Gene Gene information from NCBI Gene database.
Entrez ID 54509
Gene name Ras homolog family member F, filopodia associated
Gene symbol RHOF
Synonyms (NCBI Gene)
ARHFRIF
Chromosome 12
Chromosome location 12q24.31
miRNA miRNA information provided by mirtarbase database.
447
miRTarBase ID miRNA Experiments Reference
MIRT019255 hsa-miR-148b-3p Microarray 17612493
MIRT028419 hsa-miR-30a-5p Proteomics 18668040
MIRT031459 hsa-miR-16-5p Proteomics 18668040
MIRT679478 hsa-miR-524-3p HITS-CLIP 23824327
MIRT679477 hsa-miR-525-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity NAS 11084341
GO:0005085 Function Guanyl-nucleotide exchange factor activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618867 15703 ENSG00000139725
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HBH0
Protein name Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia)
Protein function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to genera
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 21 194 Ras family Domain
Sequence
Sequence length 211
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 29232592
★☆☆☆☆
Found in Text Mining only
Blood Coagulation Disorders Blood Coagulation Disorders BEFREE 29232592
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 36454866 Associate
★☆☆☆☆
Found in Text Mining only
Developmental Disabilities Developmental disability Pubtator 37501076 Associate
★☆☆☆☆
Found in Text Mining only
Disseminated Intravascular Coagulation Disseminated Intravascular Coagulation BEFREE 29232592
★☆☆☆☆
Found in Text Mining only
Endometriosis Endometriosis BEFREE 30649983
★☆☆☆☆
Found in Text Mining only
Eosinophilic esophagitis Eosinophilia BEFREE 30998758
★☆☆☆☆
Found in Text Mining only
Fibrinogen Deficiency Fibrinogen Deficiency BEFREE 29232592
★☆☆☆☆
Found in Text Mining only
Hematologic Neoplasms Hematologic Neoplasms BEFREE 18663754
★☆☆☆☆
Found in Text Mining only
Hydrocephalus Hydrocephalus BEFREE 31359250
★☆☆☆☆
Found in Text Mining only