Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54469
Gene name	Zinc finger AN1-type containing 6
Gene symbol	ZFAND6
Synonyms (NCBI Gene)	AWP1ZA20D3ZFAND5B
Chromosome	15
Chromosome location	15q25.1

203

Show/Hide all (203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT194174	hsa-miR-181a-5p	HITS-CLIP	21572407
MIRT194176	hsa-miR-181c-5p	HITS-CLIP	21572407
MIRT194177	hsa-miR-181d-5p	HITS-CLIP	21572407
MIRT194180	hsa-miR-4262	HITS-CLIP	21572407
MIRT194175	hsa-miR-181b-5p	HITS-CLIP	21572407
MIRT519890	hsa-miR-4662a-3p	HITS-CLIP	21572407
MIRT194179	hsa-miR-580-5p	HITS-CLIP	21572407
MIRT282242	hsa-miR-935	HITS-CLIP	21572407
MIRT194174	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT194176	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT194177	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT194180	hsa-miR-4262	PAR-CLIP	20371350
MIRT194175	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT519890	hsa-miR-4662a-3p	PAR-CLIP	20371350
MIRT194179	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT282242	hsa-miR-935	PAR-CLIP	20371350
MIRT194174	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT194176	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT194177	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT194180	hsa-miR-4262	PAR-CLIP	21572407
MIRT194175	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT519890	hsa-miR-4662a-3p	PAR-CLIP	21572407
MIRT194179	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT282242	hsa-miR-935	PAR-CLIP	21572407
MIRT194174	hsa-miR-181a-5p	PAR-CLIP	23446348
MIRT194176	hsa-miR-181c-5p	PAR-CLIP	23446348
MIRT194177	hsa-miR-181d-5p	PAR-CLIP	23446348
MIRT194180	hsa-miR-4262	PAR-CLIP	23446348
MIRT194175	hsa-miR-181b-5p	PAR-CLIP	23446348
MIRT519890	hsa-miR-4662a-3p	PAR-CLIP	23446348
MIRT194179	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT282242	hsa-miR-935	PAR-CLIP	23446348
MIRT194174	hsa-miR-181a-5p	HITS-CLIP	21572407
MIRT194176	hsa-miR-181c-5p	HITS-CLIP	21572407
MIRT194177	hsa-miR-181d-5p	HITS-CLIP	21572407
MIRT194180	hsa-miR-4262	HITS-CLIP	21572407
MIRT194175	hsa-miR-181b-5p	HITS-CLIP	21572407
MIRT519890	hsa-miR-4662a-3p	HITS-CLIP	21572407
MIRT194179	hsa-miR-580-5p	HITS-CLIP	21572407
MIRT282242	hsa-miR-935	HITS-CLIP	21572407
MIRT194174	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT194176	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT194177	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT194180	hsa-miR-4262	PAR-CLIP	20371350
MIRT194175	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT519890	hsa-miR-4662a-3p	PAR-CLIP	20371350
MIRT194179	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT282242	hsa-miR-935	PAR-CLIP	20371350
MIRT194174	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT194176	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT194177	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT194180	hsa-miR-4262	PAR-CLIP	21572407
MIRT194175	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT519890	hsa-miR-4662a-3p	PAR-CLIP	21572407
MIRT194179	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT282242	hsa-miR-935	PAR-CLIP	21572407
MIRT194174	hsa-miR-181a-5p	PAR-CLIP	23446348
MIRT194176	hsa-miR-181c-5p	PAR-CLIP	23446348
MIRT194177	hsa-miR-181d-5p	PAR-CLIP	23446348
MIRT194180	hsa-miR-4262	PAR-CLIP	23446348
MIRT194175	hsa-miR-181b-5p	PAR-CLIP	23446348
MIRT519890	hsa-miR-4662a-3p	PAR-CLIP	23446348
MIRT194179	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT282242	hsa-miR-935	PAR-CLIP	23446348
MIRT1509695	hsa-miR-1264	CLIP-seq
MIRT1509696	hsa-miR-3157-5p	CLIP-seq
MIRT1509697	hsa-miR-4279	CLIP-seq
MIRT1509698	hsa-miR-4691-3p	CLIP-seq
