678	hsa-miR-510	CLIP-seq
MIRT2227452	hsa-miR-587	CLIP-seq
MIRT1993831	hsa-miR-625	CLIP-seq
MIRT1548630	hsa-miR-626	CLIP-seq
MIRT2227453	hsa-miR-627	CLIP-seq
MIRT1548631	hsa-miR-632	CLIP-seq
MIRT990681	hsa-miR-671-3p	CLIP-seq
MIRT1993836	hsa-miR-761	CLIP-seq
MIRT1993837	hsa-miR-765	CLIP-seq
MIRT2227454	hsa-miR-767-5p	CLIP-seq
MIRT990684	hsa-miR-873	CLIP-seq
MIRT990635	hsa-miR-1293	CLIP-seq
MIRT1548625	hsa-miR-1913	CLIP-seq
MIRT2227432	hsa-miR-2114	CLIP-seq
MIRT1548626	hsa-miR-3120-5p	CLIP-seq
MIRT1548627	hsa-miR-324-3p	CLIP-seq
MIRT1548628	hsa-miR-346	CLIP-seq
MIRT1548629	hsa-miR-4288	CLIP-seq
MIRT2227443	hsa-miR-4292	CLIP-seq
MIRT2227444	hsa-miR-4308	CLIP-seq
MIRT990662	hsa-miR-4483	CLIP-seq
MIRT990670	hsa-miR-4726-3p	CLIP-seq
MIRT1548630	hsa-miR-626	CLIP-seq
MIRT2227453	hsa-miR-627	CLIP-seq
MIRT1548631	hsa-miR-632	CLIP-seq
MIRT990681	hsa-miR-671-3p	CLIP-seq
MIRT1993771	hsa-miR-1228	CLIP-seq
MIRT990637	hsa-miR-1297	CLIP-seq
MIRT990638	hsa-miR-141	CLIP-seq
MIRT990643	hsa-miR-200a	CLIP-seq
MIRT990646	hsa-miR-26a	CLIP-seq
MIRT990647	hsa-miR-26b	CLIP-seq
MIRT990653	hsa-miR-361-3p	CLIP-seq
MIRT990659	hsa-miR-4465	CLIP-seq
MIRT990666	hsa-miR-4707-5p	CLIP-seq
MIRT990670	hsa-miR-4726-3p	CLIP-seq
MIRT990681	hsa-miR-671-3p	CLIP-seq
MIRT990683	hsa-miR-802	CLIP-seq
MIRT1993771	hsa-miR-1228	CLIP-seq
MIRT990637	hsa-miR-1297	CLIP-seq
MIRT990638	hsa-miR-141	CLIP-seq
MIRT990643	hsa-miR-200a	CLIP-seq
MIRT990646	hsa-miR-26a	CLIP-seq
MIRT990647	hsa-miR-26b	CLIP-seq
MIRT990653	hsa-miR-361-3p	CLIP-seq
MIRT990659	hsa-miR-4465	CLIP-seq
MIRT990666	hsa-miR-4707-5p	CLIP-seq
MIRT990670	hsa-miR-4726-3p	CLIP-seq
MIRT990681	hsa-miR-671-3p	CLIP-seq
MIRT990683	hsa-miR-802	CLIP-seq
MIRT2227429	hsa-miR-1224-3p	CLIP-seq
MIRT1993783	hsa-miR-1910	CLIP-seq
MIRT2531339	hsa-miR-320e	CLIP-seq
MIRT1993801	hsa-miR-4264	CLIP-seq
MIRT2227442	hsa-miR-4267	CLIP-seq
MIRT990658	hsa-miR-4286	CLIP-seq
MIRT2227445	hsa-miR-4323	CLIP-seq
MIRT1993814	hsa-miR-455-3p	CLIP-seq
MIRT2531340	hsa-miR-4690-3p	CLIP-seq
MIRT1993827	hsa-miR-4797-3p	CLIP-seq
MIRT2531341	hsa-miR-766	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0005515	Function	Protein binding	IPI	22660580, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IC	22660580, 23512198
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IDA	29276034
GO:0008270	Function	Zinc ion binding	IEA
GO:0016477	Process	Cell migration	IDA	23512198
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	22660580
GO:0032452	Function	Histone demethylase activity	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	22660580
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	23512198
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0045322	Function	Unmethylated CpG binding	IDA	29276034
GO:0045322	Function	Unmethylated CpG binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	22660580, 23512198

MIM	HGNC	e!Ensembl
609085	25300	ENSG00000099364

Q6PCT2

Protein name

F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19)

Protein function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:24684802, PubMed:2

PDB

6ASB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02008	zf-CXXC	31 → 77	CXXC zinc finger domain	Domain
PF16866	PHD_4	82 → 149	PHD-finger	Domain
PF00646	F-box	423 → 466	F-box domain	Domain

Sequence

MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMK
KFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEI
VHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGW
KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKK
VGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSP
SPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS
SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGS
DHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGV
VRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR
WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS
ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLR
SCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS

Sequence length

694

Interactions

View interactions

	Reactome
			Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, PSORIATIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GRAVES DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental delay	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	20953189, 22298274	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	35479077	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	CTD_human_DG	20953189		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	22532288		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	31696201	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34564989	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	37207321	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30610161	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	24684802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	24684802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	31674730	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lewy Body Disease	Lewy body disease	Pubtator	35729600	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30610161	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	24684802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	34278444	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31210311		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASDB_DG	20953189		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	CTD_human_DG	20953189		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	GWASCAT_DG	20953189, 25574825		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	Pubtator	20953189, 22298274, 26613086	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	BEFREE	26613086		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pustulosis of Palms and Soles	Palmoplantar Pustules	CTD_human_DG	20953189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroiditis	Thyroiditis	Pubtator	31238008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

FBXL19 (F-box and leucine rich repeat protein 19)