Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54602
Gene name	Nedd4 family interacting protein 2
Gene symbol	NDFIP2
Synonyms (NCBI Gene)	N4WBP5A
Chromosome	13
Chromosome location	13q31.1

224

Show/Hide all (224)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025956	hsa-miR-7-5p	Microarray	19073608
MIRT026926	hsa-miR-192-5p	Microarray	19074876
MIRT049872	hsa-miR-31-5p	CLASH	23622248
MIRT043881	hsa-miR-378a-3p	CLASH	23622248
MIRT036778	hsa-miR-760	CLASH	23622248
MIRT035788	hsa-miR-1914-5p	CLASH	23622248
MIRT277062	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT545706	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT277063	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT277060	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT545705	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT277065	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT277059	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT545701	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT277062	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT545706	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT277063	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT277060	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT545705	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT277065	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT277059	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT545703	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT545704	hsa-miR-4263	PAR-CLIP	21572407
MIRT545702	hsa-miR-576-5p	PAR-CLIP	21572407
MIRT545701	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT532533	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT532532	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT532531	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT532530	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT532529	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT532528	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT277062	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT545706	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT277063	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT277060	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT545705	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT277065	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT277059	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT545701	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT277062	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT545706	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT277063	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT277060	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT545705	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT277065	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT277059	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT545703	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT545704	hsa-miR-4263	PAR-CLIP	21572407
MIRT545702	hsa-miR-576-5p	PAR-CLIP	21572407
MIRT545701	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT532533	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT532532	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT532531	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT532530	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT532529	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT532528	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT1178001	hsa-miR-145	CLIP-seq
MIRT1178002	hsa-miR-221	CLIP-seq
MIRT1178003	hsa-miR-222	CLIP-seq
MIRT1178004	hsa-miR-2355-5p	CLIP-seq
MIRT1178005	hsa-miR-329	CLIP-seq
MIRT1178006	hsa-miR-3613-3p	CLIP-seq
MIRT1178007	hsa-miR-362-3p	CLIP-seq
MIRT1178008	hsa-miR-3677-5p	CLIP-seq