MIRT1509699	hsa-miR-561	CLIP-seq
MIRT1509700	hsa-miR-1243	CLIP-seq
MIRT1509701	hsa-miR-155	CLIP-seq
MIRT1509702	hsa-miR-200b	CLIP-seq
MIRT1509703	hsa-miR-200c	CLIP-seq
MIRT1509704	hsa-miR-3120-3p	CLIP-seq
MIRT1509705	hsa-miR-3148	CLIP-seq
MIRT1509706	hsa-miR-3157-3p	CLIP-seq
MIRT1509707	hsa-miR-3654	CLIP-seq
MIRT1509708	hsa-miR-374c	CLIP-seq
MIRT1509709	hsa-miR-3908	CLIP-seq
MIRT1509710	hsa-miR-429	CLIP-seq
MIRT1509711	hsa-miR-4290	CLIP-seq
MIRT1509712	hsa-miR-4509	CLIP-seq
MIRT1509713	hsa-miR-4687-5p	CLIP-seq
MIRT1509714	hsa-miR-4766-5p	CLIP-seq
MIRT1509715	hsa-miR-4803	CLIP-seq
MIRT1509716	hsa-miR-548c-3p	CLIP-seq
MIRT1509717	hsa-miR-649	CLIP-seq
MIRT1509718	hsa-miR-655	CLIP-seq
MIRT1509719	hsa-miR-875-3p	CLIP-seq
MIRT1509720	hsa-miR-1279	CLIP-seq
MIRT1509721	hsa-miR-4789-5p	CLIP-seq
MIRT1509722	hsa-miR-568	CLIP-seq
MIRT1509723	hsa-miR-1305	CLIP-seq
MIRT1509724	hsa-miR-1323	CLIP-seq
MIRT1509725	hsa-miR-181a	CLIP-seq
MIRT1509726	hsa-miR-181b	CLIP-seq
MIRT1509727	hsa-miR-181c	CLIP-seq
MIRT1509728	hsa-miR-181d	CLIP-seq
MIRT1509729	hsa-miR-2467-3p	CLIP-seq
MIRT1509704	hsa-miR-3120-3p	CLIP-seq
MIRT1509706	hsa-miR-3157-3p	CLIP-seq
MIRT1509730	hsa-miR-3158-5p	CLIP-seq
MIRT1509731	hsa-miR-3678-3p	CLIP-seq
MIRT1509732	hsa-miR-3919	CLIP-seq
MIRT1509733	hsa-miR-4275	CLIP-seq
MIRT1509734	hsa-miR-4299	CLIP-seq
MIRT1509735	hsa-miR-4311	CLIP-seq
MIRT1509736	hsa-miR-4463	CLIP-seq
MIRT1509712	hsa-miR-4509	CLIP-seq
MIRT1509737	hsa-miR-4761-3p	CLIP-seq
MIRT1509715	hsa-miR-4803	CLIP-seq
MIRT1509738	hsa-miR-539	CLIP-seq
MIRT1509739	hsa-miR-548aa	CLIP-seq
MIRT1509740	hsa-miR-548o	CLIP-seq
MIRT1509741	hsa-miR-548u	CLIP-seq
MIRT1509742	hsa-miR-607	CLIP-seq
MIRT1509743	hsa-miR-1273d	CLIP-seq
MIRT1509720	hsa-miR-1279	CLIP-seq
MIRT1509744	hsa-miR-1324	CLIP-seq
MIRT1509745	hsa-miR-19a	CLIP-seq
MIRT1509746	hsa-miR-19b	CLIP-seq
MIRT1509704	hsa-miR-3120-3p	CLIP-seq
MIRT1509747	hsa-miR-3121-3p	CLIP-seq
MIRT1509748	hsa-miR-329	CLIP-seq
MIRT1509749	hsa-miR-362-3p	CLIP-seq
MIRT1509750	hsa-miR-3682-5p	CLIP-seq
MIRT1509751	hsa-miR-3941	CLIP-seq
MIRT1509752	hsa-miR-3942-3p	CLIP-seq
MIRT1509733	hsa-miR-4275	CLIP-seq
MIRT1509734	hsa-miR-4299	CLIP-seq
MIRT1509736	hsa-miR-4463	CLIP-seq
MIRT1509753	hsa-miR-4727-3p	CLIP-seq
MIRT1509721	hsa-miR-4789-5p	CLIP-seq
MIRT1509715	hsa-miR-4803	CLIP-seq
MIRT1509754	hsa-miR-518a-5p	CLIP-seq
MIRT1509755	hsa-miR-527	CLIP-seq
MIRT1509741	hsa-miR-548u	CLIP-seq
MIRT1509722	hsa-miR-568	CLIP-seq
MIRT1509756	hsa-miR-603	CLIP-seq
MIRT1509731	hsa-miR-3678-3p	CLIP-seq
MIRT1509750	hsa-miR-3682-5p	CLIP-seq
MIRT1509715	hsa-miR-4803	CLIP-seq
MIRT1509731	hsa-miR-3678-3p	CLIP-seq
MIRT1509700	hsa-miR-1243	CLIP-seq
MIRT1509701	hsa-miR-155	CLIP-seq
MIRT1509702	hsa-miR-200b	CLIP-seq
MIRT1509703	hsa-miR-200c	CLIP-seq
MIRT2666447	hsa-miR-203	CLIP-seq
MIRT2666448	hsa-miR-2276	CLIP-seq
MIRT1509729	hsa-miR-2467-3p	CLIP-seq
MIRT1509704	hsa-miR-3120-3p	CLIP-seq
MIRT1509705	hsa-miR-3148	CLIP-seq
MIRT1509706	hsa-miR-3157-3p	CLIP-seq
MIRT1509730	hsa-miR-3158-5p	CLIP-seq
MIRT1509707	hsa-miR-3654	CLIP-seq
MIRT1509731	hsa-miR-3678-3p	CLIP-seq
MIRT1509708	hsa-miR-374c	CLIP-seq
MIRT1509709	hsa-miR-3908	CLIP-seq
MIRT1509732	hsa-miR-3919	CLIP-seq
MIRT1509710	hsa-miR-429	CLIP-seq
MIRT1509711	hsa-miR-4290	CLIP-seq
MIRT1509735	hsa-miR-4311	CLIP-seq
MIRT1509712	hsa-miR-4509	CLIP-seq
MIRT1509713	hsa-miR-4687-5p	CLIP-seq
MIRT2666449	hsa-miR-4696	CLIP-seq
MIRT2666450	hsa-miR-4731-3p	CLIP-seq
MIRT1509737	hsa-miR-4761-3p	CLIP-seq
MIRT2666451	hsa-miR-4801	CLIP-seq
MIRT1509738	hsa-miR-539	CLIP-seq
MIRT1509716	hsa-miR-548c-3p	CLIP-seq
MIRT2666452	hsa-miR-548g	CLIP-seq
