Gene Gene information from NCBI Gene database.
Entrez ID 54552
Gene name G protein nucleolar 3 like
Gene symbol GNL3L
Synonyms (NCBI Gene)
GNL3B
Chromosome X
Chromosome location Xp11.22
Summary The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
miRNA miRNA information provided by mirtarbase database.
1813
miRTarBase ID miRNA Experiments Reference
MIRT001463 hsa-miR-16-5p pSILAC 18668040
MIRT020962 hsa-miR-155-5p Proteomics 20584899
MIRT021788 hsa-miR-132-3p Microarray 17612493
MIRT023356 hsa-miR-122-5p Microarray 17612493
MIRT001463 hsa-miR-16-5p Proteomics;Other 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 16189514, 19487455, 21132010, 25416956, 31515488, 32296183
GO:0005525 Function GTP binding IEA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300873 25553 ENSG00000130119
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NVN8
Protein name Guanine nucleotide-binding protein-like 3-like protein
Protein function Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein l
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01926 MMR_HSR1 254 351 50S ribosome-binding GTPase Family
Sequence
MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELK
KKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEAT
RKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPK
EVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVL
GNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIR
LLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYY
GVSGFQTTE
HFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKE
MTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTV
YKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQA
LASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
Sequence length 582
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Ribosome biogenesis in eukaryotes  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 16251348 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 27764577 Associate
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Esophageal neoplasm Pubtator 34032716 Stimulate
★☆☆☆☆
Found in Text Mining only
Gastrointestinal Neoplasms Gastrointestinal Neoplasms BEFREE 21132010
★☆☆☆☆
Found in Text Mining only
Gastrointestinal Neoplasms Gastrointestinal neoplasm Pubtator 21132010 Associate
★☆☆☆☆
Found in Text Mining only
Hereditary Autosomal Dominant Spastic Paraplegia Spastic paraplegia BEFREE 14607301
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung neoplasms Pubtator 39519555 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 11812785
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 21730156
★☆☆☆☆
Found in Text Mining only
Prostate carcinoma Prostate cancer BEFREE 11812785
★☆☆☆☆
Found in Text Mining only