MIRT1178009	hsa-miR-369-3p	CLIP-seq
MIRT1178010	hsa-miR-371b-5p	CLIP-seq
MIRT1178011	hsa-miR-374a	CLIP-seq
MIRT1178012	hsa-miR-374b	CLIP-seq
MIRT1178013	hsa-miR-376a	CLIP-seq
MIRT1178014	hsa-miR-376b	CLIP-seq
MIRT1178015	hsa-miR-377	CLIP-seq
MIRT1178016	hsa-miR-3941	CLIP-seq
MIRT1178017	hsa-miR-4422	CLIP-seq
MIRT1178018	hsa-miR-451b	CLIP-seq
MIRT1178019	hsa-miR-4639-3p	CLIP-seq
MIRT1178020	hsa-miR-4704-5p	CLIP-seq
MIRT1178021	hsa-miR-548v	CLIP-seq
MIRT1178022	hsa-miR-584	CLIP-seq
MIRT1178023	hsa-miR-603	CLIP-seq
MIRT1178024	hsa-miR-633	CLIP-seq
MIRT1178025	hsa-miR-656	CLIP-seq
MIRT1178026	hsa-miR-664	CLIP-seq
MIRT1178027	hsa-miR-888	CLIP-seq
MIRT1178028	hsa-miR-124	CLIP-seq
MIRT1178029	hsa-miR-1305	CLIP-seq
MIRT1178030	hsa-miR-2052	CLIP-seq
MIRT1178031	hsa-miR-3129-3p	CLIP-seq
MIRT1178032	hsa-miR-3153	CLIP-seq
MIRT1178033	hsa-miR-3662	CLIP-seq
MIRT1178034	hsa-miR-3671	CLIP-seq
MIRT1178035	hsa-miR-3714	CLIP-seq
MIRT1178036	hsa-miR-3910	CLIP-seq
MIRT1178037	hsa-miR-4307	CLIP-seq
MIRT1178038	hsa-miR-4426	CLIP-seq
MIRT1178039	hsa-miR-4477b	CLIP-seq
MIRT1178040	hsa-miR-450b-5p	CLIP-seq
MIRT1178041	hsa-miR-4647	CLIP-seq
MIRT1178042	hsa-miR-4662b	CLIP-seq
MIRT1178043	hsa-miR-4668-5p	CLIP-seq
MIRT1178044	hsa-miR-4696	CLIP-seq
MIRT1178045	hsa-miR-498	CLIP-seq
MIRT1178046	hsa-miR-506	CLIP-seq
MIRT1178047	hsa-miR-646	CLIP-seq
MIRT2051510	hsa-miR-21	CLIP-seq
MIRT2051511	hsa-miR-4661-5p	CLIP-seq
MIRT2051512	hsa-miR-4729	CLIP-seq
MIRT2051513	hsa-miR-579	CLIP-seq
MIRT2051514	hsa-miR-590-5p	CLIP-seq
MIRT1178026	hsa-miR-664	CLIP-seq
MIRT2280564	hsa-miR-1244	CLIP-seq
MIRT2280565	hsa-miR-141	CLIP-seq
MIRT2280566	hsa-miR-200a	CLIP-seq
MIRT2280567	hsa-miR-23a	CLIP-seq
MIRT2280568	hsa-miR-23b	CLIP-seq
MIRT2280569	hsa-miR-23c	CLIP-seq
MIRT2280567	hsa-miR-23a	CLIP-seq
MIRT2280568	hsa-miR-23b	CLIP-seq
MIRT2280569	hsa-miR-23c	CLIP-seq
MIRT2431521	hsa-miR-129-5p	CLIP-seq
MIRT2431522	hsa-miR-3152-5p	CLIP-seq
MIRT2431523	hsa-miR-4282	CLIP-seq
MIRT2431524	hsa-miR-4328	CLIP-seq
MIRT2431525	hsa-miR-4774-3p	CLIP-seq
MIRT2438945	hsa-miR-1205	CLIP-seq
MIRT2438946	hsa-miR-1910	CLIP-seq
MIRT2438947	hsa-miR-3064-3p	CLIP-seq
MIRT2438948	hsa-miR-3065-3p	CLIP-seq
MIRT1178005	hsa-miR-329	CLIP-seq
MIRT2438949	hsa-miR-337-3p	CLIP-seq
MIRT1178007	hsa-miR-362-3p	CLIP-seq
MIRT2438950	hsa-miR-3665	CLIP-seq
MIRT1178016	hsa-miR-3941	CLIP-seq
MIRT2438951	hsa-miR-4418	CLIP-seq
MIRT1178019	hsa-miR-4639-3p	CLIP-seq
MIRT2438952	hsa-miR-500a	CLIP-seq
MIRT2438953	hsa-miR-501-5p	CLIP-seq
MIRT2438954	hsa-miR-509-3-5p	CLIP-seq
MIRT2438955	hsa-miR-509-5p	CLIP-seq
MIRT2438956	hsa-miR-587	CLIP-seq
MIRT1178023	hsa-miR-603	CLIP-seq
MIRT2438957	hsa-miR-657	CLIP-seq
MIRT2438945	hsa-miR-1205	CLIP-seq
MIRT2280564	hsa-miR-1244	CLIP-seq
MIRT2579029	hsa-miR-1245b-3p	CLIP-seq
MIRT1178001	hsa-miR-145	CLIP-seq
MIRT2579030	hsa-miR-153	CLIP-seq
MIRT2579031	hsa-miR-190	CLIP-seq
MIRT2579032	hsa-miR-190b	CLIP-seq
MIRT2438946	hsa-miR-1910	CLIP-seq
MIRT2579033	hsa-miR-192	CLIP-seq
MIRT2579034	hsa-miR-215	CLIP-seq
MIRT2438947	hsa-miR-3064-3p	CLIP-seq
MIRT2438948	hsa-miR-3065-3p	CLIP-seq
MIRT1178032	hsa-miR-3153	CLIP-seq
MIRT2579035	hsa-miR-3163	CLIP-seq
MIRT2579036	hsa-miR-3201	CLIP-seq
MIRT2438949	hsa-miR-337-3p	CLIP-seq
MIRT2579037	hsa-miR-3607-5p	CLIP-seq
MIRT2579038	hsa-miR-3647-3p	CLIP-seq
MIRT1178033	hsa-miR-3662	CLIP-seq
MIRT2438950	hsa-miR-3665	CLIP-seq
MIRT1178034	hsa-miR-3671	CLIP-seq
MIRT1178009	hsa-miR-369-3p	CLIP-seq
MIRT1178011	hsa-miR-374a	CLIP-seq
MIRT1178012	hsa-miR-374b	CLIP-seq
MIRT2579039	hsa-miR-410	CLIP-seq
MIRT2579040	hsa-miR-4264	CLIP-seq
MIRT2579041	hsa-miR-4277	CLIP-seq
MIRT1178037	hsa-miR-4307	CLIP-seq
MIRT2438951	hsa-miR-4418	CLIP-seq
MIRT1178038	hsa-miR-4426	CLIP-seq
MIRT2579042	hsa-miR-448	CLIP-seq
MIRT2579043	hsa-miR-4495	CLIP-seq
MIRT1178040	hsa-miR-450b-5p	CLIP-seq
MIRT1178041	hsa-miR-4647	CLIP-seq