MIRT1509718	hsa-miR-655	CLIP-seq
MIRT1509719	hsa-miR-875-3p	CLIP-seq
MIRT1509700	hsa-miR-1243	CLIP-seq
MIRT1509701	hsa-miR-155	CLIP-seq
MIRT1509702	hsa-miR-200b	CLIP-seq
MIRT1509703	hsa-miR-200c	CLIP-seq
MIRT2666447	hsa-miR-203	CLIP-seq
MIRT2666448	hsa-miR-2276	CLIP-seq
MIRT1509729	hsa-miR-2467-3p	CLIP-seq
MIRT1509704	hsa-miR-3120-3p	CLIP-seq
MIRT1509705	hsa-miR-3148	CLIP-seq
MIRT1509706	hsa-miR-3157-3p	CLIP-seq
MIRT1509730	hsa-miR-3158-5p	CLIP-seq
MIRT1509707	hsa-miR-3654	CLIP-seq
MIRT1509731	hsa-miR-3678-3p	CLIP-seq
MIRT1509708	hsa-miR-374c	CLIP-seq
MIRT1509709	hsa-miR-3908	CLIP-seq
MIRT1509732	hsa-miR-3919	CLIP-seq
MIRT1509710	hsa-miR-429	CLIP-seq
MIRT1509711	hsa-miR-4290	CLIP-seq
MIRT1509735	hsa-miR-4311	CLIP-seq
MIRT1509712	hsa-miR-4509	CLIP-seq
MIRT1509713	hsa-miR-4687-5p	CLIP-seq
MIRT2666449	hsa-miR-4696	CLIP-seq
MIRT2666450	hsa-miR-4731-3p	CLIP-seq
MIRT1509737	hsa-miR-4761-3p	CLIP-seq
MIRT2666451	hsa-miR-4801	CLIP-seq
MIRT1509738	hsa-miR-539	CLIP-seq
MIRT1509716	hsa-miR-548c-3p	CLIP-seq
MIRT2666452	hsa-miR-548g	CLIP-seq
MIRT1509718	hsa-miR-655	CLIP-seq
MIRT1509719	hsa-miR-875-3p	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 21810480, 25416956, 30561431, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006625	Process	Protein targeting to peroxisome	IBA
GO:0006625	Process	Protein targeting to peroxisome	IEA
GO:0006625	Process	Protein targeting to peroxisome	ISS
GO:0006915	Process	Apoptotic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IBA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IEA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	ISS
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21810480
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IMP	21810480
GO:0046872	Function	Metal ion binding	IEA
GO:0071356	Process	Cellular response to tumor necrosis factor	IMP	21810480

MIM	HGNC	e!Ensembl
610183	30164	ENSG00000086666

Q6FIF0

Protein name

AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3)

Protein function

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-depend

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01754	zf-A20	12 → 35	A20-like zinc finger	Family
PF01428	zf-AN1	149 → 186	AN1-like Zinc finger	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta. {ECO:0000269|PubMed:11054541}.

Sequence

MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPATSVSSLSE
SLPVQCTDGSVPEAQSALDSTSSSMQPSPVSNQSLLSESVASSQLDSTSVDKAVPETEDV
QASVSDTAQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHN
CSYNYKADAAEKIRKENPVVVGEKIQKI

Sequence length

208

Interactions

View interactions

	Reactome
			Peroxisomal protein import

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DERMATOLOGIC DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASES, GENETIC	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arsenic Encephalopathy	Arsenic Encephalopathy	CTD_human_DG	16835338		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	CTD_human_DG	16835338		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	25273842, 26599349, 37738238	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	26599349		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	26599349	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	26599349	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	Pubtator	36036911	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	36980809	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity Abdominal	Obesity	Pubtator	26599349	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	27846195		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZFAND6 (zinc finger AN1-type containing 6)