MIRT1178042	hsa-miR-4662b	CLIP-seq
MIRT1178043	hsa-miR-4668-5p	CLIP-seq
MIRT1178044	hsa-miR-4696	CLIP-seq
MIRT2579044	hsa-miR-4719	CLIP-seq
MIRT2579045	hsa-miR-4791	CLIP-seq
MIRT2579046	hsa-miR-4797-3p	CLIP-seq
MIRT2579047	hsa-miR-495	CLIP-seq
MIRT2579048	hsa-miR-496	CLIP-seq
MIRT2438952	hsa-miR-500a	CLIP-seq
MIRT2438953	hsa-miR-501-5p	CLIP-seq
MIRT2579049	hsa-miR-507	CLIP-seq
MIRT2438954	hsa-miR-509-3-5p	CLIP-seq
MIRT2438955	hsa-miR-509-5p	CLIP-seq
MIRT2579050	hsa-miR-557	CLIP-seq
MIRT2579051	hsa-miR-580	CLIP-seq
MIRT2438956	hsa-miR-587	CLIP-seq
MIRT2579052	hsa-miR-627	CLIP-seq
MIRT2438957	hsa-miR-657	CLIP-seq
MIRT2579053	hsa-miR-924	CLIP-seq
MIRT2438945	hsa-miR-1205	CLIP-seq
MIRT2685998	hsa-miR-196a	CLIP-seq
MIRT2685999	hsa-miR-196b	CLIP-seq
MIRT2686000	hsa-miR-1976	CLIP-seq
MIRT2438948	hsa-miR-3065-3p	CLIP-seq
MIRT2686001	hsa-miR-34a	CLIP-seq
MIRT2686002	hsa-miR-34c-5p	CLIP-seq
MIRT2579037	hsa-miR-3607-5p	CLIP-seq
MIRT1178033	hsa-miR-3662	CLIP-seq
MIRT2438950	hsa-miR-3665	CLIP-seq
MIRT2686003	hsa-miR-3977	CLIP-seq
MIRT2579039	hsa-miR-410	CLIP-seq
MIRT2438951	hsa-miR-4418	CLIP-seq
MIRT2686004	hsa-miR-4436b-3p	CLIP-seq
MIRT2686005	hsa-miR-449a	CLIP-seq
MIRT2686006	hsa-miR-449b	CLIP-seq
MIRT1178040	hsa-miR-450b-5p	CLIP-seq
MIRT2686007	hsa-miR-4633-3p	CLIP-seq
MIRT2686008	hsa-miR-4703-3p	CLIP-seq
MIRT2686009	hsa-miR-4722-3p	CLIP-seq
MIRT2579047	hsa-miR-495	CLIP-seq
MIRT2438952	hsa-miR-500a	CLIP-seq
MIRT2438953	hsa-miR-501-5p	CLIP-seq
MIRT2438954	hsa-miR-509-3-5p	CLIP-seq
MIRT2438955	hsa-miR-509-5p	CLIP-seq
MIRT2686010	hsa-miR-548ag	CLIP-seq
MIRT2686011	hsa-miR-548ai	CLIP-seq
MIRT2686012	hsa-miR-610	CLIP-seq
MIRT2438957	hsa-miR-657	CLIP-seq
MIRT2686013	hsa-miR-938	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	18776082, 26363003, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IDA	12796489
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	12796489
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	12796489
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	12796489
GO:0005794	Component	Golgi apparatus	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0007034	Process	Vacuolar transport	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0010629	Process	Negative regulation of gene expression	IMP	18776082
GO:0016020	Component	Membrane	IEA
GO:0030001	Process	Metal ion transport	IEA
GO:0031398	Process	Positive regulation of protein ubiquitination	IBA
GO:0031398	Process	Positive regulation of protein ubiquitination	IMP	18776082
GO:0032410	Process	Negative regulation of transporter activity	IMP	18776082
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
GO:0048471	Component	Perinuclear region of cytoplasm	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18776082
GO:0050699	Function	WW domain binding	IPI	12796489
GO:0051224	Process	Negative regulation of protein transport	IMP	18776082

MIM	HGNC	e!Ensembl
610041	18537	ENSG00000102471

Q9NV92

Protein name

NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)

Protein function

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:12796489}.

Sequence

MARRRSQRVCASGPSMLNSARGAPELLRGTATNAEVSAAAAGATGSEELPPGDRGCRNGG
GRGPAATTSSTGVAVGAEHGEDSLSRKPDPEPGRMDHHQPGTGRYQVLLNEEDNSESSAI
EQPPTSNPAPQIVQAASSAPALETDSSPPPYSSITVEVPTTSDTEVYGEFYPVPPPYSVA
TSLPTYDEAEKAKAAAMAAAAAETSQRIQEEECPPRDDFSDADQLRVGNDGIFMLAFFMA
FIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFL
VLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL

Sequence length

336

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Crohn Disease	Crohn disease	Pubtator	26937622	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	20090362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	33159203	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NDFIP2 (Nedd4 family interacting protein 2)